Carcinogenesis最新文献_第9页

Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis. 放线菌素D与阿霉素协同作用诱导p53依赖性细胞凋亡治疗三阴性乳腺癌

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-04-12 DOI: 10.1093/carcin/bgad086

Hong Yang, Sha Li, Wan Li, Yihui Yang, Yizhi Zhang, Sen Zhang, Yue Hao, Wanxin Cao, Fang Xu, Hongquan Wang, Guanhua Du, Jinhua Wang

{"title":"Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis.","authors":"Hong Yang, Sha Li, Wan Li, Yihui Yang, Yizhi Zhang, Sen Zhang, Yue Hao, Wanxin Cao, Fang Xu, Hongquan Wang, Guanhua Du, Jinhua Wang","doi":"10.1093/carcin/bgad086","DOIUrl":"10.1093/carcin/bgad086","url":null,"abstract":"Objectives: There are three major subtypes of breast cancer, ER+, HER2+ and triple-negative breast cancer (TNBC), namely ER-, PR-, HER2-. TNBC is the most aggressive breast cancer with poor prognosis and no target drug up to now. Actinomycin D (ActD) is a bioactive metabolite of marine bacteria that has been reported to have antitumor activity. The aim of study is to investigate whether ActD has a synergetic effect on TNBC with Doxorubicin (Dox), the major chemotherapeutic drug for TNBC, and explore the underlying mechanism.Methods: TNBC cell lines HCC1937, MDA-MB-436 and nude mice were used in the study. Drug synergy determination, LDH assay, MMP assay, Hoechst 33342 staining, Flow cytometry, Flexible docking and CESTA assay were carried out. The expression of proteins associated with apoptosis was checked by Western blot and siRNA experiments were performed to investigate the role of P53 and PUMA induced by drugs.Results: There was much higher apoptosis rate of cells in the ActD + Dox group than that in ActD group or Dox group. Expression of MDM2 and BCL-2 was reduced while expression of P53, PUMA and BAX were increased in the groups treated with ActD + Dox or Dox compared to the control group. Furthermore, P53 siRNA or PUMA siRNA tremendously abrogated the cell apoptosis in the groups treated by ActD, Dox and ActD + Dox. Flexible docking and CESTA showed that ActD can bind MDM2.Conclusions: ActD had a synergetic effect on TNBC with Dox via P53-dependent apoptosis and it may be a new choice for treatment of TNBC.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"262-273"},"PeriodicalIF":4.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138298480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical stress induced tumor immune suppressive environment. 手术应激诱导的肿瘤免疫抑制环境。

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-04-12 DOI: 10.1093/carcin/bgae012

Fan Yang, Qing Hua, Xiaoyan Zhu, Pingbo Xu

引用次数: 0

Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis. 剪接因子ESRP1衍生circ_0068162通过miR-186/JAG轴促进口腔鳞状细胞癌的进展。

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad082

Shuai Chen, Yingrui Zong, Zhenzhen Hou, Zhifen Deng, Zongping Xia

{"title":"Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.","authors":"Shuai Chen, Yingrui Zong, Zhenzhen Hou, Zhifen Deng, Zongping Xia","doi":"10.1093/carcin/bgad082","DOIUrl":"10.1093/carcin/bgad082","url":null,"abstract":"Objectives: Oral squamous cell carcinoma (OSCC) is a common malignancy in the oral and maxillofacial regions with an increasing incidence rate. Circular RNA (circRNA) is a recently discovered long-chain non-coding RNA family member. The objective of this study was to analyze the role of circ_0068162 in OSCC development.Methods: We downloaded sample data GSE145608 from the Gene Expression Omnibus database. Online databases Starbase, TargetScan and miRDB were used to predict the target microRNAs (miRNAs) and genes. Cell viability and proliferation were assessed using the CCK-8 and EdU assays, respectively. Cell migration and invasion abilities were detected using transwell assay. The double luciferase reporter and RNA immunoprecipitation (RIP) assays were performed to verify the interaction relationship between the identified target molecules. RNase R and actinomycin D treatment were performed to analyze the stability of circ_0068162.Results: We found that circ_0068162 was overexpressed in the cytoplasm of OSCC cells and clinical OSCC tissues. Knockdown of circ_0068162 inhibited the growth, migration and invasion of OSCC cells. We also identified miR-186 as the target miRNA of circ_0068162, and JAG1 and JAG2 as the target genes of miR-186. The miR-186 inhibitor rescued the effects of sh-circ_0068162 and JAG1/JAG2 overexpression rescued the effects of miR-186 mimic in OSCC cells. Furthermore, ESRP1 promoted the biosynthesis of circ_0068162.Conclusions: The circ_0068162/miR-186/JAGs/ESRP1 feedback loop is closely related to OSCC development.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"107-118"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107590305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad094

Yutaro Hori, Tomoaki Yoh, Hiroto Nishino, Keisuke Okura, Makoto Kurimoto, Yuichi Takamatsu, Motohiko Satoh, Takahiro Nishio, Yukinori Koyama, Takamichi Ishii, Keiko Iwaisako, Satoru Seo, Etsuro Hatano

{"title":"Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma.","authors":"Yutaro Hori, Tomoaki Yoh, Hiroto Nishino, Keisuke Okura, Makoto Kurimoto, Yuichi Takamatsu, Motohiko Satoh, Takahiro Nishio, Yukinori Koyama, Takamichi Ishii, Keiko Iwaisako, Satoru Seo, Etsuro Hatano","doi":"10.1093/carcin/bgad094","DOIUrl":"10.1093/carcin/bgad094","url":null,"abstract":"The role of the ferroptosis-related gene glutathione peroxidase 4 (GPX4) in oncology has been extensively investigated. However, the clinical implications of GPX4 in patients with intrahepatic cholangiocarcinoma (ICC) remain unknown. This study aimed to evaluate the prognostic impact of GPX4 and its underlying molecular mechanisms in patients with ICC. Fifty-seven patients who underwent surgical resection for ICC between 2010 and 2017 were retrospectively analyzed. Based on the immunohistochemistry, patients were divided into GPX4 high (n = 15) and low (n = 42) groups, and clinical outcomes were assessed. Furthermore, the roles of GPX4 in cell proliferation, migration and gene expression were analyzed in ICC cell lines in vitro and in vivo. The results from clinical study showed that GPX4 high group showed significant associations with high SUVmax on 18F-fluorodeoxyglucose-positron emission tomography (≥8.0, P = 0.017), multiple tumors (P = 0.004), and showed glucose transporter 1 (GLUT1) high expression with a trend toward significance (P = 0.053). Overall and recurrence-free survival in the GPX4 high expression group were significantly worse than those in the GPX4 low expression group (P = 0.038 and P < 0.001, respectively). In the experimental study, inhibition of GPX4 attenuated cell proliferation and migration in ICC cell lines. Inhibition of GPX4 also decreased the expression of glucose metabolism-related genes, such as GLUT1 or HIF1α. Mechanistically, these molecular changes are regulated in Akt-mechanistic targets of rapamycin axis. In conclusion, this study suggested the pivotal value of GPX4 serving as a prognostic marker for patients with ICC. Furthermore, GPX4 can mediate glucose metabolism of ICC.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"119-130"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A radiomics and genomics-derived model for predicting metastasis and prognosis in colorectal cancer. 用于预测结直肠癌转移和预后的放射组学和基因组学衍生模型

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad098

Xue Li, Meng Wu, Min Wu, Jie Liu, Li Song, Jiasi Wang, Jun Zhou, Shilin Li, Hang Yang, Jun Zhang, Xinwu Cui, Zhenyu Liu, Fanxin Zeng

{"title":"A radiomics and genomics-derived model for predicting metastasis and prognosis in colorectal cancer.","authors":"Xue Li, Meng Wu, Min Wu, Jie Liu, Li Song, Jiasi Wang, Jun Zhou, Shilin Li, Hang Yang, Jun Zhang, Xinwu Cui, Zhenyu Liu, Fanxin Zeng","doi":"10.1093/carcin/bgad098","DOIUrl":"10.1093/carcin/bgad098","url":null,"abstract":"Approximately 50% of colorectal cancer (CRC) patients would develop metastasis with poor prognosis, therefore, it is necessary to effectively predict metastasis in clinical treatment. In this study, we aimed to establish a machine-learning model for predicting metastasis in CRC patients by considering radiomics and transcriptomics simultaneously. Here, 1023 patients with CRC from three centers were collected and divided into five queues (Dazhou Central Hospital n = 517, Nanchong Central Hospital n = 120 and the Cancer Genome Atlas (TCGA) n = 386). A total of 854 radiomics features were extracted from tumor lesions on CT images, and 217 differentially expressed genes were obtained from non-metastasis and metastasis tumor tissues using RNA sequencing. Based on radiotranscriptomic (RT) analysis, a novel RT model was developed and verified through genetic algorithms (GA). Interleukin (IL)-26, a biomarker in RT model, was verified for its biological function in CRC metastasis. Furthermore, 15 radiomics variables were screened through stepwise regression, which was highly correlated with the IL26 expression level. Finally, a radiomics model (RA) was established by combining GA and stepwise regression analysis with radiomics features. The RA model exhibited favorable discriminatory ability and accuracy for metastasis prediction in two independent verification cohorts. We designed multicenter, multi-scale cohorts to construct and verify novel combined radiomics and genomics models for predicting metastasis in CRC. Overall, RT model and RA model might help clinicians in directing personalized diagnosis and therapeutic regimen selection for patients with CRC.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"170-180"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary glyphosate levels and association with mortality in the 2013-16 National Health and Nutrition Examination Survey. 2013-2016年全国健康与营养调查(NHANES)中尿草甘膦水平及其与死亡率的关系

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad088

Matthew Untalan, Tara Ivic-Pavlicic, Emanuela Taioli

{"title":"Urinary glyphosate levels and association with mortality in the 2013-16 National Health and Nutrition Examination Survey.","authors":"Matthew Untalan, Tara Ivic-Pavlicic, Emanuela Taioli","doi":"10.1093/carcin/bgad088","DOIUrl":"10.1093/carcin/bgad088","url":null,"abstract":"Objectives: Glyphosate is the most commonly used herbicide in the USA; however, its safety is still under debate. We assessed glyphosate levels and their association with overall mortality in a representative sample of the US adult population from the 2013 to 2016 National Health and Nutrition Examination Survey.Methods: We extracted data on urinary glyphosate (N = 2910) measured by ion chromatography isotope-dilution tandem mass spectrometry. Associations between glyphosate concentrations and demographic, lifestyle and other exposures were analyzed. Data were linked to public-use Mortality Files for 2019.Results: The mean (STD) glyphosate level was 0.53 (0.59) ng/ml, with 25.7% of the subjects having glyphosate levels at or below the detection limit. At multivariate analysis, age and creatinine were associated with glyphosate urinary levels (both P < 0.0001). There was a borderline association between glyphosate levels and mortality (HRadj 1.33; 95% CI 0.99-1.77 P = 0.06). When 3,5,6-trichloropyridinol was excluded from the Cox model, glyphosate exhibits a significant association with mortality (HRadj 1.33; 95% CI 1.00-1.77; P = 0.0532).Conclusions: These nationally representative data suggest that recent exposure to glyphosate could be associated with increased mortality. More studies are necessary to understand population-level risk associated with the product, given its widespread use in agriculture.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"163-169"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138476794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction of: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds. 撤回：砷的促血管生成作用及硒衍生化合物对其的逆转作用

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad095

引用次数: 0

Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer. 人乳头瘤病毒（HPV）DNA甲基化在HPV相关头颈癌中的变化。

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgae001

Chameera Ekanayake Weeramange, Kai Dun Tang, Darryl Irwin, Gunter Hartel, Julian Langton-Lockton, Rahul Ladwa, Lizbeth Kenny, Touraj Taheri, Bernard Whitfield, Sarju Vasani, Chamindie Punyadeera

{"title":"Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer.","authors":"Chameera Ekanayake Weeramange, Kai Dun Tang, Darryl Irwin, Gunter Hartel, Julian Langton-Lockton, Rahul Ladwa, Lizbeth Kenny, Touraj Taheri, Bernard Whitfield, Sarju Vasani, Chamindie Punyadeera","doi":"10.1093/carcin/bgae001","DOIUrl":"10.1093/carcin/bgae001","url":null,"abstract":"Despite the rising incidence, currently, there are no early detection methods for HPV-driven HNC (HPV-HNC). Cervical cancer studies suggest that HPV DNA methylation changes can be used as a biomarker to discriminate cancer patients from HPV-infected individuals. As such, this study was designed to establish a protocol to evaluate DNA methylation changes in HPV late genes and long control region (LCR) in saliva samples of HPV-HNC patients and HPV-positive controls. Higher methylation levels were detected in HPV late genes (L1 and L2) in both tumour and saliva samples of HPV-HNC patients compared with HPV-positive controls. Moreover, methylation patterns between tumours and corresponding saliva samples were observed to have a strong correlation (Passing-Bablok regression analysis; τ = 0.7483, P < 0.0001). Considering the differences between HNC and controls in methylation levels in late genes, and considering primer amplification efficiencies, 13 CpG sites located at L1 and L2 genes were selected for further evaluation. A total of 18 HNC saliva samples and 10 control saliva samples were assessed for the methylation levels in the selected sites. From the CpG sites evaluated statistically significant differences were identified for CpG sites at L2-CpG 6 (P = 0.0004), L1-CpG 3 (P = 0.0144), L1-CpG 2 (P = 0.0395) and L2-CpG 19 (P = 0.0455). Our pilot data indicate that higher levels of DNA methylation in HPV late genes are indicative of HPV-HNC risk, and it is a potential supplementary biomarker for salivary HPV detection-based HPV-HNC screening.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"140-148"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study. 在病史中伴有肺大疱、肺纤维化和/或纤维瘤的梅毒患者肺部的枸橼酸氨苄青霉素灼烧：一项死后半病理研究。

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad090

S D Visonà, B Bertoglio, S Capella, E Belluso, B Austoni, C Colosio, Z Kurzhunbaeva, T Ivic-Pavlicic, E Taioli

{"title":"Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study.","authors":"S D Visonà, B Bertoglio, S Capella, E Belluso, B Austoni, C Colosio, Z Kurzhunbaeva, T Ivic-Pavlicic, E Taioli","doi":"10.1093/carcin/bgad090","DOIUrl":"10.1093/carcin/bgad090","url":null,"abstract":"The causal attribution of asbestos-related diseases to past asbestos exposures is of crucial importance in clinical and legal contexts. Often this evaluation is made based on the history of exposure, but this method presents important limitations. To assess past asbestos exposure, pleural plaques (PP), lung fibrosis and histological evidence of ferruginous bodies (FB) can be used in combination with anamnestic data. However, such markers have never been associated with a threshold value of inhaled asbestos. With this study we attempted to shed light on the dose-response relationship of PP, lung fibrosis and FBs, investigating if their prevalence in exposed individuals who died from malignant mesothelioma (MM) is related to the concentration of asbestos in lungs assessed using scanning electron microscopy equipped with energy dispersive spectroscopy. Moreover, we estimated the values of asbestos concentration in lungs associated with PP, lung fibrosis and FB. Lung fibrosis showed a significant positive relationship with asbestos lung content, whereas PP and FB did not. We identified, for the first time, critical lung concentrations of asbestos related to the presence of PP, lung fibrosis and FB at histology (respectively, 19 800, 26 400 and 27 400 fibers per gram of dry weight), that were all well-below the background levels of asbestos identified in our laboratory. Such data suggest that PP, lung fibrosis and FB at histology should be used with caution in the causal attribution of MM to past asbestos exposures, while evaluation of amphibole lung content using analytical electron microscopy should be preferred.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"131-139"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis revealed the regulation mode of intratumor microorganisms and microbial signatures in gastrointestinal cancer. 多组学分析揭示了癌症肿瘤内微生物的调节模式和微生物特征。

IF 4.7 3区医学

Carcinogenesis Pub Date : 2024-03-11 DOI: 10.1093/carcin/bgad078

Siqi Wang, Pei Liu, Jie Yu, Tongxiang Liu

{"title":"Multi-omics analysis revealed the regulation mode of intratumor microorganisms and microbial signatures in gastrointestinal cancer.","authors":"Siqi Wang, Pei Liu, Jie Yu, Tongxiang Liu","doi":"10.1093/carcin/bgad078","DOIUrl":"10.1093/carcin/bgad078","url":null,"abstract":"Objective: Gastrointestinal cancer is one of the most common malignant tumors in the world, and its incidence rate is always high. In recent years, research has shown that microorganisms may play a broad role in the diagnosis, pathogenesis, and treatment of cancer.Methods: In this study, samples were first classified according to the microbial expression data of Gastrointestinal cancer, followed by functional enrichment and Immunoassay. In order to better understand the role of intratumor microorganisms in the prognosis, we screened gene signatures and constructed risk model through univariate cox and lasso regression and multivariable cox, then screened microbial signatures using zero-inflated model regression model and constructed risk index (RI), and finally predicted the immunotherapeutic effect of the risk model.Results: The results indicate that the composition of tumor microorganisms in the C3 subtype is closely related to tumor angiogenesis, and there is a significant difference in the proportion of innate and acquired immune cells between the C2 and C1 subtypes, as well as differences in the physiological functions of immune cells. There are significant differences in the expression of microbial signatures between high and low risk subtypes, with 9 microbial signatures upregulated in high risk subtypes and 15 microbial signatures upregulated in low risk subtypes. These microbial signatures were significantly correlated with the prognosis of patients. The results of immunotherapy indicate that immunotherapy for high-risk subtypes is more effective.Conclusion: Overall, we analyze from the perspective of microorganisms within tumors, pointing out new directions for the diagnosis and treatment of cancer.","PeriodicalId":9446,"journal":{"name":"Carcinogenesis","volume":" ","pages":"149-162"},"PeriodicalIF":4.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0