Cardiology journal最新文献

{"title":"Elective cardioversion of atrial fibrillation is safe without transesophageal echocardiography in patients treated with non-vitamin K antagonist oral anticoagulants: Multicenter experience.","authors":"Iwona Gorczyca,&nbsp;Beata Uziębło-Życzkowska,&nbsp;Anna Szpotowicz,&nbsp;Magdalena Chrapek,&nbsp;Paweł Krzesiński,&nbsp;Bernadetta Bielecka,&nbsp;Agnieszka Woronowicz-Chróściel,&nbsp;Paweł Wałek,&nbsp;Małgorzata Krzciuk,&nbsp;Beata Wożakowska-Kapłon","doi":"10.5603/CJ.a2021.0010","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0010","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend electrical cardioversion (ECV) in patients with atrial fibrillation (AF) after at least 3 weeks of adequate non-vitamin K antagonist oral anticoagulant (NOAC) treatment without prior transesophageal echocardiography (TEE). However, in clinical practice in some centres, TEE is performed before ECV in patients with AF. The aim of the study was to evaluate prevalence of thromboembolic and hemorrhagic complications in patients with AF treated with NOACs and undergoing ECV without prior TEE.</p><p><strong>Methods: </strong>This observational, multicentre study included consecutive patients with AF treated with NOACs who were admitted for ECV without prior TEE. Thromboembolic events and major bleeding complications were investigated during a 30-day follow-up.</p><p><strong>Results: </strong>In the study group there were 611 patients, mean age was 66.3 ± 9.2 years, 40% were women. 52 (8.5%) patients had a low thromboembolic risk, 148 (24.2%) patients had an intermediate thromboembolic risk and 411 (67.2%) patients had a high thromboembolic risk. In the study group 253 (41.4%) patients were treated with rivaroxaban, 252 (41.2%) patients were treated with dabigatran and 106 (17.3%) patients were treated with apixaban. Reduced doses of NOACs were administered to 113 (18.9%) patients. In the entire study group, there were no thromboembolic events or major bleeding complications during the in-hospital stay and the 30-day follow-up.</p><p><strong>Conclusions: </strong>In this \"real-world\" study of AF patients treated with NOACs, it was proved that ECV is safe without a preceding TEE, regardless of the risk of thromboembolic complications and of the type of NOAC used.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"228-236"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/ca/cardj-30-2-228.PMC10129268.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9401255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vieussens' arterial ring: A blessing and a curse.","authors":"Maciej T Wybraniec,&nbsp;Wojciech Wróbel,&nbsp;Małgorzata Cichoń,&nbsp;Łukasz Dykas,&nbsp;Katarzyna Mizia-Stec","doi":"10.5603/CJ.2023.0022","DOIUrl":"https://doi.org/10.5603/CJ.2023.0022","url":null,"abstract":"This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. Cardiology Journal 2023, Vol. 30, No. 2, 331–332 DOI: 10.5603/CJ.2023.0022 Copyright © 2023 Via Medica ISSN 1897–5593 eISSN 1898–018X IMAGE IN CARDIOVASCULAR MEDICINE CLINICAL CARDIOLOGY","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"331-332"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/43/cardj-30-2-331.PMC10129264.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9403594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical classification of chronic total occlusions in coronary bifurcations.","authors":"Juan Luis Gutiérrez-Chico,&nbsp;Carlos Cortés,&nbsp;Niels Ramsing Holm,&nbsp;Evald Høj Christiansen,&nbsp;Maciej Lesiak,&nbsp;Bernward Lauer,&nbsp;Sylvia Otto,&nbsp;Francesco Lavarra,&nbsp;Viktor Sasi,&nbsp;Yiannis S Chatzizisis,&nbsp;Sudhir Rathore,&nbsp;Kambis Mashayekhi","doi":"10.5603/CJ.a2022.0115","DOIUrl":"https://doi.org/10.5603/CJ.a2022.0115","url":null,"abstract":"<p><p>Percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) in coronary bifurcation lesions (CBL) is undergoing substantial technical progress and standardization, paralleling the evolution of dedicated devices, tools, and techniques. A standard consensus to classify CTO-CBL might be instrumental to homogenize data collection and description of procedures for scientific and educational purposes. The Medina-CTO classification replicates the classical three digits in Medina classification for bifurcations, representing the proximal main vessel, distal main vessel, and side branch, respectively. Each digit can take a value of 1 if it concerns atherosclerosis and is anatomically stenosed, or 0 if it is not. In addition, the occluded segment(s) of the bifurcation are noted by a subscript, which describes key interventional features of the cap: t (tapered), b (blunt), or a (ambiguous). This approach results in 56 basic categories that can be grouped by means of different elements, depending on the specific needs of each study. Medina-CTO classification, consisting of adding a subscript describing the basic cap characteristics to the totally occluded segment(s) of the standard Medina triplet, might be a useful methodological tool to standardize percutaneous intervention of bifurcational CTO lesions, with interesting scientific and educational applications.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"6-11"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/8c/cardj-30-1-6.PMC9987547.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9418590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital outcome of re-attempted percutaneous coronary interventions for chronic total occlusion.","authors":"Jan-Erik Guelker,&nbsp;Christian Blockhaus,&nbsp;Alexander Bufe,&nbsp;Knut Kroeger,&nbsp;Julian Kürvers,&nbsp;Dimitrios Ilousis,&nbsp;Kambis Mashayekhi","doi":"10.5603/CJ.a2021.0012","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0012","url":null,"abstract":"<p><strong>Background: </strong>With the advent of novel recanalization techniques and emerging devices, percutaneous coronary intervention (PCI) has become a promising leading treatment option for patients with chronic total occlusions (CTO). The present study aims to evaluate the acute outcomes of PCI in previously failed re-attempted vs. first-attempted CTO-lesions.</p><p><strong>Methods: </strong>Between 2012 and 2019, 619 patients were included and treated with PCI of at least one CTO. 253 patients were re-attempted lesions, while 366 were initially attempted lesions.</p><p><strong>Results: </strong>Re-attempted lesions were more complex, including higher Japanese-CTO (J-CTO) score and the need for a retrograde approach. The procedure time and fluoroscopy time were longer in this group. Nevertheless, overall success rates were comparable between both groups of patients. In-hospital events were rare and without significant differences.</p><p><strong>Conclusions: </strong>Re-attempted CTO lesions are more complex than first-attempt lesions and are associated with longer procedural times. However, they can be safely intervened by experienced operators with a similar success rate.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"44-50"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/89/cardj-30-1-44.PMC9987543.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10847027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental predictive value of the combined use of the neutrophil-to-lymphocyte ratio and systolic blood pressure difference after successful drug-eluting stent implantation.","authors":"Yong Hoon Kim,&nbsp;Ae-Young Her,&nbsp;Scot Garg,&nbsp;Eun-Seok Shin","doi":"10.5603/CJ.a2021.0004","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0004","url":null,"abstract":"<p><strong>Background: </strong>Previous work has highlighted the importance of the neutrophil-to-lymphocyte ratio (NLR) and the difference in the ward-to-catheterization laboratory systolic blood pressure (ΔSBP) in prognostic stratification after acute coronary syndrome. However, there is paucity of data regarding the added value of combining these two variables to predict 5-year major clinical outcomes after percutaneous coronary intervention.</p><p><strong>Methods: </strong>A total of 1188 patients were classified into four groups according to the NLR andΔSBP (high vs. low) using cutoffs derived from an analysis of receiver operating characteristic curves. A NLR > 3.0 and aΔSBP > 25 mmHg were considered high values. The primary endpoint was the composite of all-cause death, cardiac death, and non-fatal myocardial infarction. The secondary endpoint was the composite of target lesion revascularization, target vessel revascularization, and incidence of cerebrovascular accidents.</p><p><strong>Results: </strong>The incidence of the primary endpoint was significantly higher in the high NLR and ΔSBP group than in the other three groups (2.2% vs. 4.7% vs. 4.3% vs. 13.2%, p < 0.001). The incidence of the secondary endpoint was similar among the four groups. Incorporation of high NLR and high ΔSBP into a model with conventional and meaningful clinical and procedural risk factors increased the C-statistics in predicting the primary endpoint (0.575 to 0.635, p = 0.002).</p><p><strong>Conclusions: </strong>The power to predict the primary endpoint after drug-eluting stent implantation at the 5-year follow-up was improved by combining NLR and ΔSBP.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"91-104"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/0b/cardj-30-1-91.PMC9987556.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of transcarotid versus transapical transcatheter aortic valve implantation outcomes in patients with severe aortic stenosis and contraindications for transfemoral access.","authors":"Damian Hudziak,&nbsp;Radosław Targoński,&nbsp;Wojciech Wańha,&nbsp;Radosław Gocoł,&nbsp;Adrianna Hajder,&nbsp;Radosław Parma,&nbsp;Tomasz Figatowski,&nbsp;Tomasz Darocha,&nbsp;Marek A Deja,&nbsp;Wojciech Wojakowski,&nbsp;Dariusz Jagielak","doi":"10.5603/CJ.a2021.0071","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0071","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to compare the safety and clinical outcomes of transcarotid (TC) and transapical access (TA) transcatheter aortic valve implantation (TAVI) patients whom the transfemoral approach (TF) was not feasible.</p><p><strong>Methods: </strong>The analysis included consecutive patients with severe symptomatic aortic stenosis treated from 2017 to 2020 with TC-TAVI or TA-TAVI in two high-volume TAVI centers. The approach was selected by multidisciplinary heart teams after analyzing multislice computed tomography of the heart, aorta and peripheral arteries, transthoracic echocardiography and coronary angiography.</p><p><strong>Results: </strong>One hundred and two patients were treated with alternative TAVI accesses (TC; n = 49 and TA; n = 53) in our centers. The groups were similar regarding age, gender, New York Heart Association class, and echocardiography parameters. Patients treated with TC-TAVI had significantly higher surgical risk. The procedural success rate was similar in both groups (TC-TAVI 98%; TA-TAVI 98.1%; p = 0.95). The rate of Valve Academic Research Consortium-2 defined clinical events was low in both groups. The percentage of new-onset rhythm disturbances and permanent pacemaker implantation was similar in TC and TA TAVI (4.1% vs. 11.3%; p = 0.17 and 10.2% vs. 5.7%; p = 0.39, respectively). In the TA-TAVI group, significantly more cases of pneumonia and blood transfusions were observed (11% vs. 0%; p = 0.01 and 30.2% vs. 12.2%; p = 0.03). The 30-day mortality was similar in TC and TA groups (4.1% vs. 5.7%; p = 0.71, respectively).</p><p><strong>Conclusions: </strong>Both TC and TA TAVI are safe procedures in appropriately selected patients and are associated with a low risk of complications.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"188-195"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/93/cardj-30-2-188.PMC10129253.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9400955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of transcatheter aortic valve implantation planning and procedure on acute and chronic renal failure.","authors":"Markus Jäckel,&nbsp;Simon Keller,&nbsp;Eric Peter Prager,&nbsp;Dawid Leander Staudacher,&nbsp;Christopher Schlett,&nbsp;Manfred Zehender,&nbsp;Fabian Bamberg,&nbsp;Christoph Bode,&nbsp;Constantin von Zur Mühlen,&nbsp;Peter Stachon","doi":"10.5603/CJ.a2021.0057","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0057","url":null,"abstract":"<p><strong>Background: </strong>Severe aortic valve stenosis inhibits renal perfusion, thereby potentially worsening renal function, in particular in elderly patients most often assigned to transcatheter aortic valve implantation (TAVI). Pre-TAVI diagnostics and the procedure itself may adversely impact renal function, however renal perfusion and function may also improve post-procedure. This study aimed to clarify the impact of TAVI planning and procedure on kidney function METHODS: In this retrospective study, kidney function of patients who underwent transfemoral TAVI at a tertiary university hospital between 2016 and 2019 was analyzed. The present study investigated kidney function at baseline, after computed tomography (CT) was performed for evaluation of TAVI, after TAVI, at discharge and at follow-up.</p><p><strong>Results: </strong>Among 366 patients, the prevalence of acute kidney injury (AKI) was 14.5% after TAVI. Independent predictors of AKI were arterial hypertension, baseline creatinine, AKI post CT and coronary intervention during pre-procedural diagnostics. At discharge and follow-up, 2.1% and 3.4%, respectively had sustained relevant impairment of kidney function (defined as creatinine/baseline creatinine > 1.5 or renal replacement therapy). Patients with known chronic kidney disease showed no higher rates of short- and long-term impairment, but higher rates of improvement of renal function after TAVI.</p><p><strong>Conclusions: </strong>In most cases TAVI does not worsen renal function. A sustained impairment after TAVI was found in only a few cases. This was independent of reduced baseline kidney function. Transfemoral TAVI can thus be planned and performed even in patients with higher stages of chronic kidney disease.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"247-255"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/50/cardj-30-2-247.PMC10129259.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9407261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ST-segment elevation myocardial infarction as a COVID-19 manifestation in a recent heart transplant recipient.","authors":"Alicja Radtke-Łysek,&nbsp;Michał Bohdan,&nbsp;Maksymilian Mielczarek,&nbsp;Marek Koziński,&nbsp;Marcin Gruchała","doi":"10.5603/CJ.2023.0009","DOIUrl":"https://doi.org/10.5603/CJ.2023.0009","url":null,"abstract":"<p><p>< p > < /p >.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"155-156"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/e6/cardj-30-1-155.PMC9987549.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9407504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual antiplatelet therapy after percutaneous coronary intervention in patients at high bleeding risk: A systematic review and meta-analysis.","authors":"Yan Han,&nbsp;Xiaohang Yuan,&nbsp;Xin Hu,&nbsp;Yan Fang,&nbsp;Mengting Jiang,&nbsp;Huanhuan Feng,&nbsp;Lei Gao","doi":"10.5603/CJ.a2022.0071","DOIUrl":"10.5603/CJ.a2022.0071","url":null,"abstract":"<p><strong>Background: </strong>To date, it has not been ascertained whether shortening the duration of dual antiplatelet therapy (DAPT) can benefit high bleeding risk (HBR) patients. This systematic review and meta-analysis was performed to investigate the safety and efficacy of short (≤ 3 months) DAPT in HBR patients after percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>The PubMed, Embase, and Clinical Trials databases were searched from inception until November 2021 to identify studies that evaluated the safety and efficacy of short DAPT in HBR patients implanted with new-generation drug-eluting stents (DES). Primary endpoints included major bleeding, definite or probable stent thrombosis (ST), and myocardial infarction (MI), while secondary endpoints included all-cause death and ischemic stroke. Based on the fixed and random effect model, the risk ratio (RR) and 95% confidence interval of each endpoint were measured.</p><p><strong>Results: </strong>Five observational studies and one randomized controlled trial were included, involving 15,432 HBR patients. Short DAPT for HBR patients undergoing PCI had a lower incidence of major bleeding in comparison with standard (> 3 months) DAPT (2.3% vs. 3.2%, RR 0.64 [0.44, 0.95], p = 0.03), while short DAPT was comparable to standard DAPT with regard to definite or probable ST (0.4% vs. 0.3%, RR 1.31 [0.77, 2.23], p = 0.32) and MI (2.4% vs. 2.0%, RR 1.17 [0.95, 1.45], p = 0.14).</p><p><strong>Conclusions: </strong>Among HBR patients implanted with new-generation DES, short DAPT was associated with reduced risk of major bleeding without significantly increasing the risk of definite or probable ST and MI in comparison with standard DAPT.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 4","pages":"556-566"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/73/cardj-30-4-556.PMC10508065.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10572657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related impact on clinical outcomes of patients treated with drug-eluting stents according to clinical presentation: Patient-level pooled analysis from the GRAND-DES registry.","authors":"Eun-Seok Shin,&nbsp;Eun Jung Jun,&nbsp;Jung-Kyu Han,&nbsp;Min Gyu Kong,&nbsp;Jeehoon Kang,&nbsp;Chengbin Zheng,&nbsp;Scot Garg,&nbsp;Young Jin Choi,&nbsp;Jang-Whan Bae,&nbsp;Kook-Jin Chun,&nbsp;Doo-Il Kim,&nbsp;Seung-Woon Rha,&nbsp;Sung Yun Lee,&nbsp;Jay Young Rhew,&nbsp;Seong-Ill Woo,&nbsp;Han Cheol Lee,&nbsp;Jin-Ok Jeong,&nbsp;Han-Mo Yang,&nbsp;Kyung Woo Park,&nbsp;Hyun-Jae Kang,&nbsp;Bon-Kwon Koo,&nbsp;In-Ho Chae,&nbsp;Hyo-Soo Kim","doi":"10.5603/CJ.a2021.0008","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0008","url":null,"abstract":"<p><strong>Background: </strong>The contribution of sex and initial clinical presentation to the long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) is still debated.</p><p><strong>Methods: </strong>Individual patient data from 5 Korean-multicenter drug-eluting stent (DES) registries (The GRAND-DES) were pooled. A total of 17,286 patients completed 3-year follow-up (5216 women and 12,070 men). The median follow-up duration was 1125 days (interquartile range 1097-1140 days), and the primary endpoint was cardiac death at 3 years.</p><p><strong>Results: </strong>The clinical indication for PCI was stable angina pectoris (SAP) in 36.8%, unstable angina pectoris (UAP) or non-ST-segment elevation myocardial infarction (NSTEMI) in 47.4%, and ST-segment elevation myocardial (STEMI) in 15.8%. In all groups, women were older and had a higher proportion of hypertension and diabetes mellitus compared with men. Women presenting with STEMI were older than women with SAP, with the opposite seen in men. There was no sex difference in cardiac death for SAP or UAP/NSTEMI. In STEMI patients, the incidence of cardiac death (7.9% vs. 4.4%, p = 0.001), all-cause mortality (11.1% vs. 6.9%, p = 0.001), and minor bleeding (2.2% vs. 1.2%, p = 0.043) was significantly higher in women. After multivariable adjustment, cardiac death was lower in women for UAP/NSTEMI (HR 0.69, 95% CI 0.53-0.89, p = 0.005), while it was similar for STEMI (HR 0.97, 95% CI 0.65-1.44, p = 0.884).</p><p><strong>Conclusions: </strong>There was no sex difference in cardiac death after PCI with DES for SAP and UAP/NSTEMI patients. In STEMI patients, women had worse outcomes compared with men; however, after the adjustment of confounders, female sex was not an independent predictor of mortality.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"105-116"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/8e/cardj-30-1-105.PMC9987552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10847028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}