Cardiovascular Therapy and Prevention最新文献

{"title":"Biobanking in the hospital of a multidisciplinary research medical center as a potential for a wide research range. Part I. Organizational and methodological aspects","authors":"A. I. Borisova, O. Kopylova, M. S. Pokrovskaya, I. Efimova, A. V. Pustelenin, А. I. Ershova, O. Drapkina","doi":"10.15829/1728-8800-2023-3749","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3749","url":null,"abstract":"Aim. To develop an algorithm and manage total biobanking of samples of whole blood, serum and plasma of patients in the hospital of the National Medical Research Center for Therapy and Preventive Medicine in order to create a detailed biosample collection through the integration of electronic medical records and a biobank database.Material and methods. The study includes all patients admitted to the hospital of the National Medical Research Center for Therapy and Preventive Medicine in various departments who signed informed consent for biobanking. Clinical information is collected as part of patient examination and stored in electronic medical records in the Medialog medical information system. Biobanking of blood and related products is carried out in accordance with standard operating procedures. From each patient, 12 aliquots of serum and blood plasma are stored, as well as 1 tube of whole blood with ethylenediaminetetraacetic acid potassium salt. Information about biospecimens, patient identification numbers and storage location coordinates are contained in the biobank database.Results. An algorithm for total biobanking of biomaterial and data from inpatients has been developed and put into practice. This collection is associated with large biomedical data stored in a medical information system, laboratory information system and biobank. The combined databases make it possible to search for samples in the collection according to specified criteria.Conclusion. The collection developed can be used for a wide range of studies by forming patient samples according to the necessary criteria. The developed algorithm for total biobanking in a hospital can be used in various medical centers equipped with biobanks.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"55 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal characteristics of predisposition to destructive behavior","authors":"I. M. Plugina, E. G. Abakarova, A. S. Lukyanov","doi":"10.15829/1728-8800-2023-3804","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3804","url":null,"abstract":"Aim. To identify personal characteristics determining the subject’s destructive behavior.Material and methods. Students from Stavropol State Medical University and North-Caucasus Federal University (n=609) took part in the study. The following diagnostic methods were used: a tendency to abnormal behavior (A. N. Orel), a meaning-life orientation test (D. A. Leontyev), a self-attitude test (S. R. Panteleev), a self-organization of activity questionnaire (E. Yu. Mandrikova).Results. We established that the sample corresponds to the characteristics of age-psychological and socio-professional development. The greatest severity by type of deviant behavior was found among respondents who are prone to overcoming norms and rules, and among those who have a reduced tendency to control emotional reactions. The least pronounced were tendencies to delinquent and addictive behavior, the tendency to aggression and violence. The dominant trends in this context are students’ understanding of the emotional richness of their ives, and the average psychological portrait of the respondent reflects their focus on themselves when implementing life’s tasks. On average, students are open to change, accept and value themselves, focus on their own strengths when planning and implementing future activities. They are focused on the present, understand the need to define the goals in life and activity. The study of individual parameters of personal characteristics and the severity of destructive behavior types made it possible to describe models of the relationship between these phenomena.Conclusion. The study showed that the current situation in the development of society is accompanied by risk factors that cause states of emotional stress and maladaptation, which has a negative impact on mental health and behavior. Diagnosis of personal characteristics and the severity of destructive behavior types in students made it possible to describe models of the relationship between these phenomena through regression analysis. A reflexive analysis of the results obtained made it possible to reveal an invariant part of personal characteristics in models of destructive behavior and the presence of certain personal characteristics that can manifest themselves in the variable part of a model of destructive behavior.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"406 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138985645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ageism patterns in generation Z cohort in the context of soft skill development as exemplified by medical students","authors":"N. V. Sevastyanova, K. I. Proshchaev, A. Ilnitsky, N. А. Mokicheva, L. S. Lokinskaya, M. Y. Shaposhnikova","doi":"10.15829/1728-8800-2023-3766","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3766","url":null,"abstract":"The article discusses the question of identifying ageism patterns among medical students, where it is contrasted with soft skills, especially in jobs involving human-human collaborations. Modern medical students are representatives of the generation Z. This generation will determine the trends in the development of society and healthcare, in particular, for the coming decades. Understanding these trends will make it possible to specifically manage soft skills, make adjustments to medical curricula, enhancing their competitive ability to face the global labor market.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"322 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138985789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video-ecological approach to the infographics use in education","authors":"L. S. Podymova, N. A. Podymov, E. A. Alisov, T. А. Golovyatenko","doi":"10.15829/1728-8800-2023-3738","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3738","url":null,"abstract":"Aim. To determine prerequisites, content and strategic methods for implementing the author’s video-ecological approach to the infographics use in education.Material and methods. The subject of the study was the video-ecological approach as a pedagogical system that determines the features of infographics in education. The theoretical methods involved in content creation of the video-ecological approach were the following methods: idealization, abstraction, deduction, extrapolation. The following empirical research methods were also used: sample observation, experimental conversation, questionnaire. The methods are in demand in the context of correlating digitalization and ecologization as modern trends in educational process.Results. The video-ecological approach to the infographics use in education is presented taking into account other approaches that have become widespread at the present stage: research, narrative, competence-based, functional-activity, psychodidactic. The article contains the definition and characteristics of the structural and content filling of the epistemic spaces of video-ecological approach. Particular importance is attached to the study of prerequisites for the development of a video-ecological approach. Ecological principles of visual worldview are extrapolated into strategic techniques for implementing the videoecological approach in educational practice: interpretation of infographics, data visualization, critical analysis and creation of infographics.Conclusion. The video-ecological approach is considered by the authors as an effective theoretical and methodological basis for the infographics use in education. The results are of interest to the scientific and pedagogical community, teachers, administrative workers of educational organizations, pedagogical students. ","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"35 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138985666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competency-based education of specialists at a medical university","authors":"D. Isakova, O. A. Rusakova, K. Zavedensky, E. S. Shchegolenkova, D. Dolganov, M. V. Lyapina, K. A. Vikulova, T. Vasilkova, I. M. Petrov","doi":"10.15829/17288800-2023-3665","DOIUrl":"https://doi.org/10.15829/17288800-2023-3665","url":null,"abstract":"The training of medical specialists needs systemic transformation. Educational organizations must create conditions for developing research competencies and innovative activities among future healthcare, as well as implement transversal formats for attracting and managing talented youth at all stages of professional development. To create a passport of educational program competencies and describe the results of educational activities, the \"Competency Standard\" database has been developed. The aim was to classify groups and categories of competencies, including the subject’s competencies (both educational and project), the competencies of activity development, and transversal competences applicable in any type of educational and project activities. Project-based training for students makes it possible to form following priority competencies in medicine and pharmacy: analytical, research, professional, communicative, digital, managerial and entrepreneurial. Project-based learning and new educational formats are used as an transversal technology in the implementation of innovative programs, the target audience of which is students with increased educational potential, claiming a portfolio of high-quality competencies. ","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"282 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138985578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water aerobic training in cardiac rehabilitation programs","authors":"A. L. Persiyanova- Dubrova, M. Bubnova, I. Matveeva, D. M. Aronov","doi":"10.15829/1728-8800-2023-3808","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3808","url":null,"abstract":"Water aerobic training can be considered as an additional method of exercise in the rehabilitation of cardiovascular patients. The review examines the physiological effects of water training, the potential of its use in different categories of cardiac patients, its advantages, dosing the load and monitoring its intensity in the aquatic environment. The practical aspects of aqua aerobic training are discussed, and research data on its safety and effectiveness in cardiac rehabilitation programs is provided.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of genetic risk scores for obesity on a sample of the population of Russian regions","authors":"A. Kiseleva, A. G. Soplenkova, V. Kutsenko, E. Sotnikova, Yu.V. Vyatkin, А. A. Zharikova, A. Ershova, M. Zaichenoka, V. Ramensky, O. Skirko, S. Smetnev, O. Kopylova, А. S. Limonova, A. Blokhina, M. S. Pokrovskaya, S. Shalnova, A. N. Meshkov, O. Drapkina","doi":"10.15829/1728-8800-2023-3755","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3755","url":null,"abstract":"Aim. To validate and evaluate the accuracy of 15 genetic risk scores (GRSs) for obesity, created in populations of European origin in the sample of two European Russia regions. Material and methods. Genetic testing has been performed using next generation sequencing on a sample from the Russian population (n=1179). The study included 15 GRS associated with body mass index (BMI) or waist-to-hip ratio adjusted for BMI (WHRadjBMI).Results. The predictive power of 8 out of 9 GRSs for obesity based on BMI remains the same for the Russian population. The predictive power of 6 GRSs for obesity based on WHRadjBMI is lower in the Russian population than in the reference sample. GRS reproducibility increases with the size of initial samples and number of variants included in the GRS increase. The use of GRSs for obesity based on BMI in the Russian population created on European populations is justified.Conclusion. For the first time in Russia, 15 obesity GRSs developed in European populations have been validated. The data obtained on the effectiveness of the considered GRS can be used in the future to improve the obesity prediction and prevention in Russia.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature coronary artery disease and severe hypertriglyceridemia in a patient with monogenic diabetes: a case report","authors":"V. I. Mikhailina, A. N. Meshkov, A. Kiseleva, A. Ershova, M. Zaichenoka, E. S. Luboyatnikova, M. S. Pokrovskaya, O. Drapkina","doi":"10.15829/1728-8800-2023-3768","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3768","url":null,"abstract":"Aim. Maturity- onset diabetes of the young (MODY) is a group of monogenic diseases with an autosomal dominant inheritance. This is a rarely diagnosed disease, occurring in 1 of 10 thousand adults and in 1 of 23 thousand children. Brief description. We present a case report of a patient with a monogenic diabetes HNF4A-MODY, severe hypertriglyceridemia, progressive premature coronary artery disease and a HNF4A gene pathogenic variant (ENST00000316099.8:c.1145dup).Discussion. This case demonstrates the effectiveness of triple hypoglycemic therapy, including empagliflozin for the treatment of monogenic diabetes. Despite the fact that the patient with diabetes reached the target glycated hemoglobin level, the combination of the disease with other cardiovascular risk factors (hypertension, hypertriglyceridemia, obesity, smoking, male sex) led to the progression of coronary and peripheral atherosclerosis. Considering the data of genetic testing, returning to sulfonylurea therapy should be considered. It is important for patient to follow a strict lipid-lowering diet and taking combination lipid-lowering therapy (rosuvastatin, fenofibrate and omega-3 polyunsaturated fatty acids) in order to achieve the target level of low-density lipoprotein cholesterol <1,4 mmol/l and triglycerides <1,7 mmol/l.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139209148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the humoral and cell-mediated immune response in heterologous and homologous SARS-CoV-2 revaccination","authors":"O. Drapkina, M. G. Chashchin, S. Berns, A. Gorshkov, O. V. Zhdanova, L. N. Ryzhakova, O. Litinskaya","doi":"10.15829/1728-8800-2023-3764","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3764","url":null,"abstract":"The effectiveness of humoral and cell-mediated immunity as a result of primary vaccination for Severe Acute Respiratory Syndrome- related CoronaVirus 2 (SARS-CoV-2), as well as the effectiveness of revaccination, is an important research problem. Studying and selecting optimal revaccination regimens will allow for long-term protection against coronavirus disease 2019 (COVID-19).Aim. To study the severity of humoral and cell-mediated immune response in various (homo- and heterologous) SARS-CoV-2 revaccination regimens as part of a prospective observational study 18 and 24 months after primary vaccination.Material and methods. The study was carried out within the prospective registry SATURN, which included individuals who received various SARS-CoV-2 revaccination (homo- and heterologous regimens) based on a combination of two following vaccines: Gam- COVID-Vac and CoviVac. Depending on the chosen regimen, 3 following groups were formed: group I (n=106) — participants with a homologous Gam- COVID-Vac regimen at each stage of vaccination and revaccination; group II (n=54) — participants with a heterologous regimen of sequential administration of Gam- COVID-Vac and CoviVac at the stage of vaccination and revaccination; group III (n=40) — participants with a homologous CoviVac regimen at the stage of vaccination and revaccination. At the first visit, all participants underwent a medical history collection, examination, and identification of potential contraindications to vaccination. At each subsequent visit, the level of anti- SARS-CoV-2 S-glycoprotein IgG antibodies was additionally determined. At visits 1, 3 and 5, the activity of specifically sensitized T-lymphocytes to the surface and nuclear antigen of SARS-CoV-2 was assessed. The IgG concentration was analyzed using the Abbott Architect SARS-CoV-2 IgG reagent kit, while T-cell immunity was assessed using the T-Spot.COVID test system (Oxford Immunotec). Visit 1 corresponded to the 1st stage of primary vaccination, visit 2 — 2nd stage of primary vaccination, visit 3 (12 months after visit 1) — 1st stage of revaccination, visit 3 (21 days after visit 3) — 2nd stage of revaccination, visit 5 –18 months after primary vaccination, visit 6 — 24 months after primary vaccination.Results. The average level of anti- SARS-CoV-2 S-glycoprotein IgG antibodies in group I at visit 3 was 520 [478; 540] BAU/ml, in group II — 499 [199,5; 540] BAU/ml and in group III — 456 [389; 509,5] BAU/ml. The values were comparable to those obtained at visit 6. However, in group II, IgG level at visit 5 was significantly higher compared to visit 6 (p=0,001). The greatest decrease by visit 5 in the number of active T cells responding to SARS-CoV-2 Spike stimulation was recorded in group III (5,00 [0,50; 11,50] vs 1,00 [0,00; 5,50]; relative changes -80,0%; p=0,067). Also, among patients in group III, there was a significant decrease in the number of active T cells responding to stimulation with SARS-CoV-2 nucleocapsid (10,00 [3","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers of heart failure with preserved ejection fraction in patients with unexplained dyspnea","authors":"A. A. Ivanova, E. A. Rogozhkina, Y. S. Timofeev, O. N. Dzhioeva, O. Drapkina","doi":"10.15829/1728-8800-2023-3769","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3769","url":null,"abstract":"Aim. To evaluate the prevalence of clinical, history, laboratory and ultrasound markers of heart failure with preserved ejection fraction (HFpEF) in patients with unexplained dyspnea, as well as to identify markers of structural myocardial remodeling in this group of patients.Material and methods. This retrospective study included 504 patients aged 18 to 84 years who were hospitalized from July 1, 2022 to March 31, 2023. Patients were divided into two groups depending on the presence of dyspnea. A comparative analysis of ultrasound parameters was carried out in order to identify myocardial structural remodeling.Results. A number of associated conditions and metabolic disorders, which are known to be risk factors for HFpEF, were detected more often in patients with unexplained dyspnea and myocardial remodeling. A model to determine the probability of structural remodeling was developed. Two most significant indicators were dyspnea and diabetes.Conclusion. This study demonstrated the relationship between unexplained dyspnea and structural myocardial remodeling. Identification of certain clinical and morphological signs of HFpEF in such patients requires apprehensive attitude and in-depth examination in order to rule out it.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}