Cancer letters最新文献_第9页

Pan-cancer analysis reveals multifaceted roles of nonmyelinating Schwann cells in gastrointestinal cancers 泛癌分析揭示了非髓鞘性雪旺细胞在胃肠道癌症中的多方面作用

IF 9.1 1区医学

Cancer letters Pub Date : 2025-06-03 DOI: 10.1016/j.canlet.2025.217850

Hui Li , Luju Jiang , Shan Zhang , Xiaocao Miao , Shu-Heng Jiang

{"title":"Pan-cancer analysis reveals multifaceted roles of nonmyelinating Schwann cells in gastrointestinal cancers","authors":"Hui Li , Luju Jiang , Shan Zhang , Xiaocao Miao , Shu-Heng Jiang","doi":"10.1016/j.canlet.2025.217850","DOIUrl":"10.1016/j.canlet.2025.217850","url":null,"abstract":"<div><div>Cancer neuroscience has emerged as a pivotal interdisciplinary field, offering transformative insights into tumor progression mechanisms. Nonmyelinating Schwann cells (NMSCs), integral yet understudied components of the tumor microenvironment (TME), exhibit complex roles in modulating tumor malignancy. Here, we employed deconvolution algorithms to quantify NMSC enrichment by leveraging bulk RNA-seq data. By integrating multi-omics and single-cell strategies along with comprehensive bioinformatics analyses, we delineated NMSC-mediated regulatory networks and their functional impact on gastrointestinal tumors. NMSC enrichment strongly correlated with core cancer hallmarks, notably “Activating invasion and metastasis” and “Inducing angiogenesis”. Immune profiling revealed NMSCs as multifaceted regulators of the TME: positively associated with myeloid-derived suppressor cells, natural killer cells, and regulatory T cells, but inversely correlated with CD56dim NK cells, monocytes, and neutrophils. Genomic analyses uncovered nuanced associations between NMSC abundance and somatic mutations, copy number variation, and methylation patterns, while microRNA mapping highlighted NMSC-specific networks. Single-cell resolution analysis demonstrated that NMSCs engage epithelial cells and fibroblasts via extracellular matrix-centric signaling axes. Collectively, our findings establish NMSCs as multifaceted TME orchestrators, providing mechanistic rationale for NMSC-targeted diagnostic biomarkers and stromal reprogramming therapies in precision oncology.</div></div>","PeriodicalId":9506,"journal":{"name":"Cancer letters","volume":"628 ","pages":"Article 217850"},"PeriodicalIF":9.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer" [Cancer Lett. 587 (2024) 216658]. “mettl3介导的hspa9m6a修饰通过调节外泌体死亡蛋白促进宫颈癌的恶性转化和抑制细胞衰老”[癌症杂志]. 587(2024)216658。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-06-03 DOI: 10.1016/j.canlet.2025.217827

Keyi Ao, Minuo Yin, Xiaoming Lyu, Yue Xiao, Xiaona Chen, Sheng Zhong, Xiuli Wen, Jianli Yuan, Ming Ye, Jiaming Zhang, Xin Li, Yi Hao, Xia Guo

引用次数: 0

Corrigendum to "Efficacy of the first-line immune checkpoint inhibitor plus chemotherapy for gastroesophageal cancer: A meta-analysis of phase III trials including unreported PD-L1 subgroups" [Cancer Lett. 623, (2025) 217718]. 《一线免疫检查点抑制剂联合化疗治疗胃食管癌的疗效：包括未报道的PD-L1亚组的III期试验的荟萃分析》的勘误表[癌症杂志，623,(2025)217718]。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-06-03 DOI: 10.1016/j.canlet.2025.217826

Choong-Kun Lee, Sejung Park, Yaeji Lee, Choa Yun, Moonki Hong, Chung Mo Nam, Hyun Cheol Chung, Sun Young Rha

引用次数: 0

Tumor-associated Schwann cells promote salivary adenoid cystic carcinoma stem-like reprogramming via IGF2/IGF1R induced histone H3 lysine 18 lactylation 肿瘤相关的雪旺细胞通过IGF2/IGF1R诱导的组蛋白H3赖氨酸18乙酰化促进唾液腺样囊性癌干细胞样重编程。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-06-02 DOI: 10.1016/j.canlet.2025.217847

Su Chen , Guangzhao Huang , Zhiyong Guo , Zijian Guo , Chang Cao , Guile Zhao , Grace Paka Lubamba , Yuncong Huang , Jiajin Yang , Haosen Lian , Yufei Hua , Cheng Miao , Jiefei Shen , Ming Xuan , Xiufa Tang , Zhangfan Ding , Chunjie Li

{"title":"Tumor-associated Schwann cells promote salivary adenoid cystic carcinoma stem-like reprogramming via IGF2/IGF1R induced histone H3 lysine 18 lactylation","authors":"Su Chen , Guangzhao Huang , Zhiyong Guo , Zijian Guo , Chang Cao , Guile Zhao , Grace Paka Lubamba , Yuncong Huang , Jiajin Yang , Haosen Lian , Yufei Hua , Cheng Miao , Jiefei Shen , Ming Xuan , Xiufa Tang , Zhangfan Ding , Chunjie Li","doi":"10.1016/j.canlet.2025.217847","DOIUrl":"10.1016/j.canlet.2025.217847","url":null,"abstract":"<div><div>Salivary adenoid cystic carcinoma (SACC) is characterized by an exceptionally dense neural network within its tumor microenvironment. Schwann cells (SCs), an essential component of this neural network, have recently emerged as critical mediators of tumor progression. However, SACC-induced SCs reprogramming, as well as the functional significance and molecular mechanisms of tumor-associated Schwann cells (TA-SCs), remains largely elusive. We employed tissue-clearing-based three-dimensional imaging to evaluate the SACC tumor microenvironment with high spatial resolution. We also characterized SCs heterogeneity using single-cell RNA sequencing data from GEO. We investigated the biological phenotypes transformation and revealed the transcriptome characteristics of TA-SCs in SACC, indicating that TGF-β1 exerts its function through c-Jun activation, which is pivotal for driving TA-SCs reprogramming. Furthermore, we determined that TA-SCs enhance SACC cell proliferation, migration, invasion, cisplatin resistance, and stemness. We further discovered that TA-SCs elevate histone lactylation in SACC via paracrine IGF2 signaling. Inhibition of IGF2/IGF1R signaling curbed histone H3 lysine 18 lactylation (H3K18la) in SACC and attenuated the IGF2-driven stem-like reprogramming effect, while simultaneous blockade of TGF-βR1 and IGF1R activation maximally restricted this reprogramming. These findings underscore the pivotal role of TA-SCs in SACC progression and stem-like reprogramming via IGF2/IGF1R-H3K18la axis, representing promising therapeutic targets for this malignancy.</div></div>","PeriodicalId":9506,"journal":{"name":"Cancer letters","volume":"628 ","pages":"Article 217847"},"PeriodicalIF":9.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell differentiation-related signaling pathways in hepatocellular carcinoma metastasis 肝细胞癌转移中细胞分化相关信号通路的研究

IF 9.1 1区医学

Cancer letters Pub Date : 2025-05-31 DOI: 10.1016/j.canlet.2025.217846

Ze Xiang , Jiarui Li , Yunyang Xu , Chenhao Xu , Shusen Zheng , Jian Chen , Xuyong Wei , Xiao Xu

{"title":"Cell differentiation-related signaling pathways in hepatocellular carcinoma metastasis","authors":"Ze Xiang , Jiarui Li , Yunyang Xu , Chenhao Xu , Shusen Zheng , Jian Chen , Xuyong Wei , Xiao Xu","doi":"10.1016/j.canlet.2025.217846","DOIUrl":"10.1016/j.canlet.2025.217846","url":null,"abstract":"<div><div>Primary liver cancer is the third leading cause of cancer-related deaths worldwide, with persistently high incidence and mortality rates. Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, has a complex pathogenesis. Moreover, due to the low rate of early diagnosis and limited treatment options, the prognosis for HCC patients is poor, with a median overall survival of approximately one year for advanced-stage HCC. Cancer metastasis is one of the main reasons for HCC-related deaths. During the metastatic process, tumor cells undergo a series of complex biological changes, including epithelial-mesenchymal transition, extracellular matrix remodeling, angiogenesis, and resistance to anoikis, which are key steps. These changes promote the invasion and migration of tumor cells and are central mechanisms of cancer progression. In the metastatic process of HCC, signaling pathways that regulate cell proliferation, differentiation, and apoptosis, such as Hippo-YAP/TAZ, Wnt/β-catenin, Notch, Hedgehog and JAK/STAT, become dysregulated and play a promoting role in the aggressive growth and distant migration of HCC cells. Treatment strategies targeting these pathways are currently being developed. These new agents, being more targeted, may have better tolerability and fewer adverse effects. This review focuses on the role of these key signaling pathways in the metastatic process of HCC and summarizes the treatment strategies targeting these pathways.</div></div>","PeriodicalId":9506,"journal":{"name":"Cancer letters","volume":"627 ","pages":"Article 217846"},"PeriodicalIF":9.1,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of 7-dehydrocholesterol in inducing ER stress and apoptosis of head and neck squamous cell carcinoma 7-脱氢胆固醇在头颈部鳞状细胞癌内质网应激及凋亡中的作用。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-05-31 DOI: 10.1016/j.canlet.2025.217842

Bok-Soon Lee , Yea-In Park , Hengtian Liu , Sang Gyu Kim , Hyo Jeong Kim , Ji-Hye Choi , Si Hyun Rho , Joselyn Padilla , Jin Roh , Hyun Goo Woo , Hae Jin Seo , Man Ho Choi , Yu-Jin Jeong , Evan C. Lien , Syed Hassan Mehdi , Dongjoon Lee , Donghoon Yoon , Chul-Ho Kim , Jiyoung Lee

{"title":"The role of 7-dehydrocholesterol in inducing ER stress and apoptosis of head and neck squamous cell carcinoma","authors":"Bok-Soon Lee , Yea-In Park , Hengtian Liu , Sang Gyu Kim , Hyo Jeong Kim , Ji-Hye Choi , Si Hyun Rho , Joselyn Padilla , Jin Roh , Hyun Goo Woo , Hae Jin Seo , Man Ho Choi , Yu-Jin Jeong , Evan C. Lien , Syed Hassan Mehdi , Dongjoon Lee , Donghoon Yoon , Chul-Ho Kim , Jiyoung Lee","doi":"10.1016/j.canlet.2025.217842","DOIUrl":"10.1016/j.canlet.2025.217842","url":null,"abstract":"<div><div>Alterations of metabolic pathways that sustain cancer cell survival often offer promising therapeutic avenues. Here, we show that enhanced <em>de novo</em> cholesterol biosynthesis is crucial for the survival of head and neck squamous cell carcinoma (HNSCC). Transcriptomic analysis of HNSCC tissues identified profound dysregulation in steroid and cholesterol metabolism compared to normal tissues. Inhibition of two key enzymes, DHCR7 and DHCR24, which mediate cholesterol biosynthesis, induced apoptosis in HNSCC cells, even when cholesterol levels were restored. Metabolomic profiling revealed the accumulation of 7-dehydrocholesterol (7-DHC) upon DHCR7 or DHCR24 inhibition, triggering endoplasmic reticulum (ER) stress and promoting further cell death. These findings suggest that HNSCC cells adapt to ER stress by modulating 7-DHC levels through enhancing DHCR7 and DHCR24 levels, highlighting a metabolic vulnerability in HNSCC and demonstrating a direct link between cholesterol metabolism and ER stress in cancer cell viability.</div></div>","PeriodicalId":9506,"journal":{"name":"Cancer letters","volume":"628 ","pages":"Article 217842"},"PeriodicalIF":9.1,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Targeting mitochondrial ribosomal protein expression by andrographolide and melatonin for colon cancer treatment" [Cancer Lett. 619 (2025) 1-11 217647]. “利用穿心莲内酯和褪黑素靶向线粒体核糖体蛋白表达治疗结肠癌”[j].中华癌症杂志，2016(1):1-11。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-05-30 DOI: 10.1016/j.canlet.2025.217784

Advaitha Midde, Navpreet Arri, Tibor Kristian, Suprabhat Mukherjee, Parth Sarthi Sen Gupta, Yuji Zhang, Mariuz Karbowski, Jaylyn Waddell, Maharajan Nagarajan, Michal Zalzman, Aditi Banerjee

引用次数: 0

Structural and material basis of neuron–glioma interactions 神经胶质瘤相互作用的结构和物质基础。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-05-30 DOI: 10.1016/j.canlet.2025.217843

Jun Wang , Tian-hua Shen , Jie Liu , Qian Wen , Xian-yan Yang , Yun Deng , Jiang-jie Duan , Shi-cang Yu

引用次数: 0

Lactylation in tumor microenvironment and immunotherapy resistance: New mechanisms and challenges 肿瘤微环境中的乳酸化与免疫治疗耐药性：新的机制和挑战。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-05-28 DOI: 10.1016/j.canlet.2025.217835

Wenlong Zhu , Chang Fan , Yizhuo Hou, Yanjie Zhang

{"title":"Lactylation in tumor microenvironment and immunotherapy resistance: New mechanisms and challenges","authors":"Wenlong Zhu , Chang Fan , Yizhuo Hou, Yanjie Zhang","doi":"10.1016/j.canlet.2025.217835","DOIUrl":"10.1016/j.canlet.2025.217835","url":null,"abstract":"<div><div>Tumor microenvironment (TME) is a highly intricate and variable system. The Warburg effect has made researchers further realize that TME is a highly hypoxic microenvironment. Currently, it is reported that lactate is not merely a metabolic waste but also serves important biological functions, which provides a large number of reaction substrates for lactylation. Post-translational modification (PTM) is crucial for signaling and physiological regulation in both normal and cancer cells. Various PTMs play pathological roles in tumor proliferation, metabolism, and the remodeling of the tumor immunosuppressive microenvironment (TIME). Lactylation, as a newly reported PTM, plays an important role in shaping TIME and aggravating tumor immunotherapy resistance. Numerous studies have demonstrated that histone lactylation can directly stimulate gene transcription within chromatin, thereby contributing to tumor promotion and diminishing the efficacy of therapeutic agents against tumors. Advancements in multi-omics technology enable researchers to investigate lactylation-related substrates more effectively. By precisely targeting these sites, it is possible to reduce histone lactylation in order to mitigate their effects on tumor immune resistance. Despite the existence of numerous studies, there remains a notable deficiency of systematic reviews in this field. Therefore, this review focuses on the novel mechanisms of lactylation that promote tumor progression and its impact on tumor immune resistance. Finally, we propose relevant therapeutic regimens for reversing lactylation to guide tumor combined therapy, thus providing benefits upon more patients with tumor immune resistance.</div></div>","PeriodicalId":9506,"journal":{"name":"Cancer letters","volume":"627 ","pages":"Article 217835"},"PeriodicalIF":9.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved survival in pancreatic ductal adenocarcinoma: Exciting promise of multimodal management strategies. 提高胰腺导管腺癌的生存率：多模式管理策略的令人兴奋的前景。

IF 9.1 1区医学

Cancer letters Pub Date : 2025-05-27 DOI: 10.1016/j.canlet.2025.217828

Murray Korc, Min Li

引用次数: 0