Calcified Tissue International最新文献_第9页

A Qualitative Approach to Quality of Life in Fibrous Bone Dysplasia /McCune Albright Syndrome: Looking Beyond Quantitative Analysis. 纤维性骨发育不良/ mcune - Albright综合征患者生活质量的定性方法：超越定量分析。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01332-y

Juliette Jousse, Blandine Merle, Elodie Feurer, Emmanuelle Vignot, Roland Chapurlat

{"title":"A Qualitative Approach to Quality of Life in Fibrous Bone Dysplasia /McCune Albright Syndrome: Looking Beyond Quantitative Analysis.","authors":"Juliette Jousse, Blandine Merle, Elodie Feurer, Emmanuelle Vignot, Roland Chapurlat","doi":"10.1007/s00223-024-01332-y","DOIUrl":"10.1007/s00223-024-01332-y","url":null,"abstract":"This study explores FD/MAS patient's perceptions about their disease and its impact on their quality of life. We have evaluated quality of life (QoL) in French Fibrous Dysplasia/MacCune-Albright Syndrome (FD/MAS) patients using a qualitative approach with focus groups to explore perceptions, symptoms and limitations associated with FD/MAS and a quantitative method with the Short Form-36 (SF36) to quantify QoL. Focus groups revealed the heterogeneity of FD forms and allowed for understanding the reasons of reduced QoL. Patients identified pain as the dominant symptom. The impact on mental health was explained by diagnostic uncertainty, disease chronicity and rarity and the inconsistent effectiveness of therapies. Patients talked about disability but also of coping strategies. They expressed their need for comprehensive and multi-disciplinary care from medical and paramedical professionals familiar with their pathology. The quantitative questionnaire SF36 confirmed reduced QoL in these patients compared with the French general population in all sub-domains: physical function (72.1 versus 84.4, p = 0.0001), physical role (60.5 versus 81.1, p = 0.0004), body pain (58.7 versus 72.4, p = 0.0004), general health (50.08 versus 67.6, p < 0.0001), energy (44.58 versus 57.2, p < 0.0001), social function (61.34 versus 80.5, p < 0.0001), emotional role (57.98 versus 81.3, p = 0.0002) and emotional well-being (57.98 versus 81.3, p = 0.0097). Polyostotic patients had poorer QoL compared with monostotic patients. A better understanding of the disease experience and expectations of FD patients will enable practitioners to provide care better adapted to patients' needs, and pave the way for optimizing DF care.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"18"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association between Social Support and Musculoskeletal Health in Community-Dwelling Older Adults: Findings from the Hertfordshire Cohort Study. 社区居住老年人社会支持与肌肉骨骼健康之间的关系：来自赫特福德郡队列研究的发现

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01307-z

Gregorio Bevilacqua, Stefania D'Angelo, Faidra Laskou, Elena Zaballa, Nicholas C Harvey, Elaine M Dennison

{"title":"The Association between Social Support and Musculoskeletal Health in Community-Dwelling Older Adults: Findings from the Hertfordshire Cohort Study.","authors":"Gregorio Bevilacqua, Stefania D'Angelo, Faidra Laskou, Elena Zaballa, Nicholas C Harvey, Elaine M Dennison","doi":"10.1007/s00223-024-01307-z","DOIUrl":"10.1007/s00223-024-01307-z","url":null,"abstract":"Previous studies suggest social support is associated with musculoskeletal health in later life. We explored this relationship further in community-dwelling older adults, by considering associations between different aspects of social support and musculoskeletal health in community-dwelling adults. Participants from the Hertfordshire Cohort Study reported level of confiding/emotional, practical, and negative support using the Close Persons Questionnaire. Muscle strength was measured by grip strength dynamometry, and physical capability by timed up-and-go, chair rises, and walking speed tests. Bone mineral density (BMD) was assessed using dual-energy x-ray absorptiometry. Linear regression, adjusted for age, sex, body mass index (BMI), alcohol, smoking, physical activity, social class, and diet, was used for analysis. 1842 men and women (mean age 65.7 years) participated. Low emotional support correlated with weaker grip strength and poorer physical capability tests, although estimates were not robust to adjustment for confounders. Low practical support was linked to shorter timed up-and-go (β - 0.171, 95%CI - 0.319, - 0.024) and walking speed times (β - 0.157, 95%CI - 0.306, - 0.007), following adjustment for confounders. Negative support (i.e. the perceived inadequacy of the support received) was associated with lower grip strength (β - 0.145, 95%CI - 0.223, - 0.067) and slower walking speeds (β 0.159, 95%CI 0.004, 0.314). No social support exposures were associated with BMD. Different types of social support are linked to various measures of musculoskeletal health in older adults. Limited requirement for practical support correlated with better physical capability, while negative support correlated with poorer outcomes. No social support measure was associated with BMD.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"8"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of a Novel Col1a1^G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations. 一种新型Col1a1G643S/+成骨不全小鼠模型的表征及其对骨骼表型、脆弱性和治疗评估的见解

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01320-2

Hiroyuki Saitou, Yasuhisa Ohata, Shinji Takeyari, Chiaki Nishizawa, Hirofumi Nakayama, Makoto Fujiwara, Yasuji Kitabatake, Takuo Kubota, Keiichi Ozono

{"title":"Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.","authors":"Hiroyuki Saitou, Yasuhisa Ohata, Shinji Takeyari, Chiaki Nishizawa, Hirofumi Nakayama, Makoto Fujiwara, Yasuji Kitabatake, Takuo Kubota, Keiichi Ozono","doi":"10.1007/s00223-024-01320-2","DOIUrl":"10.1007/s00223-024-01320-2","url":null,"abstract":"Osteogenesis imperfecta (OI) is an inheritable skeletal disorder characterized by bone fragility often caused by pathogenic variants in the COL1A1 gene. Current OI mouse models with a glycine substitution in Col1a1 exhibit excessive severity, thereby limiting long-term pathophysiological analysis and drug effect assessments. To address this limitation, we constructed a novel OI mouse model mimicking a patient with OI type III. This was achieved by introducing a G-to-A transversion at nucleotide position 2428 in the Col1a1 gene via CRISPR-Cas9 technology in C57BL/6 J mice. The resulting heterozygous variant mice (Col1a1G643S/+) displayed reduced body weight and pronounced skeletal abnormalities. Micro-CT analysis at 12 weeks revealed decreased vertebral bone parameters and altered cortical bone characteristics, indicative of bone fragility. Additionally, the abnormalities of the anisotropy, complexity, connectivity, and structure of trabecular bone were revealed. A three-point bending test confirmed the fragility, with reduced displacement and fracture energy in both sexes. Furthermore, we evaluated the effect of 4-phenylbutyric acid on the bone in Col1a1G643S/+ mice at 12 weeks, observing no significant effects, likely due to the absence of collagen retention in the ER in this model. Despite being a moderate OI model, Col1a1G643S/+ mice manifest a distinct and fragile bone phenotype, making them suitable for extended studies. This model offers a valuable platform for investigating long-term pathophysiological aspects of OI and assessing the efficacy of potential therapeutic interventions.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"13"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Disease Associated with Inactivating Aromatase Mutations and its Management. 与失活芳香酶突变相关的骨病及其管理。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01330-0

G Cavati, D Merlotti, P Cardamone, G Dipasquale, L Gennari

引用次数: 0

Helicobacter pylori-Related Chronic Gastritis as a Risk Factor for Lower Bone Mineral Density. 幽门螺杆菌相关慢性胃炎是低骨密度的危险因素。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01310-4

Izumi Inoue, Noriko Yoshimura, Toshiko Iidaka, Chiaki Horii, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Toru Akune, Takao Maekita, Kanae Mure, Kozo Nakamura, Sakae Tanaka, Satoshi Mochida, Masao Ichinose

{"title":"Helicobacter pylori-Related Chronic Gastritis as a Risk Factor for Lower Bone Mineral Density.","authors":"Izumi Inoue, Noriko Yoshimura, Toshiko Iidaka, Chiaki Horii, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Toru Akune, Takao Maekita, Kanae Mure, Kozo Nakamura, Sakae Tanaka, Satoshi Mochida, Masao Ichinose","doi":"10.1007/s00223-024-01310-4","DOIUrl":"10.1007/s00223-024-01310-4","url":null,"abstract":"We evaluated the role of Helicobacter pylori (H. pylori)-related chronic gastritis in the development of osteoporosis in a population-based study. A total of 1690 subjects in the cohort of the Research on Osteoarthritis/ osteoporosis Against Disability (ROAD) were investigated, and the association between gastritis and osteoporosis was evaluated by the presence of serologically assessed H. pylori-related chronic gastritis and its stage, based on H. pylori antibody titer and pepsinogen. The presence of the gastritis was associated with significantly lower bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry and a significant risk of lower BMD was observed in femoral neck (adjusted odds ratio [OR]: 0.78, 95% confidence interval [CI]: 061-0.99). The progression of the gastritis appeared to further increase the risk. In the stage of non-atrophic gastritis, the risk of lower BMD was significantly high, especially in a subgroup with higher gastritis activity in the femoral neck (adjusted OR: 0.61, 95% CI: 0.42-0.89). Meanwhile, in the stage of atrophic gastritis, the highest and significant risk of lower BMD was observed in a subgroup with the most extensive and severe atrophy in femoral neck (adjusted OR: 0.62, 95% CI: 0.42-0.91). These results suggest that H. pylori-related chronic gastritis is involved in the risk of osteoporosis, with higher activity of gastritis and more extensive atrophy leading to further increased risk. The serologically assessed stage of the gastritis could be used to identify a high-risk group for osteoporosis in H. pylori-infected subjects from general population.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"16"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Natural Hydroxyapatite and Synthetic Collagen Hydroxyapatite Enhance Bone Regeneration and Implant Fixation Similar to Allograft in a Sheep Model of Implant Integration. 天然羟基磷灰石和合成胶原羟基磷灰石长期增强骨再生和种植体固定，类似于同种异体移植物在绵羊种植体整合模型中的作用。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01309-x

Emma-Emilie Knudsen, Chris H Dreyer, Søren Overgaard, Yuan Zhang, Ming Ding

{"title":"Long-Term Natural Hydroxyapatite and Synthetic Collagen Hydroxyapatite Enhance Bone Regeneration and Implant Fixation Similar to Allograft in a Sheep Model of Implant Integration.","authors":"Emma-Emilie Knudsen, Chris H Dreyer, Søren Overgaard, Yuan Zhang, Ming Ding","doi":"10.1007/s00223-024-01309-x","DOIUrl":"10.1007/s00223-024-01309-x","url":null,"abstract":"There is an increasing demand for a suitable bone substitute to replace current clinical gold standard autografts or allografts. Majority of previous studies have focused on the early effects of substitutes on bone formation, while information on their long-term efficacies remains limited. This study investigated the efficacies of natural hydroxyapatite (nHA) derived from oyster shells and synthetic hydroxyapatite mixed with collagen (COL/HA) or chitosan (CS/HA) on bone regeneration and implant fixation in sheep. Titanium implants were inserted into critical-size defects in distal femur condyles bilaterally, and circumferential gaps around implants were filled with substitute materials or allografts (as control). 14 or 24 weeks post-operatively, the implant-bone blocks were harvested and evaluated using microarchitectural, histomorphometric, and mechanical methods. The nHA and COL/HA groups showed significant bone formation at both 14 and 24 weeks. There was a pronounced increase in bone tissue volume and ingrowth into titanium implant's porous surfaces, significantly enhancing mechanical fixation strength at 24 weeks. CS/HA had a limited ability to induce bone formation and implant fixation. We conclude that nHA and COL/HA revealed long-term effects on enhancing bone formation and implant fixation that were at least as good as allograft after 24 weeks, and both nHA and COL/HA appear to be good alternative materials to bone allograft.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"19"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Base of Skull & Spinal Canal Narrowing in an Adolescent with Autosomal Recessive Hypophosphatemic Rickets Type 2. 常染色体隐性低磷血症2型佝偻病青少年的颅底和椎管狭窄。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01324-y

P R Gokul, C Jarvis, G Kassab, S Armitage, M Z Mughal, D Hughes, R Ramakrishnan

{"title":"Base of Skull & Spinal Canal Narrowing in an Adolescent with Autosomal Recessive Hypophosphatemic Rickets Type 2.","authors":"P R Gokul, C Jarvis, G Kassab, S Armitage, M Z Mughal, D Hughes, R Ramakrishnan","doi":"10.1007/s00223-024-01324-y","DOIUrl":"10.1007/s00223-024-01324-y","url":null,"abstract":"Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) is an uncommon hereditary form of rickets characterised by chronic renal phosphate loss and impaired bone mineralisation. This results from compound heterozygous or homozygous pathogenic variants in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), a key producer of extracellular inorganic pyrophosphate (PPi) and an inhibitor of fibroblast growth factor23 (FGF23). ENPP1 deficiency impacts FGF23 and increases its activity. Inactivating ENPP1 variants are associated with both Generalised Arterial Calcification of Infancy (GACI) and ARHR2, even within the same family. Both conditions share a deficiency of ENPP1, displaying clinical variability without a clear genotype-phenotype correlation. Whilst pathogenic ENPP1 variants are known to be associated with various phenotypes, including vascular calcification, hearing loss, ossification of the posterior longitudinal ligament (OPLL), and pseudoxanthoma elasticum (PXE), skull changes have not been reported to our knowledge. We present herein a case of a 10-year-old girl with ARHR2, due to compound heterozygous pathogenic ENPP1 variants, who was found to have papilledema on a routine eye test. Neuroimaging revealed enlarged lateral ventricles, compression of the spinal cord at the foramen magnum with Chiari 1 malformation and a retroverted odontoid peg. She underwent two endoscopic third ventriculostomy procedures to manage the hydrocephalus and a further foramen magnum decompression procedure to alleviate her headaches and neck pain concerns. Individuals with ARHR2 may experience alterations at the base of the skull, potentially leading to base of skull narrowing, chronic hydrocephalus, and Chiari malformation.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"20"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank. 多性状全基因组分析在UK Biobank中鉴定出20个新的肌少症相关性状位点。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01312-2

Shu Ran, XiTong Lin, SiQi Wang, ZhuoQi Li, BaoLin Liu

{"title":"Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank.","authors":"Shu Ran, XiTong Lin, SiQi Wang, ZhuoQi Li, BaoLin Liu","doi":"10.1007/s00223-024-01312-2","DOIUrl":"10.1007/s00223-024-01312-2","url":null,"abstract":"This study aims to identify novel loci associated with sarcopenia-related traits in UK Biobank (UKB) through multi-trait genome-wide analysis. To identify novel loci associated with sarcopenia, we integrated the genome-wide association studies (GWAS) of usual walking pace (UWP) and hand grip strength (HGS) to conduct a joint association study known as multi-trait analysis of GWAS (MTAG). We performed a transcriptome-wide association study (TWAS) to analyze the results of MTAG in relation to mRNA expression data for genes identified in skeletal muscle. Additionally, we utilized Weighted Gene Co-Expression Network Analysis (WGCNA) and Protein-Protein Interaction (PPI) networks to explore the relationships between the identified genes and hub genes related to sarcopenia. We identified 15 novel loci associated with UWP and 5 novel loci associated with HGS at the genome wide significance level (GWS, <math><mrow><mi>p</mi> <mo><</mo> <mn>5</mn> <mo>×</mo> <msup><mrow><mn>10</mn></mrow> <mrow><mo>-</mo> <mn>8</mn></mrow> </msup> </mrow> </math> ). After TWAS ( <math> <mrow><msub><mi>p</mi> <mrow><mi>TWAS</mi></mrow> </msub> <mo><</mo> <mn>6.659</mn> <mo>×</mo> <msup><mrow><mn>10</mn></mrow> <mrow><mo>-</mo> <mn>6</mn></mrow> </msup> <mo>,</mo> <mn>0.05</mn> <mo>/</mo> <mn>7509</mn></mrow> </math> ), we found two significant genes: PPP1R3A, located at 7q31.1 and associated with HGS, and ZBTB38, located at 3q23 and associated with UWP. 11 identified genes associated with hub genes for sarcopenia were obtained through WGCNA. Our findings offer new insights into biological mechanisms underlying sarcopenia and identify several novel genes related to sarcopenia that warrant in-depth study.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"10"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Gastrointestinal Diseases in Osteogenesis Imperfecta: A Nationwide, Register-Based Cohort Study. 成骨不全患者胃肠道疾病的风险：一项全国性、基于登记的队列研究。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01311-3

Christian Krause Anderesen, Issam Al-Najami, Winnie Liu, Eric Orwoll, Lars Folkestad

{"title":"Risk of Gastrointestinal Diseases in Osteogenesis Imperfecta: A Nationwide, Register-Based Cohort Study.","authors":"Christian Krause Anderesen, Issam Al-Najami, Winnie Liu, Eric Orwoll, Lars Folkestad","doi":"10.1007/s00223-024-01311-3","DOIUrl":"10.1007/s00223-024-01311-3","url":null,"abstract":"Osteogenesis imperfecta (OI) is a group of rare genetic disorders most commonly caused by reduced amount of biologically normal collagen type I, a structural component of the gastrointestinal tract and abdominal wall. The risk of gastrointestinal (GI) disease in individuals with OI is not well understood, despite GI complaints being frequently reported by the OI population. To investigate the risk of GI diseases in individuals with OI. A Danish nationwide register-based cohort study utilizing data from the Danish National Patient Register and the Danish National Prescription Register. All individuals registered with an OI diagnosis in Denmark from 1995 through 2018, along with a reference population matched 1:5 based on sex, birth year, and month. Sub-hazard ratios (SHR) for peptic ulcer disease, diverticular disease, gastrointestinal cancers, intestinal obstruction with ileus, constipation, abdominal wall hernia, and other reasons for abdominal discomfort. The study included 864 individuals with OI (472 women) and 4,276 in the reference population (2,332 women). The SHR was significantly increased for ulcer (3.28 [95% CI 2.21-4.28]), constipation (2.67 [1.91-3.74]), and hernia (among women: 1.85 [1.22-2.80]). Higher SHRs were also observed for inflammatory bowel disease, biliary and pancreatic diseases, appendicitis, and unspecified abdominal pain. SHRs were not statistically significantly increased for diverticular disease, gastrointestinal cancers, intestinal obstruction with ileus, kidney stones or hemorrhoid disease. Individuals with OI have a higher risk of peptic ulcer disease, constipation, hernia among women, inflammatory bowel diseases, biliary and pancreatic diseases, appendicitis, and unspecified abdominal pain, compared with the general population.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"15"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructural Analysis of Age-Related Changes Affecting Human Dentin. 影响人类牙本质的年龄相关变化的纳米结构分析。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2025-01-03 DOI: 10.1007/s00223-024-01318-w

Chika Akabane, Mitsuo Kimura, Yukio Yamamoto, Nobukata Shimizu, Richard Weinkamer, Wolfgang Wagermaier, Peter Fratzl, Yoichiro Kashiwagi, Keigo Sawada, Shinya Murakami

{"title":"Nanostructural Analysis of Age-Related Changes Affecting Human Dentin.","authors":"Chika Akabane, Mitsuo Kimura, Yukio Yamamoto, Nobukata Shimizu, Richard Weinkamer, Wolfgang Wagermaier, Peter Fratzl, Yoichiro Kashiwagi, Keigo Sawada, Shinya Murakami","doi":"10.1007/s00223-024-01318-w","DOIUrl":"10.1007/s00223-024-01318-w","url":null,"abstract":"Human dentin performs its function throughout life, even though it is not remodeled like bone. Therefore, dentin must have extreme durability against daily repetitive loading. Elucidating its durability requires a comprehensive understanding of its shape, structure, and anisotropy at various levels of its structure. However, few studies have examined the nanostructure of dentin as a whole and not much is known about its age-related changes. Our aim is to characterize the mineral particle characteristics of human dentin and age-related changes using synchrotron scanning small- and wide-angle X-ray scattering. 30 molar and premolar teeth extracted from 16 to 77-year-old individuals for orthodontic or periodontal reasons were used. Synchrotron-based X-ray scattering was employed to acquire two-dimensional maps of nanostructural features. These maps revealed a negative gradient of particle size toward the pulp chamber. The preferential orientation of particles was position-dependent, with a higher orientation in the area from the pulp horn to the cusp tip and root region. These patterns were maintained in different tooth types. The mineral particle thickness of the inner crown increased significantly with age. This increase could relate to the filling of tubules and, therefore, likely contribute to the deterioration of the mechanical performance of teeth with age.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"12"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0