Case Reports in Oncological Medicine最新文献_第8页

Hepatocellular Carcinoma: First Manifestation as Solitary Humeral Bone Metastasis. 肝细胞癌：首次表现为孤立的肱骨骨转移。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2020-12-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8254236

Sumera Bukhari, Kristine Ward, Michael Styler

{"title":"Hepatocellular Carcinoma: First Manifestation as Solitary Humeral Bone Metastasis.","authors":"Sumera Bukhari, Kristine Ward, Michael Styler","doi":"10.1155/2020/8254236","DOIUrl":"10.1155/2020/8254236","url":null,"abstract":"Hepatocellular carcinoma (HCC) most commonly presents with abdominal pain or mass, fever of unknown etiology, weight loss, and decompensation of known liver disease or at an asymptomatic stage through surveillance. Rarely, presenting symptoms can be exclusively related to extrahepatic metastases. Herein, we write a case of a patient with no known liver disease, presenting with a pathological fracture of the proximal humerus bone secondary to a massive solitary metastasis from HCC. This case represents an unusual appendicular skeletal metastasis in a patient with unknown primary HCC, successfully treated with sorafenib. The prognosis of HCC patients with extrahepatic metastasis is poor, and in the presence of bone metastases, the mean survival rate is severely reduced. However, the multikinase inhibitor sorafenib has been the standard of treatment. Recently, there has been developments of other therapeutic class of drugs (i.e., immune check inhibitors), which have shown promising benefits and better side effect profiles. Still, there is a need for further studies, owing to challenges in recognizing cellular and molecular markers.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"8254236"},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38733505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delays in Diagnosis of Pulmonary Lymphangitic Carcinomatosis due to Benign Presentation. 良性表现对肺淋巴管癌诊断的延误。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-11-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4150924

Swati Pandey, Shishir Ojha

引用次数: 2

Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer. 手术加Lenvatinib成功治疗甲状腺乳头状癌肾上腺转移1例。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-11-05 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2107430

Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroki Sakamoto, Naotaka Hayasaka, Kazuma Ishikawa, Yuki Ikeda, Makoto Yoshida, Satoshi Iyama, Ko Kobayashi, Tetsuya Shindo, Shintaro Sugita, Koji Miyanishi, Masayoshi Kobune, Naoya Masumori, Junji Kato

{"title":"Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer.","authors":"Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroki Sakamoto, Naotaka Hayasaka, Kazuma Ishikawa, Yuki Ikeda, Makoto Yoshida, Satoshi Iyama, Ko Kobayashi, Tetsuya Shindo, Shintaro Sugita, Koji Miyanishi, Masayoshi Kobune, Naoya Masumori, Junji Kato","doi":"10.1155/2020/2107430","DOIUrl":"https://doi.org/10.1155/2020/2107430","url":null,"abstract":"Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"2107430"},"PeriodicalIF":0.9,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2107430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38720786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diffuse Pancreatic Carcinoma with Hepatic Metastases. 弥漫性胰腺癌伴肝转移。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-10-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8815745

Hoang Quan Nguyen, Ngoc Trinh Thi Pham, Van Trung Hoang, Hoang Anh Thi Van, Chinh Huynh, Duc Thanh Hoang

引用次数: 1

Incidence of Gastrointestinal Neuroendocrine Tumor: Case Series, Armed Forces Hospital Southern Region, Hospital-Based Tumor Board Registry. 胃肠神经内分泌肿瘤的发病率:病例系列，南区武装部队医院，医院肿瘤委员会登记。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-10-20 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8819392

Abdullah Mohammed Albishi, Ahmed Mostafa Mohamed Mostafa, Hatim Mahgoub Ali, Yahia Atiah Alhagawi, Mohamed F Bazeed, Mahmoud R A Hussein, Elshfeia Elhag Mohmed Ali Aloba, Ahmed Youssef Aboelyazid

引用次数: 3

Management of Low-Grade Appendiceal Mucinous Neoplasm with Extensive Peritoneal Spread Diagnosed during Pregnancy: Two Case Reports and Literature Review. 妊娠期确诊的伴有腹膜广泛扩散的低级别阑尾黏液性肿瘤的治疗：两例病例报告和文献综述

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2020-10-15 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8853704

Ekaterina Baron, Vadim Gushchin, Mary Caitlin King, Andrei Nikiforchin, Armando Sardi

{"title":"Management of Low-Grade Appendiceal Mucinous Neoplasm with Extensive Peritoneal Spread Diagnosed during Pregnancy: Two Case Reports and Literature Review.","authors":"Ekaterina Baron, Vadim Gushchin, Mary Caitlin King, Andrei Nikiforchin, Armando Sardi","doi":"10.1155/2020/8853704","DOIUrl":"10.1155/2020/8853704","url":null,"abstract":"Background: Clinical decisions in patients with peritoneal dissemination of low-grade appendiceal mucinous neoplasms (LAMN) diagnosed during pregnancy are challenging. However, their slow progression and favorable prognosis allow deferring definitive treatment until after spontaneous delivery, a reasonable period of breastfeeding, and fertility preservation. Case Presentation. Two pregnant patients were incidentally diagnosed with LAMN and extensive peritoneal spread at 20 weeks gestation and at cesarean section. Treatment with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in both cases was delayed until spontaneous delivery at term and breastfeeding in the first patient and breastfeeding and fertility preservation in the second patient. Both patients remain disease-free for over 5 years, and their children are healthy. The literature review highlights the challenges that physicians face in treating pregnant patients with stage IV appendiceal tumors.Conclusion: Pregnancy management decisions in patients with peritoneal spread from mucinous appendiceal tumor should be based on understanding the tumor biology and prognosis. Definitive treatment in pregnant patients with favorable tumors, such as LAMN, may be delayed until spontaneous delivery without compromising maternal survival.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"8853704"},"PeriodicalIF":0.6,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38551509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy. Rosai-Dorfman病伴发阑尾和直肠肿块并伴有igg4阳性浆细胞的独特表现

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-10-09 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8814871

Jenna J Poldemann, Benjamin H Hinrichs, Abouelmagd Makramalla

引用次数: 0

A Case of Pulmonary Epithelioid Hemangioendothelioma with Literature Review. 肺上皮样血管内皮瘤1例并文献复习。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-10-08 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8048056

Thu Thu Aung, Andrew Chu, Divya Kondapi, Danny Markabawi, Kanish Mirchia, Pratibha Kaul

引用次数: 4

Limited Renal Intravascular Lymphoma: A Case Report and Review of the Literature. 局限性肾血管内淋巴瘤1例报告及文献复习。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-10-06 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7052536

Guillermo Enrique Quintero Vega, Daniel Osorio, José Antonio de la Hoz Valle, Daniela Rodríguez Feria

{"title":"Limited Renal Intravascular Lymphoma: A Case Report and Review of the Literature.","authors":"Guillermo Enrique Quintero Vega, Daniel Osorio, José Antonio de la Hoz Valle, Daniela Rodríguez Feria","doi":"10.1155/2020/7052536","DOIUrl":"https://doi.org/10.1155/2020/7052536","url":null,"abstract":"Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma. It is characterized by the proliferation of cancerous cells into the intraluminal space of the blood vessels. It has a low incidence rate of 0.095 cases per 1,000,000. The clinical presentation is insidious and unspecific, often delaying the diagnosis. IVLBCL can be diagnosed through body images and histopathology analysis. This neoplasm averages a 60% response rate to current chemotherapy treatment, favoring rituximab, and doxorubicin-based regimen if it is diagnosed in time. Here, we present the case of a 56-year-old man admitted to our hospital with a fever who was eventually diagnosed with IVLBCL. He presented to the consultation with anemia, fever, and splenomegaly. An infection panel, a bone marrow biopsy, and a PET-CT scan were performed and ruled out the possibility of infections and neoplasms. The patient later developed edematous syndrome. As a result, a renal biopsy was performed which tested positive for intravascular large B-cell lymphoma. Currently, the patient has been in complete remission for 33 months. Along with presenting this specific case, we also reviewed previously published cases of IVLBCL to illustrate the renal involvement of this pathology.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"7052536"},"PeriodicalIF":0.9,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7052536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38516940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regionally Metastatic Merkel Cell Carcinoma Associated with Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis. 伴有副肿瘤性抗N-甲基-D-天冬氨酸受体脑炎的区域转移性梅克尔细胞癌

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-09-26 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1257587

Sophia Z Shalhout, Kevin S Emerick, Peter M Sadow, Jenny J Linnoila, David M Miller

{"title":"Regionally Metastatic Merkel Cell Carcinoma Associated with Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis.","authors":"Sophia Z Shalhout, Kevin S Emerick, Peter M Sadow, Jenny J Linnoila, David M Miller","doi":"10.1155/2020/1257587","DOIUrl":"10.1155/2020/1257587","url":null,"abstract":"Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine cancer with a high risk of recurrence and metastasis. MCC is generally associated with advanced age, fair skin, sun exposure, immunosuppression, and in the majority of cases, the Merkel cell polyomavirus. Neuroendocrine malignancies are associated with a variety of paraneoplastic neurological syndromes (PNS), characterized as autoimmune responses to malignancy-associated expression of neural antigens. Our literature review underscores previous case reports of MCC-associated PNS with voltage-gated calcium channel (VGCC) and anti-Hu (or ANNA-1) autoantibodies. We present the case of a 59-year-old male with regionally metastatic Merkel cell carcinoma complicated by the paraneoplastic manifestation of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. His primary lower neck subcutaneous MCC and metastasis were initially treated with surgery. Additional recurrent lymph node metastases were successfully treated with definitive intensity-modulated radiation therapy. His PNS improved with rituximab therapy. Although rare, this case highlights that in the setting of seizures and prominent psychiatric symptoms accompanying an MCC diagnosis, evaluation for autoimmune paraneoplastic encephalitis is warranted. Awareness and detection of preexisting PNS are crucial in the era of immune checkpoint inhibitors (ICI) for advanced MCC, where treatment with ICI has the potential to exacerbate preexisting autoimmune PNS and lead to worsened or even lethal neurologic immune-related adverse events (nirAEs).","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"1257587"},"PeriodicalIF":0.9,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38493839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0