Case Reports in Rheumatology最新文献_第6页

Granulomatosis with Polyangiitis Overlapping with IgG4-Related Disease. 肉芽肿伴多血管炎与igg4相关疾病重叠。

Case Reports in Rheumatology Pub Date : 2022-09-02 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2360060

Aureliano Pistone, Muhammad Soyfoo

引用次数: 1

Neuropsychiatric Lupus and Lupus Nephritis Successfully Treated with Combined IVIG and Rituximab: An Alternative to Standard of Care. 联合IVIG和利妥昔单抗成功治疗神经精神性狼疮和狼疮肾炎:标准治疗的替代方案。

Case Reports in Rheumatology Pub Date : 2022-08-28 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5899188

Mohamed M Cheikh, Abdullah K Bahakim, Moayad K Aljabri, Saad M Alharthi, Sanad M Alharthi, Abdullah K Alsaeedi, Saad F Alqahtani

{"title":"Neuropsychiatric Lupus and Lupus Nephritis Successfully Treated with Combined IVIG and Rituximab: An Alternative to Standard of Care.","authors":"Mohamed M Cheikh, Abdullah K Bahakim, Moayad K Aljabri, Saad M Alharthi, Sanad M Alharthi, Abdullah K Alsaeedi, Saad F Alqahtani","doi":"10.1155/2022/5899188","DOIUrl":"https://doi.org/10.1155/2022/5899188","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unpredictable course and flares. The clinical manifestation can vary from mild to severe and life-threatening disease. Infection is the primary cause of mortality in hospitalized SLE patients. There is a paucity of evidence to support the co-management of SLE with major organ involvement and sepsis. We describe the clinical response of a 35-year-old male diagnosed with SLE; then, he developed severe sepsis and a flare of SLE with major organ involvement including lupus nephritis (LN), myocarditis, and neuropsychiatric systemic lupus erythematosus (NPSLE). Based on the patient's condition, a treatment dilemma was encountered, and after a multidisciplinary meeting, the decision was made to use a combination of rituximab (RTX), intravenous immunoglobulin (IVIG), and pulse steroid. Shortly, the patient's condition started to improve, and his symptoms were resolved. In conclusion, our clinical case suggests that combined RTX, IVIG, and pulse steroid seem to be effective and safe in achieving clinical response, thus representing a good choice for managing severe SLE flares in sepsis.","PeriodicalId":9622,"journal":{"name":"Case Reports in Rheumatology","volume":"2022 ","pages":"5899188"},"PeriodicalIF":0.0,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33450150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Transient Pneumonitis as a Possible Adverse Reaction to the BNT162b2 COVID-19 mRNA Vaccine in a Patient with Rheumatoid Arthritis: A Case Report and Review of the Literature. 类风湿性关节炎患者短暂性肺炎可能是BNT162b2 COVID-19 mRNA疫苗的不良反应:1例报告和文献综述

Case Reports in Rheumatology Pub Date : 2022-08-23 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3124887

Yusuke Ohkubo, Shin-Ichiro Ohmura, Ryuhei Ishihara, Toshiaki Miyamoto

引用次数: 0

An Unusual Cause of Necrotising Fasciitis in a Young Male with Juvenile Dermatomyositis. 一个不寻常的原因坏死性筋膜炎的年轻男性与少年皮肌炎。

Case Reports in Rheumatology Pub Date : 2022-08-09 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8758263

Adelaide Ankomaa Asante, Josephine Nsaful, Dzifa Dey

{"title":"An Unusual Cause of Necrotising Fasciitis in a Young Male with Juvenile Dermatomyositis.","authors":"Adelaide Ankomaa Asante, Josephine Nsaful, Dzifa Dey","doi":"10.1155/2022/8758263","DOIUrl":"https://doi.org/10.1155/2022/8758263","url":null,"abstract":"Juvenile dermatomyositis (JDM) is a rare condition worldwide, affecting children younger than 16 years. It is characterized by weakness in the proximal skeletal muscles and a pathognomonic skin rash. Patients with JDM develop complications that are usually a consequence of vasculopathy affecting multiple organ systems. Occult gastrointestinal (GI) perforation is an uncommon complication and is associated with an increased risk of mortality due to a delay in diagnosis. We report on a 14-year-old male with JDM with an aggressive course over two years and severe clinical manifestations. The patient developed necrotizing fasciitis, an unusual rapidly progressing lethal infection of the fascia resulting from bowel contents seeping from multiple intestinal perforations. This case, less commonly seen in males, highlights the occurrence of multiple phenomena-JDM complicated by skin and gastrointestinal vasculopathy with resultant development of multiple GI perforations and consequently life-threatening necrotizing fasciitis of the leg. Physicians need a high index of suspecting GI perforation in JDM patients as the delayed recognition of this complication can result in significant morbidity and/or mortality since the typical symptoms of perforation may be absent.","PeriodicalId":9622,"journal":{"name":"Case Reports in Rheumatology","volume":" ","pages":"8758263"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40621791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kikuchi-Fujimoto Disease: A Differential for When It is Not Systemic Lupus Erythematosus. 菊池-藤本病:当它不是系统性红斑狼疮的鉴别。

Case Reports in Rheumatology Pub Date : 2022-08-09 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7709246

Taskeen R Kazmi, Emma L Greear, Catherine A Lavallee, Michael S Stump, Adegbenga A Bankole

引用次数: 1

A Case of Severe Multisystem Inflammatory Syndrome in Children (MIS-C) Treated with Multiple Biologics. 多种生物制剂治疗儿童严重多系统炎症综合征1例。

Case Reports in Rheumatology Pub Date : 2022-08-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6181922

Beenish Zulfiqar, Hira Imran, Kathleen Collins

{"title":"A Case of Severe Multisystem Inflammatory Syndrome in Children (MIS-C) Treated with Multiple Biologics.","authors":"Beenish Zulfiqar, Hira Imran, Kathleen Collins","doi":"10.1155/2022/6181922","DOIUrl":"https://doi.org/10.1155/2022/6181922","url":null,"abstract":"The COVID-19 virus has impacted global health on a wide scale, affecting humans of all ages and ethnicities. While most have mild upper respiratory viral symptoms, some have died due to severe pneumonia, acute respiratory distress syndrome (ARDS), or coagulopathies to mention a few. It has been postulated that the COVID-19 virus can initiate an autoinflammatory reaction in the body via multiple pathways of cytokine activation. The virus can cause delayed response after 4-8 weeks of acute infection, which resembles a cytokine storm or MAS (macrophage activation syndrome). This highly inflammatory syndrome, called MIS-C or multisystem inflammatory response syndrome, needs to be diagnosed and treated early to prevent multiorgan damage and mortality. There are widespread lab abnormalities including highly elevated acute phase reactants ferritin, D-Dimer, lactate dehydrogenase (LDH), creatinine kinase (CK), sedimentation rate (ESR), and C-reactive protein (CRP) as well as markers of cardiac damage including troponin and brain natriuretic peptide (BNP). The syndrome can present in unique ways from classic MIS-C with hypovolemic shock to Kawasaki disease-like presentation. We present a case of a 12-year-old boy who presented to Le Bonheur Children's Hospital in Memphis with classic signs and symptoms of \"severe\" MIS-C requiring intubation, multiple pressors, ECMO, and renal replacement therapy. He was treated successfully with immunomodulating medicines including intravenous immune globulin (IVIG), steroids, interleukin-6 inhibitor, tumor necrosis factor-a inhibitor, interleukin-1 inhibitor, and Janus kinase inhibitor.","PeriodicalId":9622,"journal":{"name":"Case Reports in Rheumatology","volume":" ","pages":"6181922"},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40710498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hypertrophic Osteoarthropathy Associated with Probable Smear-Negative Pulmonary Tuberculosis. 肥厚性骨关节病与可能的涂片阴性肺结核有关。

Case Reports in Rheumatology Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5429138

Mohamed Ahmed Ghassem, Abdelhamid Biyi, Julien H Djossou, Toufik Hamza, Abderrahim Majjad, Lahsen Achemlal

{"title":"Hypertrophic Osteoarthropathy Associated with Probable Smear-Negative Pulmonary Tuberculosis.","authors":"Mohamed Ahmed Ghassem, Abdelhamid Biyi, Julien H Djossou, Toufik Hamza, Abderrahim Majjad, Lahsen Achemlal","doi":"10.1155/2022/5429138","DOIUrl":"https://doi.org/10.1155/2022/5429138","url":null,"abstract":"Association of hypertrophic osteoarthropathy (HOA) with pulmonary tuberculosis is rarely reported, especially with smear-negative pulmonary tuberculosis (SNPT), in which its diagnosis is a challenge. We used a systematic approach to analyze all relevant literature reviews, and we identified only two cases of HOA associated with pulmonary tuberculosis in the last 10 years. We report the case of a 36-year-old man who presented with bilateral symmetric polyarthralgia and digital clubbing. Laboratory exams associated elevated acute phase reactants with negative immunological examinations. Two series of three acid-fast Bacillus (AFB) smear microscopy in sputum, separated by 15 days of broad-spectrum antibiotic therapy, were negative. A sputum culture was negative for Mycobacterium tuberculosis. A chest X-ray and computed tomography (CT) showed an apical pulmonary cavity. Plain X-ray and bone scintigraphy revealed periostosis of the tubular bones. Therefore, the diagnosis of HOA associated with probable SNPT was made. HOA symptoms had remitted after 3 months of antitubercular therapy. After 7 months of treatment, chest CT and bone scintigraphy showed a regression of the pulmonary cavity and disappearance of periostosis. The search for tuberculosis in front of any HOA seems to be justified in our epidemiological context.","PeriodicalId":9622,"journal":{"name":"Case Reports in Rheumatology","volume":"2022 ","pages":"5429138"},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33442355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Infection with Hidden Malignancy Mimicking the Clinical Presentation of an Autoimmune Disease. 慢性感染伴隐性恶性肿瘤模拟自身免疫性疾病的临床表现

Case Reports in Rheumatology Pub Date : 2022-07-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5392858

Ammar Bakhsh, Khalil Miyajan, Abdulghani Sadaqa, Amer Eisa, Ghali Faidah, Hani Almoallim

引用次数: 0

Treatment of Down Syndrome-Associated Arthritis with JAK Inhibition. JAK抑制治疗唐氏综合征相关性关节炎。

Case Reports in Rheumatology Pub Date : 2022-07-16 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4889102

Jordan T Jones

引用次数: 1

Hydroxychloroquine and Fabry Disease: Three Case Reports Examining an Unexpected Pathologic Link and a Review of the Literature. 羟氯喹和法布里病:三例报告，检查一个意想不到的病理联系和文献复习。

Case Reports in Rheumatology Pub Date : 2022-07-11 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2930103

Rouhin Sen, Kathleen Borghoff, Kirk W Foster, Stanley J Radio, Alan Erickson, Michelene Hearth-Holmes

{"title":"Hydroxychloroquine and Fabry Disease: Three Case Reports Examining an Unexpected Pathologic Link and a Review of the Literature.","authors":"Rouhin Sen, Kathleen Borghoff, Kirk W Foster, Stanley J Radio, Alan Erickson, Michelene Hearth-Holmes","doi":"10.1155/2022/2930103","DOIUrl":"https://doi.org/10.1155/2022/2930103","url":null,"abstract":"Background: Hydroxychloroquine is an effective and widely used treatment in multiple autoimmune connective tissue diseases that gained a lot of publicity in the coronavirus disease 2019 (COVID-19) pandemic. Our case reports are unique in that they explore the rare and sometimes overlooked effects of this drug on multiple organ systems, specifically the kidney, cardiac muscle, and skeletal muscle. We include key histologic features in images which aid in identifying and distinguishing hydroxychloroquine toxicity from mimickers. Lastly, we report the very interesting similarity in the intracellular action of hydroxychloroquine to the pathology of Fabry disease (and its associated lysosomal enzyme, α-galactosidase A). Case Presentation. We will examine the case presentations of three female Caucasian patients: a 22-year-old with lupus nephritis class V, a 72-year-old with long-standing systemic lupus erythematosus, and a 74-year-old with undifferentiated connective tissue disease. All three patients were on hydroxychloroquine therapy for varying amounts of time with histologic evidence of hydroxychloroquine toxicity that is three is present in histological samples of the kidney, the heart, and the skeletal muscle.Conclusions: Hydroxychloroquine is a very important and beneficial medication used for various autoimmune connective tissue diseases. Clinicians should be aware of the rare but sometimes serious side effects that can result from the medication, which at times can mimic manifestations of the connective tissue disease itself or Fabry disease. A thorough investigation should be performed in these cases to properly elucidate the cause followed by the appropriate targeted therapy.","PeriodicalId":9622,"journal":{"name":"Case Reports in Rheumatology","volume":" ","pages":"2930103"},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40622065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1