Cardiovascular Research最新文献

{"title":"ULK1 phosphorylation and cardiomyocyte senescence: unveiling a molecular nexus in cardiac aging.","authors":"Maria Cristina Vinci","doi":"10.1093/cvr/cvaf132","DOIUrl":"https://doi.org/10.1093/cvr/cvaf132","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"723 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing obesity and subsequent cardiovascular risk in primary care: the relevance of high- and low-resource settings.","authors":"Aletta E Schutte","doi":"10.1093/cvr/cvaf094","DOIUrl":"10.1093/cvr/cvaf094","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"1135-1137"},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes","authors":"Diana Luna Buitrago, Eva Jover, Eleonora Mameli, David Mellis, Ryszard Nosalski, Laura Charlton, Rosa Bauza Sanso, Hywel Dunn-Davies, Mark G MacAskill, Adriana A S Tavares, Alexander J Fletcher, Jennifer Nash, Natalia López-Andrés, Marc R Dweck, Patrick W F Hadoke, Derek S Gilchrist, Brad D Wagner, Michael L Robinson, Andrew H Baker, David E Newby, Tijana Mitić, Andrea Caporali","doi":"10.1093/cvr/cvaf117","DOIUrl":"https://doi.org/10.1093/cvr/cvaf117","url":null,"abstract":"Aims Vascular calcification is the abnormal deposition of calcium phosphates within blood vessels. This condition is significantly associated with the development of cardiovascular disease, yet the underlying mechanisms remain largely unknown. MicroRNAs (miRNAs) may be crucial in initiating vascular calcification by regulating a network of specific cellular targets. In this study, we explored for the first time the potential role of microRNA-26b (miR-26b) in vascular calcification. Methods and results Using micro-positron emission tomography and computed tomography (micro-PET/CT) imaging with 18F–sodium fluoride, we measured aortic calcification in miR-26b knockout mice (miR-26bKO). We conducted bulk RNA sequencing (RNA-seq), single-cell RNA sequencing, and network analysis to identify cell-specific targets and the cellular complexity contributing to the observed phenotype. Additionally, we examined aortic tissues from patients with aortic aneurysm or valvular-related aortopathy to determine how the expression levels of miR-26b and its targets correlate with calcification. Our findings revealed that miR-26b is downregulated in the aortic tissues of patients with aortic calcification, whereas miR-26b expression negatively correlates with calcification levels. Similarly, miR-26bKO mice developed spontaneous age-related aortic microcalcifications. Combining single-cell transcriptomics with network analyses, we identified and mapped cell-type specific targets of miR-26b and regulatory pathways. Furthermore, we validated the cell-specific expression of Smad1 in smooth muscle cells (SMCs) and characterized the cell–cell communication between aortic cells, exposing the bone morphogenetic protein (BMP) pathway. The development of microcalcification was attributed to Bmp4 released from fibroblasts (FBLs), leading to Smad1 phosphorylation and calcium accumulation in SMCs of miR-26bKO mice. We found that aortic microcalcification could be pharmacologically reversed by disrupting cellular communication. Lastly, we demonstrated an inverse correlation between miR-26b and SMAD1 levels in calcified aortic tissues. Conclusion The deficiency of miR-26b is crucial for initiating and promoting aortic calcification, revealing new therapeutic targets for aortic disease.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"68 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation.","authors":"Guillermo Luxán,Timm Winkelmeier,Colin Bodemer,Büşra Nur Toğru,Mariana Shumliakivska,Marion Muhly-Reinholz,Ariane Fischer,Mariano Ruz Jurado,David John,Wesley T Abplanalp,Stefanie Dimmeler","doi":"10.1093/cvr/cvaf128","DOIUrl":"https://doi.org/10.1093/cvr/cvaf128","url":null,"abstract":"AIMSCardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progressive deterioration of the cardiac structures and function. Here, we have combined single-nucleus-RNA-sequencing, imaging, and molecular and cell biology approaches to explore the maladaptive signals that drive cardiac ageing.METHODS AND RESULTSSingle-nucleus-RNA-sequencing analysis of young (3 months) and old (18 months) murine hearts revealed that the expression of decorin, a secreted proteoglycan expressed in the extracellular matrix of endothelial cells, is induced by ageing. Decorin treatment via osmotic mini-pump induced diastolic dysfunction and a pro-inflammatory environment in the myocardium characterized by increased infiltration of immune cells, increased expression of IL-1β in endothelial cells and microvascular leakage in 3 months old mice. In vitro, decorin treatment induces cardiomyocyte hypertrophy, the expression of different pro-inflammatory cytokines like IL1B in endothelial cells in a TLR2 dependent mechanism, and compromises the endothelial barrier function.CONCLUSIONSTogether, our results identify non-glycanated decorin as a novel player contributing to cardiac aging and disease. This form of decorin contributes to the age-related structural and functional dysfunction of the heart by inducing a pro-inflammatory environment in the myocardial microvasculature, a hallmark of cardiac ageing.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"68 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early awakenings New insights into graft-host coupling in cardiac cell therapy.","authors":"Filippo Perbellini,Charles E Murry,Danny El-Nachef","doi":"10.1093/cvr/cvaf130","DOIUrl":"https://doi.org/10.1093/cvr/cvaf130","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"4565 2 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the histopathology of aortic abdominal aneurysms: a step toward precision medicine.","authors":"Tomasz P Mikolajczyk,Piotr Szczepaniak,Tomasz J Guzik","doi":"10.1093/cvr/cvaf131","DOIUrl":"https://doi.org/10.1093/cvr/cvaf131","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"723 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S913 phosphorylation of Ulk1 protects the heart from aging through inhibition of cardiac senescence.","authors":"Peiyong Zhai,Eun-Ah Sung,Koichiro Takayama,Soichiro Ikeda,Masato Matsushita,Yasuki Nakada,Yimin Tian,Junichi Sadoshima","doi":"10.1093/cvr/cvaf129","DOIUrl":"https://doi.org/10.1093/cvr/cvaf129","url":null,"abstract":"AIMSWe have previously shown that prevention of GSK-3β inactivation with GSK-3β (S9A), stimulates autophagy through phosphorylation of Ulk1 at Ser913. In the current study, we investigated whether cardiac aging is accelerated in Ulk1S913A knock in mice and whether cardiomyocyte senescence plays an important role in the development of aging cardiomyopathy in these mice.METHODS AND RESULTSIn systemic heterozygous Ulk1S913A knock in mice (shS913A), cardiac dysfunction (evidenced by lower ejection fraction and fractional shortening, lower dP/dtmaximum, higher end-diastolic pressure and higher dP/dtminimum) and fibrosis, along with increased cardiomyocyte senescence (increased P16, P21, IL6, γH2AX, and P53), were observed at 18 months old. RNA-seq analysis showed that numerous genes are differentially expressed in shS913A and littermate wild type (WT) hearts, including those involved in glucose metabolism, cardiac fibrosis, and cellular senescence. The glycolytic activity was higher in adult mouse cardiomyocytes isolated from shS913A than in those from littermate WT mice. In cultured neonatal rat ventricular cardiomyocytes, overexpression of Ulk1S912A induced cellular senescence. Heterozygous cardiac-specific Ulk1S913A knock in mice (chS913A) developed cardiac dysfunction, hypertrophy, fibrosis, and senescence at 7 months old. ABT-263 treatment (senolysis) attenuated the cardiac dysfunction, hypertrophy, and fibrosis while decreasing the number of γH2AX-positive cardiomyocytes.CONCLUSIONSThe chS913A mice exhibit premature cardiac aging, which is mediated through stimulation of cardiomyocyte senescence. The results support the role of the GSK-3β-Ulk1-autophagy pathway in the heart during aging. Thus, these mice could be useful in studying cardiac aging and senescence.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"59 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 reloaded: Sirtuin-1 as a post-translational checkpoint for LDL-C control.","authors":"Angela Pirillo,Alberico L Catapano","doi":"10.1093/cvr/cvaf126","DOIUrl":"https://doi.org/10.1093/cvr/cvaf126","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"25 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let food be thy medicine: anti-inflammatory diets and the hidden properties of coronary plaque.","authors":"Eiry Jones,Tomasz J Guzik","doi":"10.1093/cvr/cvaf115","DOIUrl":"https://doi.org/10.1093/cvr/cvaf115","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"109 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hypertension in Africa in the last two decades: Systematic review and meta-analysis.","authors":"Paul Olowoyo,Akinkunmi Paul Okekunle,Osahon Jeffery Asowata,Segun Atolani,Moustafa I Morsy,Elisabetta Caiazzo,Bamba Gaye,David Danladi Kadan,Dario Bruzzese,Tomasz J Guzik,Pasquale Maffia,Mayowa O Owolabi","doi":"10.1093/cvr/cvaf125","DOIUrl":"https://doi.org/10.1093/cvr/cvaf125","url":null,"abstract":"AIMSDespite being the most common cardiovascular risk factor, the actual burden of hypertension is poorly characterized in Africa. We meta-analyzed the most extensive pooled data to determine the overall prevalence of hypertension in Africa.METHODS AND RESULTSFollowing PRISMA guidelines, we systematically searched Google Scholar, PubMed, ScienceDirect, and Web of Science databases to retrieve prevalence studies only on hypertension among Africans published between 2002 and 2023. Furthermore, we meta-analyzed the crude and age-adjusted prevalences of hypertension using a random effect model due to the expected high heterogeneity, with logit transformation of the original proportions.Seventy-eight (out of an initial 779 screened) articles with complete data were included, with a total number of hypertension cases of 71,004 and a denominator population of 286,575, mostly from community-based studies in 23 countries. The pooled crude prevalence of hypertension was 28⸱5/100 persons [95% confidence interval (CI): 25⸱3%-31⸱8%] and a 95% prediction interval of 7⸱6%-65⸱6%; the pooled prevalence increased with age and was highest among the aged ≥75 years: 51⸱4% (95%CI: 42⸱0%-60⸱6%) and remained highest in the Southern Africa region overall (34⸱8%) and in the last decade (2013-2023; 44⸱5%). The point estimate of the pooled crude prevalence was higher among urban dwellers, 32⸱9% (95%CI: 26⸱8%-39⸱5%), than rural residents, 26⸱3% (95%CI: 20⸱4%-33⸱3%). In a subset of twenty-one articles reporting age stratification consistent with the WHO standard population, the pooled age-standardized prevalence was 27⸱2/100 persons (95%CI: 20⸱9%-33⸱6%).CONCLUSIONThe burden of hypertension remains high, especially in urban areas and with increasing age. Frequent screening and treatment are recommended, especially in urban areas.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"35 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}