Cell & developmental biology最新文献_第7页

Leptin Contributes to the Development of the Corpus Luteum. 瘦素有助于黄体的发育。

Cell & developmental biology Pub Date : 2017-01-01 Epub Date: 2017-12-12 DOI: 10.4172/2168-9296.1000190

Michelle R Garcia

{"title":"Leptin Contributes to the Development of the Corpus Luteum.","authors":"Michelle R Garcia","doi":"10.4172/2168-9296.1000190","DOIUrl":"https://doi.org/10.4172/2168-9296.1000190","url":null,"abstract":"The mechanistic events of female infertility have been investigated for over 50 years and despite progress many causes of infertility remain elusive. However, over half of idiopathic infertility issues have been attributed to a defective ovarian tissue responsible for the maintenance of a conceptus, the corpus luteum (CL). Many CL defects are attributed, in part, to abnormal vascularization (angiogenesis), which occurs primarily during the developmental stage of the luteal lifespan. A few well-established angiogenic growth promotants have been implicated in luteal angiogenic processes but the mechanisms of the process are still under investigation. Recent evidence supports a role for the adipokine hormone leptin as a probable component in the angiogenic and developmental processes of a CL. Leptin expression is present during the developmental and maturation stages of the luteal lifespan and stimulates the expression of angiogenic hormones in the CL. Induced leptin deficient CL have a higher occurrence of abnormal, underdeveloped gross morphology and an increase in the number of large diameter vessels and large luteal cells. Leptin replacement therapy in leptin deficient CL accelerates tissue development, increasing overall tissue mass and forming a structure that resembled a mature CL during the early stages of development. Collectively, the evidence supports the supposition that leptin is involved in the angiogenic and developmental processes of luteal tissue.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2168-9296.1000190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35793607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

"Obesity Paradox" in Heart Failure: The Possible Role of Progenitor Endothelial Cell Dysfunction 心力衰竭中的“肥胖悖论”:祖内皮细胞功能障碍的可能作用

Cell & developmental biology Pub Date : 2017-01-01 DOI: 10.4172/2168-9296.1000179

A. Berezin

引用次数: 1

Impaired Autophagy in Retinal Pigment Epithelial Cells Induced from iPS Cells obtained from a Patient with Sialidosis 唾液中毒患者诱导的iPS细胞诱导视网膜色素上皮细胞自噬受损

Cell & developmental biology Pub Date : 2017-01-01 DOI: 10.4172/2168-9296.1000188

Odontuya Davaadorj, H. Akatsuka, Yoshiki Yamaguchi, Chisa Okada, Masatoshi Ito, N. Fukunishi, Y. Sekijima, H. Ohnota, K. Kawai, Takahiro Suzuki, Takehito Sato, Yasuyuki Suzuki

引用次数: 3

Differential Response of Human Embryonic Stem and Somatic Cells to Non-Cytotoxic Hydrogen Peroxide Exposure: An Attempt to Model In Vitro the Effects of Oxidative Stress on the Early Embryo. 人类胚胎干细胞和体细胞对非细胞毒性过氧化氢暴露的差异反应:早期胚胎氧化应激的体外模型研究

Cell & developmental biology Pub Date : 2016-08-31 DOI: 10.4172/2168-9296.1000177

M. Barandalla, S. Colleoni, G. Lazzari

{"title":"Differential Response of Human Embryonic Stem and Somatic Cells to Non-Cytotoxic Hydrogen Peroxide Exposure: An Attempt to Model In Vitro the Effects of Oxidative Stress on the Early Embryo.","authors":"M. Barandalla, S. Colleoni, G. Lazzari","doi":"10.4172/2168-9296.1000177","DOIUrl":"https://doi.org/10.4172/2168-9296.1000177","url":null,"abstract":"Human Embryonic Stem Cells (hESCs) potentially offer a unique in vitro model to study how an adverse environment during the early developmental stages post-fertilization can affect the physiology of the undifferentiated embryonic stem cells existing in the early embryo and predispose to long term effects on the offspring, according to the Developmental Origins of Health and Disease (DOHaD) concept. A number of unfavourable conditions can affect the development of the early embryo inducing oxidative stress both in vivo, for instance in gestational diabetes and in vitro, when embryos are derived from Assisted Reproductive Technologies (ART). Therefore, the aim of this study was the development of a novel in vitro model to analyse the effects of oxidative stress and the antioxidant response against Reactive Oxygen Species (ROS) in embryonic stem cells in comparison with somatic cells, fibroblasts and endothelial cells. To this purpose we designed an in vitro protocol based on hydrogen peroxide (H2O2) treatment of 72 h, in order to better resemble the period of embryonic development from the early cleavages to the blastocyst stage. We demonstrate that H2O2 treatment induces the modification of crucial oxidative stress biomarkers like ROS and lipid peroxidation levels, and mobilizes several antioxidant enzymes through NFkβ translocation. Moreover we show differences between somatic and embryonic cells in their antioxidant response towards H2O2 induced damage. Therefore this study presents a promising in vitro model to investigate the effects of oxidative stress conditions on early human embryonic cells.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88874796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Molecular Characterization and Expression Profiling of ENOX2 Gene in Response to Heat Stress in Goats 山羊热应激反应中ENOX2基因的分子特征及表达谱分析

Cell & developmental biology Pub Date : 2016-08-31 DOI: 10.4172/2168-9296.1000176

R. Kaushik, M. Dige, P. Rout

引用次数: 8

Current Drug Design Studies for Hsp70 in Oncological Applications 当前Hsp70在肿瘤应用中的药物设计研究

Cell & developmental biology Pub Date : 2016-07-17 DOI: 10.4172/2168-9296.1000E140

K. Coskun, L. Tutar, Yusuf Tutar

引用次数: 2

Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury. 细胞外囊泡促进肺损伤发病机制中的细胞间通讯。

Cell & developmental biology Pub Date : 2016-07-07 DOI: 10.4172/2168-9296.1000175

Heedoo Lee, Duo Zhang, J. Minhas, Yang Jin

{"title":"Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury.","authors":"Heedoo Lee, Duo Zhang, J. Minhas, Yang Jin","doi":"10.4172/2168-9296.1000175","DOIUrl":"https://doi.org/10.4172/2168-9296.1000175","url":null,"abstract":"Extracellular vesicles (EVs) are a group of heterogeneous, nano-sized structures surrounded by lipid bilayer membranes that are released by cells. Depending on their size and mechanisms of formation, EVs are often referred to as exosomes, microvesicles (MVs) and apoptotic bodies (AB). EVs are evolutionally conserved vesicles that mediate intercellular communications and cross-talk, via transferring proteins, lipids and nucleic acids. Accumulating evidence suggests that EVs exert essential physiological and pathological functions on both their mother and recipient cells. Therefore, growing interests focus on the potentials of EVs to serve as novel targets for the development of therapeutic and diagnostic strategies. Currently, extensive reports are yielded from cancer research. However, besides malignancy, EVs may also serve as crucial regulators in other devastating conditions, such as the acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). The generation, regulation and function of EVs in ARDS/ALI are largely unexplored. In this mini review, we will briefly review the current understanding of EVs and their known physiological/pathological functions in the pathogenesis of ARDS/ALI. Previously, only scattered reports have been published in this field. We believe that further investigations focusing on EVs and their compositions will shed light on novel insights in the research of ARDS/ALI.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78945806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Neurodegenerative Diseases: In Vitro Culture of Neural Progenitor and Neural Stem Cells Challenges and Hopes 神经退行性疾病:神经祖细胞和神经干细胞体外培养的挑战与希望

Cell & developmental biology Pub Date : 2016-07-07 DOI: 10.4172/2168-9296.1000174

M. Lopez-Diaz

引用次数: 1

Utilization of Novel Delivery Drug Systems Based on Release of Extracellular Vesicles in Heart Failure 基于细胞外囊泡释放的新型给药系统在心力衰竭中的应用

Cell & developmental biology Pub Date : 2016-06-15 DOI: 10.4172/2168-9296.1000173

A. Berezin

引用次数: 0

Methylenetetrahydrofolate Reductase Gene Polymorphisms and Cardiovascular Diseases 亚甲基四氢叶酸还原酶基因多态性与心血管疾病

Cell & developmental biology Pub Date : 2016-05-21 DOI: 10.4172/2168-9296.1000172

M. A. Alam

引用次数: 4