{"title":"Long-term outcome of manual aspiration thrombectomy for acute proximal deep vein thrombosis.","authors":"Akihiro Tsuji, Hiroya Hayashi, Ryo Takano, Hiroki Horinouchi, Akiyuki Kotoku, Shinya Fujisaki, Hiroyuki Endo, Naruhiro Nishi, Takatoyo Kiko, Ryotaro Asano, Jin Ueda, Tatsuo Aoki, Tetsuya Fukuda, Takeshi Ogo","doi":"10.1007/s12928-025-01168-9","DOIUrl":"10.1007/s12928-025-01168-9","url":null,"abstract":"<p><p>Manual aspiration thrombectomy (MAT) is a catheter intervention for cases with a high risk of bleeding. It is a rapid, simple, inexpensive, and single-session intervention for patients with proximal deep vein thrombosis (DVT). We evaluated the long-term outcome of MAT for patients with proximal DVT. All consecutive patients with acute proximal DVT treated at our center from April 2012 to December 2022 were retrospectively screened. Twenty-one patients who underwent MAT were enrolled. We evaluated the incidence and clinical characteristics of post-thrombotic syndrome (PTS) post-MAT in the chronic phase. The venous clot burden extent was assessed using the venographic segment (VS) score during catheter intervention. We evaluated the pre- and post-treatment total VS score. PTS was evaluated by PTS onset at any time between 6 and 24 months. We compared the clinical characteristics of patients with and without PTS (PTS and non-PTS groups, respectively). PTS onset at any time between 6 and 24 months post-MAT was 33%. The PTS group had a significantly higher post-treatment total VS score and lower thrombus aspiration success rate than the non-PTS group. Furthermore, the PTS group had a significantly longer duration from onset to intervention than the non-PTS group. PTS onset post-MAT was 33% in the chronic phase. The PTS group showed a lower thrombus aspiration success rate and longer duration from DVT onset to intervention than the non-PTS group. These findings suggest that earlier and substantial thrombus reduction with MAT may be associated with a lower risk of PTS.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"890-899"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Time trends and clinical outcomes of transcatheter patent ductus arteriosus closure in adults: insights from a Japanese nationwide registry.","authors":"Takumi Osawa, Mistuyoshi Takahara, Toshiro Shinke, Shun Kohsaka, Tomoya Hoshi, Mike Saji, Hidehiko Hara, Testuya Amano, Naoto Kawamatsu, Tomoko Machino-Ohtsuka, Tomoko Ishizu, Ken Kozuma","doi":"10.1007/s12928-025-01174-x","DOIUrl":"10.1007/s12928-025-01174-x","url":null,"abstract":"<p><p>Large-scale data on the current status, outcomes, and complications of transcatheter patent ductus arteriosus (PDA) closure in adults remain limited. This study aimed to elucidate the current status of transcatheter PDA closure in adults. Patient data (age ≥ 16 years) between January 2015 and December 2023 were extracted from the Japanese Structural Heart Disease (J-SHD) registry. We assessed the current practice of transcatheter PDA closure in Japan, focusing on the clinical characteristics, in-hospital mortality, intraoperative deaths, and adverse events. Procedural success was defined as appropriate device implantation without any adverse events. A total of 377 adult patients (median age, 65 years [interquartile range, 50-74 years]; 18.3% male) who underwent transcatheter PDA closure were included. Overall, 9.8% (n = 24) of the patients were New York Heart Association class III/IV. The most common comorbidities were hypertension (43.0%, n = 162), hyperlipidemia (16.7%, n = 63), and renal dysfunction (10.9%, n = 41). The median Qp/Qs ratio was 1.5 [1.3-1.8], and the median procedural time was 100 [65-120] minutes. The procedural success rate was 99.2% (n = 374). The rate of failed deployment was 0.3% (n = 1). No intraoperative deaths occurred, and complications were rare; 0.5% (n = 2) of the patients required emergency surgery. No hemorrhage requiring transfusion, vascular rupture, vessel obstruction, or contrast-induced nephropathy was observed after the procedures. Real-world data demonstrated that transcatheter PDA closure is safe and effective in adults. However, the high prevalence of comorbidities and the rare occurrence of emergency surgery underscore the need for careful postprocedural management.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"988-997"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ex vivo micro-computed tomography analysis of the fracking technique for a nodular calcification in the common femoral artery.","authors":"Norihito Nakamura, Yuki Matsumoto, Manabu Shiozaki, Sho Torii","doi":"10.1007/s12928-025-01152-3","DOIUrl":"10.1007/s12928-025-01152-3","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"1011-1012"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term outcomes of endovascular therapy for chronic limb-threatening ischemia patients with connective tissue disease.","authors":"Shohei Ouchi, Kao Takehisa, Naotaka Murata, Iwao Okai, Yuichi Chikata, Hirokazu Konishi, Masashi Nakao, Shinya Okazaki, Junichi Yamaguchi, Toru Minamino","doi":"10.1007/s12928-025-01157-y","DOIUrl":"10.1007/s12928-025-01157-y","url":null,"abstract":"<p><p>In patients with connective tissue disease (CTD) and chronic limb-threatening ischemia (CLTI), revascularization is reported to be ineffective, with a poor prognosis and a high rate of lower-limb amputation. However, limited actual data are available. To study the long-term outcomes of endovascular therapy for CLTI patients with CTD, we established a multicenter registry (retrospective cohort study) in Japan. This study looked at major adverse extremity events, amputation-free survival, and all-cause mortality to better understand these rates. We registered 44 consecutive patients. The patients' mean age was 69.6 ± 11.4 years. There were 19 patients (43.2%) with diabetes, but only 4 patients (9.1%) were on dialysis. The average follow-up was 36.1 ± 31.7 months. In 11 patients (25.0%), the target wound healed without requiring lower-limb amputation. Target lesion revascularization occurred in 19 cases (43.2%), while unexpected minor amputations occurred in 11 cases (25.0%), major amputations in 8 cases (18.2%), and death in 15 cases (34.1%). The rates of freedom from major adverse extremity events at 1 and 3 years were 40.3% and 22.3%, respectively. The amputation-free survival rates were 69.3% at 1 year and 58.3% at 3 years. The survival rates were 85.5% at 1 year and 70.3% at 3 years. We conducted a multicenter study to look into the outcomes of CLTI patients with CTD who received endovascular therapy. Given the poor outcomes, more therapeutic advances for CLTI in CTD patients are needed.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"860-867"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparable clinical characteristics and outcomes of patients undergoing endovascular treatment for aorto-iliac or femoropopliteal lesions.","authors":"Yuichi Saito, Yuji Ohno, Kayo Yamamoto, Norikiyo Oka, Masayuki Takahara, Sakuramaru Suzuki, Raita Uchiyama, Masahiro Suzuki, Tadahiro Matsumoto, Yo Iwata, Hideki Kitahara, Yoshio Kobayashi","doi":"10.1007/s12928-025-01143-4","DOIUrl":"10.1007/s12928-025-01143-4","url":null,"abstract":"<p><p>Lower extremity peripheral arterial disease is usually a consequence of advanced atherosclerosis, leading to high mortality and morbidity. Although clinical characteristics and outcomes may differ among patients having peripheral disease in different arterial territories, contemporary data are scarce. From January 2019 to December 2022, this multicenter registry study included 712 patients undergoing endovascular treatment (EVT) for either aorto-iliac (AI) or femoropopliteal (FP) lesions. Patient characteristics and outcomes were compared between AI-EVT and FP-EVT groups. Clinical endpoints included major adverse cardiovascular events, major adverse limb events (MALE), and all-cause mortality, stratified by chronic limb-threatening ischemia (CLTI). Of the 712 patients, 217 (30.5%) and 495 (69.5%) underwent AI-EVT or FP-EVT. Patients undergoing AI-EVT were more likely to be men and current smokers, while diabetes was more frequent in the FP-EVT group. The prevalence of CLTI was significantly higher in the FP-EVT group. In the entire study population, the FP-EVT rather than the AI-EVT group had a significantly higher rate of MALE and mortality, but the incidence of major adverse cardiovascular events was similar between the two groups. When focusing only on patients without CLTI, the mortality risk was similar, while the MALE risk was still higher in the FP-EVT group. In conclusion, patients undergoing EVT for AI and FP lesions in contemporary settings were differently characterized by baseline factors. Although the worse clinical outcomes in the FP-EVT group were mainly driven by the higher prevalence of CLTI, the MALE risk was still increased in patients without CLTI.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"852-859"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesse M Schafer, Brian Q Gacioch, Tyler Beals, Daniel S Balk, Stephen H Thomas, Beatrice Hoffmann
{"title":"Doppler extremity arterial diagnosis for optimization of treatment in the emergency department (DEAD FOOT).","authors":"Jesse M Schafer, Brian Q Gacioch, Tyler Beals, Daniel S Balk, Stephen H Thomas, Beatrice Hoffmann","doi":"10.1007/s12928-025-01150-5","DOIUrl":"10.1007/s12928-025-01150-5","url":null,"abstract":"<p><p>Outcomes in acute limb ischemia (ALI) depend on early recognition. Rapid evaluation methods in the emergency department (ED) include physical exam, hand-held Doppler (HH), or spectral Doppler (SD) using point-of-care ultrasound (POCUS). This study aims to estimate performance characteristics of HH versus emergency medicine (EM)-performed SD compared to angiography along with clinician confidence when evaluating for ALI. This was a prospective observational pilot study. A convenience sample of patients presenting to an urban, academic ED with concern for ALI who underwent angiography were eligible. The primary aim evaluated diagnostic performance of HH and SD in correctly classifying flow in posterior tibial (PT) and dorsalis pedis (DP) arteries in patients with 100% angiographic occlusion of the proximal vasculature. Binomial exact 95% confidence intervals (CIs) and Fisher's exact tests were used. Twenty-six patients were enrolled. Three cases (11.5% of 26) had normal angiography, five (19.2%) had partial occlusion, and 18 (69.2%) had 100% occlusion. For cases with 100% occlusion, HH always classified PT or DP as abnormal (sensitivity 100, 95% CI 81.5-100%). SD also showed high sensitivity (94.4, 95% CI 72.7-99.9%). Limited utility of specificity calculations was due to low true negatives (n = 3), but these measures were low for HH (66.7, 95% CI 9.4-99.2%) and SD (33.3, 95% CI 0.8-90.6%). There was no association (p = .305) between sonographer confidence and correct diagnostic classification for either HH or SD. In a patient population with suspected ALI, EM-performed HH and SD performed extremely well at identifying abnormal PT or DP flow in patients with complete (100%) angiographic occlusion. These results are useful to power larger trials to determine the role that SD may play in complementing HH evaluation for ALI.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"840-851"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Device indication for calcified coronary lesions based on coronary imaging findings.","authors":"Yuji Ikari, Teruyasu Sugano, Nobuhiko Ogata, Shinjo Sonoda, Kazuhiko Nakazato, Junya Ako, Toshiro Shinke, Yoshio Kobayashi, Ken Kozuma","doi":"10.1007/s12928-025-01179-6","DOIUrl":"10.1007/s12928-025-01179-6","url":null,"abstract":"<p><p>Performing percutaneous coronary intervention (PCI) for heavily calcified coronary lesions remains a significant clinical challenge. In 2023, following the availability of intravascular lithotripsy (IVL), a consensus document was published outlining imaging-guided device selection strategies for the treatment of calcified lesions. Since the publication of that document, the DUAL-PREP study has demonstrated the safety of combining rotational atherectomy (rotablator) with IVL, a strategy previously contraindicated in the original consensus. As a result, a revision of the consensus document became necessary. In the updated consensus, the fundamental principle of imaging-guided treatment planning is retained. However, a key modification is the acknowledgment that IVL may now be considered in cases where post-atherectomy imaging reveals persistent heavy calcification and further atherectomy is deemed either ineffective or potentially harmful to the patient.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"733-735"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12431884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}