Calcified Tissue International最新文献_第8页

Patients with Periprosthetic Femoral Hip Fractures are Commonly Classified as Having Osteoporosis Based on DXA Measurements. 根据 DXA 测量结果，人工股骨髋关节周围骨折患者通常被归类为骨质疏松症患者。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-04 DOI: 10.1007/s00223-024-01237-w

Jacob Ritter, Assil-Ramin Alimy, Alexander Simon, Jan Hubert, Christian Ries, Tim Rolvien, Frank Timo Beil

{"title":"Patients with Periprosthetic Femoral Hip Fractures are Commonly Classified as Having Osteoporosis Based on DXA Measurements.","authors":"Jacob Ritter, Assil-Ramin Alimy, Alexander Simon, Jan Hubert, Christian Ries, Tim Rolvien, Frank Timo Beil","doi":"10.1007/s00223-024-01237-w","DOIUrl":"10.1007/s00223-024-01237-w","url":null,"abstract":"Periprosthetic femoral hip fractures are subject to an increasing incidence and are often considered to be related to osteoporosis. However, there are no available studies that have determined the frequency of osteoporosis in affected patients using gold standard dual-energy X-ray absorptiometry (DXA). In this retrospective comparative study, we analyzed the DXA results of 40 patients with periprosthetic femoral hip fractures who were treated surgically in our department. DXA measurements were performed at the total hip and the lumbar spine to determine bone mineral density T-scores. Data were compared to two age-, sex-, and BMI-matched control groups in which patients underwent DXA prior to aseptic revision surgery for other causes or primary THA (consisting of 40 patients each). The mean T-score in the periprosthetic fracture cohort was significantly lower (- 1.78 ± 1.78) than that of the aseptic revision (- 0.65 ± 1.58, mean difference - 1.13 [95% CI - 1.88 to - 0.37]; p = 0.001) and the primary THA cohort (- 0.77 ± 1.34, mean difference - 1.01 [95% CI - 1.77 to - 0.26]; p = 0.005). Accordingly, osteoporosis was detected more frequently (45%) in the fracture cohort compared to patients undergoing aseptic revision (12.5%) and primary THA (10%). In conclusion, almost half of the patients with periprosthetic femoral hip fractures have osteoporosis according to DXA measurements. A regular assessment of bone health in THA enables identification of patients with osteoporosis who likely benefit from initiation of osteoporosis medication and cemented stem fixation.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"142-149"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Association Between Osteomalacia, Phosphaturic Mesenchymal Tumor, and Ovarian Cancer: A Case Report and Literature Review. 骨质疏松症、磷酸化间质瘤与卵巢癌之间的罕见关联：病例报告与文献综述。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI: 10.1007/s00223-024-01231-2

Marcodomenico Mazza, Gaetano Paride Arcidiacono, Ilda Hoxhaj, Virginia Padoan, Giulia Tasca, Marta Burei, Stefania Sella, Paolo Simioni, Sandro Giannini, Simone Mocellin

{"title":"A Rare Association Between Osteomalacia, Phosphaturic Mesenchymal Tumor, and Ovarian Cancer: A Case Report and Literature Review.","authors":"Marcodomenico Mazza, Gaetano Paride Arcidiacono, Ilda Hoxhaj, Virginia Padoan, Giulia Tasca, Marta Burei, Stefania Sella, Paolo Simioni, Sandro Giannini, Simone Mocellin","doi":"10.1007/s00223-024-01231-2","DOIUrl":"10.1007/s00223-024-01231-2","url":null,"abstract":"Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by hypophosphatemia, bone mineralization disorders with increased risk of fragility fractures, muscle pain, and progressive weakness. TIO has been associated with increased production of the phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) usually by mesenchymal tumors of soft tissue or bone (Phosphaturic Mesenchymal Tumors-PMTs). In rare cases TIO may be observed in association with other malignancies. We report the case of a 66-year-old woman with an occasional diagnosis of both a PMT and an ovarian cancer during the evaluation of TIO. We also systematically review the literature to discover possible correlations between osteomalacia, FGF23 production, and ovarian cancer. Four studies were eligible for the analysis. Two case reports described an association between TIO development and ovarian cancer, whereas the two case-control studies hypothesized a possible correlation between FGF/FGF receptor axis and cancer development. Although it does not provide conclusive evidence regarding the association between TIO and ovarian cancer, this case report highlights the possibility that in the diagnostic workup of suspected TIO, both FGF23-secreting tumors distinct from PMT and tumors unrelated to the clinical presentation of TIO could be identified. This information is important for guiding successful tumor staging and determining the necessity for surgical intervention and/or eventual adjuvant therapy.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"196-203"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption. 原发性牙齿萌出失败的病因机制以及与 PTH1R 相关的遗传/生物调节。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-04 DOI: 10.1007/s00223-024-01227-y

Xiao-Xia Li, Man-Ting Wang, Zhi-Fang Wu, Qiang Sun, Noriaki Ono, Mizuki Nagata, Xiao-Long Zang, Wanida Ono

{"title":"Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption.","authors":"Xiao-Xia Li, Man-Ting Wang, Zhi-Fang Wu, Qiang Sun, Noriaki Ono, Mizuki Nagata, Xiao-Long Zang, Wanida Ono","doi":"10.1007/s00223-024-01227-y","DOIUrl":"10.1007/s00223-024-01227-y","url":null,"abstract":"Primary failure of eruption (PFE) is a rare disorder that is characterized by the inability of a molar tooth/teeth to erupt to the occlusal plane or to normally react to orthodontic force. This condition is related to hereditary factors and has been extensively researched over many years. However, the etiological mechanisms of pathogenesis are still not fully understood. Evidence from studies on PFE cases has shown that PFE patients may carry parathyroid hormone 1 receptor (PTH1R) gene mutations, and genetic detection can be used to diagnose PFE at an early stage. PTH1R variants can lead to altered protein structure, impaired protein function, and abnormal biological activities of the cells, which may ultimately impact the behavior of teeth, as observed in PFE. Dental follicle cells play a critical role in tooth eruption and root development and are regulated by parathyroid hormone-related peptide (PTHrP)-PTH1R signaling in their differentiation and other activities. PTHrP-PTH1R signaling also regulates the activity of osteoblasts, osteoclasts and odontoclasts during tooth development and eruption. When interference occurs in the PTHrP-PTH1R signaling pathway, the normal function of dental follicles and bone remodeling are impaired. This review provides an overview of PTH1R variants and their correlation with PFE, and highlights that a disruption of PTHrP-PTH1R signaling impairs the normal process of tooth development and eruption, thus providing insight into the underlying mechanisms related to PTH1R and its role in driving PFE.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"101-116"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spondyloocular Syndrome: First Case of Rare Osseous and Ocular Syndrome from India with Novel Mutation and Expanded Phenotypic Spectrum. 脊柱眼综合征：印度首例罕见骨眼综合征：新型突变和表型谱扩大

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI: 10.1007/s00223-024-01234-z

Raiz Ahmad Misgar, Ankit Chhabra, Sidharth Arora, Ajaz Qadir, Mir Iftikhar Bashir, Arshad Iqbal Wani

{"title":"Spondyloocular Syndrome: First Case of Rare Osseous and Ocular Syndrome from India with Novel Mutation and Expanded Phenotypic Spectrum.","authors":"Raiz Ahmad Misgar, Ankit Chhabra, Sidharth Arora, Ajaz Qadir, Mir Iftikhar Bashir, Arshad Iqbal Wani","doi":"10.1007/s00223-024-01234-z","DOIUrl":"10.1007/s00223-024-01234-z","url":null,"abstract":"Spondyloocular syndrome (SOS) is a rare autosomal recessive skeletal and ocular disorder with variable phenotypes. It is caused by pathogenic mutation in the XYLT2 gene, which encodes the enzyme xylo-transferase, necessary for the synthesis of proteoglycan. It is characterized by generalized osteoporosis, short stature, hearing impairment, eye abnormalities, and cardiac defects. Till date only 24 cases have been reported worldwide with no cases documented from India. We subjected the patient to relevant biochemical investigations and Dual Energy X-ray Absorptiometry (DEXA) scan along with Next Generation Clinical Exome Sequencing (NGCES). We report a case of 23-year-old male who presented with recurrent long bone fractures, congenital heart defects, eye abnormalities (bilateral corneal opacities and atrophic bulbi), and short stature. In addition, our patient also had genu valgum and right-sided hydrocele which have never been reported in SOS till date. On genetic analysis, NGCES revealed a novel pathogenic frameshift variant c.191_192 delCA, p.(Thr64fs*22) in the XYLT2 gene. The patient is doing well on six monthly zoledronic acid infusions.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"204-210"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Weeks of Continuous Opioid Treatment in an Adenine-Induced Mouse Model of Chronic Kidney Disease Exacerbates the Bone Inflammatory State and Increases Osteoclasts. 在腺嘌呤诱导的慢性肾病小鼠模型中连续治疗两周阿片类药物会加剧骨炎状态并增加破骨细胞。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI: 10.1007/s00223-024-01239-8

Corinne E Metzger, Gregory G Grecco, Landon Y Tak, Brady K Atwood, Matthew R Allen

{"title":"Two Weeks of Continuous Opioid Treatment in an Adenine-Induced Mouse Model of Chronic Kidney Disease Exacerbates the Bone Inflammatory State and Increases Osteoclasts.","authors":"Corinne E Metzger, Gregory G Grecco, Landon Y Tak, Brady K Atwood, Matthew R Allen","doi":"10.1007/s00223-024-01239-8","DOIUrl":"10.1007/s00223-024-01239-8","url":null,"abstract":"Patients with chronic kidney disease (CKD) report high pain levels, but reduced renal clearance eliminates many analgesic options; therefore, 30-50% of CKD patients have chronic opioid prescriptions. Opioid use in CKD is associated with higher fracture rates. Opioids may directly alter bone turnover directly through effects on bone cells and indirectly via increasing inflammation. We hypothesized that continuous opioid exposure would exacerbate the high bone turnover state of CKD and be associated with elevated measures of inflammation. Male C57Bl/6J mice after 8 weeks of adenine-induced CKD (AD) and non-AD controls (CON) had 14-day osmotic pumps (0.25-µL/hr release) containing either saline or 50-mg/mL oxycodone (OXY) surgically implanted in the subscapular region. After 2 weeks, all AD mice had elevated blood urea nitrogen, parathyroid hormone, and serum markers of bone turnover compared to controls with no effect of OXY. Immunohistochemical staining of the distal femur showed increased numbers of osteocytes positive for the mu opioid and for toll-like receptor 4 (TLR4) due to OXY. Osteocyte protein expression of tumor necrosis factor-α (TNF-α) and RANKL were higher due to both AD and OXY so that AD + OXY mice had the highest values. Trabecular osteoclast-covered surfaces were also significantly higher due to both AD and OXY, resulting in AD + OXY mice having 4.5-fold higher osteoclast-covered surfaces than untreated CON. These data demonstrate that opioids are associated with a pro-inflammatory state in osteocytes which increases the pro-resorptive state of CKD.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"174-184"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Chronic Kidney Disease on All-Cause Mortality After Hip Fracture Surgery: A Retrospective Cohort Study. 慢性肾病对髋部骨折术后全因死亡率的影响：回顾性队列研究

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-17 DOI: 10.1007/s00223-024-01238-9

Yun Seo Jang, Hyunkyu Kim, Soo Young Kim, Yu Shin Park, Il Yun, Eun-Cheol Park, Suk-Yong Jang

{"title":"Effect of Chronic Kidney Disease on All-Cause Mortality After Hip Fracture Surgery: A Retrospective Cohort Study.","authors":"Yun Seo Jang, Hyunkyu Kim, Soo Young Kim, Yu Shin Park, Il Yun, Eun-Cheol Park, Suk-Yong Jang","doi":"10.1007/s00223-024-01238-9","DOIUrl":"10.1007/s00223-024-01238-9","url":null,"abstract":"In this retrospective cohort study, we investigated: (1) The impact of comorbid chronic kidney disease (CKD) on postoperative mortality in patients with a hip fracture; (2) mortality variations by dialysis type, potentially indicating CKD stage; (3) the efficacy of different hip fracture surgical methods in reducing mortality for patients with CKD. This study included 25,760 patients from the Korean National Health Insurance Service-Senior cohort (2002-2019) who underwent hip fracture surgery. Participants were categorized as CKD and Non-CKD. Mortality rate was determined using a generalized linear model with a Poisson distribution. The effect size was presented as a hazard ratio (HR) through a Cox proportional-hazard model. During follow-up, we ascertained that 978 patients (3.8%) had CKD preoperatively. Compared to the Non-CKD group, the mortality risk (HR) in the CKD group was 2.17 times higher (95% confidence interval [CI], 1.99-2.37). In sensitivity analysis, the mortality risk of in patients who received peritoneal dialysis and hemodialysis was 6.21 (95% CI, 3.90-9.87) and 3.62 times (95% CI, 3.11-4.20) higher than that of patients who received conservative care. Mortality risk varied by surgical method: hip hemiarthroplasty (HR, 2.11; 95% CI, 1.86-2.40), open reduction and internal fixation (HR, 2.21; 95% CI, 1.94-2.51), total hip replacement (HR, 2.27; 95% CI, 1.60-3.24), and closed reduction and percutaneous fixation (HR, 3.08; 95% CI, 1.88-5.06). Older patients with CKD undergoing hip fracture surgery had elevated mortality risk, necessitating comprehensive pre- and postoperative assessments and management.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"150-159"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teriparatide Does not Have Beneficial Effects on Bone Healing in Complete Atypical Femur Fractures. 特立帕肽对完全性非典型股骨骨折患者的骨愈合无益处。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-21 DOI: 10.1007/s00223-024-01244-x

Gill Song, Yerang Jeong, Woo Dong Nam, Keong-Hwan Kim

{"title":"Teriparatide Does not Have Beneficial Effects on Bone Healing in Complete Atypical Femur Fractures.","authors":"Gill Song, Yerang Jeong, Woo Dong Nam, Keong-Hwan Kim","doi":"10.1007/s00223-024-01244-x","DOIUrl":"10.1007/s00223-024-01244-x","url":null,"abstract":"Teriparatide is an anabolic drug sometimes administered to patients who have atypical femoral fracture (AFF). However, whether teriparatide has beneficial effects on bone healing remains uncertain. The present study aimed to analyze the association between teriparatide and bone healing in complete AFF. A total of 59 consecutive cases (58 patients) who underwent intramedullary nailing for complete AFF were categorized based on postoperative use of teriparatide into the non-teriparatide (non-TPTD, n = 34) and teriparatide groups (TPTD, n = 25). Time-to-bone union was evaluated and compared between the two groups. Additionally, multiple regression analysis was performed to evaluate factors affecting time-to-bone union. All participants were women, with a mean age of 77.6 years (range: 62-92). No significant difference in time-to-bone union was found between the non-TPTD and TPTD groups (5.5 months vs. 5.8 months, p = 0.359). Two patients in the non-TPTD group underwent reoperation (p = 0.503) due to failure caused by inadequate fixation, and both achieved bone healing after additional fixation with blocking screws. Multiple regression analysis revealed that the anterior gap of the fracture site postoperatively was a factor affecting time-to-bone union (p = 0.014). The beneficial effect of teriparatide on bone healing in complete AFF could not be confirmed. Additional randomized controlled trials are required. Nonetheless, appropriate techniques, including efforts to reduce the gap on the tensile side during the surgery, are important for reliable bone healing.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"169-173"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Intestinal Leak with Sarcopenia and Physical Disability in Patients with Various Stages of Chronic Kidney Disease. 不同阶段慢性肾病患者的肠漏与肌少症和身体残疾的关系。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI: 10.1007/s00223-024-01233-0

Rizwan Qaisar, Ayousha Burki, Asima Karim, Shahjahan Ustrana, Firdos Ahmad

{"title":"The Association of Intestinal Leak with Sarcopenia and Physical Disability in Patients with Various Stages of Chronic Kidney Disease.","authors":"Rizwan Qaisar, Ayousha Burki, Asima Karim, Shahjahan Ustrana, Firdos Ahmad","doi":"10.1007/s00223-024-01233-0","DOIUrl":"10.1007/s00223-024-01233-0","url":null,"abstract":"Sarcopenia is related to disease severity in chronic kidney disease (CKD) patients; however, its pathophysiology remains poorly known. We investigated the associations of biomarkers of intestinal leak with sarcopenia in various stages of CKD. We recruited 61-76-year-old male controls and patients with various stages of CKD (n = 36-57/group) for measuring plasma lipopolysaccharide-binding protein (LBP) and zonulin (markers of intestinal leak), handgrip strength (HGS), skeletal mass index (SMI), and gait speed (markers of sarcopenia), and short physical performance battery (SPPB; marker of physical capacity). CKD stages 4 and 5 were associated with lower HGS, SMI, gait speed, and cumulative SPPB scores and a higher sarcopenia prevalence than controls and patients with CKD stages 1 and 2 (all p < 0.05). CKD patients (stages 1 and 2) had elevated plasma zonulin and LBP when compared with CKD stages 4 and 5. Plasma zonulin and LBP exhibited significant correlations with renal function, HGS, gait speed, SPPB scores, and oxidative stress markers in CKD stages 4 and 5 (all p < 0.05). However, similar relations were not found in early CKD. Collectively, intestinal leak may be contributing to sarcopenia and physical disability in the advanced stages of CKD.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"132-141"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Decline of Paget's Disease of Bone and Domestic Coal Use-A Hypothesis. 骨质疏松症的减少与家用煤炭的使用--一个假说。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI: 10.1007/s00223-024-01241-0

Tim Cundy

{"title":"The Decline of Paget's Disease of Bone and Domestic Coal Use-A Hypothesis.","authors":"Tim Cundy","doi":"10.1007/s00223-024-01241-0","DOIUrl":"10.1007/s00223-024-01241-0","url":null,"abstract":"The cause of Paget's disease of bone (PDB) is unknown. It emerged as a distinct entity in Britain in the late nineteenth century when it was prevalent, and florid presentation not uncommon. Epidemiological surveys in the 1970s showed that Britain had a substantially higher prevalence of PDB than any other country. Studies in the late twentieth and early twenty-first centuries have documented an unexplained change in presentation, with a greatly reduced prevalence and less severe disease than formerly. The emergence of PDB in Britain coincided with rapid industrialization which, in turn, was driven by the use of coal for energy. In the home, bituminous coal was customarily burnt on an open hearth for heating. Using data on coal production, population size, and estimates of domestic use, the estimated exposure to domestic coal burning rose threefold in Britain during the nineteenth century and began to fall after 1900. This pattern fits well with the decline in PDB documented from death certification and prevalence surveys. Colonists moving from Britain to North America, Australia and New Zealand established coal mines and also used coal for domestic heating. PDB was found in these settler populations, but was largely absent from people indigenous to these lands. In all parts of the world PDB prevalence has fallen as the burning of coal in open hearths for domestic heating has reduced. The nature of the putative factor in coal that could initiate PDB is unknown, but possible candidates include both organic and inorganic constituents of bituminous coal.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"117-123"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive Effects of Dental Pulp Stem Cell-conditioned Media on Anti-RANKL Antibody-Related Osteonecrosis of the Jaw. 牙髓干细胞调节培养基对抗 RANKL 抗体相关性颌骨坏死的预防作用

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-08-01 Epub Date: 2024-05-29 DOI: 10.1007/s00223-024-01232-1

Kento Kaminogo, Satoshi Yamaguchi, Hui Chen, Hideo Yagita, Naoto Toyama, Yusuke Urata, Hideharu Hibi

{"title":"Preventive Effects of Dental Pulp Stem Cell-conditioned Media on Anti-RANKL Antibody-Related Osteonecrosis of the Jaw.","authors":"Kento Kaminogo, Satoshi Yamaguchi, Hui Chen, Hideo Yagita, Naoto Toyama, Yusuke Urata, Hideharu Hibi","doi":"10.1007/s00223-024-01232-1","DOIUrl":"10.1007/s00223-024-01232-1","url":null,"abstract":"Medication-related osteonecrosis of the jaw is a serious disease occurring in patients with cancer and osteoporosis, who are undergoing treatment with antiresorptive agents (ARAs) such as bisphosphonate (BP) or denosumab, an antibody targeting receptor activator of NF-κB ligand. Recently, stem cell-based therapy has been shown to be effective in preventing the development of bisphosphonate-related osteonecrosis of the jaw. However, studies on denosumab-related osteonecrosis of the jaw (DRONJ) remain limited. Here, the efficacy of treatment with dental pulp stem cell conditioned media (DPSC-CM) in preventing DRONJ in a murine model was evaluated. Local administration of DPSC-CM into the extraction socket of a mouse with DRONJ decreased the number of empty osteocyte lacunae and the prevalence of ONJ. In tissues surrounding the extraction sockets in the DPSC-CM-treated group, the expression of inflammatory cytokines was attenuated and that of osteogenesis-related molecules was enhanced compared to that in the control group. Further, the expression of Wnt signaling molecules, which had been suppressed, was improved. These findings collectively suggest that DPSC-CM prevents ONJ development in a murine DRONJ model.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"185-195"},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0