Central European Journal of Urology最新文献

{"title":"Review of vasocutaneous fistulas and other rare complications after vasectomy.","authors":"Robby P A Lamoury,&nbsp;Jasper Pauwels,&nbsp;Stefan De Wachter,&nbsp;Tim Brits","doi":"10.5173/ceju.2023.04","DOIUrl":"10.5173/ceju.2023.04","url":null,"abstract":"<p><strong>Introduction: </strong>Vasectomy is a surgical procedure for male sterilization. It is a very common procedure in daily urological practice with a low complication rate. Haematoma formation, wound infection, chronic scrotal pain, and spontaneous recanalization are well-known complications. Fistula formation and testicular infarction are less common following a vasectomy. In this article we provide a review of literature regarding rare complications after vasectomy.</p><p><strong>Material and methods: </strong>A manual electronic search of the PubMed Medline and Web of Science Core Collection databases was performed encompassing all included reports until 30 September 2022 to identify studies that assessed patient complications after a vasectomy.</p><p><strong>Results: </strong>Urethrovasocutaneous fistulas are by far the most prevalent, while vasocutaneous, vasovenous, and arteriovenous fistulas are seldom reported. In discharging fistulas, a fluid analysis can be done to discriminate different types. In all cases scrotal exploration and ligation of the fistula was performed. If present, an underlying bladder outlet obstruction should be treated. Scrotal infarction is another infrequently reported complication of vasectomy. Diagnosis is made by scrotal ultrasound and colour Doppler. Treatment is usually conservative, but orchiectomy should be considered in larger infarctions. Simple wound infections are common in patients post vasectomy. More complex infections are rare but can result in serious and even fatal complications.</p><p><strong>Conclusions: </strong>Common complications after vasectomy are well known and usually well discussed with patients. However, rare complications can occur, and it is important that they are recognized by clinicians.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 2","pages":"155-161"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/fe/CEJU-76-4.PMC10357828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9866163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pelvic floor muscle training on urodynamic parameters in women with stress urinary incontinence.","authors":"Ioannis Tsikopoulos, Lazaros Lazarou, Lazaros Tzelves, Vasileios Sakalis, Christina Papathanasiou, Michael Samarinas","doi":"10.5173/ceju.2023.148","DOIUrl":"10.5173/ceju.2023.148","url":null,"abstract":"<p><strong>Introduction: </strong>Pelvic floor muscle training (PFMT) is suggested for women with stress urinary incontinence (SUI). The aim of our study is to examine the effectiveness of PFMT on urodynamic (UDS) parameters.</p><p><strong>Material and methods: </strong>This is a prospective observational study enrolling women with SUI. Pelvic surgery, prolapse, body mass index >30, and cognitive disability were exclusion criteria. Patients had baseline UDS, then PFMT only (Group A) or PFMT plus biofeedback (BFD) (Group B) for 6 months and UDS 3 months after treatment. The primary investigated parameters were the number of pads used per day and Valsalva leak point pressure (VLPP).</p><p><strong>Results: </strong>Forty-six women completed the study, 22 in Group A and 24 in Group B. At baseline, all patients documented SUI with 3 median pads used per day. Urodynamic SUI was documented with a median Valsalva leak point pressure (mVLPP) of 45 cmH₂O. At the re-evaluation, 12 women (26.1%) had SUI in BDs with median number pads per day of 1, which was statistically different to baseline (p = 0.02). Urodynamic SUI was reported in 8 (17.4%) women with a mVLPP of 88 cmH₂O.Six patients were from Group A and 6 from Group B. In Group A, the median number of pads per day was 1, and urodynamic SUI was found in 3 women. In Group B, the median number of pads per day was 1, and urodynamic SUI was found in 5 women. Thirty-four women (73.9%) were dry - 16 (47.1%) from Group A and 18 (52.9%) from Group B.</p><p><strong>Conclusions: </strong>PFMT improves urodynamic parameters among women with SUI.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"315-321"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of percussion, diuresis and inversion therapy on RIRS success for lower renal pole stones.","authors":"Caglar Sarioglu, Samet Senel, Emre Uzun, Muhammed Emin Polat, Kazim Ceviz, Oner Odabas, Antonios Koudonas","doi":"10.5173/ceju.2023.189","DOIUrl":"10.5173/ceju.2023.189","url":null,"abstract":"<p><strong>Introduction: </strong>Inversion of the patient, forced diuresis after hydration, and mechanical percussion technique was developed for lower renal pole (LRP) stones with extracorporeal shock wave (ESWL). In this study, we aimed to analyze the effect of percussion, diuresis and inversion (PDI) therapy on the success rates of retrograde intrarenal surgery (RIRS) for the LRP stones.</p><p><strong>Material and methods: </strong>114 patients who underwent RIRS for LRP stones <2cm were included in this study. Patients' demographic, clinical, radiological and anatomical features and success status were recorded prospectively. The patients were divided into two groups. One group received RIRS procedure only (non-PDI group) and the other group received PDI therapy after the RIRS procedure (PDI group).</p><p><strong>Results: </strong>PDI was performed to 60 (52.6%) patients, and not performed to 54 (47.4%) patients. The success rate (58.3%) for the PDI group was higher than the non-PDI group (25.9%), and this difference was statistically significant (p <0.001). In multivariate logistic regression analysis, stone size (OR = 1.306; 95% CI = 1.019-1.674; p <0.001), IU (OR = 1.702; 95% CI = 1.383-2.096; p <0.001) and not performing PDI therapy (p <0.001) OR = 9.455; 95% Cl = 2.426-10.853; p = 0.001) were revealed to be independent risk factors for failure.</p><p><strong>Conclusions: </strong>PDI therapy increases the success rates of RIRS performed for the LRP stones.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"325-330"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflection points in urology as witnessed by Mark Soloway Part 2: Prostate and kidney cancers.","authors":"Mark S Soloway","doi":"10.5173/ceju.2023.3E","DOIUrl":"10.5173/ceju.2023.3E","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"283-286"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative evaluation of radical prostatectomy using laparoscopic and open method in view of surgical margins","authors":"","doi":"10.5173/ceju.2023.77","DOIUrl":"https://doi.org/10.5173/ceju.2023.77","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation after radical prostatectomy in elderly patients - a SEER database-derived competing-risk survival analysis of propensity score-matched age groups.","authors":"Piotr Zapała, Aleksander Ślusarczyk, Łukasz Zapała, Tomasz Borkowski, Paweł Rajwa, Grzegorz Niemczyk, Piotr Radziszewski","doi":"10.5173/ceju.2023.144","DOIUrl":"10.5173/ceju.2023.144","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate cancer-specific (CSM) and other-cause mortality (OCM) in elderly patients with prostate cancer treated with radical prostatectomy (RP) and postoperative radiotherapy (RT).</p><p><strong>Material and methods: </strong>The Surveillance, Epidemiology, and End Results (SEER) database was searched for clinically non-metastatic prostate cancer (PCa) treated with RT after RP between 2010 and 2015. Patients were stratified according to age groups and underwent propensity score (PS) matching. The Kaplan-Meier method and competing-risk Cox regression (CRR) were used for survival analysis.</p><p><strong>Results: </strong>In total, 5385 patients were analysed, including 738 (13.7%) elderly patients (≥70 years old) and 4647 (86.29%) younger individuals. A total of 54 (7.32%) and 69 (9.35%) patients aged ≥70 years died due to PCa and competing reasons, respectively. Among younger patients these included 275 (5.92%) and 208 (4.48%) deaths, respectively. At a median follow-up of 80 months, patients ≥70 years old had significantly shorter OCM (p <0.0001) than PS-matched younger controls without significant impairment of cancer-specific survival when compared to controls (p = 0.19). In CRR analysis older patients were at significantly higher risk of OCM (HR = 2.24, p = 0.0002 and HR = 3.3, p = 0.011 for patients aged ≥70 and ≥75 years, respectively). Simultaneously, the CRR revealed no increased risk of CSM for patients older than 70 and 75 years (HR = 1.2, p = 0.33 and HR = 1.53, p = 0.29, respectively).</p><p><strong>Conclusions: </strong>Elderly patients with PCa are at high risk of dying due to competing reasons, which might prevent the survival benefit of RT after RP. Selection for salvage and adjuvant RT in these individuals should be cautious.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"293-299"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics vs radiologist in bladder and renal cancer. Results from a systematic review.","authors":"Pietro Tramanzoli,&nbsp;Daniele Castellani,&nbsp;Virgilio De Stefano,&nbsp;Carlo Brocca,&nbsp;Carlotta Nedbal,&nbsp;Giuseppe Chiacchio,&nbsp;Andrea Benedetto Galosi,&nbsp;Rodrigo Donalisio Da Silva,&nbsp;Jeremy Yuen-Chun Teoh,&nbsp;Ho Yee Tiong,&nbsp;Nithesh Naik,&nbsp;Bhaskar K Somani,&nbsp;Vineet Gauhar","doi":"10.5173/ceju.2023.252","DOIUrl":"https://doi.org/10.5173/ceju.2023.252","url":null,"abstract":"<p><strong>Introduction: </strong>Radiomics in uro-oncology is a rapidly evolving science proving to be a novel approach for optimizing the analysis of massive data from medical images to provide auxiliary guidance in clinical issues. This scoping review aimed to identify key aspects wherein radiomics can potentially improve the accuracy of diagnosis, staging, and grading of renal and bladder cancer.</p><p><strong>Material and methods: </strong>A literature search was performed in June 2022 using PubMed, Embase, and Cochrane Central Controlled Register of Trials. Studies were included if radiomics were compared with radiological reports only.</p><p><strong>Results: </strong>Twenty-two papers were included, 4 were pertinent to bladder cancer, and 18 to renal cancer. Radiomics outperforms the visual assessment by radiologists in contrast-enhanced computed tomography (CECT) to predict muscle invasion but are equivalent to CT reporting by radiologists in predicting lymph node metastasis. Magnetic resonance imaging (MRI) radiomics outperforms radiological reporting for lymph node metastasis. Radiomics perform better than radiologists reporting the probability of renal cell carcinoma, improving interreader concordance and performance. Radiomics also helps to determine differences in types of renal pathology and between malignant lesions from their benign counterparts. Radiomics can be helpful to establish a model for differentiating low-grade from high-grade clear cell renal cancer with high accuracy just from contrast-enhanced CT scans.</p><p><strong>Conclusions: </strong>Our review shows that radiomic models outperform individual reports by radiologists by their ability to incorporate many more complex radiological features.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 1","pages":"12-19"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/b8/CEJU-76-252.PMC10091893.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9316747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and accuracy of prostate cancer risk calculators in prediction of prostate cancer, extraprostatic extension as well as the risk of lymph nodes metastasis.","authors":"Kacper Kulik,&nbsp;Rafał Brzóska,&nbsp;Ewelina Mazurek,&nbsp;Magdalena Ostrowska,&nbsp;Adam Ostrowski,&nbsp;Filip Kowalski,&nbsp;Jacek Wilamowski,&nbsp;Tomasz Drewa,&nbsp;Jan Adamowicz,&nbsp;Kajetan Juszczak","doi":"10.5173/ceju.2023.168","DOIUrl":"https://doi.org/10.5173/ceju.2023.168","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this article was to evaluate the accuracy of European Randomized study of Screening for Prostate Cancer (ERSPC 4) and Prostate Cancer Prevention Trial (PCPT 2.0) risk calculator on predicting high-grade prostate cancer (HGPCa) and accuracy of Partin and Briganti nomograms on organ confined (OC) or extraprostatic cancer (EXP), seminal vesicles invasion (SVI) and risk of lymph nodes metastasis.</p><p><strong>Material and methods: </strong>A cohort of 269 men aged between 44-84 years, who underwent radical prostatectomy was retrospectively analysed. Based on estimated calculator risk, patients were divided into risk groups: low (LR), medium (MR) and high (HR). Results obtained with calculators were compared to post-surgical final pathology outcome.</p><p><strong>Results: </strong>In ERPSC4, the average risk for HGPC was LR = 5%, MR = 21%, and HR = 64%. In PCPT 2.0, the average risk for HG was: LR - 8%, MR - 14%, and HR - 30%. In the final results, HGPC was observed in: LR = 29%, MR = 67%, and HR = 81%. In Partin, LNI was estimated to occur in: LR = 1%, MR = 2%, and HR = 7.5% and in Briganti: LR = 1.8%, MR = 11.4%, and HR = 44.2% while finally it was found in: LR = 1.3%, MR = 0%, and HR = 11.6%.</p><p><strong>Conclusions: </strong>ERPSC 4 and PCPT 2.0 corresponded well with each other as well as Partin and Briganti. ERPSC 4 was more accurate in predicting HGPC than PCPT 2.0. Partin was more accurate as for LNI than Briganti. In this study group a large underestimation was observed in reference to Gleason grade.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 1","pages":"20-24"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/2f/CEJU-76-168.PMC10091896.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9316749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polish version of the Acute Cystitis Symptom Score for patients with acute uncomplicated cystitis.","authors":"Kurt G Naber,&nbsp;Jakhongir F Alidjanov,&nbsp;Tomasz Blicharski,&nbsp;Magdalena Cerska,&nbsp;Waldemar Gadzinski,&nbsp;Jan Kawecki,&nbsp;Wojciech Krajewski,&nbsp;Pawel Miotla,&nbsp;Piotr Napora,&nbsp;Maciej Paszkowski,&nbsp;Slawomir Poletajew,&nbsp;Marcin Sieczkowski,&nbsp;Marcin Zaremba,&nbsp;Adrian Pilatz,&nbsp;Florian M E Wagenlehner","doi":"10.5173/ceju.2023.120","DOIUrl":"10.5173/ceju.2023.120","url":null,"abstract":"<p><strong>Introduction: </strong>The Acute Cystitis Symptom Score (ACSS) is a self-reporting questionnaire to evaluate the symptoms and quality of life in women with uncomplicated acute cystitis (AC). The aim of the current study was the additional cognitive and clinical validation of the Polish version.</p><p><strong>Material and methods: </strong>Professional forward and backward translations from original Russian to Polish were performed by Mapi SAS. For cognitive assessment, women with different ages and educational levels were asked to comment on each item of the Polish ACSS to establish the final study version. The clinical validation was performed as a prospective, non-interventional cohort study. Women with AC (Patients) and those without (Controls) filled in the Polish ACSS during their visits to a physician's office and at a follow-up visit. Statistical analysis included ordinary descriptive values, calculation of reliability, validity, discriminative ability, responsiveness (sensitivity, specificity), and comparative analysis.</p><p><strong>Results: </strong>The cognitive assessment was performed in 60 women with a median (range) age of 44.5 (21-88) years and different educational levels: grade school (n = 8), high school (n = 25), college (n = 22), and postgraduate education (n = 5). Forty-three patients were recruited for the clinical validation study along with 34 controls. Statistical analyses resulted in excellent values of internal consistency, discriminative ability, and validity for diagnosis of AC. At a summary score of 6 and higher in the ´Typical´ domain, positive and negative predictive values were 97% and 79%, and sensitivity and specificity were 79% and 97%, respectively.</p><p><strong>Conclusions: </strong>The Polish version of the ACSS has demonstrated benefits for diagnosis and patient-reported outcome assessment. It is objective, fast, and cost-effective, and it may help to easily confirm the accurate diagnosis of AC. The Polish ASCSS can now be recommended for use in clinical and epidemiological studies, in clinical practice, or for self-diagnosis and patient-reported outcome in women with symptoms of AC.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 2","pages":"144-154"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/6c/CEJU-76-120.PMC10357829.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9864200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of the type and number of D'Amico high-risk criteria with rates of pathologically non-organ-confined prostate cancer.","authors":"Francesco Chierigo,&nbsp;Rocco Simone Flammia,&nbsp;Gabriele Sorce,&nbsp;Benedikt Hoeh,&nbsp;Lukas Hohenhorst,&nbsp;Zhe Tian,&nbsp;Fred Saad,&nbsp;Michele Gallucci,&nbsp;Alberto Briganti,&nbsp;Francesco Montorsi,&nbsp;Felix K H Chun,&nbsp;Markus Graefen,&nbsp;Shahrokh F Shariat,&nbsp;Giovanni Guano,&nbsp;Guglielmo Mantica,&nbsp;Marco Borghesi,&nbsp;Nazareno Suardi,&nbsp;Carlo Terrone,&nbsp;Pierre I Karakiewicz","doi":"10.5173/ceju.2023.030","DOIUrl":"10.5173/ceju.2023.030","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to assess the association between the type and number of D'Amico high-risk criteria (DHRCs) with rates of pathologically non-organ-confined (NOC) prostate cancer in patients treated with radical prostatectomy (RP) and pelvic lymphadenectomy (PLND).</p><p><strong>Material and methods: </strong>In the Surveillance, Epidemiology, and End Results database (2004-2016), we identified 12961 RP and PLDN patients with at least one DHRC. We relied on descriptive statistics and multivariable logistic regression models.</p><p><strong>Results: </strong>Of 12 961 patients, 6135 (47%) exclusively harboured biopsy Gleason score (GS) 8-10, 3526 (27%) had clinical stage ≥T2c, and 1234 (9.5%) had prostate-specific antigen (PSA) >20 ng/mL. Only 1886 (15%) harboured any combination of 2 DHRCs. Finally, all 3 DHRCs were present in 180 (1.4%) patients. NOC rates increased from 32% for clinical T stage ≥T2c to 49% for either GS 8-10 only or PSA >20 ng/mL only and to 66-68% for any combination of 2 DHRCs, and to 84% for respectively all 3 DHRCs, which resulted in a multivariable logistic regression OR of 1.00, 2.01 (95% CI 1.85-2.19; p <0.001), 4.16 (95% CI 3.69-4.68; p <0.001), and 10.83 (95% CI 7.35-16.52; p <0.001), respectively.</p><p><strong>Conclusions: </strong>Our study indicates a stimulus-response effect according to the type and number of DHRCs. Hence, a formal risk-stratification within high-risk prostate cancer patients should be considered in clinical decision-making.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 2","pages":"104-108"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/4e/CEJU-76-30.PMC10357822.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9864202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}