Cancer treatment and research最新文献_第4页

Immunotherapy in Gastrointestinal Cancers. 胃肠道癌症的免疫疗法。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_14

Hazel Lote, Ian Chau

{"title":"Immunotherapy in Gastrointestinal Cancers.","authors":"Hazel Lote, Ian Chau","doi":"10.1007/978-3-031-61238-1_14","DOIUrl":"https://doi.org/10.1007/978-3-031-61238-1_14","url":null,"abstract":"Immunotherapy has revolutionised cancer treatment over the past decade. Long-term durable responses can be achieved in some cancer patient populations that were previously facing terminal disease. In this chapter, we summarise current phase 3 clinical trial evidence for the use of immunotherapy in gastrointestinal cancers (oesophageal squamous cell carcinoma, oesophago-gastric adenocarcinoma, pancreatic cancer, biliary cancer, hepatocellular carcinoma, colorectal cancer, and squamous cell cancer of the anus). We discuss meaningful biomarkers used in clinical trials to select patients most likely to benefit from immunotherapy, such as mismatch-repair deficiency (MMRd)/microsatellite instability (MSI) and programmed-death-ligand-1 (PD-L1) immunohistochemistry (IHC) expression. Clinical questions are arising regarding the role of immunotherapy in the adjuvant/perioperative setting, optimal timing of surgery in patients who respond to immunotherapy, and toxicities specific to patients with gastrointestinal malignancies. We outline the current landscape and future horizon of immunotherapy in gastrointestinal cancers, such as strategies to increase effectiveness of checkpoint blockade through combinations with other checkpoint inhibitors, cytotoxic chemotherapy, targeted agents, radiotherapy, CAR-T therapy, and cancer vaccines.","PeriodicalId":9486,"journal":{"name":"Cancer treatment and research","volume":"192 ","pages":"277-303"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Hepatic Artery Infusion Chemotherapy for Unresectable Colorectal Cancer Liver Metastases. 使用肝动脉灌注化疗治疗无法切除的结直肠癌肝转移灶

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_13

Dominic J Vitello, Ryan P Merkow

引用次数: 0

Metabolic Carcinogenesis. 代谢致癌

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-55622-7_2

Mahwish Ali, Syeda Mehpara Farhat, Abdul Haleem

引用次数: 0

Pathologic Features of Esophageal and Gastric Malignancies. 食管和胃恶性肿瘤的病理特征。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_2

Sanaa Al-Nattah, Eduard Matkovic, Michael Schwalbe, Kristina A Matkowskyj

{"title":"Pathologic Features of Esophageal and Gastric Malignancies.","authors":"Sanaa Al-Nattah, Eduard Matkovic, Michael Schwalbe, Kristina A Matkowskyj","doi":"10.1007/978-3-031-61238-1_2","DOIUrl":"https://doi.org/10.1007/978-3-031-61238-1_2","url":null,"abstract":"Esophageal cancer is the eighth most common cancer globally, affecting approximately 570,000 people worldwide and currently ranking sixth among cancer-related mortality (Uhlenhopp et al. in, Clin J Gastroenterol 13:1010-1021, 2020). The prognosis is poor as many patients present with locally incurable or metastatic disease. In spite of advancements in treatment, the overall 5-year survival rates are in the realm of 10% whereas the 5-year post-esophagectomy survival rates are in the realm of 15-40% [2]. The incidence rates vary dramatically worldwide, which can be attributed to demographic and socioeconomic factors. Although the vast majority of esophageal neoplasms arise from the epithelial layer and include squamous cell carcinoma (SCC) and adenocarcinoma (AC), a subset of neuroendocrine and soft tissue tumors can also occur in the esophagus. Several tasks are presented to the surgical pathologist when dealing with esophageal carcinoma that include rendering a diagnosis, classifying the histological type, and assessing prognostic factors. This narrative review aims to evaluate current literature on various esophageal neoplasms and highlight pathological factors that impact clinical decision making and prognosis.","PeriodicalId":9486,"journal":{"name":"Cancer treatment and research","volume":"192 ","pages":"19-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathologic Features of Primary Pancreatic Malignancies. 原发性胰腺恶性肿瘤的病理特征。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_5

Tarek Abi-Saab, Ashley M Cunningham, Patrick S Rush, Kristina A Matkowskyj

引用次数: 0

Gastrointestinal Malignancies: Pancreatic Cancer Clinical Trials in Neoadjuvant Chemotherapy. 胃肠道恶性肿瘤：胰腺癌新辅助化疗临床试验。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_6

Paola Barrios, Akhil Chawla

引用次数: 0

Hepatocellular Carcinoma: Surgical Management and Evolving Therapies. 肝细胞癌：手术治疗和不断发展的疗法。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_10

Emanuel Eguia, Talia Baker, Marshall Baker

引用次数: 0

Nutrition and Dietary Intervention in Cancer: Gaps, Challenges, and Future Perspectives. 癌症的营养和膳食干预：差距、挑战和未来展望。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-55622-7_11

Falak Zeb, Aqsa Mehreen, Huma Naqeeb, Muneeb Ullah, Afraa Waleed, Uzma Azeem Awan, Adnan Haider, Muhammad Naeem

{"title":"Nutrition and Dietary Intervention in Cancer: Gaps, Challenges, and Future Perspectives.","authors":"Falak Zeb, Aqsa Mehreen, Huma Naqeeb, Muneeb Ullah, Afraa Waleed, Uzma Azeem Awan, Adnan Haider, Muhammad Naeem","doi":"10.1007/978-3-031-55622-7_11","DOIUrl":"https://doi.org/10.1007/978-3-031-55622-7_11","url":null,"abstract":"The term \"cancer\" refers to the state in which cells in the body develop mutations and lose control over their replication. Malignant cancerous cells invade in various other tissue sites of the body. Chemotherapy, radiation, and surgery are the first-line modalities for the majority of solid cancers. These treatments work by mitigating the DNA damage of cancerous cells, but they can also cause harm to healthy cells. These side effects might be immediate or delayed, and they can cause a high rate of morbidity and mortality. Dietary interventions have a profound impact on whole-body metabolism, including immunometabolism and oncometabolism which have been shown to reduce cancer growth, progression, and metastasis in many different solid tumor models with promising outcomes in early phase clinical studies. Dietary interventions can improve oncologic or quality-of-life outcomes for patients that are undergoing chemotherapy or radiotherapy. In this chapter, we will focus on the impact of nutritional deficiencies, several dietary interventions and their proposed mechanisms which are used as a novel therapy in controlling and managing cancers.","PeriodicalId":9486,"journal":{"name":"Cancer treatment and research","volume":"191 ","pages":"281-307"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Genomics and Cancer Prevention. 营养基因组学与癌症预防。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-55622-7_9

Shaista Aslam, Riffat Iqbal, Rida Fatima Saeed, Nuzhat Akram, Farhat Ijaz, Irfana Liaqat, Ahmed Sohaib Aslam

{"title":"Nutritional Genomics and Cancer Prevention.","authors":"Shaista Aslam, Riffat Iqbal, Rida Fatima Saeed, Nuzhat Akram, Farhat Ijaz, Irfana Liaqat, Ahmed Sohaib Aslam","doi":"10.1007/978-3-031-55622-7_9","DOIUrl":"https://doi.org/10.1007/978-3-031-55622-7_9","url":null,"abstract":"The scientific innovations have emphasized the importance of diet for one's health and wellbeing. The genetic revolution has enhanced our understanding about the effect of nutrients on genomic and transcriptomic profiles and gene-nutrition interactions (nutritional genomics). Furthermore, the contribution of micronutrient insufficiencies and macronutrient excess is evident in the development and progression of many diseases, especially cancer. It is speculated that nutrients have capacity to implicitly affect the physiological and pathophysiological processes via gene expression various regulatory processes. Moreover, the nutrients are known to affect the cellular networks involved in cancer progression and cancer inhibitory mechanisms targeting apoptosis or impaired angiogenesis. The interplay of regulatory processes in physiological systems and nutrients provides basis for the nutrigenomics. The functional genomics data further argue that cellular and molecular processes involved in the cancer progression are possibly programed genes during early development which may persist into adulthood and become detrimental. The incorporation of the functional interactions between nutrients and the genome has revolutionized the field of personalized medicine and provided the foundation for targeted cancer therapy through nutrients. There is growing evidence on the beneficial impacts of eating habits on lowering the risk of cancer, even if it can be difficult to pinpoint the precise role of nutrients. The nutrigenomic information may provide bases to develop disease prevention and treatment via nutrition, at the molecular level.","PeriodicalId":9486,"journal":{"name":"Cancer treatment and research","volume":"191 ","pages":"217-244"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern Treatment Strategies for Borderline Resectable Pancreatic Cancer. 边界可切除胰腺癌的现代治疗策略。

Cancer treatment and research Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61238-1_4

Dominic Vitello, Mark S Talamonti

引用次数: 0