Canadian Medical Association journal最新文献

{"title":"Actively holding the line.","authors":"Kirsten Patrick","doi":"10.1503/cmaj.250418","DOIUrl":"10.1503/cmaj.250418","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E325-E326"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Canadian guidance should present formula and breast- or chestfeeding as equivalent options for parents with virally suppressed HIV\".","authors":"","doi":"10.1503/cmaj.250412","DOIUrl":"10.1503/cmaj.250412","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E329"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perte auditive neurosensorielle subite.","authors":"Daniel Newsted, Munir Demir Bajin, Peng You","doi":"10.1503/cmaj.240457-f","DOIUrl":"10.1503/cmaj.240457-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E340-E341"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture en bâton de craie chez un homme de 81 ans atteint de spondylarthrite ankylosante.","authors":"Janis Timsans, Raine Tiihonen, Markku Kauppi","doi":"10.1503/cmaj.241337-f","DOIUrl":"10.1503/cmaj.241337-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E342-E343"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and the (full) cost of doing business.","authors":"William A Ghali","doi":"10.1503/cmaj.250406","DOIUrl":"10.1503/cmaj.250406","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E327-E328"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes trial (TC4): a Bayesian pragmatic cluster randomized controlled trial.","authors":"Stephen A Kutcher, Nandini Dendukuri, Sonny Dandona, Lyne Nadeau, James M Brophy","doi":"10.1503/cmaj.241862","DOIUrl":"10.1503/cmaj.241862","url":null,"abstract":"<p><strong>Background: </strong>Dual antiplatelet therapy is the standard of care for acute coronary syndrome, but uncertainty exists regarding the optimal regimen for patients in North America. We sought to compare the effectiveness and safety of acetylsalicylic acid (ASA) and ticagrelor or clopidogrel in patients with acute coronary syndrome from a single tertiary academic centre in Montréal, Canada.</p><p><strong>Methods: </strong>We conducted a pragmatic, open-label, time-clustered (bimonthly between October 2018 and March 2021), randomized controlled trial. The primary effectiveness end point was a composite of all-cause mortality, nonfatal myocardial infarction, or ischemic stroke. The primary safety end point was hospital admissions for bleeding. We ascertained 12-month outcomes from the Quebec universal electronic health databases. We designed and analyzed the study within a Bayesian paradigm to supplement existing knowledge. The primary analysis was a Bayesian logistic regression model with an informed focused prior from previously randomly assigned North American patients. Robustness was evaluated with vague and other prespecified informative priors, spanning reasonable pre-existing beliefs. We defined clinically important benefits and harms as risk reductions exceeding a 10% difference.</p><p><strong>Results: </strong>We randomly assigned 1005 patients with acute coronary syndrome to ticagrelor (<i>n</i> = 450) or clopidogrel (<i>n</i> = 555). Major acute cardiovascular events occurred in 50 (11.1%) patients assigned to ticagrelor and 64 (11.5%) assigned to clopidogrel (relative risk [RR] 0.95, 95% credible interval 0.67-1.35, with a vague prior). The primary analysis with an informed focused prior resulted in probabilities of a clinically meaningful ticagrelor benefit (RR < 0.9), equivalence (0.9 ≤ RR ≤ 1.1) or harm (RR ≥ 1.1) of 2%, 41%, and 57%, respectively. For the safety end point, there was no consistent signal of benefit or harm with ticagrelor. Sensitivity analyses with a range of prior beliefs gave generally consistent results.</p><p><strong>Interpretation: </strong>Whether we analyzed this trial with a vague or a range of reasonable informed priors, we found no strong evidence for the superiority of ticagrelor over clopidogrel in North American patients. Current guidelines favouring ticagrelor over clopidogrel might take this new evidence into future consideration.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov no. NCT04057300.</p>","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E309-E318"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal giardiasis and spirochetosis causing unintentional weight loss in a 40-year-old man.","authors":"Eshita Kapoor, Tara O'Brien, Lianne Tile, Brandon Tang","doi":"10.1503/cmaj.241507","DOIUrl":"10.1503/cmaj.241507","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E319-E322"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bouger plus, bien vieillir : la prescription d’activité physique aux personnes aînées.","authors":"Jane S Thornton, William N Morley, Samir K Sinha","doi":"10.1503/cmaj.231336-f","DOIUrl":"10.1503/cmaj.231336-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E330-E339"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing comorbid sleep issues in patients with attention-deficit/hyperactivity disorder.","authors":"Ayan Dey, Thuy Linh Do, Doron Almagor, Atul Khullar","doi":"10.1503/cmaj.241262","DOIUrl":"10.1503/cmaj.241262","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E323-E324"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction à l’article « Homme de 58 ans présentant une ischémie digitale subaiguë aux 4 membres ».","authors":"","doi":"10.1503/cmaj.250394-f","DOIUrl":"10.1503/cmaj.250394-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E344"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}