Central European Journal of Immunology最新文献_第3页

CSF3R as a potential prognostic biomarker and immunotherapy target in glioma. CSF3R 作为胶质瘤潜在的预后生物标记物和免疫疗法靶点。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-06-21 DOI: 10.5114/ceji.2024.140651

Minglei Huang, Longze Zhang, Yan Wu, Xue Zhou, Yanyang Wang, Jidong Zhang, Ye Liu, Zhixu He, Xianyao Wang

{"title":"CSF3R as a potential prognostic biomarker and immunotherapy target in glioma.","authors":"Minglei Huang, Longze Zhang, Yan Wu, Xue Zhou, Yanyang Wang, Jidong Zhang, Ye Liu, Zhixu He, Xianyao Wang","doi":"10.5114/ceji.2024.140651","DOIUrl":"https://doi.org/10.5114/ceji.2024.140651","url":null,"abstract":"Introduction: Gliomas are the most common malignant brain tumors, with complicated etiology and poor prognosis. However, there is still a lack of specific biomarkers for the diagnosis, treatment and prognosis assessment for glioma patients. Hence, the purpose of this study was to screen biomarkers for prognostic assessment and therapeutic interventions in gliomas.Material and methods: We utilized The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases to investigate the role of colony-stimulating factor 3 receptor (CSF3R) in glioma. Data analysis was conducted using R, GEPIA 2, TISCH and DepMap.Results: CSF3R was up-regulated in glioma and associated with the clinical pathological features of the patients. Kaplan-Meier survival analysis indicated a significant association between the expression of CSF3R and prognosis in patients. Univariate and multivariate Cox analyses revealed that patients with high expression of CSF3R have a worse prognosis, and the expression of CSF3R was an independent prognostic factor in gliomas. The nomogram constructed based on the expression of CSF3R demonstrated lower 1-, 3-, and 5-year overall survival (OS) in patients with high CSF3R expression. The biological functional analysis of CSF3R demonstrated its association with various immune regulatory signals. Furthermore, CSF3R was linked to the expression of immune checkpoints and resistance to immunotherapy. Notably, CSF3R was predominantly detected in monocytes/macrophages.Conclusions: Our study suggested that CSF3R might potentially function as an independent prognostic factor for glioma and hold promise as a biomarker and target for immunotherapy in glioma.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 2","pages":"155-168"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of periodontal health and disease on interleukin 1β and nesfatin-1 levels in gingival crevicular fluid: A cross-sectional study. 牙周健康和疾病对牙龈龈沟液中白细胞介素 1β 和内司蛋白-1 水平的影响：一项横断面研究。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-07-10 DOI: 10.5114/ceji.2024.140637

Meral Uzunkaya, Eda Çetin Özdemir, Hasan Gündoğar, Ergül Belge Kurutaş

{"title":"The effect of periodontal health and disease on interleukin 1β and nesfatin-1 levels in gingival crevicular fluid: A cross-sectional study.","authors":"Meral Uzunkaya, Eda Çetin Özdemir, Hasan Gündoğar, Ergül Belge Kurutaş","doi":"10.5114/ceji.2024.140637","DOIUrl":"https://doi.org/10.5114/ceji.2024.140637","url":null,"abstract":"Introduction: Periodontitis, a chronic inflammatory disease associated with dental biofilm, poses a significant threat to oral health. This study explores the roles of interleukin 1β (IL-1β) and nesfatin-1 in periodontal diseases, aiming to contribute to the molecular understanding of their pathogenesis.Material and methods: A diverse cohort of 62 participants was recruited, spanning ages 20 to 60, and categorized into healthy, gingivitis, and periodontitis groups. Clinical measurements, including plaque index, gingival index, probing pocket depth, and bleeding on probing, were conducted. Gingival crevicular fluid (GCF) samples were collected for IL-1β and nesfatin-1 analysis using enzyme-linked immunosorbent assay (ELISA). Statistical analysis employed Kruskal-Wallis and Spearman correlation tests.Results: Significant differences in oral hygiene habits were observed among groups, particularly in the 40-60 age range. Clinical indices showed variations, with the highest IL-1β levels in the periodontitis group and the lowest nesfatin-1 levels. Correlation analysis revealed positive associations between IL-1β, nesfatin-1, and oral indices.Conclusions: While providing valuable insights, we acknowledge this study's limitations, including a cross-sectional design and a specific age range. Future research should employ longitudinal designs and larger cohorts, and explore broader inflammatory markers, genetic influences, and confounding variables for a more comprehensive understanding of periodontal diseases. The findings underscore the complex interplay between inflammatory markers and periodontal health.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 2","pages":"187-193"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA DLEU1 contributes to the progression of septic myocardial dysfunction by targeting miR-381-3p.

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-11-12 DOI: 10.5114/ceji.2024.144199

Tian Tian, Na Zhang, Guoxin Hu, Rong Lu, Jian Liu

{"title":"LncRNA DLEU1 contributes to the progression of septic myocardial dysfunction by targeting miR-381-3p.","authors":"Tian Tian, Na Zhang, Guoxin Hu, Rong Lu, Jian Liu","doi":"10.5114/ceji.2024.144199","DOIUrl":"10.5114/ceji.2024.144199","url":null,"abstract":"Introduction: Cardiac dysfunction is a common complication of sepsis. This study aimed to elucidate the regulatory effect of DLEU1 on sepsis-induced myocardial injury.Material and methods: HL-1 cardiomyocytes were treated with lipopolysaccharide (LPS) to mimic sepsis-induced myocardial injury in vitro, and the mouse septic model was established through cecum ligation and perforation (CLP). Cell viability was evaluated using Cell Counting Kit-8 (CCK-8), while apoptosis was assessed via Annexin-V staining. Pro-inflammatory factors including tumor necrosis factor α (TNF-α), interleukin (IL)-1 β, IL-6, and oxidative stress indicators were detected by ELISA kits. Cardiac function in mice was determined using cardiac ultrasound, and myocardial indices were detected by ELISA.Results: DLEU1 levels were up-regulated gradually in HL-1 cardiomyocytes after LPS treatment in a dose-dependent manner, along with the overactivation of inflammatory responses and oxidative stress. DLEU1 downregulation alleviated LPS-induced cell apoptosis, inflammatory response and oxidative stress. In vivo, DLEU1 knockdown improved the cardiac function of septic mice, and alleviated inflammation and oxidative stress. MiR-381-3p, acting as a competing endogenous RNA (ceRNA) of DLEU1, reversed the effects of DLEU1 in both septic cell and mouse models.Conclusions: The results indicate that the DLEU1/miR-381-3p axis is an intrinsic regulator of myocardial injury in sepsis.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 3","pages":"227-237"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function.

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-11-09 DOI: 10.5114/ceji.2024.144071

Filip Lewandowski, Paulina Niedźwiedzka-Rystwej

{"title":"New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function.","authors":"Filip Lewandowski, Paulina Niedźwiedzka-Rystwej","doi":"10.5114/ceji.2024.144071","DOIUrl":"10.5114/ceji.2024.144071","url":null,"abstract":"Recent advances in immunology have challenged the conventional division of T-lymphocyte function by uncovering novel subpopulations with diverse roles and characteristics. This article reviews these discoveries and their implications for understanding immune regulation and disease pathogenesis. Innovative techniques have enabled the identification of previously unrecognized T-lymphocyte subsets, disrupting the classical classification system. Helper lymphocytes, including Tfh1, Tfh2, Tfh17, GC-Tfh, and circulating Tfh cells, exhibit distinct functions in immune responses and disease states. Additionally, newly identified cytotoxic T-cell subsets, such as CD8+CD39+ and CD8+CD28+ cells, demonstrate unique effector properties with potential therapeutic applications in cancer immunothe- rapy. Furthermore, the discovery of CD20+ T cells challenges traditional views, offering new avenues for immunotherapy in cancer, autoimmune disorders, and infectious diseases. These findings expand our understanding of T-lymphocyte biology and suggest targets for more effective therapeutic interventions. Further research is essential to fully elucidate the clinical relevance and therapeutic potential of these T-lymphocyte subpopulations, paving the way for personalized and targeted immune-based treatments.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 3","pages":"308-314"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the interplay between influenza vaccination and SARS-CoV-2 immune responses. 揭示流感疫苗接种与 SARS-CoV-2 免疫反应之间的相互作用。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-05-09 DOI: 10.5114/ceji.2024.139512

Jacek Tabarkiewicz, Urszula Radzikowska, Andrzej Eljaszewicz

引用次数: 0

Progression patterns in patients with advanced hepatocellular carcinoma treated with local therapy, targeted drugs, and PD-1/PD-L1 inhibitors. 接受局部治疗、靶向药物和 PD-1/PD-L1 抑制剂治疗的晚期肝细胞癌患者的病情进展模式。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-08-26 DOI: 10.5114/ceji.2024.142418

Yanan Zhao, Di Wu, Quanjun Yao, Hang Yuan, Hongtao Hu, Hailiang Li

{"title":"Progression patterns in patients with advanced hepatocellular carcinoma treated with local therapy, targeted drugs, and PD-1/PD-L1 inhibitors.","authors":"Yanan Zhao, Di Wu, Quanjun Yao, Hang Yuan, Hongtao Hu, Hailiang Li","doi":"10.5114/ceji.2024.142418","DOIUrl":"https://doi.org/10.5114/ceji.2024.142418","url":null,"abstract":"Introduction: To explore the progression patterns of advanced hepatocellular carcinoma (HCC) in patients treated with a combination of local therapies, targeted drugs, and PD-1/PD-L1 inhibitors.Material and methods: A retrospective study involving 86 patients with Barcelona Clinic Liver Cancer stage C HCC was conducted between August 2018 and April 2022. All patients received local therapy, targeted drugs, and PD-1/PD-L1 inhibitors. Disease progression was evaluated using computed tomography or magnetic resonance imaging after combination therapy. Peripheral blood immune cells were analyzed using flow cytometry.Results: For intrahepatic progression, the median time to first progression was 5.3 months in 60 patients (95% confidence interval (CI): 2.3-7.1 months), and the median time to second progression was 9.3 months in 40 patients (95% CI: 4.8-11.8 months, p < 0.0001). For extrahepatic progression, the median time to first progression was 5.8 months in 61 patients (95% CI: 1.6-8.4 months), and the median time to second progression was 8.7 months in 39 patients (95% CI: 4.5-10.9 months, p < 0.0001). The common sites of extrahepatic progression are the lymph nodes and lungs. The percentages of PD-1+ cells gradually decreased after combination treatment but then gradually increased at follow-up in extrahepatic progression. The percentages of CD3+ T cells, CD3+CD4+ T cells, CD3+CD8+ T cells and CD16+CD56+ cells exhibited different trends in intrahepatic and extrahepatic progression.Conclusions: After combination treatment, patients with advanced HCC exhibit different characteristics of disease progression and composition of peripheral blood immune cells. Lymph nodes and lungs were the most susceptible sites for disease progression.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 2","pages":"147-154"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of thyroid dysfunction in patients with rheumatoid arthritis. 类风湿性关节炎患者甲状腺功能障碍的风险因素。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-06-17 DOI: 10.5114/ceji.2024.140634

Lan Li, Fuda Jiao, Jinmei Zhao, Lizhi Duan

{"title":"Risk factors of thyroid dysfunction in patients with rheumatoid arthritis.","authors":"Lan Li, Fuda Jiao, Jinmei Zhao, Lizhi Duan","doi":"10.5114/ceji.2024.140634","DOIUrl":"https://doi.org/10.5114/ceji.2024.140634","url":null,"abstract":"Introduction: The study aimed to investigate the complicating thyroid dysfunction situation in patients with rheumatoid arthritis (RA) and to analyze the related risk factors of thyroid dysfunction in RA patients.Material and methods: The retrospective analysis of the clinical data and laboratory examinations of 290 cases of RA and 200 healthy individuals undergoing the physical examination was carried out. The thyroid function, anti-thyroid antibodies, and routine laboratory test items were measured. The RA disease activity score (DAS28) was determined in RA patients. Logistic analysis was used to identify risk factors associated with thyroid dysfunction in RA patients.Results: The detection rate of RA combined with thyroid dysfunction was 30.0%, which was higher than in the control group (7%, 14 cases). In the thyroid function test, levels of total triiodothyronine (T3) and free triiodothyronine (FT3) were lower, while thyrotropin (TSH), antithyroid peroxidase antibody (TPOAb), and antithyroglobulin antibody (TgAb) were higher in the RA group. There was a difference in hemoglobin (HGB) and total cholesterol (TC) in RA patients with and without abnormal thyroid function.Conclusions: Rheumatoid arthritis patients are more prone to develop thyroid dysfunction than healthy individuals, especially hypothyroidism. HGB and TC were correlated with thyroid hormones and antibodies and were risk factors correlated with thyroid dysfunction in RA patients. Clinical work should pay full attention to changes in thyroid function in patients with RA.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 2","pages":"126-131"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High mobility group box protein 1 sensitizes mononuclear cells to further contact with lipopolysaccharide. 高迁移率基团盒蛋白 1 可使单核细胞进一步接触脂多糖。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-04-19 DOI: 10.5114/ceji.2024.138600

Jakub Piotrowski, Tomasz Jędrzejewski

{"title":"High mobility group box protein 1 sensitizes mononuclear cells to further contact with lipopolysaccharide.","authors":"Jakub Piotrowski, Tomasz Jędrzejewski","doi":"10.5114/ceji.2024.138600","DOIUrl":"10.5114/ceji.2024.138600","url":null,"abstract":"Fever is an adaptive host-defense response to infection and nowadays is rightly considered to be an expression of a healthy body and a well-functioning immune system. The condition is that it must be tightly regulated. Therefore, in individual cases, fever may be detrimental and should be treated. Specific excessive febrile reaction to pathogens which occurs after aseptic injuries is one among such cases. We previously found that among necrotic products, high mobility group box protein 1 (HMGB1) released from the site of aseptic injury affects immune effectors (cells) to mediate higher fever in response to further contact with bacterial lipopolysaccharide (LPS). Here we observed that intraperitoneal (i.p.) pre-injection of recombinant HMGB1 (5 µg/rat i.p.) provoked an increase in plasma levels of prostaglandin E2 (PGE2) in rats and augmented release of interleukin (IL)-1β and IL-6 after LPS administration at a dose of 50 µg/kg i.p. compared to rats pre-injected with saline or heat-denatured HMGB1. Furthermore, peripheral blood mononuclear cells (PBMCs) isolated from rats injected with HMGB1 were more sensitized to produce enhanced levels of IL-1β and PGE2 when stimulated with LPS in vitro (1 µg/ml/106 cells for 4 h) compared to control animals injected with saline or heat-denatured HMGB1. We also noted a significant increase in activation of nuclear factor κB (NF-κB) in cells isolated from rats injected with HMGB1. Altogether, the obtained results suggest that HMGB1 participates in priming of immune cells to further contact with pathogens.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 1","pages":"52-59"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of trigeminal neuralgia that occurred after COVID-19 vaccination. 接种 COVID-19 疫苗后出现三叉神经痛的病例。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-08-26 DOI: 10.5114/ceji.2024.142414

Zeliha Ünlü, İlhan Celil Özbek

引用次数: 0

Immune regulation is more effective in the U937 inflammation model with mesenchymal stem cell extracellular vesicles stimulated by pro-inflammatory cytokines.

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-11-12 DOI: 10.5114/ceji.2024.143726

Canan Öztürk, Zehra S Halbutoğulları

{"title":"Immune regulation is more effective in the U937 inflammation model with mesenchymal stem cell extracellular vesicles stimulated by pro-inflammatory cytokines.","authors":"Canan Öztürk, Zehra S Halbutoğulları","doi":"10.5114/ceji.2024.143726","DOIUrl":"10.5114/ceji.2024.143726","url":null,"abstract":"Mesenchymal stem cells (MSCs), which are multipotent adult cells with many therapeutic effects, can be derived from stromal tissues. MSCs also exert immunoregulatory effects through extracellular vesicles (EVs), cell membrane structures that carry paracrine factors. It is thought that the mediators (cytokines, growth factors, etc.) secreted by stem cells change under inflammatory conditions, and the therapeutic activity of MSCs increases. The purpose of this study was to investigate the possible effects of stimulated human Wharton's jelly-derived mesenchymal stem cell extracellular vesicles, obtained with or without stimulation with inflammatory cytokines, on inflammation. The study aimed to determine the effects of pro-inflammatory cytokines interleukin 1 β (IL-1 β), interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) stimulated extracellular vesicles (sEVs) on the inflammation model U937 macrophages induced by phorbol-12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS) treatment. Experimental studies were designed to investigate the effects of EVs obtained without stimulation with inflammatory cytokines and those obtained after stimulation with inflammatory cytokines in the macrophage cell line U937. Flow cytometry, gene expression, and immunofluorescence analyses were performed to investigate the apoptotic and antiproliferative effects of EVs and sEVs in the U937 macrophage inflammation model. WJ-MSC EVs obtained after culture with inflammatory cytokines had a greater apoptotic effect on U937 cells and reduced inflammatory cytokine release than EVs cultured in standard medium.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"49 3","pages":"282-299"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0