Basic and Clinical Scientists Working Together-Do We Make the Best of Both Worlds?

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Willem F Lems, Athanasios D Anastasilakis, Christina Møller Andreasen, Julien Paccou, Tim Rolvien, Michaela Tencerova, Jan Tuckermann, Maria P Yavropoulou, Kent Søe
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Abstract

Musculoskeletal disorders, affecting as many as 1.3 billion people worldwide, are the leading cause of disability and impose a substantial health and socioeconomic burden. Despite the high prevalence of these conditions, translational research in this field is far from optimal, highlighting the need for stronger collaboration between basic and clinical scientists. This paper, authored by members of the basic and clinical action groups of the European Calcified Tissue Society (ECTS) and endorsed by the Board of the ECTS, examines the key barriers to effective translational research in musculoskeletal diseases, including clinician workload, differences in professional language and culture, physical distance between research sites, and insufficient interdisciplinary funding. Through interviews with eight institutional managers across five European countries, we observed that in some institutions, the collaboration between basic scientists and clinicians was regarded as no concern (but with room for improvement), and in most institutions it was recognised as a serious issue. We found consensus on the importance of collaboration yet identified discrepancies in the provision of structural and financial support. Based on these findings, we propose strategic initiatives to bridge the gap between basic and clinical research. Suggested measures include dedicated translational funding, integrated research facilities, collaborative scientific forums, strategic collaborations, establishment of physician-scientists, and, finally, bringing basic and clinical researchers together in the same building or even in a combined department. Notable successes, such as the development of the anti-osteoporotic drugs, romosozumab and denosumab, underscore the value of a coordinated approach and exemplify how shared insights between laboratory research and clinical practice can lead to impactful therapeutic advances. Moving forward, we advocate for institutional commitments to foster a robust translational research environment, as well as tailored funding initiatives to support such efforts. This paper serves as a call for discussion and action to enhance interdisciplinary cooperation to advance musculoskeletal medicine and improve outcomes for patients with debilitating musculoskeletal diseases.

基础和临床科学家携手合作——我们能两全其美吗?
肌肉骨骼疾病影响到全世界多达13亿人,是导致残疾的主要原因,并造成巨大的健康和社会经济负担。尽管这些疾病的患病率很高,但该领域的转化研究远未达到最佳状态,这突出了基础科学家和临床科学家之间加强合作的必要性。这篇论文由欧洲钙化组织学会(ECTS)的基础和临床行动小组成员撰写,并由ECTS理事会批准,研究了肌肉骨骼疾病有效转化研究的主要障碍,包括临床医生工作量、专业语言和文化差异、研究地点之间的物理距离以及跨学科资金不足。通过对5个欧洲国家的8位机构管理者的采访,我们观察到,在一些机构中,基础科学家和临床医生之间的合作被认为是不值得关注的(但有改进的空间),而在大多数机构中,这被认为是一个严重的问题。我们就合作的重要性达成共识,但发现在提供结构和财政支持方面存在差异。基于这些发现,我们提出了弥合基础研究和临床研究之间差距的战略举措。建议的措施包括专门的转化资金,整合研究设施,合作科学论坛,战略合作,建立医师-科学家,最后,将基础和临床研究人员聚集在同一栋楼,甚至在一个合并的部门。显著的成功,如抗骨质疏松药物romosozumab和denosumab的开发,强调了协调方法的价值,并举例说明了实验室研究和临床实践之间的共享见解如何导致有影响力的治疗进步。展望未来,我们提倡机构承诺培育一个强大的转化研究环境,以及量身定制的资助计划来支持这些努力。本文旨在呼吁加强跨学科合作,以促进肌肉骨骼医学和改善衰弱性肌肉骨骼疾病患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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