Cardiovascular Journal of Africa最新文献

{"title":"Assessment of papillary muscle free strain in hypertrophic cardiomyopathy and hypertension-induced left ventricular hypertrophy.","authors":"Cennet Yildiz, Atilla Koyuncu, Lutfi Ocal, Mustafa Ozan Gursoy, Ersan Oflar, Gokhan Kahveci","doi":"10.5830/CVJA-2022-070","DOIUrl":"10.5830/CVJA-2022-070","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to evaluate and compare papillary muscle free strain in hypertrophic cardiomyopathy (HCMP) and hypertensive (HT) patients.</p><p><strong>Methods: </strong>Global longitudinal strain (GLS), and longitudinal myocardial strain of the anterolateral (ALPM) and posteromedial papillary muscles (PMPM) were obtained in 46 HCMP and 50 HT patients.</p><p><strong>Results: </strong>Interventricular septum (IVS)/posterior wall (PW) thickness ratio, left ventricular mass index (LVMI), left atrial anteroposterior diameter (LAAP) and mitral E/E' were found to be increased in patients with HCMP compared to HT patients. Left ventricular cavity dimensions were smaller in HCMP patients. GLS of HCMP and HT patients were - 14.52 ± 3.01 and -16.85 ± 1.36%, respectively (<i>p</i> < 0.001). Likewise, ALPM and PMPM free strain values were significantly reduced in HCMP patients over HT patients [-14.00% (-22 to -11%) and -15.5% (-24.02 to -10.16%) vs -23.00% (-24.99 to -19.01%) and -22.30% (-26.48 to -15.95%) (<i>p</i> = 0.016 and <i>p</i> = 0.010)], respectively. ALPM free strain showed a statistically significant correlation with GLS, maximal wall thickness, IVS thickness and LVMI. PMPM free strain showed a significant correlation with GLS, IVS thickness and LAAP. The GLS value of - 13.05 had a sensitivity of 61.9% and a specificity of 97.4% for predicting HCMP. ALPM and PMPM free strain values of -15.31 and -17.17% had 63 and 76.9% sensitivity and 85.7 and 76.9% specificity for prediction of HCMP.</p><p><strong>Conclusions: </strong>Besides other echocardiographic variables, which were investigated in earlier studies, papillary muscle free strain also could be used in HCMP to distinguish HCMP- from HT-associated hypertrophy.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 3","pages":"169-174"},"PeriodicalIF":0.7,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10145616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined systolic velocities using tissue Doppler imaging could predict the severity of cirrhosis: a prospective cohort study.","authors":"Ibrahim Dönmez, Emrah Acar","doi":"10.5830/CVJA-2023-034","DOIUrl":"10.5830/CVJA-2023-034","url":null,"abstract":"<p><strong>Aim: </strong>Recent research has demonstrated that the contractile characteristics of the right ventricular outflow tract (RVOT) play a significant role in right ventricular function. Pulmonary annular motion velocity (PAMVUT) is a reliable marker of RVOT function. Also, combined systolic velocity [PAMVUT added to tricuspid annular systolic velocity (St)] has been revealed as a suitable parameter for right ventricular systolic function. In this study, we examined the association between the severity of the illness in cirrhotic patients and the combined S velocities (CSV).</p><p><strong>Methods: </strong>Seventy-four patients with cirrhosis went to the echocardiography laboratory of the Cardiology Department in our centre. Traditional echocardiographic measurements, PAMVUT and CSV values were recorded. The Child-Pugh classes of the patients were determined.</p><p><strong>Results: </strong>Receiver operating characteristic curve analysis demonstrated that a CSV of 23 cm/s constituted the cut-off value for predicting a moderate-to-severe form of cirrhosis with 76% sensitivity and 65.3% specificity (area uder the curve = 0.735, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>CSV values could predict the severity of cirrhosis more precisely than traditional right ventricular systolic function parameters.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 3","pages":"175-180"},"PeriodicalIF":0.7,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10140579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electric cardioversion in patients treated with oral anticoagulants: embolic material in the left atrial appendage.","authors":"Jarosław Karwowski, Jerzy Rekosz, Mateusz Solecki, Renata Mączyńska-Mazuruk, Karol Wrzosek, Joanna Sumińska-Syska, Mirosław Dłużniewski","doi":"10.5830/CVJA-2022-060","DOIUrl":"10.5830/CVJA-2022-060","url":null,"abstract":"<p><p>Atrial fibrillation (AF) remains the most common arrhythmia. The sinus rhythm restoration procedure without adequate anticoagulant preparation may lead to a thromboembolic event in approximately 5-7% of patients. The initiation of oral anticoagulation significantly reduces this risk by inhibiting formation of embolic material in the heart cavities, especially in the left atrial appendage (LAA). However, there is a group of patients who develop embolic material in the LAA despite oral anticoagulation treatment. The best treatment method to dissolve thrombus in the LAA is not clear, due to the lack of studies with adequate power and endpoints that can determine the best management strategy. We present clinical trials comparing the efficacy and safety of oral anticoagulants in patients undergoing AF cardioversion. We evaluate the frequency of LAA thrombus formation in patients with AF on treatment with oral anticoagulants. Furthermore, we discuss the effectiveness of various treatment strategies on LAA thrombus resolution.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 3","pages":"181-188"},"PeriodicalIF":0.7,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10203864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and outcomes of cardiovascular disease admissions in Lagos, Nigeria: a 16-year review.","authors":"Amam C Mbakwem, Casmir Ezenwa Amadi, Jayne N Ajuluchukwu, Oyewole A Kushimo","doi":"10.5830/CVJA-2022-037","DOIUrl":"10.5830/CVJA-2022-037","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD)-related admissions are on the increase in Nigeria and the rest of Africa. This study was carried out to highlight the burden, patterns and outcomes of CVD admissions in a tertiary hospital over a 16-year period in Lagos, Nigeria.</p><p><strong>Methods: </strong>Admissions records of patients admitted into the medical wards within the study period (January 2002 to December 2017) were reviewed and relevant information pertaining to the study objectives was retrieved for analysis.</p><p><strong>Results: </strong>There were a total of 21 369 medical admissions and 4 456 (20.8%) CVD-related admissions. A total of 3 582 medical deaths were recorded and 1 090 (30.4%) CVD-related deaths. The median age of the patients was 56.6 (46.0-68.0) years and 51.4% of these were males. Stroke, heart failure, hypertensive disease and acute coronary syndrome constituted 51.2, 36.2, 11.3 and 1.6% of all CVD admissions, respectively. There was a cumulative increase in the number of CVD admissions and deaths (<i>p</i> < 0.001, respectively) during the period under review.</p><p><strong>Conclusions: </strong>CVD admissions are not only common in Nigeria, but there was also a temporal exponential increase in both the admission and death rates, most likely reflecting the epidemiological transition in Nigeria.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 3","pages":"140-148"},"PeriodicalIF":0.7,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the mechanism of Shexiang Baoxin pill-mediated angiogenesis in acute myocardial infarction.","authors":"Jingxun Wei,&nbsp;Binchang Dong,&nbsp;Xin Du,&nbsp;Huipu Xu","doi":"10.5830/CVJA-2023-030","DOIUrl":"https://doi.org/10.5830/CVJA-2023-030","url":null,"abstract":"<p><strong>Aim: </strong>The Shexiang Baoxin pill (SBP) is a commonly used drug for the treatment of coronary artery disease in China. More recently, some studies have found that it improved coronary microvascular function. This study aimed to explore the possible mechanism by which the SBP promotes angiogenesis after acute myocardial infarction (AMI).</p><p><strong>Methods: </strong>A rabbit model of acute myocardial infarction was established by ligating the left anterior descending coronary artery with silk thread, and the limb lead electrocardiogram was recorded to determine the success of the model. The rabbits were divided into a control group (SBP + normal rabbit group), a sham operation group, a saline + AMI group and an SBP + AMI group. There were 10 rabbits in each group. The animals were sacrificed and myocardial tissue was collected seven days after the operation. Haematoxylin-eosin staining was used to observe the histological changes in the rabbit myocardium in each group. The degree of acute myocardial infarction was observed with picric acid staining, which was used to detect the expression of vascular endothelial growth factor (VEGF), silent information regulator 1 (SIRT1), Beclin1 and mTOR protein in the myocardial tissue of each group. Immunofluorescence CD31-labelled microvascular density (MVD) was used to observe the vascular regeneration of the rabbits in each group.</p><p><strong>Results: </strong>Compared with the normal saline + AMI group, the myocardial infarction area of the SBP + AMI group decreased and CD31 immunofluorescence-labelled MVD increased. Compared with the control and sham operation groups, the expression of VEGF, Beclin1 and mTOR in the normal saline + AMI group and the SBP + AMI group increased, while the expression of SIRT1 decreased. Compared with the normal saline + AMI group and the SBP + AMI group, the positive expression of VEGF, Beclin1, mTOR and SIRT1 in the SBP + AMI group was significantly increased.</p><p><strong>Conclusion: </strong>Autophagy was enhanced after acute myocardial infarction. SBP may affect angiogenesis through the SIRT1/mTOR signalling pathway after acute myocardial infarction to inhibit ventricular remodelling and a decline in cardiac function.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 ","pages":"1-7"},"PeriodicalIF":0.7,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right ventricular function in treatment-naïve human immunodeficiency virus-infected patients.","authors":"Bassey Effiong,&nbsp;Victor Ansa,&nbsp;Joseph Andy,&nbsp;Idongesit Odudu-Umoh,&nbsp;Taiwo Shogade,&nbsp;Aquaowo Udosen,&nbsp;Udeme Ekripko","doi":"10.5830/CVJA-2023-031","DOIUrl":"https://doi.org/10.5830/CVJA-2023-031","url":null,"abstract":"<p><strong>Background: </strong>Right ventricular dysfunction carries a poorer prognosis in human immunodeficiency virus (HIV)-positive patients. The objectives of this study were to ascertain the prevalence of right ventricular systolic and diastolic dysfunction, as well as its predictors, in antiretroviral therapy-naïve HIV-positive patients.</p><p><strong>Methods: </strong>Participants in this cross-sectional, descriptive study comprised 60 HIV-positive patients and 60 HIV-negative controls. All participants had transthoracic echocardiography done to assess right ventricular systolic and diastolic function. The HIV-positive patients had their CD4 counts measured.</p><p><strong>Results: </strong>The mean age of the study population was 34.63 ± 8.7 years versus that of the controls (34.45 ± 9.40 years) (<i>p</i> = 1.000). Right ventricular systolic dysfunction was found in 11.6% of the HIV-positive patients versus the controls (3.33%, <i>p</i> = 0.166) while right ventricular diastolic dysfunction was found in 15.0% of HIV-positive patients versus the controls (1.7%, <i>p</i> = 0.021). The CD4 count did not contribute to the frequency and degree of right ventricular systolic or diastolic dysfunction.</p><p><strong>Conclusion: </strong>Right ventricular systolic and diastolic dysfunction was common in treatment-naïve HIV-infected individuals but the frequency and degree were not associated with the CD4 count or other measured parameters.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 ","pages":"1-6"},"PeriodicalIF":0.7,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intravenous sodium thiosulfate on vascular calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis.","authors":"Yu-Huan Song,&nbsp;AiBing Ning,&nbsp;Na Guo,&nbsp;Ying Yang,&nbsp;Fei Tang,&nbsp;Na Zhao,&nbsp;Jun Hu,&nbsp;Hong Wu,&nbsp;Ting Peng,&nbsp;Yue-Fei Xiao,&nbsp;Guang-Yan Cai","doi":"10.5830/CVJA-2023-020","DOIUrl":"https://doi.org/10.5830/CVJA-2023-020","url":null,"abstract":"<p><strong>Background: </strong>In dialysis patients, vascular calcification is a common complication and is closely related to the morbidity and mortality of cardiovascular disease. We performed a systematic review to determine the efficacy and safety of sodium thiosulfate (STS) in the progression of vascular calcification in dialysis patients with end-stage renal disease.</p><p><strong>Methods: </strong>The PubMed, Web of Science, Embase, Cochrane Library, Wanfang, CNKI, China Biology Medicine disc and Weipu databases were searched up to 9 March 2022 for clinical trials to synthesise findings on the efficacy and safety of STS in the progression of vascular calcification in dialysis patients. The primary outcome was coronary artery calcification scores (CACS) or abdominal aortic calcification scores (AACS) or Kauppila index. The secondary outcome was pulse-wave velocity (PWV). Laboratory data were shown in safety data. A random-effect model was used to provide the summary measures of effect [standardised mean difference (SMD) and 95% confidence interval (CI)].</p><p><strong>Results: </strong>Seven randomised, controlled trials and one nonrandomised, controlled trial involving 370 patients were included. Six studies reported that the progression of CACS or AACS was slower in the intravenous STS group compared with the control group (SMD -3.24, 95% CI: -5.29, -1.18, <i>p</i> = 0.002). Two studies showed the increase in PWV was less in the STS group compared with the control group (SMD -0.52, 95% CI: -0.92, -0.13, <i>p</i> = 0.009). During the trial period, a lower high-sensitivity C-reactive protein level (SMD 1.61, 95% CI: 0.19, 3.04, <i>p</i> = 0.03), a decrease in serum bicarbonate level (SMD 0.67, 95% CI: 0.22, 1.11, <i>p</i> = 0.003) and an increase in serum phosphate level (SMD -0.32, 95% CI: -0.62, -0.03, <i>p</i> = 0.03) were noted in the intravenous STS group compared with the control group. However, serum calcium and parathyroid hormone levels showed no difference between the two groups after the trials. The most common adverse events were temporary nausea and vomiting, which occurred in 12.5 to 75% of patients.</p><p><strong>Conclusions: </strong>Intravenous STS may slow down the progression of vascular calcification and ameliorate arterial stiffness in dialysis patients. Reliably defining the efficacy and safety of intravenous STS in attenuating the progression of vascular calcification requires a high-quality trial with a large sample size.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 ","pages":"1-10"},"PeriodicalIF":0.7,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Editor's Desk.","authors":"P J Commerford","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 3","pages":"131"},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10527222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in blood pressure after catheter-based renal denervation in South Africa.","authors":"Iftikhar O Ebrahim,&nbsp;Mpiko Ntsekhe,&nbsp;Brian Rayner,&nbsp;Martin Fahy,&nbsp;Giuseppe Mancia,&nbsp;Michael Böhm","doi":"10.5830/CVJA-2023-021","DOIUrl":"https://doi.org/10.5830/CVJA-2023-021","url":null,"abstract":"<p><strong>Background: </strong>Renal denervation (RDN) is an interventional treatment for patients with uncontrolled hypertension. The Global SYMPLICITY Registry (GSR) is a prospective, all-comer, world-wide registry designed to assess the safety and efficacy of RDN. We evaluated the outcomes in South African patients in the GSR over 12 months.</p><p><strong>Methods: </strong>Eligible patients with hypertension had a daytime mean blood pressure (BP) > 135/85 mmHg or night-time mean BP > 120/70 mmHg. Office and 24-hour ambulatory systolic BP reduction and adverse events over 12 months were evaluated.</p><p><strong>Results: </strong>South African patients (<i>n</i> = 36) in the GSR had a mean age of 54.4 ± 9.9 years with a median of four prescribed antihypertensive medication classes. At 12 months, mean changes in office and 24-hour ambulatory systolic BP were -16.9 ± 24.2 and -15.3 ± 18.5 mmHg, respectively, with only one adverse event recorded.</p><p><strong>Conclusions: </strong>RDN safety and efficacy in South African patients were consistent with world-wide GSR results.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 ","pages":"1-4"},"PeriodicalIF":0.7,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9693802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of insulin resistance on left ventricular remodelling in essential hypertensives: a cross-sectional study.","authors":"Bernard Kianu Phanzu,&nbsp;Aliocha Nkodila Natuhoyila,&nbsp;Eleuthère Kintoki Vita,&nbsp;Benjamin Longo-Mbenza,&nbsp;Jean-René M'Buyamba Kabangu","doi":"10.5830/CVJA-2023-024","DOIUrl":"https://doi.org/10.5830/CVJA-2023-024","url":null,"abstract":"<p><strong>Background: </strong>In clinical practice, left ventricular hypertrophy (LVH) is defined by physical findings and electrocardiographic criteria, which are useful but imperfect tools, echocardiographic criteria and cardiac magnetic resonance imaging. In echocardiography, LVH is defined not by left ventricular wall thicknesses but by left ventricular mass. The latter is calculated according to Devereux's formula, and is increased by insulin resistance/hyperinsulinaemia. It is however unclear whether insulin resistance, hyperinsulinaemia, or both, is actually causative and what their collective or individual influence is on the components of Devereux's formula and parameters of left ventricular diastolic function. This study evaluated the associations of the homeostatic model assessment for insulin resistance (HOMAIR) and fasting plasma insulin levels with components of Devereux's formula and parameters of left ventricular diastolic function.</p><p><strong>Methods: </strong>Relevant clinical data were collected from 220 hypertensive patients recruited between January and December 2019. The associations of components of Devereux's formula and parameters of diastolic function with insulin resistance were tested using binary ordinal, conditional and classical logistic regression models.</p><p><strong>Results: </strong>Thirty-two (14.5%) patients (43.9 ± 9.1 years), 99 (45%) patients (52.4 ± 8.7 years) and 89 (40.5%) patients (53.1 ± 9.8 years) had normal left ventricular geometry, concentric left ventricular remodelling and concentric left ventricular hypertrophy, respectively. In multivariable adjusted analysis, 46.8% of variation in interventricular septum diameter (R^² = 0.468; overall <i>p</i> = 0.001) and 30.9% of E-wave deceleration time (R^² = 0.309; overall <i>p</i> = 0.003) were explained by insulin level and HOMAIR, 30.1% of variation in left ventricular end-diastolic diameter (R^² = 0.301; <i>p</i> = 0.013) by HOMAIR alone, and 46.3% of posterior wall thickness (R^² = 0.463; <i>p</i> = 0.002) and 29.4% of relative wall thickness (R^² = 0.294; <i>p</i> = 0.007) by insulin level alone.</p><p><strong>Conclusions: </strong>Insulin resistance and hyperinsulinaemia did not have the same influence on the components of Devereux's formula. Insulin resistance appeared to act on left ventricular end-diastolic diameter, while hyperinsulinaemia affected the posterior wall thickness. Both abnormalities acted on the interventricular septum and contributed to diastolic dysfunction via the E-wave deceleration time.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"34 ","pages":"1-8"},"PeriodicalIF":0.7,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}