Case Reports in Endocrinology最新文献_第8页

Thyrotoxicosis after COVID-19 Infection with a Delay in Graves' Disease Antibody Positivity. COVID-19感染后甲状腺毒症伴Graves病抗体阳性延迟。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/8402725

Dennis C Boyle, Jamie A Mullally

{"title":"Thyrotoxicosis after COVID-19 Infection with a Delay in Graves' Disease Antibody Positivity.","authors":"Dennis C Boyle, Jamie A Mullally","doi":"10.1155/2023/8402725","DOIUrl":"https://doi.org/10.1155/2023/8402725","url":null,"abstract":"Background and Objective. Mounting evidence implicates COVID-19 as a cause of thyroid dysfunction, including thyrotoxicosis due to both thyroiditis and Graves' disease (GD). In this report, we present a case of thyrotoxicosis following COVID-19 infection that was ultimately found to represent GD with significantly delayed diagnostic serum antibody positivity. Case Report. A 65-year-old woman with a history of uncomplicated COVID-19 infection one month prior, presented to the Emergency Department with exertional dyspnea and palpitations, and was found to be in atrial fibrillation with rapid ventricular response (AF with RVR). Labs showed subclinical hyperthyroidism and the patient was started on a beta-blocker and methimazole. One month later, thyroid-stimulating immunoglobulin (TSI) resulted negative and thyroid function tests had normalized. The clinical picture suggested thyroiditis, and methimazole was stopped. One month later, the patient again presented in AF with RVR, with labs showing overt biochemical thyrotoxicosis. Antibodies were re-tested, and the thyrotropin receptor antibody (TRAb) and TSI resulted positive, confirming GD. Discussion. Most notable in this case is the feature of delayed GD antibody positivity: the diagnostic immunoassay for GD resulted negative one and two months after infection, but was ultimately positive three months after infection. To the authors' knowledge, this represents the longest delayed antibody positivity reported to date, amongst cases of new-onset GD following COVID. Conclusion. The clinical course of GD following COVID-19 infection is highly variable. This case underscores the need for vigilance in monitoring for delayed GD antibody positivity due to the important therapeutic implications of distinguishing thyroiditis from GD.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"8402725"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Glucocorticoid Use and the Risk of Posttransplant Diabetes. 局部使用糖皮质激素与移植后糖尿病的风险。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/3648178

Simon Bøtker, Henrik Birn, Lara Aygen Øzbay

引用次数: 2

Riedel's Thyroiditis: Pitfalls in Diagnosis and Subsequent Complications. 里德尔甲状腺炎:诊断缺陷及后续并发症。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/9989953

R Pandev, M Khan, V Ratheesh

{"title":"Riedel's Thyroiditis: Pitfalls in Diagnosis and Subsequent Complications.","authors":"R Pandev, M Khan, V Ratheesh","doi":"10.1155/2023/9989953","DOIUrl":"https://doi.org/10.1155/2023/9989953","url":null,"abstract":"Riedel's thyroiditis is a rare disease of chronic inflammation with fibrotic infiltration of the thyroid gland and its surrounding vital structures. Due to its low incidence, there are often delays in diagnosis as it is commonly mistaken for other thyroid diseases. We report the case of a 34-year-old female patient who presented with a firm, enlarged mass in the neck, compression symptoms, and hypothyroidism. Lab tests showed elevated A-TG (thyroglobulin antibodies) and A-TPO (thyroid peroxidase antibodies) levels. Based on the disease presentation and supporting lab findings, the patient was misdiagnosed with Hashimoto's thyroiditis and treated accordingly. Yet the patient's symptoms grew progressively worse. She was discovered to have severe tracheal compression and bilateral RLN (recurrent laryngeal nerve) palsy. Tracheotomy became a necessary surgical intervention after the development of respiratory failure, but this procedure was complicated by the development of an intraoperative pneumothorax. After an open biopsy, histology revealed Riedel's thyroiditis. A new treatment was introduced, with which the patient's condition improved. However, she continued to suffer from the open tracheocutaneous fistula left by the tracheostomy, which adversely affected her everyday life. A follow-up operation was performed to close the fistula. In this case report, we discuss the consequences of misdiagnosing the patient and delaying the appropriate treatment for her disease.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"9989953"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9391105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Iatrogenic Cushing's Syndrome following Use of an Over-the-Counter Arthritis Supplement. 使用非处方关节炎补充剂后发生医源性库欣综合征1例。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/4769258

Colin Dunn, Joshua Amaya, Patrick Green

引用次数: 3

Sitosterolemia: A Case Report and a Concise Literature Review. 谷固醇血症:1例报告及简明文献回顾。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/4451595

Moeber M Mahzari

引用次数: 1

A Rare Observation of Brachymetacarpia and Brachymetatarsia in a Patient with Primary Idiopathic Hypoparathyroidism. 原发性特发性甲状旁腺功能减退症患者掌跖不足和跖不足的罕见观察。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/4149677

Parackrama Karunathilake, Arun Rajaratnam, W K S Kularatne

引用次数: 0

Sodium-Glucose Transport Protein 2 Inhibitors Association with Euglycemic Diabetic Ketoacidosis. 钠-葡萄糖转运蛋白2抑制剂与糖尿病酮症酸中毒的关系。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/6835882

Caroline Wojtas, Alex P Rasarmos, Naja Naddaf

引用次数: 1

Management of Neonatal Diabetes due to a KCNJ11 Mutation with Automated Insulin Delivery System and Remote Patient Monitoring. KCNJ11突变引起的新生儿糖尿病的自动胰岛素输送系统和远程患者监测的管理。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/8825724

Ming Yeh Lee, Anna L Gloyn, David M Maahs, Priya Prahalad

引用次数: 0

Acute Sheehan's Syndrome Presenting with Hyponatremia Followed by a Spontaneous Pregnancy. 以低钠血症伴自然妊娠的急性希恩综合征。

IF 1.1

Case Reports in Endocrinology Pub Date : 2022-11-25 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9181365

Maria M Pineyro, Leonardo Diaz, Macarena Guzzetti, Mariana Risso, Jimena Pereda

{"title":"Acute Sheehan's Syndrome Presenting with Hyponatremia Followed by a Spontaneous Pregnancy.","authors":"Maria M Pineyro, Leonardo Diaz, Macarena Guzzetti, Mariana Risso, Jimena Pereda","doi":"10.1155/2022/9181365","DOIUrl":"https://doi.org/10.1155/2022/9181365","url":null,"abstract":"Background: Acute Sheehan's syndrome is rare, as well as hyponatremia as its initial manifestation. In addition, spontaneous pregnancy in patients after Sheehan's syndrome is unusual. To our knowledge, no cases of spontaneous pregnancy after acute Sheehan's syndrome have been reported. We describe a case of Sheehan's syndrome that presented with acute hyponatremia and a spontaneous pregnancy.Case: A 34-year-old female developed blood loss during delivery, which required a blood transfusion. On day seven postpartum, she presented with headaches, lethargy, and difficulty in breastfeeding. The workup showed hyponatremia (118 mEq/l), secondary hypothyroidism, and low prolactin levels. Magnetic resonance imaging showed pituitary necrosis. She was treated with NaCl, hydrocortisone (cortisol results were not available), and levothyroxine. Laboratory tests six weeks after discharge showed low IGF-1 and 8 AM cortisol and normal FT4, LH, FSH, and PRL levels. She was able to partially breastfeed until 4 months postpartum. Regular menstrual cycles started three months later. She became spontaneously pregnant one year later.Conclusion: Acute Sheehan's syndrome should be considered in the evaluation of postpartum patients with suggestive symptoms. Physicians should be aware that hyponatremia could be an initial manifestation of Sheehan's syndrome, which requires a high index of suspicion for diagnosis. Spontaneous pregnancy can occur after acute Sheehan's syndrome.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":" ","pages":"9181365"},"PeriodicalIF":1.1,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35207478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Thyroiditis after mRNA Vaccination for COVID-19. 新冠病毒mRNA疫苗接种后甲状腺炎。

IF 1.1

Case Reports in Endocrinology Pub Date : 2022-11-09 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7604295

Arunava Saha, Sanjita Chittimoju, Nitin Trivedi

{"title":"Thyroiditis after mRNA Vaccination for COVID-19.","authors":"Arunava Saha, Sanjita Chittimoju, Nitin Trivedi","doi":"10.1155/2022/7604295","DOIUrl":"https://doi.org/10.1155/2022/7604295","url":null,"abstract":"Background: SARS-CoV-2 has been known to cause multisystemic involvement, gaining entry through ACE-2 and TMPRSS2 receptors. COVID-19 vaccine-associated thyroiditis cases are now being reported. Case Report. Case 1. A 36-year-old woman with a history of right hemithyroidectomy for a benign thyroid nodule, on a stable dose of levothyroxine with euthyroid labs, presented with progressively worsening left neck pain, episodic palpitations, and heat intolerance after the second dose of mRNA1273 (Moderna) vaccine. Examination revealed an enlarged and tender left lobe of the thyroid with suppressed TSH but normal free T4 and ESR, signifying subacute thyroiditis. She was managed conservatively without corticosteroids or beta-blockers, and her symptoms resolved. A follow-up revealed increasing TSH, and levothyroxine was restarted. Case 2. A 33-year-old man with a history of anxiety disorder on Sertraline, presented with a two-week history of palpitations, heat intolerance, and 10-pound weight loss after the second dose of BNT162b2 (Pfizer-BioNTech) vaccine. Examination revealed a normal thyroid gland with no tenderness with elevated thyroid peroxidase and thyroglobulin antibodies. Ultrasound showed a diffusely heterogeneous thyroid with increased vascularity, suggesting silent thyroiditis. Follow-up revealed a hypothyroid phase with high TSH for which levothyroxine supplementation was started. Discussion. COVID-19 vaccine-associated subacute and silent thyroiditis have occurred following all three kinds of available vaccines, characterized by an initial thyrotoxic phase, followed by a hypothyroid phase and a recovery phase. Hypotheses include an immune response triggering thyroid inflammation or cross-reactivity with viral proteins.Conclusions: COVID-19 vaccine-associated thyroiditis is rare, but long-term monitoring of these patients is essential to ensure appropriate diagnosis and management of the potential hypothyroid phase.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":" ","pages":"7604295"},"PeriodicalIF":1.1,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40503673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4