Cardiovascular Therapeutics最新文献

{"title":"The Effect of Stress Ball on Anxiety and Pain Levels in Angiography: A Randomized Controlled Trial","authors":"Dilan Yüksel,&nbsp;Dilek Güneş","doi":"10.1155/2024/5049092","DOIUrl":"https://doi.org/10.1155/2024/5049092","url":null,"abstract":"<p><b>Background:</b> Coronary angiography, an invasive diagnostic procedure, often induces pain and anxiety in patients. Despite the potential for alleviating discomfort, the use of stress balls as a nonpharmacological intervention during angiography remains underexplored.</p><p><b>Objective:</b> This study is aimed at investigating the impact of stress ball application on pain and anxiety levels in patients undergoing angiography.</p><p><b>Methods:</b> This randomized controlled trial was conducted on adult patients undergoing angiography at a Cardiovascular Surgery Clinic in Eastern Turkey between January 2023 and June 2023. A total of 120 patients were randomly assigned to receive stress ball application in addition to routine care. Data collection utilized the Numerical Rating Scale (NRS), Patient Information Form, and State-Trait Anxiety Inventory (STAI).</p><p><b>Results:</b> Analysis revealed a significantly lower increase in mean NRS posttest scores among patients in the experimental group compared to the control group (<i>p</i> &lt; 0.05). Additionally, the mean STAI posttest score demonstrated a significant decrease (<i>p</i> &lt; 0.05) in the experimental group. A positive and significant correlation was observed between the mean NRS and STAI posttest scores among study group patients (<i>p</i> &lt; 0.05), indicating a reduction in anxiety levels with decreasing pain.</p><p><b>Conclusion:</b> The application of stress balls during angiography was associated with decreased anxiety and pain levels in patients. Stress ball intervention may serve as a beneficial adjunct to pharmacological treatments. This study underscores the potential of nonpharmacological interventions in enhancing patient comfort during invasive procedures.</p><p><b>Trial Registration:</b> ClinicalTrials.gov Identifier: NCT06131606 (http://clinicaltrials.gov).</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5049092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and Validation of Potential Serum Biomarkers for Heart Failure by Untargeted Metabolomics","authors":"Guisheng Zhou,&nbsp;Junzhi Zhang,&nbsp;Hongli Guo,&nbsp;Xiaochao Hu,&nbsp;Yingzhuo Wang,&nbsp;Kunqun Shi,&nbsp;Tongtong Liu,&nbsp;Shengyan Yin,&nbsp;Huanhuan Liu,&nbsp;Chunling Liu,&nbsp;Shijia Liu","doi":"10.1155/2024/7004371","DOIUrl":"https://doi.org/10.1155/2024/7004371","url":null,"abstract":"<p>Detection of biomarkers was extremely important for the early diagnosis, prognosis, and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy control (HC) and to diagnose HF qualitatively. In this study, serum samples from 83 patients with HF and 35 HCs were used as the research subjects for untargeted metabolomic analysis using ultraperformance liquid chromatography combined with quadrupole-time of flight mass spectrometry (UPLC-QTOF/MS) technology. Potential biomarkers were screened and validated using the orthogonal partial least squares discriminant analysis (OPLS-DA), random forest (RF), binary logistic regression (BLR), and receiver operating characteristic (ROC) analysis. The results indicated that a total of 43 metabolites were considered as differentially expressed metabolites (DEMs). Among these DEMs, glycodeoxycholate was identified as a specific biomarker of HF. A ROC curve analysis for HC versus HF discrimination showed an area under the ROC curve (AUC) of 0.9853 (95% CI: 0.9859–1.0000), a sensitivity of 95%, and a specificity of 100%. Hence, glycodeoxycholate might serve as a potential biomarker for HF. Furthermore, the amino acid metabolism was screened as the most significantly altered pathway in patients with HF. By identifying serum biomarkers and analyzing metabolic pathways, our study provided opportunities to enhance the understanding of the pathogenesis and early diagnosis of HF.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7004371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary Exercise Testing-Guided Exercise Therapy in Hypertensive Patients: A Single Center Study","authors":"Qin Lu,&nbsp;Jingjing Lu,&nbsp;Che Li,&nbsp;Ping Huang,&nbsp;Fenfen Jiang,&nbsp;Xia Zhao,&nbsp;Jianqin Zhang,&nbsp;Yi Huang,&nbsp;Zhenliang Chu","doi":"10.1155/2024/8476971","DOIUrl":"https://doi.org/10.1155/2024/8476971","url":null,"abstract":"<p><b>Objective:</b> To observe the effects of cardiac rehabilitation guided by cardiopulmonary exercise testing (CPET) on cardiorespiratory reserve function, blood pressure, blood pressure variability, and lipid metabolism in patients with hypertension.</p><p><b>Methods:</b> A randomized trial enrolled 67 Grade 1 hypertensive patients on antihypertensive drugs, divided into conventional (<i>n</i> = 35) and CPET (<i>n</i> = 32) groups. Antihypertensive drugs were not adjusted in both groups during the study period. Blood pressure, cardiorespiratory indicators, lipid profile, and BMI were assessed pre/post 12 weeks.</p><p><b>Results:</b> Postintervention, the CPET group exhibited significantly lower blood pressure levels and improved cardiac indicators compared to the conventional group (<i>p</i> &lt; 0.05). CPET group showed greater improvements in cardiorespiratory endurance indicators (<i>p</i> &lt; 0.05). The cardiorespiratory endurance indicators showed significantly greater increases in the CPET group compared to the conventional group (<i>p</i> &lt; 0.05). Low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and body mass index (BMI) were significantly lower in the CPET group (<i>p</i> &lt; 0.05).</p><p><b>Conclusion:</b> In addition to drug treatment, cardiac rehabilitation guided by CPET can effectively improve blood pressure control, reduce blood pressure variability, improve cardiorespiratory function and lipid metabolism, and increase exercise endurance in patients with Grade 1 hypertension. Its efficacy is clear and safe, with clinical value for promotion.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8476971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 Infection on Abdominal Aortic Aneurysms: Mechanisms and Clinical Implications","authors":"Zenghan Cao,&nbsp;Jianhang Gao,&nbsp;Jianqiang Wu,&nbsp;Yuehong Zheng","doi":"10.1155/2024/7288798","DOIUrl":"https://doi.org/10.1155/2024/7288798","url":null,"abstract":"<p><b>Background:</b> The COVID-19 virus not only has significant pathogenicity but also influences the progression of many diseases, altering patient prognosis. Cardiovascular diseases, particularly aortic aneurysms, are among the most life-threatening conditions.</p><p><b>Main Idea:</b> COVID-19 infection is reported to accelerate the progression of abdominal aortic aneurysms (AAAs) and increase the risk of rupture; however, a comprehensive understanding of the underlying mechanisms remains elusive. This article primarily reviews the relevant foundational research, focusing on disruptions in the renin-angiotensin-aldosterone system (RAAS), immune system activation, and coagulation disorders. Furthermore, we summarize related clinical research, including the epidemiology of aortic aneurysms during the pandemic and specific case studies.</p><p><b>Conclusion:</b> COVID-19 infection can influence the onset and progression of aortic aneurysms by affecting the RAAS, triggering inflammation and immune dysregulation in the arterial wall, and inducing a hypercoagulation state. It is crucial to comprehensively understand the impact of pandemic viral infections on aortic diseases at the foundational and clinical levels, thereby identifying potential preventative or therapeutic approaches and preparing for potential future outbreaks.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7288798","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats","authors":"Mahtab Fouladi,&nbsp;Maryam Mahmoudabady,&nbsp;Zahra Gholamnezhad,&nbsp;Sadegh Shabab,&nbsp;Saeed Niazmand,&nbsp;Hossein Salmani","doi":"10.1155/2024/6025911","DOIUrl":"https://doi.org/10.1155/2024/6025911","url":null,"abstract":"<p>Given the heightened risk of diabetes-related cardiovascular events associated with inactivity, this study investigates the molecular mechanisms of vascular damage in streptozotocin (STZ)-induced diabetic rats. The aim is to elucidate the impact of different exercises (interval and continuous training) and metformin on biochemical parameters, aortic injury, oxidative stress, and inflammation to provide insights into potential therapeutic interventions for diabetes-associated vascular complications. Male Wistar rats were administered a single dose of STZ (60 mg/kg) to induce diabetes. Diabetic rats underwent either interval training or continuous training (40 min/day, 5 days/week, 6 weeks), received metformin (300 mg/kg), or a combination of metformin and exercise. After 6 weeks, biochemical parameters in serum and oxidative stress markers and mRNA expression of endothelial nitric oxide synthase (eNOS), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and intercellular adhesion molecule-1 (ICAM-1) in aorta tissue were assessed. Serum levels of fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), TG/HDL, TC/HDL, and LDL/HDL ratios were significantly reduced in all treatment groups compared to the diabetes group. Both types of exercises, metformin, and exercise+metformin combinations, significantly reduced oxidative stress by decreasing malondialdehyde (MDA) and enhancing the antioxidant status in the aortic tissue compared to the diabetic group. In addition, in exercise groups, metformin, and combination groups, the expression of eNOS was significantly elevated, while LOX-1 and ICAM-1 expression significantly decreased compared to the diabetic group. In most cases, the combination of exercise and metformin (especially interval training) was more effective than exercise alone. It seems that exercise along with taking metformin can be considered as a therapeutic method by improving hyperglycemia and hyperlipidemia and reducing oxidative stress and vascular inflammatory responses, leading to ameliorating biomarkers function related to endothelial damage in experimental diabetes conditions.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6025911","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141583959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-Pump Coronary Artery Bypass Graft (OCABG) Surgery Outcome: AKI Incidence, Serum Uric Acid, and Cut-Offs of Variables","authors":"Mohamad Reza Zare-Khormizi,&nbsp;Fatemeh Pourrajab","doi":"10.1155/2024/5945687","DOIUrl":"https://doi.org/10.1155/2024/5945687","url":null,"abstract":"<p><b>Purpose:</b> One of the most important challenges of the medical community is to find out the success rate of coronary artery bypass surgery and control complications after surgery, including acute kidney injury (AKI). The present study was conducted with the aim of determining the predictive effect of serum uric acid (SUA) (UA) level in patients undergoing off-pump coronary artery bypass (OCABG) surgery.</p><p><b>Methods:</b> The present descriptive-analytical study included 144 patients who underwent OCABG and met the inclusion criteria. SUA and related indicators, duration of hospitalization and stay in ICU, AKI and in-hospital mortality, and 6-month follow-up mortality were investigated.</p><p><b>Results:</b> Patients were divided into high and normal groups based on SUA levels. The prevalence of postoperative AKI was 20% and was significantly associated with the preoperative UA levels (OR: 2.04; CI: 95%; 1.03–4.20). The mortality rate of patients was between 2% and 9%, which increased to 13% in patients with high SUA (<i>p</i> value ~0.224). The average duration of ICU and hospitalization in patients with high UA was longer than the other group (<i>p</i> value ~0.06 and <i>p</i> value ~0.002, respectively).</p><p><b>Conclusion:</b> SUA levels are independently associated with a higher risk of AKI and outcome complications after off-pump CABG, and confounding factors at specific cutoffs affect the odds ratio of UA for AKI occurrence.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5945687","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing, Validation, and Feasibility of Integrated Approach of Heartfulness Meditation and Yoga Protocol (IAHFNM & YP) for Hypertensive Participants","authors":"Pooja S. Singh,&nbsp;Veronique Nicolai,&nbsp;Yogesh Patil,&nbsp;Neelam Yeram,&nbsp;Bhusan Bhukte,&nbsp;Kapil Thakur,&nbsp;Mitesh Thakker,&nbsp;Haresh Mehta,&nbsp;Mansee K. Thakur","doi":"10.1155/2024/9289232","DOIUrl":"https://doi.org/10.1155/2024/9289232","url":null,"abstract":"<p>The module was designed and developed at Heartfulness Institute, Kanha Shanti Vanam, Hyderabad. The Department of Medicine, MGM Medical College &amp; Hospital, MGMIHS, Navi Mumbai, carried out the validation and subsequently pilot-tested on volunteers. Forty experts were selected to validate the contents of IAHFNM &amp; YP which was designed after a thorough review of meditation and yoga literature. A total of 23 items were included, and each item was rated as essential or not essential by the experts, based on which the content validity ratio (CVR), Item-Level Content Validity Index (I-CVI), and Scale-Level Content Validity Index Average (S-CVI/Ave) were calculated. Reliability analysis and a pilot study for the feasibility of IAHFNM &amp; YP for hypertensive patients were also done. All 23 practices exhibited significant CVR (≥ 0.29), I-CVI (&gt; 0.79), and S-CVI/Ave (&gt; 0.9); thus, the tool was found to have valid contents. Cronbach’s alpha value for the tool was 0.95 which was highly reliable. Feasibility analysis in hypertensive participants showed that the tool is reliable and implementable. The IAHFNM &amp; YP tool designed for hypertensive patients is valid, reliable, and feasible. The patients showed a willingness to continue with heartfulness meditation and yoga practices for participation in research for a longer duration. Further studies to confirm the tool’s efficacy should be conducted with a large sample size.</p><p><b>Trial Registration:</b>CTRI/2024/01/061035</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9289232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achievement of LDL-Cholesterol Goals in Patients Receiving LLT in Primary Care: TERESA-AP Study","authors":"Sergio Cinza-Sanjurjo,&nbsp;Vivencio Barrios,&nbsp;David Fierro-González,&nbsp;Jose Polo-García,&nbsp;Vicente Pallarés-Carratalá","doi":"10.1155/2024/4227941","DOIUrl":"https://doi.org/10.1155/2024/4227941","url":null,"abstract":"<p><b>Background and Aim:</b> Since 2019, LDL-cholesterol (LDL-C) is the risk factor with the strictest goals and the most difficult to reach, due to its role in the development of atherosclerotic plaque and, therefore, cardiovascular risk. The objective of the TERESA-AP study is to analyze the degree of LDL-C control in patients followed up in primary care with lipid-lowering drug treatment (LLT).</p><p><b>Methods:</b> Observational, multicenter, cross-sectional, nationwide study was conducted, in which 50 PC physicians recruited 929 patients who were receiving LLT during at least the preceding 6 months. The variables required to estimate the patients’ cardiovascular risk and LDL control were recorded.</p><p><b>Results:</b> Nearly half of sample was women (50.5%), and the mean age was 67.8 (10.4) years. High blood pressure (65.3%) and sedentary lifestyle (59.7%) were the most frequent risk factors. Recommended goals were reached in 26.0% (95% CI: 23.3%–29.0%) of patients, with a slightly higher percentage in patients with cardiovascular disease (CVD) (26.7%), diabetes mellitus (DM) (35.5%), and a lower one in patients with chronic kidney disease (CKD) (12.1%). The most frequent drug treatments were statin monotherapy (69.0%) and statin with ezetimibe combination (27.6%), with moderate-intensity statins being the most commonly used in both groups.</p><p><b>Conclusions:</b> On average, only a quarter of the patients followed up in PC and who receive drug treatment reach their therapeutic targets. This percentage is slightly higher if the patients have CVD and DM and lower if they have CKD. The most commonly used therapeutic strategy is moderate-intensity statins, both in monotherapy and in combination with ezetimibe.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4227941","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzoylaconine: Potential Therapeutic Agent for Cardiovascular Diseases From Fuzi","authors":"Chenggang Xu,&nbsp;Le Tang,&nbsp;Lixin Hu,&nbsp;Yunzhe Huang,&nbsp;Jin Tang,&nbsp;Xiaohu Wang,&nbsp;Feng Wang","doi":"10.1155/2024/4878103","DOIUrl":"https://doi.org/10.1155/2024/4878103","url":null,"abstract":"<p>Modern pharmacological studies have elucidated the presence of aconitine (AC) alkaloids, polysaccharides, and saponins as the primary bioactive constituents of Fuzi. Among these, benzoylaconine, a pivotal active compound, demonstrates notable pharmacological properties including antitumor, anti-inflammatory, and cardiovascular protective effects. In recent years, benzoylaconine has garnered significant attention in basic research on heart diseases, emerging as a focal point of investigation. This paper presents a comprehensive review of the pharmacological effects of benzoylaconine, alongside an overview of advancements in metabolic characterization. The objective is to furnish valuable insights that can serve as a cornerstone for further exploration, utilization, and advancement of benzoylaconine in pharmacological research.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4878103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Endoplasmic Reticulum Stress-Related Biomarkers in Coronary Artery Disease","authors":"Yuanyuan Lin,&nbsp;Lin Ni,&nbsp;Luqun Yang,&nbsp;Hao Li,&nbsp;Zelin Chen,&nbsp;Yuping Gao,&nbsp;Kaiyi Zhu,&nbsp;Yanni Jia,&nbsp;Zhifang Wu,&nbsp;Sijin Li","doi":"10.1155/2024/4664731","DOIUrl":"https://doi.org/10.1155/2024/4664731","url":null,"abstract":"<p>Coronary artery disease (CAD) is caused by atherosclerotic lesions in the coronary vessels. Endoplasmic reticulum stress (ERS) acts in cardiovascular disease, and its role in CAD is not clear. A total of 13 differentially expressed ERS-related genes (DEERSRGs) in CAD were identified. Functional enrichment analysis demonstrated the DEERSRGs were mainly enriched in endoplasmic reticulum (ER)-related pathways. Then, eight genes (RCN2, HRC, DERL2, RNF183, CRH, TMED2, PPP1R15A, and IL1A) were authenticated as ERS-related biomarkers in CAD by least absolute shrinkage and selection operator (LASSO). The receiver operating characteristic (ROC) analysis showed that the LASSO logistic model constructed based on biomarkers had a better diagnostic effect, which was confirmed by the ANN and GSE23561 datasets. Also, ROC results showed that seven of the eight biomarkers had better diagnostic effects. The nomogram model had good predictive power, and biomarkers were mostly enriched in pathways associated with CAD. The biomarkers were significantly associated with 10 immune cells, and RCN2, DERL2, TMED2, and RNF183 were negatively correlated with most chemokines. Eight biomarkers had significant correlations with both immunoinhibitors and immunostimulators. In addition, eight biomarkers were significantly different in both CAD and control samples, CRH and HRC were upregulated in CAD. The quantitative reverse transcription-polymerase chain reaction (qRT-PCR) showed that RCN2, HRC, DERL2, CRH, and IL1A were consistent with the bioinformatics analysis. RCN2, HRC, DERL2, RNF183, CRH, TMED2, PPP1R15A, and IL1A were identified as biomarkers of CAD. Functional enrichment analysis and immunoassays for biomarkers provide new ideas for the treatment of CAD.</p>","PeriodicalId":9582,"journal":{"name":"Cardiovascular Therapeutics","volume":"2024 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4664731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}