Cardiovascular Research最新文献

{"title":"Combined circulating microRNA and peptide biomarkers for prognostication in heart failure.","authors":"Lee Lee Wong,Hiromi W L Koh,Hyungwon Choi,Ruiyang Zou,Lihan Zhou,Jia Yuen Lim,Dominic C Y Phua,Oi Wah Liew,Jenny P C Chong,Jessica Y X Ng,Siew Pang Chan,Yei-Tsung Chen,Poh Shuan D Yeo,Lieng H Ling,David Sim,Kui Toh G Leong,Hean Y Ong,Fazlur Jaufeerally,Raymond Wong,Ping Chai,Adrian F Low,Mayanna Lund,Gerry Devlin,Richard Troughton,Robert N Doughty,Carolyn S P Lam,Heng Phon Too,Arthur Mark Richards","doi":"10.1093/cvr/cvaf065","DOIUrl":"https://doi.org/10.1093/cvr/cvaf065","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"44 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiny trouble: microplastics, nanoplastics, and their heartfelt impact on cardiovascular health","authors":"Tongyao Zhang, Yajie Liao, Jitao Ling, Jing Zhang, Deju Zhang, Xiaoping Yin, Peng Yu, Xiao Liu","doi":"10.1093/cvr/cvaf068","DOIUrl":"https://doi.org/10.1093/cvr/cvaf068","url":null,"abstract":"Microplastics and nanoplastics are ubiquitous environmental pollutants that pose significant health risks. Several studies have reported the presence of these particles in various human tissues, including the heart, arterial plaques, and bloodstream of patients undergoing percutaneous coronary interventions. Emerging research suggests an association between these particles and an increased risk of cardiovascular diseases. In vitro and in vivo studies reveal that micro- and nanoplastics induce endothelial cell toxicity, disrupt lipid metabolism, promote oxidative stress, and facilitate foam cell formation, thereby exacerbating atherosclerosis. Furthermore, they activate inflammatory pathways, compromising vascular barrier integrity. These particles also influence coagulation dynamics by altering clotting cascade activation and promoting thrombus formation. Additionally, they induce hemolysis, alter red blood cell morphology, and impair immune cell functions, including those of macrophages and lymphocytes, by modulating cytokine secretion and inflammatory responses. Understanding these mechanisms is essential for devising effective public health strategies to mitigate the cardiovascular impact of micro- and nanoplastics.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"27 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of MRAP2 in MC4R neurons protect from obesity-associated autonomic and cardiovascular dysfunctions","authors":"Deng Fu Guo, Paul A Williams, Alexis Olson, Donald A Morgan, Hussein Herz, Jon Resch, Deniz Atasoy, Harald M Stauss, Julien A Sebag, Kamal Rahmouni","doi":"10.1093/cvr/cvaf067","DOIUrl":"https://doi.org/10.1093/cvr/cvaf067","url":null,"abstract":"Aims The melanocortin receptor accessory protein 2 (MRAP2), which is abundantly expressed in the brain including the hypothalamus, has emerged as a key regulator of melanocortin-4 receptor (MC4R) activity. We sought to delineate the physiological significance of MRAP2 in MC4R neurons, with a particular focus on autonomic and cardiovascular functions. Methods and Results Selective deletion of MRAP2 in MC4R neurons causes obesity that was associated with hyperphagia and impairment in glucose homeostasis and insulin sensitivity. MC4R agonist Melatonan II (MTII)-induced anorectic effects were blunted in mice lacking MRAP2 in MC4R neurons, whereas Celastrol retained its efficacy in reducing food intake and body weight. MRAP2 deletion also reduced baseline sympathetic nerve activity (SNA), particularly the SNA subserving the kidney. This was associated with reduced innervation of the kidney. In addition, MTII-induced increases in renal and brown adipose tissue (BAT) SNA as well as hepatic vagal nerve activity were significantly attenuated in MC4R neuron MRAP2-deficient mice. Anatomical tracing revealed that MC4R neurons projecting to BAT and kidneys were localized to specific brain nuclei including the paraventricular nucleus of the hypothalamus, providing anatomical substrate for MRAP2 regulation of sympathetic outflow. Although loss of MRAP2 in MC4R neurons did not affect arterial pressure, it caused a significant decrease in heart rate and baroreflex sensitivity. Finally, MRAP2 deficiency in MC4R neurons attenuated MTII-induced increase in arterial pressure and heart rate. Conclusion These findings demonstrate that in addition to its role in energy balance and glucose homeostasis MRAP2 in MC4R neurons is crucial for cardiovascular autonomic regulation and is required for the development of obesity-associated hypertension and autonomic dysfunction.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"108 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revivifying research on relaxin receptor-targeted therapy for cardiovascular diseases.","authors":"Xiao-Jun Du","doi":"10.1093/cvr/cvaf057","DOIUrl":"https://doi.org/10.1093/cvr/cvaf057","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"7 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinning the web of platelet tetraspanins under stress.","authors":"Madhumita Chatterjee","doi":"10.1093/cvr/cvaf062","DOIUrl":"https://doi.org/10.1093/cvr/cvaf062","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"18 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction","authors":"Carolina Janssen-Telders, Etto C Eringa, Joris R de Groot, Frances S de Man, M Louis Handoko","doi":"10.1093/cvr/cvaf056","DOIUrl":"https://doi.org/10.1093/cvr/cvaf056","url":null,"abstract":"Heart failure with preserved ejection fraction (HFpEF) is a growing global health problem characterized by high morbidity and mortality, with limited effective therapies available. Obesity significantly influences haemodynamic and structural changes in the myocardium and vasculature, primarily through the accumulation and action of visceral adipose tissue. Particularly, epicardial adipose tissue (EAT) contributes to HFpEF through inflammation and lipotoxic infiltration of the myocardium. However, the precise signalling pathways leading to diastolic stiffness in HFpEF require further elucidation. This review explores the dynamic role of EAT in health and disease. Drawing upon insights from studies in other conditions, we discuss potential EAT-mediated inflammatory pathways in HFpEF and how they may contribute to functional and structural myocardial and endothelial derangements, including intramyocardial lipid infiltration, fibrosis, endothelial dysfunction, cardiomyocyte stiffening, and left ventricular hypertrophy. Lastly, we propose potential targets for novel therapeutic avenues.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"29 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incretin-based weight loss therapies and heart failure with preserved ejection fraction: guideline impactful results, but mechanisms unclear.","authors":"Katarzyna Stefanska, Naveed Sattar","doi":"10.1093/cvr/cvaf001","DOIUrl":"10.1093/cvr/cvaf001","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"1-3"},"PeriodicalIF":10.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the cusps of the second heart field: insights from zebrafish into arterial valve origins and disease.","authors":"Robert G Kelly","doi":"10.1093/cvr/cvae249","DOIUrl":"10.1093/cvr/cvae249","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"6-7"},"PeriodicalIF":10.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy.","authors":"Beatrijs Bartelds, Daphne Merkus","doi":"10.1093/cvr/cvae262","DOIUrl":"10.1093/cvr/cvae262","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"4-5"},"PeriodicalIF":10.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke risk management in carotid atherosclerotic disease: a clinical consensus statement of the ESC Council on Stroke and the ESC Working Group on Aorta and Peripheral Vascular Diseases.","authors":"Piotr Musialek, Leo H Bonati, Richard Bulbulia, Alison Halliday, Birgit Bock, Laura Capoccia, Hans-Henning Eckstein, Iris Q Grunwald, Peck Lin Lip, Andre Monteiro, Kosmas I Paraskevas, Anna Podlasek, Barbara Rantner, Kenneth Rosenfield, Adnan H Siddiqui, Henrik Sillesen, Isabelle Van Herzeele, Tomasz J Guzik, Lucia Mazzolai, Victor Aboyans, Gregory Y H Lip","doi":"10.1093/cvr/cvad135","DOIUrl":"10.1093/cvr/cvad135","url":null,"abstract":"<p><p>Carotid atherosclerotic disease continues to be an important cause of stroke, often disabling or fatal. Such strokes could be largely prevented through optimal medical therapy and carotid revascularization. Advancements in discovery research and imaging along with evidence from recent pharmacology and interventional clinical trials and registries and the progress in acute stroke management have markedly expanded the knowledge base for clinical decisions in carotid stenosis. Nevertheless, there is variability in carotid-related stroke prevention and management strategies across medical specialities. Optimal patient care can be achieved by (i) establishing a unified knowledge foundation and (ii) fostering multi-specialty collaborative guidelines. The emergent Neuro-Vascular Team concept, mirroring the multi-disciplinary Heart Team, embraces diverse specializations, tailors personalized, stratified medicine approaches to individual patient needs, and integrates innovative imaging and risk-assessment biomarkers. Proposed approach integrates collaboration of multiple specialists central to carotid artery stenosis management such as neurology, stroke medicine, cardiology, angiology, ophthalmology, vascular surgery, endovascular interventions, neuroradiology, and neurosurgery. Moreover, patient education regarding current treatment options, their risks and advantages, is pivotal, promoting patient's active role in clinical care decisions. This enables optimization of interventions ranging from lifestyle modification, carotid revascularization by stenting or endarterectomy, as well as pharmacological management including statins, novel lipid-lowering and antithrombotic strategies, and targeting inflammation and vascular dysfunction. This consensus document provides a harmonized multi-specialty approach to multi-morbidity prevention in carotid stenosis patients, based on comprehensive knowledge review, pinpointing research gaps in an evidence-based medicine approach. It aims to be a foundational tool for inter-disciplinary collaboration and prioritized patient-centric decision-making.</p>","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"13-43"},"PeriodicalIF":10.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10065392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}