Canadian journal of comparative medicine : Revue canadienne de medecine comparee最新文献

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Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus. 猫实验性接种人冠状病毒229E并随后攻毒猫传染性腹膜炎病毒。
J E Barlough, C M Johnson-Lussenburg, C A Stoddart, R H Jacobson, F W Scott
{"title":"Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus.","authors":"J E Barlough,&nbsp;C M Johnson-Lussenburg,&nbsp;C A Stoddart,&nbsp;R H Jacobson,&nbsp;F W Scott","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Minimal-disease cats exposed to live human coronavirus 229E developed homologous antibody responses that suggested little or no replication of the virus in inoculated animals. Oronasal and subcutaneous inoculation of coronavirus 229E did not elicit an antibody response by heterologous (transmissible gastroenteritis virus, canine coronavirus) neutralization or by heterologous (transmissible gastroenteritis virus) kinetics-based enzyme-linked immunosorbent assay. No clinical signs attributable to coronavirus 229E were seen in inoculated cats. Although the number of animals in each of the five experimental groups was small (n = 2), antibodies produced in response to the virus did not appear to sensitize cats to subsequent feline infectious peritonitis virus challenge, but neither did they cross-protect cats against the challenge dose.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"303-7"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236175/pdf/compmed00003-0067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14129316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cleavage of bovine immunoglobulin G1 in whey by an extracellular material from Brucella abortus. 流产布鲁氏菌细胞外物质切割乳清中的牛免疫球蛋白G1。
K Nielsen
{"title":"Cleavage of bovine immunoglobulin G1 in whey by an extracellular material from Brucella abortus.","authors":"K Nielsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Culture extracts of in vitro grown Brucella abortus were demonstrated to cleave a part of the Fc portion of bovine immunoglobulin G1 in whey but not in serum or as a purified protein from serum. Supernates from Strains 19 and 2308 of B. abortus were both capable of this hydrolysis whereas living cells were not. The cleavage process was independent of antibody activity to B. abortus, appeared to require factor(s) found only in some whey samples and was ineffective with the other bovine immunoglobulins.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"337-9"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236183/pdf/compmed00003-0101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15044181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of oral phenylbutazone on whole blood platelet aggregation in the dog. 口服苯丁酮对犬全血血小板聚集的影响。
M L Jackson, G P Searcy, D W Olexson
{"title":"The effect of oral phenylbutazone on whole blood platelet aggregation in the dog.","authors":"M L Jackson,&nbsp;G P Searcy,&nbsp;D W Olexson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Platelet aggregation to collagen, arachidonic acid and adenosine diphosphate was evaluated in six dogs using a whole blood electronic aggregometer. The six dogs were then given phenylbutazone orally according to four different dosage levels and durations of treatment. Aggregation responses were measured at established intervals of time following phenylbutazone administration. Data on untreated dogs indicated that arachidonic acid, at a final concentration of 50 micrograms/mL and collagen, at a final concentration of 5 micrograms/mL, were useful agents for studying whole blood platelet aggregation in the dog, but adenosine diphosphate, at a final concentration of 30 microM was not. The high single dose (900 mg) of phenylbutazone significantly inhibited platelet aggregation to arachidonic acid at 1.5,4,7 and 12 hours following administration. The results indicated that the whole blood electronic aggregometer was of limited value in detecting subtle changes in platelet aggregation. It was concluded, however, that the instrument is potentially useful as a rapid screening aid for detecting canine patients at high risk of platelet-related bleeding problems.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"271-7"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236170/pdf/compmed00003-0035.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15044178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of androgens and gonadotropins on testicular development in the prepubertal rat. 雄激素和促性腺激素对青春期前大鼠睾丸发育的影响。
R I Kennedy, N C Rawlings, B D Murphy
{"title":"The effects of androgens and gonadotropins on testicular development in the prepubertal rat.","authors":"R I Kennedy,&nbsp;N C Rawlings,&nbsp;B D Murphy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Treatment of male rat pups from five to 34 days of age with dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, resulted in reduced testicular size at 35 days of age. This appeared to be due to decreased tubular diameters and reduced spermatocyte numbers, especially late pachytene cells in stages X to XIII. In rat pups treated with dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, treatment with luteinizing hormone resulted in some restoration of tubular diameter and spermatocyte numbers. In 5 alpha-androstane-3 alpha, 17 beta-diol treated rat pups partial restoration of testes size resulted from follicle-stimulating hormone treatment, but tubular diameter and spermatocyte numbers were depressed. Single serum samples collected at 35 days of age were analysed for luteinizing and follicle-stimulating hormone concentrations. These data indicated that the effects of administered androgens were due primarily to depression of circulating gonadotropin concentrations but a direct inhibition at the level of the testis could not be ruled out.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"333-6"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236182/pdf/compmed00003-0097.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15044180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The sensitivity and specificity of postbreeding plasma progesterone levels as a pregnancy test for dairy cows. 种后血浆孕酮水平作为奶牛妊娠试验的敏感性和特异性。
M E Montgomery, K E Leslie, S W Martin
{"title":"The sensitivity and specificity of postbreeding plasma progesterone levels as a pregnancy test for dairy cows.","authors":"M E Montgomery,&nbsp;K E Leslie,&nbsp;S W Martin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma progesterone levels on day 4 and day 8 postbreeding were measured for one hundred and eighty-four dairy cows. These two parameters (PPD4, PPD8), their absolute difference (PPDIFF) and their ratio (PPRATIO) were assessed for their ability to identify cows not conceiving, using the principles of sensitivity and specificity. PPD4 was significantly higher (p less than 0.10) and PPD8, PPDIFF and PPRATIO were significantly lower (p less than 0.01) in cows remaining open than in pregnant cows. Evaluating each parameter separately, PPDIFF greater than 3.00 units had the highest specificity, 85.7%, but a low sensitivity (27.0%). Combining two parameters using series interpretation to increase specificity resulted in the best combination of specificity (87%) and sensitivity (27%). Maximum specificity was 97% for PPD4 less than or equal to 1.00 units and PPD8 greater than 4.00 units, and also for PPD4 less than or equal to 1.00 units and PPDIFF greater than 3.00 units, but sensitivity was very low (7% and 10% respectively). Predictive values of the test results with the best specificity were evaluated; given the population pregnancy rate of 54%, none exceeded 50%, indicating that the plasma progesterone parameters were not very useful for identifying open dairy cows.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"346-9"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236186/pdf/compmed00003-0110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15153905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salmonellae and salmonellosis in captive reptiles. 圈养爬行动物中的沙门氏菌和沙门氏菌病。
D K Onderka, M C Finlayson
{"title":"Salmonellae and salmonellosis in captive reptiles.","authors":"D K Onderka,&nbsp;M C Finlayson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a survey of 150 pet reptiles submitted for necropsy, 51% of snakes, 48% of lizards and 7% of turtles were infected with Salmonella. About one third of the positive animals had died due to various manifestations of salmonellosis. Thirty-one Salmonella serotypes were identified including three isolates new to Canada. The public health implications are discussed in view of the restricted popularity of reptiles and their possible infection from domestic agricultural products.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"268-70"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236169/pdf/compmed00003-0032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15154629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parvovirus-like particles associated with diarrhea in unweaned piglets. 与未断奶仔猪腹泻有关的细小病毒样颗粒。
S Dea, M A Elazhary, G P Martineau, J Vaillancourt
{"title":"Parvovirus-like particles associated with diarrhea in unweaned piglets.","authors":"S Dea,&nbsp;M A Elazhary,&nbsp;G P Martineau,&nbsp;J Vaillancourt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Numerous parvovirus-like particles, 18 to 26 nm in diameter, were detected by electron microscopy in the intestinal contents of two to three week old piglets with mild to severe diarrhea, in six Quebec pig herds. Hemagglutination of guinea pig and African green monkey red blood cells was obtained with clarified intestinal contents. Two isolates were found to be antigenically related to porcine and canine parvoviruses, while another differed from the porcine parvovirus using the hemagglutination-inhibition test. Three isolates could be cultivated in cell cultures as demonstrated by the development of a cytopathic effect, hemagglutination activity, immunofluorescence and identification of the virions in the cell culture fluids by electron microscopy. The possibility of a primary etiological role for these parvoviruses in diarrhea of unweaned piglets is discussed.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"343-5"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236185/pdf/compmed00003-0107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13560295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathology of acute 3-acetyldeoxynivalenol toxicity in mice. 小鼠急性3-乙酰脱氧雪腐镰刀醇毒性的病理研究。
H B Schiefer, S Nicholson, O B Kasali, D S Hancock, R Greenhalgh
{"title":"Pathology of acute 3-acetyldeoxynivalenol toxicity in mice.","authors":"H B Schiefer,&nbsp;S Nicholson,&nbsp;O B Kasali,&nbsp;D S Hancock,&nbsp;R Greenhalgh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mice were killed 2, 4, 6, 12, 24, 48 and 96 hours after intragastrical administration of 0, 5, 10, 20, or 40 mg/kg body weight of 3-acetyldeoxynivalenol. The animals became clinically ill after 12 hours and some animals in the highest dose group died. Histological examination of duodenal crypts, thymus and spleen revealed, in all dose groups, presence of the characteristic lesions that are known to be produced by trichothecenes, but the intensity of lesions in the 40 mg group corresponded to lesions known to be caused by 4 mg/kg of T-2 toxin. A rabbit skin bioassay with 3-acetyldeoxynivalenol gave negative results on one occasion and a mild reaction to 100 to 500 micrograms/mL on another. It is concluded that 3-acetyldeoxynivalenol is considerably less toxic than T-2 toxin, but causes acute effects in the dividing cells of the body in a manner characteristic of trichothecenes.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"315-8"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236178/pdf/compmed00003-0079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15153903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary recruitment of neutrophils and bacterial clearance in mice inoculated with aerosols of Pasteurella haemolytica or Staphylococcus aureus. 接种溶血性巴氏杆菌或金黄色葡萄球菌气雾剂的小鼠肺中性粒细胞募集和细菌清除率。
J Martínez-Burnes, A López, M Merino-Moncada, P Ochoa-Galván, I Mondragón
{"title":"Pulmonary recruitment of neutrophils and bacterial clearance in mice inoculated with aerosols of Pasteurella haemolytica or Staphylococcus aureus.","authors":"J Martínez-Burnes,&nbsp;A López,&nbsp;M Merino-Moncada,&nbsp;P Ochoa-Galván,&nbsp;I Mondragón","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pulmonary alveolar macrophages are considered to be the main phagocytic cell of the pulmonary defense mechanism. However recent studies indicate that neutrophils may also participate in the defense against inhaled bacteria. The aim of this investigation was to study in mice the correlation between numbers of phagocytic cells in the bronchoalveolar space and the pulmonary clearance of bacteria. White mice were exposed to aerosols of Pasteurella haemolytica (n = 129) or Staphylococcus aureus (n = 129) in three different experimental replicates. Another group of mice (n = 22) was sham exposed to an aerosol of sterile phosphate buffered solution in a single replicate. Animals were sacrificed at various times postaerosolization. The numbers of neutrophils and alveolar macrophages in lung lavages and the pulmonary bacterial clearance rates were determined and statistically analysed. No significant differences (p greater than 0.05) were observed in the rates of pulmonary clearance between the two genera of bacteria, but P. haemolytica had a significant (p less than 0.05) replicate effect. The number of alveolar macrophages was not significantly affected by either bacteria or phosphate buffered solution. Exposure to P. haemolytica resulted in dramatic, significant (p less than 0.01) but transient increases in neutrophils in the bronchoalveolar space as well as a significant (p less than 0.01) increase in the weights of lung. The correlation between neutrophils and clearance was positive for P. haemolytica but negative for S. aureus. These results indicate that both species of bacteria are rapidly eliminated from the lung despite a rather different cellular response.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"327-32"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236181/pdf/compmed00003-0091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15153906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrelationships between ambient temperature, age at calving, postpartum reproductive events and reproductive performance in dairy cows: a path analysis. 环境温度、产犊年龄、产后繁殖事件与奶牛繁殖性能之间的相互关系:一种通径分析。
W G Etherington, S W Martin, I R Dohoo, W T Bosu
{"title":"Interrelationships between ambient temperature, age at calving, postpartum reproductive events and reproductive performance in dairy cows: a path analysis.","authors":"W G Etherington,&nbsp;S W Martin,&nbsp;I R Dohoo,&nbsp;W T Bosu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Path analysis was used to determine the interrelationships between ambient temperature, age at calving, postpartum reproductive events and reproductive performance in dairy cows. The data used in the analysis were collected on 226 Holstein-Friesian cows calving in a commercial dairy herd during a 17 month period (May 1, 1981 to October 1, 1982). The data were obtained from a double blind study evaluating the effects of gonadotrophin releasing hormone and cloprostenol in postpartum cows. Rectal palpation to assess uterine involution and ovarian activity was performed on each cow on days 15, 24 and 28 postpartum. At the same time, blood samples were collected for subsequent progesterone assay. Data were recorded on the occurrence of reproductive diseases and events from the time of parturition until the diagnosis of pregnancy or until the cow left the herd in the case of culled cows. There was an increase in the incidence of retained placenta, in the percentage of cows with abnormal vaginal discharge in the early postpartum period as well as a delay in uterine involution during the winter months. In addition, cows calving during the winter had prolonged intervals to first estrus, first service and conception compared to cows calving during the summer. (Cows calving during the warmest months, on average, were seen in estrus 24 days sooner, received first service 42 days sooner and conceived 27 days sooner than cows calving during the coldest months of the year).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 3","pages":"254-60"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236166/pdf/compmed00003-0018.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15154628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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