Case Reports in Endocrinology最新文献_第8页

Spontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review. 阿哌沙班抗凝治疗抗磷脂综合征患者自发性肾上腺出血伴轻度肾上腺功能减退:1例报告及文献复习。

IF 1.1

Case Reports in Endocrinology Pub Date : 2022-01-01 DOI: 10.1155/2022/6538800

Jia Wei Tan, Anant Shukla, Jiun-Ruey Hu, Sachin K Majumdar

{"title":"Spontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review.","authors":"Jia Wei Tan, Anant Shukla, Jiun-Ruey Hu, Sachin K Majumdar","doi":"10.1155/2022/6538800","DOIUrl":"https://doi.org/10.1155/2022/6538800","url":null,"abstract":"Background: Adrenal hemorrhage (AH) is a serious endocrine complication of antiphospholipid syndrome (APLS). Case Presentation. We report a 45-year-old man who presented with several deep venous thromboses and was initially treated with apixaban, who later developed bilateral AH. Laboratory findings were consistent with cortisol deficiency yet preserved aldosterone physiology. He was diagnosed with APLS and treated with warfarin. After 8 months of follow-up, he remained on cortisol replacement with no evidence of recovery. We reviewed PubMed/MEDLINE indexed articles from 1950 to 2022 for cases of AH in APLS patients on anticoagulation. Six cases of patients on direct oral anticoagulants (DOACs) were reported. Discussion. The unique vasculature of the adrenal glands creates a \"functional vascular dam\" in the zona reticularis, which is susceptible to thrombosis in situ and hemorrhage. DOACs may further increase the risk of AH.Conclusion: Depending on the degree of adrenal involvement in AH, patients can present with partial or complete primary adrenal insufficiency. More data are needed to characterize adrenal function after AH, and the safety of DOAC versus warfarin in patients with APLS warrants further studies.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2022 ","pages":"6538800"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multifocal Multisystem Langerhans Cell Histiocytosis Involving Pituitary Masquerading as Crohn's Disease: A Case Report and Review of the Literature. 垂体多病灶多系统朗格汉斯细胞组织细胞增多症伪装成克罗恩病:1例报告及文献复习。

IF 1.1

Case Reports in Endocrinology Pub Date : 2022-01-01 DOI: 10.1155/2022/4672473

Mohd Ashraf Ganie, Bhanu Malhotra, Manpreet Saini, Arshiya Dutta, Atul Sharma, Kim Vaiphie, Pinaki Dutta

{"title":"Multifocal Multisystem Langerhans Cell Histiocytosis Involving Pituitary Masquerading as Crohn's Disease: A Case Report and Review of the Literature.","authors":"Mohd Ashraf Ganie, Bhanu Malhotra, Manpreet Saini, Arshiya Dutta, Atul Sharma, Kim Vaiphie, Pinaki Dutta","doi":"10.1155/2022/4672473","DOIUrl":"https://doi.org/10.1155/2022/4672473","url":null,"abstract":"Background/Objective. We present a case of Langerhans cell histiocytosis (LCH) with gastrointestinal involvement masquerading as inflammatory bowel disease (IBD) in a patient who initially had features of central diabetes insipidus (CDI). Case Report. A 19-year-old male presented at 14 years of age with central diabetes insipidus. He subsequently developed panhypopituitarism and sellar-suprasellar mass, the biopsy of which was inconclusive. Secondary causes for hypophysitis were ruled out. Five years later, he developed perianal pus discharging sinuses, positive ASCA, and sacroiliitis. Rectal ulcer biopsy showed nonspecific inflammation and necrosis. Hence, he was managed as inflammatory bowel disease (IBD). Due to nonresponsiveness of symptoms, doubt about diagnosis was invoked and rectal ulcer biopsy was repeated, which then showed infiltration by Langerhans cells. Hence, he was diagnosed with LCH and showed resolution of symptoms on initiating steroids and vinblastine. Discussion. Gastrointestinal involvement by LCH is unusual and only rarely has represented a prominent clinical manifestation. In most cases, such involvement suggests widespread multisystem disease. Its distinctive morphologic and immunohistochemical features allow LCH to be distinguished from other inflammatory infiltrations found in mucosal biopsy specimens. Conclusion. Preceding CDI and hypopituitarism may predict LCH in patients with IBD-like diseases.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2022 ","pages":"4672473"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10362496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Cholestasis: A Rare and Unusual Presentation of Pituitary Stalk Interruption Syndrome. 新生儿胆汁淤积症：新生儿胆汁淤积症：垂体茎突中断综合征罕见而不寻常的表现形式

IF 1.1

Case Reports in Endocrinology Pub Date : 2021-05-22 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6161508

R El Qadiry, A Ouayad, H Nassih, A Bourrahouat, I Ait Sab

{"title":"Neonatal Cholestasis: A Rare and Unusual Presentation of Pituitary Stalk Interruption Syndrome.","authors":"R El Qadiry, A Ouayad, H Nassih, A Bourrahouat, I Ait Sab","doi":"10.1155/2021/6161508","DOIUrl":"10.1155/2021/6161508","url":null,"abstract":"Pituitary stalk interruption syndrome (PSIS) is a very rare entity, and the clinical manifestations are nonspecific. Neonatal cholestasis due to endocrine disorders is rare and poorly recognized. Our case report describes a case of PSIS in a Moroccan infant revealed by isolated neonatal cholestasis, which is an unusual presentation in children. Case report. A 40-day-old girl was admitted to our department for progressive cholestatic jaundice appeared on the third day of life. She was born from a non-consanguineous marriage, and her prenatal and perinatal history went without incident. Physical examination showed icteric skin and sclera, without hepatomegaly. Analysis of pituitary hormones revealed panhypopituitarism. On brain magnetic resonance imaging (MRI), the pituitary stalk was absent, the posterior pituitary was ectopic, and the anterior pituitary was hypoplastic. The patient was diagnosed with interrupted pituitary stalk syndrome. The treatment consisted of hormone replacement with rapid improvement of her clinical condition. Conclusion. Panhypopituitarism, a consequence of PSIS, is a rare cause of neonatal cholestasis. However, pediatricians should keep this syndrome in mind for patients who present with neonatal cholestasis.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2021 ","pages":"6161508"},"PeriodicalIF":1.1,"publicationDate":"2021-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10593370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyrotoxic Periodic Paralysis Causing Back Pain and Leg Weakness: An Unusual Presentation of Hyperthyroidism. 甲状腺毒性周期性麻痹引起背部疼痛和腿部无力:甲亢的一种不寻常的表现。

IF 1.1

Case Reports in Endocrinology Pub Date : 2021-01-01 DOI: 10.1155/2021/6622658

Henrik Elenius, Marie Cesa, Corina C Nava Suarez, Abhishek Nimkar, Prasanta Basak, Nandita Sinha

{"title":"Thyrotoxic Periodic Paralysis Causing Back Pain and Leg Weakness: An Unusual Presentation of Hyperthyroidism.","authors":"Henrik Elenius, Marie Cesa, Corina C Nava Suarez, Abhishek Nimkar, Prasanta Basak, Nandita Sinha","doi":"10.1155/2021/6622658","DOIUrl":"https://doi.org/10.1155/2021/6622658","url":null,"abstract":"Thyrotoxic periodic paralysis (TPP) is a rare muscular disorder, characterized by muscle weakness and hypokalemia triggered by thyrotoxicosis. In Asian populations, 2% of patients with thyrotoxicosis are affected, compared to only 0.1-0.2% of non-Asians. The vast majority of patients are male. Muscle weakness ranges in severity from very mild to life-threatening, due to respiratory compromise. We present a case of a previously healthy 39-year-old Hispanic male who presented with sudden quadriparesis and quickly recovered after being treated for hypokalemia and thyrotoxicosis. TPP, although unusual, is important to recognize as it is a potentially fatal condition that requires close monitoring and is readily reversible with appropriate therapy. Any cause of thyroid hormone excess can cause TPP, with Graves' disease being the most common etiology. Acute treatment includes potassium repletion, while long-term management focuses on determining and treating the cause of thyrotoxicosis, since maintaining a euthyroid state will prevent further episodes of TPP.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2021 ","pages":"6622658"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10424322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Adverse Effects of Ramadan Fasting in a Girl with Salt-Losing Congenital Adrenal Hyperplasia. 斋月禁食对女童失盐性先天性肾上腺增生的不良影响。

IF 1.1

Case Reports in Endocrinology Pub Date : 2020-12-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6688927

Valeria Calcaterra, Francesco Bassanese, Andrea Martina Clemente, Rossella Amariti, Corrado Regalbuto, Anna Sala, Gian Vincenzo Zuccotti

{"title":"Adverse Effects of Ramadan Fasting in a Girl with Salt-Losing Congenital Adrenal Hyperplasia.","authors":"Valeria Calcaterra, Francesco Bassanese, Andrea Martina Clemente, Rossella Amariti, Corrado Regalbuto, Anna Sala, Gian Vincenzo Zuccotti","doi":"10.1155/2020/6688927","DOIUrl":"https://doi.org/10.1155/2020/6688927","url":null,"abstract":"Objective: Congenital adrenal hyperplasia (CAH) is the most common cause of adrenal insufficiency in pediatrics. Chronic glucocorticoid replacement is the mainstay of treatment in the classic forms of CAH, and mineralocorticoid replacement therapy is mandatory in the salt-wasting form. Fasting is a mild stressor, which can expose to dehydration, hypotension, hypoglycemia, and acute adrenal crisis in patients with adrenal insufficiency.Case: We report the case of an adolescent affected by the classic form with salt-losing CAH, who observed Ramadan for 30 days, without individualized therapeutic management plan. After Ramadan, a dramatic increase of ACTH level (1081 pg/ml, n.v. 6-57), reduced cortisolemia, tendency to hypotension, and weight loss were recorded. She experienced insomnia, intense thirst, asthenia, and headache. The symptoms disappeared restarting the previous therapy schedule and increasing the total hydrocortisone daily dose with progressive restoring of hormonal control.Conclusion: Our case confirms that patients with CAH are vulnerable, especially during fasting in Ramadan, with a higher risk of acute adrenal crisis. CAH patients should reform and individualize their treatment plan and be submitted to careful monitoring.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2020 ","pages":"6688927"},"PeriodicalIF":1.1,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38749000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Glucose-Lowering Effects of Coconut Oil: A Case Report and Review of the Literature. 椰子油的降血糖作用:1例报告及文献复习。

IF 1.1

Case Reports in Endocrinology Pub Date : 2020-12-27 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8841781

Samar Malaeb, Christopher Spoke

{"title":"The Glucose-Lowering Effects of Coconut Oil: A Case Report and Review of the Literature.","authors":"Samar Malaeb, Christopher Spoke","doi":"10.1155/2020/8841781","DOIUrl":"https://doi.org/10.1155/2020/8841781","url":null,"abstract":"Background: Coconut oil, a saturated fat comprised mostly of the medium-chain fatty acid, lauric acid, has become increasingly popular over the past few decades due to its touted anti-inflammatory, metabolic, and lipid-lowering properties. There have been many studies with mixed results evaluating the effects of coconut oil consumption on lipid metabolism and cardiometabolic risk. However, the effects on glucose metabolism are less clear. There are few trials on the effects of coconut oil on glucose homeostasis but no case reports prior to the current one.Case: We present a case of a 66-year-old man with a history of type 2 diabetes managed with insulin who developed recurrent hypoglycemia and required reduction in insulin therapy quickly after consuming coconut oil supplementation.Conclusion: This is the first known case report of coconut oil supplementation in a diabetic patient on insulin resulting in hypoglycemia. Review of the literature shows that coconut oil supplementation can have a favorable effect on glycemic control, possibly through phenolic compounds mediating anti-inflammatory effects. This effect is inconsistent throughout the studies reviewed, likely due to variations in types of coconut oil supplementation and scarcity of trials. Further research is required both in animal models and in humans before coconut oil intake is widely advised and popularized. This is especially true in patients with diabetes, who are at increased risk of cardiovascular disease, and in whom reduction in saturated fat intake is advised.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2020 ","pages":"8841781"},"PeriodicalIF":1.1,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38803259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Delayed Diagnosis of Congenital Hypothyroidism in a Child with Trisomy 21 and Biotinidase Deficiency and Successful Use of Levothyroxine Sodium Oral Solution. 21三体合并生物素酶缺乏儿童先天性甲状腺功能减退症的延迟诊断及左旋甲状腺素钠口服液的成功应用。

IF 1.1

Case Reports in Endocrinology Pub Date : 2020-12-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8883969

Matthew M Feldt

{"title":"Delayed Diagnosis of Congenital Hypothyroidism in a Child with Trisomy 21 and Biotinidase Deficiency and Successful Use of Levothyroxine Sodium Oral Solution.","authors":"Matthew M Feldt","doi":"10.1155/2020/8883969","DOIUrl":"https://doi.org/10.1155/2020/8883969","url":null,"abstract":"Endocrine disorders are more common and appear earlier in people with trisomy 21 (T21) than in the general population, with thyroid dysfunction being the most common, including both congenital and acquired hypothyroidism. The treatment for biotinidase deficiency, a condition that occurs in approximately 1 : 110,000 people, is with biotin (vitamin B7) supplementation. However, biotin can interfere with endocrine laboratory assays and cause falsely low thyroid-stimulating hormone (TSH) and elevated free thyroxine (FT4) levels. This can interfere with the timely diagnosis and subsequent treatment of congenital hypothyroidism (CH). This case report describes an infant with partial biotinidase deficiency that was confirmed on day 10 of life. Routine screening erroneously reported \"normal\" TSH that caused delayed diagnosis of CH due to interference with the TSH assay from concurrent biotin use. Once the biotin treatment was withheld for 4 days and the thyroid function tests repeated, an elevated TSH became apparent. Treatment with tablet levothyroxine (L-T4) was started and subsequently changed to L-T4 oral solution (Tirosint®-SOL) to overcome treatment administration difficulties encountered with the tablet form. This resulted in improved TSH control due to more accurate and consistent dosing compared with the tablet formulation. This is the first report of the use of L-T4 oral solution in an infant with T21 and biotinidase deficiency.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2020 ","pages":"8883969"},"PeriodicalIF":1.1,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38803737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Recurrent Thyroid Storm Caused by a Complete Hydatidiform Mole in a Perimenopausal Woman. 围绝经期妇女完全包虫状痣引起复发性甲状腺风暴。

IF 1.1

Case Reports in Endocrinology Pub Date : 2020-12-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8842987

Anuradha Jayasuriya, Dimuthu Muthukuda, Preethi Dissanayake, Shyama Subasinghe

{"title":"Recurrent Thyroid Storm Caused by a Complete Hydatidiform Mole in a Perimenopausal Woman.","authors":"Anuradha Jayasuriya, Dimuthu Muthukuda, Preethi Dissanayake, Shyama Subasinghe","doi":"10.1155/2020/8842987","DOIUrl":"https://doi.org/10.1155/2020/8842987","url":null,"abstract":"Background: Gestational trophoblastic disease (GTD) which includes hydatidiform mole, invasive mole, placental site trophoblastic tumor, and choriocarcinoma is a rare cause of hyperthyroidism due to excess production of placental human chorionic gonadotrophin hormone (hCG) by tumor cells. Molecular mimicry between hCG and thyroid stimulating hormone (TSH) leads to continuous stimulation of TSH receptor by extremely high levels of hCG seen in these tumors. Consequently, biochemical and clinical hyperthyroidism ensues and it is potentially complicated by thyrotoxic crisis which is fatal unless urgent therapeutic steps are undertaken. Case Description. We present a 49-year-old perimenopausal woman who presented with recurrent thyroid storm and high output cardiac failure. The initial workup revealed suppressed TSH, high-free thyroxine (FT4), and free triiodothyronine (FT3) levels with increased vascularity of the normal-sized thyroid on ultrasonography. She was managed with parenteral beta blockers, steroids, and high-dose carbimazole. Her lower abdominal tenderness led to further investigations which revealed tremendously elevated beta-hCG and a snow storm appearance on transabdominal ultrasound suggestive of GTD. She underwent curative surgery and was diagnosed with complete hydatidiform mole postoperatively by histology.Conclusion: Recurrent thyroid crisis in gestational trophoblastic disease is an exceedingly rare presentation and that is highly fatal. This case highlights the importance of early detection and treatment of the etiology of thyrotoxicosis to eliminate mortality.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2020 ","pages":"8842987"},"PeriodicalIF":1.1,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38803736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Graves' Disease Presenting with Complete Atrioventricular Block. Graves病表现为完全性房室传导阻滞。

IF 1.1

Case Reports in Endocrinology Pub Date : 2020-12-15 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6656875

Young Sil Eom, Pyung Chun Oh

引用次数: 4

Functional Adrenal Collision Tumor in a Patient with Cushing's Syndrome. 库欣综合征患者的功能性肾上腺碰撞瘤。

IF 1.1

Case Reports in Endocrinology Pub Date : 2020-12-14 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7415762

Cathy Zhou, Ghaneh Fananapazir, Michael J Campbell

引用次数: 1