Matthias Lippert, Gabriella d' Albenzio, Kathrine Rydén Suther, Karl-Andreas Dumont, Rafael Palomar, Hans Henrik Odland, Ole Jakob Elle, Bjørn Bendz, Henrik Brun
{"title":"HoloPatch: improving intracardiac patch fit through holographically modelled templates.","authors":"Matthias Lippert, Gabriella d' Albenzio, Kathrine Rydén Suther, Karl-Andreas Dumont, Rafael Palomar, Hans Henrik Odland, Ole Jakob Elle, Bjørn Bendz, Henrik Brun","doi":"10.1093/ehjimp/qyae103","DOIUrl":"10.1093/ehjimp/qyae103","url":null,"abstract":"<p><strong>Aims: </strong>Structural heart defects, including congenital ventricular septal defect closure or intracardiac rerouting, frequently require surgical reconstruction using hand-cut patch materials. Digitally modelled patch templates may improve patch fit and reduce outflow tract obstruction, residual defect risk, and conduction system damage. In this study, we benchmarked mixed-reality and a desktop application against a digitalized model of a real implanted patch.</p><p><strong>Methods and results: </strong>Ten patients scheduled for the repair of various defects consented to prospective inclusion in the study. After surgery, a digital model of the implanted patch was created from the residual material. Five clinical experts created 10 digital patches, 1 per patient, both in mixed-reality and desktop application, for comparison with the reference measurements, including the digitalized model of the real patch used during the surgery. Subjective residual shunt risk prediction was performed using both modalities. Digital patches created in mixed-reality closely matched the surgical material, whereas those created using desktop applications were significantly smaller. Different evaluators showed varying preferences for the application of the residual shunt risk and area.</p><p><strong>Conclusion: </strong>Digitally created patches can assist surgeons in preoperatively sizing of patch implants, potentially reducing post-operative complications.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae103"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Echocardiographic red flags of ATTR cardiomyopathy a single centre validation.","authors":"Michael Y Henein, Björn Pilebro, Per Lindqvist","doi":"10.1093/ehjimp/qyae105","DOIUrl":"10.1093/ehjimp/qyae105","url":null,"abstract":"<p><strong>Aims: </strong>Echocardiography plays an important role in suspecting the presence of transthyretin cardiomyopathy (ATTR-CM) in patients with heart failure, based on parameters proposed as 'red flags' for the diagnosis of ATTR-CM. We aimed to validate those measurements in a group of patients with ATTR-CM including ATTRv and ATTRwt.</p><p><strong>Methods and results: </strong>We tested a number of echocardiographic red flags in 118 patients with confirmed diagnosis of ATTR-CM. These variables were validated against healthy controls and patients with heart failure with left ventricular hypertrophy (LVH) but not ATTR-CM. The red flag measures outside the proposed cut-off values were also revalidated. In ATTR-CM, all conventional echocardiographic parameters were significantly abnormal compared with controls. Comparing ATTR-CM and LVH, LV wall thickness, LV diameter, E velocity, and relative apical sparing (RELAPS) were all different. Eighty-three per cent of ATTR-CM patients had RELAPS > 1.0, 73% had relative wall thickness (RWT) > 0.6, 72% had LVEF > 50%, 24% had global longitudinal strain (GLS) > -13%, 33% had LVEF/GLS > 4, and 54% had increased left atrial volume index (>34 mL/m<sup>2</sup>). Forty per cent of ATTR-CM patients had stroke volume index < 30 mL/m<sup>2</sup> and 52% had cardiac index < 2.5 L/min/m<sup>2</sup>. RELAPS, LVEF, and RWT, in order of accuracy, were the three best measures for the presence ATTR-CM in the patient cohort, who all had thick myocardium. The concomitant presence of the three disturbances was found in only 50% but the combination of RELAPS > 1.0 and RWT > 0.6 was found in 72% of the patient cohort.</p><p><strong>Conclusion: </strong>Increased relative apical sparing proved the most accurate independent marker of the presence of ATTR-CM followed by normal LV ejection fraction and then increased relative wall thickness. The other proposed red flags for diagnosing ATTR-CM did not feature as reliable disease predictors.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae105"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Issue at a glance.","authors":"Oliver Gaemperli","doi":"10.1093/ehjimp/qyae090","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae090","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 2","pages":"qyae090"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anders T Bråten, Fredrik E Fossan, Lucas O Muller, Arve Jørgensen, Knut H Stensæth, Leif R Hellevik, Rune Wiseth
{"title":"Automated computed tomography-derived fractional flow reserve model for diagnosing haemodynamically significant coronary artery disease: a prospective validation study.","authors":"Anders T Bråten, Fredrik E Fossan, Lucas O Muller, Arve Jørgensen, Knut H Stensæth, Leif R Hellevik, Rune Wiseth","doi":"10.1093/ehjimp/qyae102","DOIUrl":"10.1093/ehjimp/qyae102","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to assess the diagnostic performance of a novel computed tomography-derived fractional flow reserve (CT-FFR) algorithm and to compare its accuracy at three predefined sites: (i) at the location of invasive FFR measurements (CT-FFR<sub>atloc</sub>), (ii) at selected sites determined by an automated module integrated within the algorithm (CT-FFR<sub>auto</sub>), and (iii) distally in the vessel (CT-FFR<sub>distal</sub>).</p><p><strong>Methods and results: </strong>We prospectively recruited 108 consecutive patients with stable symptoms of coronary artery disease and at least one suspected obstructive lesion on coronary computed tomography angiography (CCTA). CT-FFR was validated against invasive FFR as gold standard using FFR ≤ 0.80 to define myocardial ischaemia. CT-FFR<sub>atloc</sub> showed good correlation with invasive FFR (<i>r</i> = 0.67) and improved the ability to detect myocardial ischaemia compared with CCTA at both lesion [area under the curve (AUC) 0.83 vs. 0.65, <i>P</i> < 0.001] and patient level (AUC 0.87 vs. 0.74, <i>P</i> = 0.007). CT-FFR<sub>auto</sub> demonstrated similar diagnostic accuracy to CT-FFR<sub>atloc</sub> and significantly improved specificity compared with CT-FFR<sub>distal</sub> (86% vs. 49%, <i>P</i> < 0.001). High end CT quality improved the diagnostic performance of CT-FFR<sub>auto</sub>, demonstrating an AUC of 0.92; similarly, the performance was improved in patients with low-to-intermediate coronary artery calcium score with an AUC of 0.88.</p><p><strong>Conclusion: </strong>Implementing an automated module to determine the site of CT-FFR evaluations was feasible, and CT-FFR<sub>auto</sub> demonstrated comparable diagnostic accuracy to CT-FFR<sub>atloc</sub> when assessed against invasive FFR. Both CT-FFR<sub>atloc</sub> and CT-FFR<sub>auto</sub> improved the diagnostic performance compared with CCTA and improved specificity compared with CT-FFR<sub>distal</sub>. High end CT quality and low-to-intermediate calcium burden improved the diagnostic performance of our algorithm.</p><p><strong>Clinicaltrialsgov identifier: </strong>NCT03045601.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae102"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fredrik Edbom, Per Lindqvist, Urban Wiklund, Björn Pilebro, Intissar Anan, Frank A Flachskampf, Sandra Arvidsson
{"title":"Assessing left atrial dysfunction in cardiac amyloidosis using LA-LV strain slope.","authors":"Fredrik Edbom, Per Lindqvist, Urban Wiklund, Björn Pilebro, Intissar Anan, Frank A Flachskampf, Sandra Arvidsson","doi":"10.1093/ehjimp/qyae100","DOIUrl":"10.1093/ehjimp/qyae100","url":null,"abstract":"<p><strong>Aims: </strong>Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative disease of the myocardium in which extracellular deposits of amyloid cause progressive cardiac impairment. We aimed to evaluate left atrial (LA) deformation and its association with left ventricular (LV) deformation using LA-LV strain loops in patients with ATTR-CM and patients with LV hypertrophy (LVH). We hypothesized that LA strain in ATTR-CM patients is abnormal and more independent of LV strain, compared to LVH patients.</p><p><strong>Methods and results: </strong>Retrospective study based on echocardiographic data including 30 patients diagnosed with ATTR-CM based on an end-diastolic interventricular septal (IVSd) thickness of ≥14 mm, and 29 patients with LVH (IVSd ≥ 14 mm and no ATTR-CM diagnosis) together with 30 controls. LV global longitudinal strain (LV-GLS) and LA strain, assessed as peak atrial longitudinal strain (PALS), were acquired and plotted to construct LA-LV strain loops and used regression line to determine a LA-LV strain slope. Significantly lower PALS and LA-LV strain slope values were detected in ATTR-CM patients compared to LVH patients (<i>P</i> = 0.004 and <i>P</i> = 0.014, respectively). A receiver operating characteristic (ROC) curve demonstrated similar area under the curve (AUC) using PALS (AUC 0.72) and LA-LV slope (AUC 0.71), with both resulting in higher values than recorded for LV-GLS (AUC 0.62).</p><p><strong>Conclusion: </strong>LA deformation demonstrates an independent ability to differentiate ATTR-CM from LVH. Combining LV strain and LA deformation analysis displays the mechanical LA-LV dissociation in ATTR cardiac amyloidosis and potentially unmasks LA amyloid infiltration; this could potentially enable quicker diagnosis and initiation of treatment for ATTR-CM.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae100"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Intravital imaging of cardiac tissue utilizing tissue-stabilized heart window chamber in live animal model.","authors":"","doi":"10.1093/ehjimp/qyae095","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae095","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ehjimp/qyae062.].</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae095"},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Covadonga Fernández-Golfín, Ana García-Martín, Irene Carrión, Luisa Salido Tahoces, Jose Luis Zamorano
{"title":"Less is more: X-ray-TEE fusion with a new mini probe.","authors":"Covadonga Fernández-Golfín, Ana García-Martín, Irene Carrión, Luisa Salido Tahoces, Jose Luis Zamorano","doi":"10.1093/ehjimp/qyae088","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae088","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae088"},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Chiou, Melody Hermel, Christina Rodriguez Ruiz, Alexander van Rosendael, Tim Burton, Francesca Calicchio, Samantha Bagsic, Eric Hu, Elizabeth Epstein, Casey Joye, Shawn Newlander, Michael Salerno, Sanjeev P Bhavnani, Austin Robinson, Jorge Gonzalez, George E Wesbey
{"title":"Can artificial intelligence-derived coronary atherosclerotic characteristics using CCTA/CACS predict the future onset of atrial fibrillation?","authors":"Andrew Chiou, Melody Hermel, Christina Rodriguez Ruiz, Alexander van Rosendael, Tim Burton, Francesca Calicchio, Samantha Bagsic, Eric Hu, Elizabeth Epstein, Casey Joye, Shawn Newlander, Michael Salerno, Sanjeev P Bhavnani, Austin Robinson, Jorge Gonzalez, George E Wesbey","doi":"10.1093/ehjimp/qyae098","DOIUrl":"10.1093/ehjimp/qyae098","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae098"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Saber Hashemi, Yasaman Farsiani, Gregg S Pressman, M Reza Amini, Arash Kheradvar
{"title":"Effect of cross-platform variations on transthoracic echocardiography measurements and clinical diagnosis.","authors":"Mohammad Saber Hashemi, Yasaman Farsiani, Gregg S Pressman, M Reza Amini, Arash Kheradvar","doi":"10.1093/ehjimp/qyae097","DOIUrl":"10.1093/ehjimp/qyae097","url":null,"abstract":"<p><strong>Aims: </strong>Accurate cardiac chamber quantification is essential for clinical decisions and ideally should be consistent across different echocardiography systems. This study evaluates variations between the Philips EPIQ CVx (version 9.0.3) and Canon Aplio i900 (version 7.0) in measuring cardiac volumes, ventricular function, and valve structures.</p><p><strong>Methods and results: </strong>In this gender-balanced, single-centre study, 40 healthy volunteers (20 females and 20 males) aged 40 years and older (mean age 56.75 ± 11.57 years) were scanned alternately with both systems by the same sonographer using identical settings for both 2D and 4D acquisitions. We compared left ventricular (LV) and right ventricular (RV) volumes using paired <i>t</i>-tests, with significance set at <i>P</i> < 0.05. Correlation and Bland-Altman plots were used for quantities showing significant differences. Two board-certified cardiologists evaluated valve anatomy for each platform. The results showed no significant differences in LV end-systolic volume and LV ejection fraction between platforms. However, LV end-diastolic volume (LVEDV) differed significantly (biplane: <i>P</i> = 0.018; 4D: <i>P</i> = 0.028). Right ventricular (RV) measurements in 4D showed no significant differences, but there were notable disparities in 2D and 4D volumes within each platform (<i>P</i> < 0.01). Significant differences were also found in the LV systolic dyssynchrony index (<i>P</i> = 0.03), LV longitudinal strain (<i>P</i> = 0.04), LV twist (<i>P</i> = 0.004), and LV torsion (<i>P</i> = 0.005). Valve structure assessments varied, with more abnormalities noted on the Philips platform.</p><p><strong>Conclusion: </strong>Although LV and RV volumetric measurements are generally comparable, significant differences in LVEDV, LV strain metrics, and 2D vs. 4D measurements exist. These variations should be considered when using different platforms for patient follow-ups.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae097"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}