Caries Research最新文献

{"title":"Increasing Global Trends in Early Childhood Caries Prevalence over the Last Decade: Global Burden of Disease Study 2021.","authors":"Cayara Mattos Costa, Silas Alves-Costa, Fernando Neves Hugo, Antonio Marcus de Andrade Paes, Cinthia Pereira Machado Tabchoury, Jaime Aparecido Cury, Cecilia Claudia Costa Ribeiro","doi":"10.1159/000549128","DOIUrl":"10.1159/000549128","url":null,"abstract":"<p><strong>Introduction: </strong>Global trends in early childhood caries (ECC) remain unclear, with previous studies reporting either stable or declining rates over the past three decades. Given the short functional lifespan of the primary dentition and the urgency of targeted public health policies, the absence of focused investigation into the most recent decade constitutes a critical gap. This study, therefore, aimed to analyze temporal trends in the global prevalence of caries in deciduous teeth across 204 countries and seven super-regions from 2010 to 2021.</p><p><strong>Methods: </strong>Prevalence rates (/100,000 population) of dental caries in deciduous teeth among children under 5 years of age were obtained from the Global Burden of Disease Study 2021. Temporal trends were assessed using Prais-Winsten linear regression, and annual percentage change (APC) was calculated.</p><p><strong>Results: </strong>Over the past decade, the global prevalence of caries in deciduous teeth has exhibited an increasing trend (APC = 0.73%; p < 0.001), with the most marked increases observed in High-Income countries (APC = 6.51%; p = 0.005) and in Latin America and the Caribbean (APC = 2.17%; p < 0.001). The USA (APC = 19.32%; p = 0.002) and Brazil (APC = 5.27%; p < 0.001) recorded the highest increases within their respective super-regions.</p><p><strong>Conclusion: </strong>Focusing on the last decade underscores in ECC prevalence that may not be evident the aggregated data over the last three decades. The upward trend underscores the urgent need for policies that address both commercial and social determinants, promote reductions in sugar consumption, and ensure equitable access to fluoride for effective caries control.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotin Limitation Attenuates <italic>Streptococcus mutans</italic> Cariogenicity by Disrupting Metabolic Flux and Virulence Pathways.","authors":"Zirui Qin, Zhenyu Yang, Yi Zhang, Linlong Qi, Yan Peng, Shuli Deng, Yuan Wang","doi":"10.1159/000548822","DOIUrl":"10.1159/000548822","url":null,"abstract":"<p><strong>Introduction: </strong>Our previous metagenomic analysis revealed higher frequencies of biotin-related genes (i.e., bioY, bioM, bccP) in caries-active children, indicating a potential role of biotin in caries pathogenesis. This study investigated a biotin limitation strategy against the primary cariogenic bacterium Streptococcus mutans (S. mutans), including its effects on cariogenic phenotypes, gene expression, and metabolomics.</p><p><strong>Methods: </strong>S. mutans UA159 was cultured in biotin-free medium supplemented with different biotin concentrations. The cariogenic phenotypes of the strain, including growth kinetics, biofilm formation, exopolysaccharide production, lactate synthesis, acid/oxidative tolerance, and membrane fluidity, were measured and compared across biotin concentrations. Biofilm architecture was visualized via confocal laser-scanning microscopy and scanning electron microscopy. Quantitative real-time polymerase chain reaction was employed to analyze the expression of genes associated with virulence and biotin metabolism. Metabolomic analysis was performed to characterize metabolic perturbations induced by biotin limitation in S. mutans.</p><p><strong>Results: </strong>Under biotin limitation, S. mutans exhibited significantly reduced cariogenic phenotypes, accompanied by cell elongation and reduced membrane fluidity. At the molecular level, biotin limitation suppressed the expression of key virulence-associated genes and induced a compensatory upregulation of genes involved in biotin uptake and biotin-dependent carboxylases. Metabolomic analysis under biotin-limited conditions in S. mutans revealed perturbed pathways in central carbon metabolism and nucleotide metabolism.</p><p><strong>Conclusion: </strong>Biotin limitation significantly reduced the cariogenic potential of S. mutans by disrupting metabolic flux and virulence gene expression, highlighting biotin uptake and metabolism as potential targets for anticaries therapies.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-Wide Association Studies on Dental Caries: A Systematic Review.","authors":"Ke Zhou, Chenyi Gao, Jianhua Wu, Avijit Banerjee, Mark Ide, Jing Kang","doi":"10.1159/000548693","DOIUrl":"10.1159/000548693","url":null,"abstract":"<p><strong>Introduction: </strong>Dental caries is a complex, multifactorial pathological disease. Despite advances in dental care, dental caries continues to pose a significant public health challenge. In addition to the behavioural factors (e.g., sugar exposure) and environmental/oral hygiene factors (e.g., fluoride exposure in water and/or toothpaste) on the development of dental caries, potential genetic influence on dental caries susceptibility is possible, but evidence is inconclusive, especially from a candidate gene approach. Over the past 2 decades, a genome-wide association study (GWAS) approach has also been applied to understand the genetic variants associated with dental caries. This study aims to systematically review GWAS on dental caries and identify relevant genetic risk variants of dental caries.</p><p><strong>Methods: </strong>A systematic search was conducted in five databases (PubMed; ScienceDirect; Embase, Global Health, MEDLINE) and one GWAS registry: GWAS Catalog in March 2024. Studies published after 2005 using GWAS approach were eligible. Q-Genie tool was used for the quality assessment. Study information and single-nucleotide polymorphisms (SNPs) at conventional (5 × 10-8) or suggestive (5 × 10-6) GWAS significance level were extracted and synthesized.</p><p><strong>Results: </strong>A total of 16 papers were included, identifying 20 risk SNPs associated with dental caries at conventional GWAS significance level and 33 SNPs at suggestive level. No common conventional SNPs or shared gene regions were found between studies. Of these studies, the sample sizes in majority were relatively small and only one study reported all recommended quality control steps. Most studies focused on the white or European-American population and dental caries on permanent teeth. In addition, some data resources were used repeatedly in multiple studies, particularly the Center for Oral Health Research in Appalachia (COHRA) cohorts, which was used in 9 studies.</p><p><strong>Conclusion: </strong>This study explored the GWAS on dental caries and summarized the heterogeneities of the included studies, leading to inconsistent results. Guideline and more GWAS with larger sample size and multiethnicities are needed to fully understand the genetic basis of dental caries.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"1-20"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Caries Research.","authors":"Livia M A Tenuta","doi":"10.1159/000545156","DOIUrl":"10.1159/000545156","url":null,"abstract":"","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"85-86"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is History of Cardiovascular Disease Associated with Increased Caries Experience among Taiwanese Adults?","authors":"Lin-Yang Chi, Po-Yen Lin, Le-Yin Hsu, Shao-Yuan Chuang, Shao-Ching Chen, Lin-Yang Chi","doi":"10.1159/000543769","DOIUrl":"10.1159/000543769","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined the association between cardiovascular disease (CVD) history and their dental caries experience status.</p><p><strong>Methods: </strong>Conducted from January 2021 to June 2023, this cross-sectional cohort study involved 7,138 participants who underwent oral examinations. Data on demographic background, oral health-related behaviors, and smoking status were collected using a structured questionnaire. Dental caries was diagnosed at the cavitation level according to the World Health Organization criteria and calculated into caries experience indices including decayed, missing, and filled teeth (DMFT), decayed teeth, missing teeth and filled teeth. Information on CVD history was obtained from the Taiwan National Health Insurance Research Database, including acute myocardial infarction, ischemic stroke, and coronary artery disease. Multivariate linear regression models were used to assess the association between CVD history and its dental caries experience status.</p><p><strong>Results: </strong>Of the participants, 158 (2.2%) had a prior diagnosis of CVD. Participants with CVD history had a significantly higher mean DMFT index (21.21 ± 8.37) than did those without CVD history (13.4 ± 7.82; p < 0.0001). After adjusting for confounding factors, participants with CVD history had a mean DMFT index that was 2.11 higher (95% CI = 0.99, 3.24, p < 0.01) and 2.21 more missing teeth (95% CI = 1.42, 3.00, p < 0.0001) than did those without CVD history. Subgroup analyses indicated that participants aged ≥65 years were predominantly affected.</p><p><strong>Conclusion: </strong>Older participants with CVD history were associated with an increased number of missing teeth. The present study design could not conclude a positive association between CVD history and its DMFT status, partly due to the lack of data on the reason for missing teeth.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"406-414"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediation Pathway Linking Dental Caries and Academic Performance in Children.","authors":"Mir Faeq Ali Quadri, Basaruddin Ahmad","doi":"10.1159/000540883","DOIUrl":"10.1159/000540883","url":null,"abstract":"<p><strong>Introduction: </strong>There is little discussion in the literature on the pathway linking oral health problems and academic performance (AP) in children. This study investigated the hypothesis that the influence of dental caries on academic performance is mediated through toothache and impacted sleep and study activities.</p><p><strong>Methods: </strong>This cross-sectional study on children aged 12-14 years collected data on the exposure (decayed tooth index), outcome (school examination results), and mediator (school absence due to toothache, and oral health impact on sleep and study performances using the Child-Oral Impact on Daily Performance instrument) variables. It used mediation analysis to examine the indirect effects of a single and two serial mediators using model 4 (caries → mediator → AP) and model 6 (caries → mediator 1 → mediator 2 → AP), respectively, in PROCESS macro add-on software in IBM SPSS v24. Analyses were carried out separately for boys and girls at a 5% significance level.</p><p><strong>Results: </strong>In model 4, school absence due to toothache (boys: 95% CI: 0.42, 1.01; girls: 95% CI: 0.58, 0.98), and impacted sleep (95% CI: 0.13, 0.41; 95% CI: 2.17, 13.03), and study (95% CI: 0.05, 0.42; 95% CI: 0.54, 0.94) performance were significant single mediators in both sexes. In model 6, school absence due to toothache and impacted sleep activity (boys: 95% CI: 0.02, 0.29 and girls: 95% CI: 1.37, 12.81), and school absence due to toothache and impacted study activity (girls: 95% CI: 1.37, 12.81) were significant two serial-mediators.</p><p><strong>Conclusion: </strong>This study provides empirical evidence showing that dental caries and toothache can impact academic performance as they disrupt sleep and study performances to influence the learning and cognition process. The finding bridges the understanding of the mechanism underpinning the relationship and thus, further emphasizes the importance of caries prevention in children with high caries risk for improving their health outcomes and educational experience.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption and Effect of Sealants for Occlusal Noncavitated Caries in a Large Dental Network in the USA.","authors":"Nilesh H Shah, Jeffrey L Fellows, Deborah E Polk","doi":"10.1159/000540884","DOIUrl":"10.1159/000540884","url":null,"abstract":"<p><strong>Introduction: </strong>Dental sealants applied to occlusal pit-and-fissure surfaces have been shown to prevent caries and arrest occlusal noncavitated carious lesions (NCCLs). The American Dental Association (ADA) recommends that oral healthcare providers apply sealants on occlusal NCCLs. Though the evidence is clear that sealants are effective, few studies have examined the adoption of the ADA guideline by dentists and the duration of protection provided by sealants in a large real-world setting.</p><p><strong>Methods: </strong>This study used observational electronic health record (EHR) data from a network of dental clinics to follow teeth over a 2 year time period from when they were diagnosed as having an occlusal NCCL until either they were treated with a restoration or the time period ended with no restoration. The objectives of the study were to determine: (1) the degree to which dentists adopted the guideline, (2) whether the duration of protection was different for teeth that received a sealant from teeth that did not receive a sealant, and (3) whether dentists' experience placing sealants was associated with the duration of protection.</p><p><strong>Results: </strong>Overall, there were 7,299 teeth in the sample. Of those, dentists restored 591 teeth and applied sealants on 164. The sealant application rate for eligible teeth was 2.2%. Sealant application was associated with provider, with 1.9% of providers placing more than half of the sealants. By the end of the observation period, the proportion of teeth progressing to restorations was 8.2% for teeth that had not received a sealant and 3.0% for teeth that had received one (RR = 0.37; 95% CI: 0.16-0.88; p = 0.02). Multilevel survival analysis showed that teeth that had not received a sealant were restored sooner than teeth that had received a sealant (aHR = 0.11; 95% CI: 0.03-0.36; p < 0.01). Overall, teeth that received a sealant had an 89% reduced hazard of restoration within 2 years compared with teeth that did not receive sealants.</p><p><strong>Conclusion: </strong>This study found that by arresting decay, the presence of sealants led to fewer restorations and delayed restorations compared with teeth not receiving a sealant or restoration in the 2 years following diagnosis of occlusal NCCL in clinical settings.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"11-21"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and Factors Influencing Oral Health Behaviours in 2-Year-Old Children: A Cross-Sectional Analysis of Data from the KUNO-Kids Health Study.","authors":"Áine M Lennon, Christoph Musiol, Karl-Anton Hiller, Nils Gade, Wolfgang Buchalla, Susanne Brandstetter, Angela Köninger, Michael Melter, Christian Apfelbacher, Michael Kabesch, Áine M Lennon","doi":"10.1159/000542913","DOIUrl":"10.1159/000542913","url":null,"abstract":"<p><p><p>Introduction: This questionnaire-based investigation aimed to assess oral health behaviour (OHB) in 2-year-old children taking part in a birth cohort study and to identify relationships between general health, socioeconomic as well as psychosocial factors and OHB.</p><p><strong>Methods: </strong>Factors examined were single-parent status, migration background, child's sex, parity, maternal age, education and social support, paternal employment, parental mental and physical health, and child health, data for which were collected at birth, 4 weeks, or 1 year. Participants who answered all OHB questions at 2 years (n = 730) were included. Nutritional score (NS), toothbrushing score (TS), and dental check-up score (CS) were used to calculate overall OHB score.</p><p><strong>Results: </strong>Overall OHB in this cohort was good. 62% ate fruit or vegetables daily, 75% brushed 2-3 times daily, and 61% had already had a dental check-up. Children of single mothers had significantly lower OHB scores. NS was significantly higher for children with migration background, children of mothers with better physical health or higher educational level, but lower for children of mothers reporting poor social support. TS was significantly lower in children of single mothers and children of fathers reporting poorer mental health. CS was significantly higher in children of multiparous mothers. This study highlights the relevance of social support and parental health, in contributing to OHB patterns.</p><p><strong>Conclusion: </strong>Families with special healthcare needs or less robust social support may have difficulty maintaining good OHB. </p>.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"237-254"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"72nd ORCA Congress Abstracts.","authors":"Livia Tenuta","doi":"10.1159/000546564","DOIUrl":"10.1159/000546564","url":null,"abstract":"","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":"59 3","pages":"315-384"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of Intraoral Optical Coherence Tomography and Bitewing Radiography for Detecting Approximal Carious Lesions.","authors":"Michaela Strumpski, Hartmut Schneider, Claudia Rüger, Jana Schmidt, Ellen Schulz-Kornas, Rainer Haak","doi":"10.1159/000544789","DOIUrl":"10.1159/000544789","url":null,"abstract":"<p><strong>Introduction: </strong>This in vitro study evaluated the validity and reliability of spectral-domain optical coherence tomography (SD-OCT) to detect approximal carious lesions compared to bitewing radiography.</p><p><strong>Methods: </strong>Forty extracted human premolars and molars with fifty-four unrestored approximal surfaces (ICDAS ll score 0-3) were mounted in a patient-equivalent simulator and imaged by digital radiography (DR) and the prototype of an intraoral OCT probe. The lesion status of the tooth surfaces was validated histologically and by microtomography (µCT). Five calibrated raters with low to high level of clinical expertise analyzed the DR and OCT images at intervals of 2-4 weeks each. Intra- and interrater agreement (weighted Cohen's kappa κ, Fleiss' kappa), sensitivity, and specificity were calculated.</p><p><strong>Results: </strong>The sensitivity of OCT (0.66-0.91) was higher than that of DR (0.46-0.82), as was the specificity (OCT: 0.67-0.92; DR: 0.33-0.58). Intrarater agreement with OCT was moderate to substantial (κ: 0.53-0.77; p < 0.001) and fair to substantial for DR (κ: 0.36-0.78; p < 0.05). The DR interpersonal agreement ranged from slight to substantial (κ: 0.1-0.74, Fleiss' κ: 0.23/0.24; p < 0.001) toward fair to substantial with OCT (κ: 0.27-0.62; Fleiss' κ: 0.23/0.18; p < 0.001). Agreement between histology and µCT was almost perfect (κ: 0.82; p < 0.001).</p><p><strong>Conclusions: </strong>In a clinically oriented simulation, OCT was more sensitive in detecting early approximal carious lesions than DR without impairing specificity or reproducibility. Clinical studies will have to show whether OCT can confirm these promising results.</p>","PeriodicalId":9620,"journal":{"name":"Caries Research","volume":" ","pages":"476-489"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}