Markers of heart failure with preserved ejection fraction in patients with unexplained dyspnea

Q3 Social Sciences

Cardiovascular Therapy and Prevention Pub Date : 2023-11-29 DOI:10.15829/1728-8800-2023-3769

A. A. Ivanova, E. A. Rogozhkina, Y. S. Timofeev, O. N. Dzhioeva, O. Drapkina

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引用次数: 0

Abstract

Aim. To evaluate the prevalence of clinical, history, laboratory and ultrasound markers of heart failure with preserved ejection fraction (HFpEF) in patients with unexplained dyspnea, as well as to identify markers of structural myocardial remodeling in this group of patients.Material and methods. This retrospective study included 504 patients aged 18 to 84 years who were hospitalized from July 1, 2022 to March 31, 2023. Patients were divided into two groups depending on the presence of dyspnea. A comparative analysis of ultrasound parameters was carried out in order to identify myocardial structural remodeling.Results. A number of associated conditions and metabolic disorders, which are known to be risk factors for HFpEF, were detected more often in patients with unexplained dyspnea and myocardial remodeling. A model to determine the probability of structural remodeling was developed. Two most significant indicators were dyspnea and diabetes.Conclusion. This study demonstrated the relationship between unexplained dyspnea and structural myocardial remodeling. Identification of certain clinical and morphological signs of HFpEF in such patients requires apprehensive attitude and in-depth examination in order to rule out it.

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不明原因呼吸困难患者中射血分数保留型心力衰竭的标志物

目的评估不明原因呼吸困难患者中射血分数保留型心力衰竭（HFpEF）的临床、病史、实验室和超声标记物的患病率，并确定这类患者的心肌结构重塑标记物。这项回顾性研究纳入了 504 名年龄在 18 至 84 岁之间、于 2022 年 7 月 1 日至 2023 年 3 月 31 日期间住院治疗的患者。根据是否存在呼吸困难，患者被分为两组。对超声参数进行了对比分析，以确定心肌结构重塑情况。在不明原因呼吸困难和心肌重塑的患者中，更常发现一些相关疾病和代谢紊乱，而这些疾病和紊乱是已知的高频心衰的危险因素。我们建立了一个模型来确定结构重塑的概率。两个最重要的指标是呼吸困难和糖尿病。这项研究证明了不明原因的呼吸困难与结构性心肌重塑之间的关系。在此类患者中识别 HFpEF 的某些临床和形态学体征需要采取谨慎的态度和深入的检查，以排除 HFpEF。

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来源期刊

Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

0.00%

发文量

155

审稿时长

6-12 weeks

期刊介绍： The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.