Cell & developmental biology最新文献_第8页

Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast 端粒酶的生物学和分子多样性:人类、脊椎动物和酵母中端粒酶的特征

Cell & developmental biology Pub Date : 2016-04-20 DOI: 10.4172/2168-9296.1000170

E. Abdollahi, P. Mehdipour

引用次数: 1

Trailing the Spawning Horseshoe Crab Tachypleus Gigas (MÃ¼ller, 1785)at Designated Natal Beaches on the East Coast of Peninsular Malaysia 在马来西亚半岛东海岸的指定纳塔尔海滩，追踪产卵的马蹄蟹Tachypleus Gigas (MÃ¼ller, 1785)

Cell & developmental biology Pub Date : 2016-04-02 DOI: 10.4172/2168-9296.1000171

Azwarfarid Manca, Faridah Mohamad, Bryan Raveen Nelson Muhd Fawwaz Afham Mohd Sofa, A. Alia’m, N. Ismail

{"title":"Trailing the Spawning Horseshoe Crab Tachypleus Gigas (MÃ¼ller, 1785)at Designated Natal Beaches on the East Coast of Peninsular Malaysia","authors":"Azwarfarid Manca, Faridah Mohamad, Bryan Raveen Nelson Muhd Fawwaz Afham Mohd Sofa, A. Alia’m, N. Ismail","doi":"10.4172/2168-9296.1000171","DOIUrl":"https://doi.org/10.4172/2168-9296.1000171","url":null,"abstract":"Due to limited availability of literature on the spawning activity of Malaysian horseshoe crab, Tachypleus gigas (Muller, 1785), the reproduction behaviour and biology of this arthropod remains poorly understood. Hence, an investigation was carried out from April-July to trail spawning horseshoe crab amplexus at Balok and Cherating, the only known T. gigas spawning grounds on the east coast of Peninsular Malaysia. Through visual tracking during daytime full moon spring tides, the release of air bubbles indicate nest digging by female crabs. While air bubble formation aggravated, flagged aluminium poles were carefully driven into the sediment to mark the nest. Out of the 13 spawning T. gigas amplexus tracked, only one pair was able to dig up to 12 nests and release up to 2,575 eggs within the 2.5 hour spawning period. The female crabs dug nests at the intertidal regions, ranging 1.3-43.2 m from the highest tide marking on the beach. Interestingly after spawning, the horseshoe crabs returned to high seas during the residing tides as amplexus because the male crabs remained clinging onto the female crab’s opisthosoma. The incidence of recapturing a tagged female crab with different attached male crab at Cherating indicates this spawning ground as natal beach. In addition, the presence of 8 horseshoe crab amplexus at Balok compared to only 5 amplexus at Cherating highlight preferable beach settings for spawning and/or the presence of larger spawning crab assemblages at the former beach. Since only 13 spawning horseshoe crab pairs were witnessed at Balok and Cherating, identification of factors that alter beach sediment composition and water chemistry as well as gender-specific poaching and excessive boating activities should be regulated to restore wild T. gigas populations.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86129495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Single Nucleotide Polymorphisms: A New Paradigm in Predicting the Risk of Prostate Cancer 单核苷酸多态性:预测前列腺癌风险的新范式

Cell & developmental biology Pub Date : 2016-02-24 DOI: 10.4172/2168-9296.1000168

S. Ghagane

{"title":"Single Nucleotide Polymorphisms: A New Paradigm in Predicting the Risk of Prostate Cancer","authors":"S. Ghagane","doi":"10.4172/2168-9296.1000168","DOIUrl":"https://doi.org/10.4172/2168-9296.1000168","url":null,"abstract":"Prostate cancer (PC) is a most important health care problem because of its high prevalence, health-related costs, and mortality. Even though most patients have clinically localized and indolent tumors at diagnosis, worldwide, this disease still holds second place in the leading causes of cancer deaths. Research on susceptibility genes is one of hot issues in risk factors of prostate cancer. Nevertheless, the confirmation of prostate cancer susceptibility genes has been challenging. Thus focusing on the increasing number of single nucleotide polymorphisms (SNPs) that have been suggested to be implicated in the development and progression of PC. While individual SNPs are only moderately associated with PC risk, in combination, they have a stronger association. Therefore, identification of numerous variations in genes and analysis of their effects may lead to a better understanding of their impact on gene function and health of an individual. This improved knowledge may provide a starting point for the development of new useful SNP markers for medical testing and a safer individualized medication to treat the most common devastating disorders. This will revolutionize the medical field in the future. To illustrate the effect of SNPs on gene function and phenotype, this review focuses on genetic susceptibility of prostate cancer and role of single nucleotide polymorphism and revealing the impact of SNPs on the development and progression of prostate cancer.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83640177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Characterization of Ion-Uptake for Single Osteoblast Cell under Electrical Stimuli 电刺激下单个成骨细胞离子摄取的表征

Cell & developmental biology Pub Date : 2016-02-19 DOI: 10.4172/2168-9296.1000169

S. Sarkar

引用次数: 0

Study of the Bovine Sarcosporidiosis in the Slaughterhouses of the North of Algeria: Case of the Slaughterhouses of El Harrach (Algiers) 阿尔及利亚北部屠宰场牛肉孢子虫病的研究——以阿尔及尔埃尔哈拉赫屠宰场为例

Cell & developmental biology Pub Date : 2016-02-04 DOI: 10.4172/2168-9296.1000167

M. Aissi

引用次数: 7

Chemotaxis in the Model Organism Dictyostelium discoideum and Human Neutrophils 模式生物盘状盘基骨菌与人中性粒细胞的趋化性

Cell & developmental biology Pub Date : 2016-01-02 DOI: 10.4172/2168-9296.1000e139

Xuehua Xu

{"title":"Chemotaxis in the Model Organism Dictyostelium discoideum and Human Neutrophils","authors":"Xuehua Xu","doi":"10.4172/2168-9296.1000e139","DOIUrl":"https://doi.org/10.4172/2168-9296.1000e139","url":null,"abstract":"Copyright: © 2016 Xu X. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Chemotaxis is referred as directional cell migration guided by chemoattractant gradients and plays critical roles in many physiological processes, including neuron patterning [1], the recruitment of neutrophils to sites of inflammation [2], metastasis of cancer cells [3], and development of model organism Dictyostelium discoideum [4]. All eukaryotic cells detect chemoattractants by G proteincoupled receptors (GPCRs) and share remarkable similarities in the signaling pathways which control chemotaxis [5]. D. discoideum has been proven as a powerful model system to identify new components essential for chemotaxis. During postdoc training, I developed and applied the state-of-the-art live cell/single molecule imaging techniques to visualize spatiotemporal dynamics of GPCR-mediated signaling network that leads to the chemotaxis in D. discoideum [6,7]. The interplay between computational simulation and experimental verification, my studies have revealed a locally-controlled inhibitory mechanism in the GPCR signaling network upstream of PI3K [8]. Ras is a key component of the chemosensing machinery upstream of PI3K. My long-term research interests is to investigate molecular mechanisms underlining chemotaxis in multiple systems: first, identify novel components and signaling pathways essential for chemotaxis using model organism D. discoideum; next, understand the roles of their mammalian counter partners in mammalian systems to identify new therapeutic strategies for inflammatory diseases and metastasis of breast cancer.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91312818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anticancer Drug Combinations, Studies from Different Pathways 抗癌药物组合，从不同途径的研究

Cell & developmental biology Pub Date : 2015-12-31 DOI: 10.4172/2168-9296.1000166

D. Lu

引用次数: 14

Artificial miRNAs for Specific Gene Silencing and Engineering Virus Resistance in Plants 用于植物特异性基因沉默和病毒抗性工程的人工mirna

Cell & developmental biology Pub Date : 2015-12-10 DOI: 10.4172/2168-9296.1000E137

M. Rajam

引用次数: 5

Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells. 肿瘤抑制因子与P19胚胎干细胞内胚层分化。

Cell & developmental biology Pub Date : 2015-12-01 Epub Date: 2015-12-30 DOI: 10.4172/2168-9296.1000e138

Jyotshna Kanungo

{"title":"Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells.","authors":"Jyotshna Kanungo","doi":"10.4172/2168-9296.1000e138","DOIUrl":"https://doi.org/10.4172/2168-9296.1000e138","url":null,"abstract":"The P19 embryonic stem (ES) cells are derivatives of the inner cell mass of a mouse blastoderm, are multipotent and can give rise to all three germ layers [1]. They are anchorage-independent, display no contact inhibition, and are tumorigenic [2]. The P19 ES cell line was originally derived from a teratocarcinoma in C3H/HE mice, produced by grafting an embryo at 7 days of gestation to the testes of an adult male mouse [3, 4]. Depending on the nature of inducers, P19 ES cells can be driven to differentiate into derivatives of all three germ layers, an advantage that has been extensively exploited to study early developmental events. Dimethyl sulfoxide (DMSO) treatment of P19 ES cell aggregates (embryoid bodies) results in differentiation into cardiac- and skeletal muscle-like cells [1], whereas retinoic acid (RA) induces differentiation into neurons, glia, and fibroblast-like cells [5]. On the other hand, monolayers of P19 ES cells, when treated with RA, differentiate into cells with endodermal and mesodermal phenotypes [6]. The type of differentiation of P19 ES cell aggregates also depends on the RA concentration; with low concentration (10 nM) of RA, these cells differentiate into primitive endoderm-like cells and with high concentrations (1 µM) of RA, differentiation is shifted towards neurons and glia [3, 7, 8].","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2168-9296.1000e138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34666537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Moderator Bands (Trabecula septomarginalis) of Mature Buffalo (Bosbubalis L.) with Special Emphasis on the Structure and Distribution of thePurkinje Cardiomyocytes: Histological and Histochemical 成熟水牛(Bosbubalis L.)的调节带(中隔小梁)，特别强调浦肯野心肌细胞的结构和分布:组织学和组织化学

Cell & developmental biology Pub Date : 2015-12-01 DOI: 10.4172/2168-9296.1000165

W. Ghonimi

{"title":"Moderator Bands (Trabecula septomarginalis) of Mature Buffalo (Bosbubalis L.) with Special Emphasis on the Structure and Distribution of thePurkinje Cardiomyocytes: Histological and Histochemical","authors":"W. Ghonimi","doi":"10.4172/2168-9296.1000165","DOIUrl":"https://doi.org/10.4172/2168-9296.1000165","url":null,"abstract":"Ten hearts of mature healthy Buffalo (Bos bubalis L.) were employed to investigate the histological and histochemical structures of the moderator bands. Hearts were gently dissected and the moderator bands were collected. The specimens were processed histologically and subjected to different stains. Grossly, the moderator band (Septomarginal trabeculae) was a single muscular band that was found only in the right ventricle of the buffalo heart. It extended from the interventricular septum to the free ventricular wall especially at the base of the papillary muscle, crossing and passing through the ventricular cavity. Histologically, the moderator band was invested in a dense capsule of connective tissue, endocardium that is mainly consisting of three layers; the endothelial layer of simple squamous epithelium, subendothelial layer of loose connective tissue and the subendocardial layer that connects the endocardium with myocardium. Internally, about 4/5 of the core, myocardium is of the cardiac muscle fibers that arranged in bundles of one direction while only about 1/5 is lodged by purkinje cardiomyocytes that were arranged in bundles distributing mainly in two areas within the moderator band; the subendocardial layer beneath the subendothelial connective tissue and myocardium in between the cardiac myocytes bundles. Centrally, a medium-sized artery of thick wall and a very distinct internal elastic lamina was observed running at the center of the band myocardium and is surrounded with the cardiac myocytes bundles.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84358567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5