Chest最新文献

{"title":"A New Dawn for Bronchoscopy for Peripheral Lung Lesions?","authors":"Ley T Chan, Christopher M Orton, Pallav L Shah","doi":"10.1016/j.chest.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.chest.2024.06.004","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"931-933"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Diagnosis and Management of Pulmonary Hypertension in Interstitial Lung Disease.","authors":"Lu Hao, Jisu Xue","doi":"10.1016/j.chest.2024.06.3806","DOIUrl":"https://doi.org/10.1016/j.chest.2024.06.3806","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"e175-e176"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on the Recent Study on Minocycline for Delirium Prevention in Patients in the ICU.","authors":"Xiaozhen Zhao, Caifeng Li","doi":"10.1016/j.chest.2024.05.048","DOIUrl":"https://doi.org/10.1016/j.chest.2024.05.048","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"e168-e169"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response.","authors":"Felipe Dal-Pizzol, Cristiane Ritter","doi":"10.1016/j.chest.2024.06.3825","DOIUrl":"https://doi.org/10.1016/j.chest.2024.06.3825","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"e169-e170"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis.","authors":"Melanie Holtrop, Sophia Cosmich, MinJae Lee, Ashley Keller, Raksha Jain","doi":"10.1016/j.chest.2024.05.019","DOIUrl":"10.1016/j.chest.2024.05.019","url":null,"abstract":"<p><strong>Background: </strong>Historically, studies show that female patients with cystic fibrosis (CF) have worse pulmonary outcomes than male patients, including decreased life expectancy. It is unknown whether this disparity persists in the new era of highly effective modulator therapies. Ivacaftor has been available in the United States for > 10 years, allowing for the opportunity to understand the impact this therapy may have on sex disparities in CF. We hypothesized that female patients will continue to show worse outcomes because we suspect that the disparity is not driven solely by ion channel dysfunction.</p><p><strong>Research question: </strong>Does a difference in outcomes between male and female patients persist after the initiation of ivacaftor in people with CF?</p><p><strong>Study design and methods: </strong>We conducted a retrospective cohort study using the CF Foundation Patient Registry comparing changes in pulmonary exacerbation rate, lung function (FEV₁ % predicted), and presence of Pseudomonas aeruginosa among male patients vs female patients before and after initiation of treatment with the highly effective modulator ivacaftor.</p><p><strong>Results: </strong>The cohort comprised 1,900 people with CF who were treated with ivacaftor between 2010 and 2017; 928 patients (48.84%) were male and 972 patients (51.16%) were female with a mean age of 33.09 years. Male patients showed a significant decrease in pulmonary exacerbations after ivacaftor treatment (from 0.38 to 0.34; adjusted rate ratio, 0.89; P = .028), whereas female patients did not (from 0.48 to 0.45; adjusted rate ratio, 0.95; P = .174). FEV₁ % predicted similarly decreased in both male and female patients before vs after ivacaftor treatment. P aeruginosa prevalence decreased to a similar extent in both male and female patients after ivacaftor treatment.</p><p><strong>Interpretation: </strong>Our findings demonstrate that sex disparities in CF persist in those treated with ivacaftor because of differences in pulmonary exacerbations. More research is needed to determine the specific pathophysiologic drivers of this disparity.</p>","PeriodicalId":9782,"journal":{"name":"Chest","volume":" ","pages":"951-962"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Age at Smoking Initiation, Age at Smoking Cessation, and Lower Respiratory Mortality: Prospective Study of 500,000 Adults in the United States.","authors":"Blake Thomson, Ahmedin Jemal, Farhad Islami","doi":"10.1016/j.chest.2024.04.022","DOIUrl":"10.1016/j.chest.2024.04.022","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":" ","pages":"1151-1154"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 54-Year-Old Man With High-Grade Fever, Cough, Dyspnea, and Vesiculobullous Skin Eruptions.","authors":"Anna Oppliger, Patrick M Meyer Sauteur, Robert Dahmen, Adrian Schibli, Bertram Feil, Mattia Arrigo, Lars C Huber","doi":"10.1016/j.chest.2024.05.034","DOIUrl":"https://doi.org/10.1016/j.chest.2024.05.034","url":null,"abstract":"<p><strong>Case presentation: </strong>A 54-year-old Egyptian man with a 5-day history of worsening cough, high-grade fever, and progressive dyspnea was referred to our hospital. A 3-day course of ceftriaxone provided in an outpatient setting showed no clinical improvement. Medical history was unremarkable, except for bilateral pulmonary embolism diagnosed 3 years earlier. The patient actively smoked and denied the use of alcohol and illicit drugs. The patient worked as cook and had lived in Switzerland for the past 10 years. Five weeks before the actual presentation, he had traveled to Egypt. One of his children showed symptoms of a respiratory infection approximately 2 weeks before that. His only regular medication was rivaroxaban.</p>","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"e141-e145"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the Loop on Diagnostic Testing in Interstitial Lung Disease.","authors":"Daniel C Chambers, John A Mackintosh","doi":"10.1016/j.chest.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.chest.2024.08.001","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"909-910"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant With Recurrent Infections Found to Have a Duplication of the Respiratory Tract.","authors":"Ziyin Shang, Cuiwei Liu, Yingxing Liu, Chun Hong, Chaoxiang Yang, Yuan Si","doi":"10.1016/j.chest.2024.05.039","DOIUrl":"https://doi.org/10.1016/j.chest.2024.05.039","url":null,"abstract":"<p><strong>Case presentation: </strong>A 10-month-old boy with a weight of 5 kg demonstrated recurrent respiratory infections after birth, respiratory distress after feeding, and slow weight gain. At the time of presentation, he had been experiencing a cough accompanied by pyrexia for > 20 days. Prenatal ultrasound examinations revealed no abnormalities. He was born at full term via cesarean delivery and weighed 2.9 kg at birth. He was hospitalized three times because of pneumonia.</p>","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"e137-e140"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Insights Into Air Pollution: Unraveling the Respiratory Impact Through the UK Biobank.","authors":"Min Hyung Ryu","doi":"10.1016/j.chest.2024.08.024","DOIUrl":"https://doi.org/10.1016/j.chest.2024.08.024","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"166 5","pages":"899-900"},"PeriodicalIF":9.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}