Critical reviews in biomedical engineering最新文献

{"title":"A Numerical Comparison of Magnetic Nanoparticle Hyperthermia in Breast, Muscle, and Prostate Tumors.","authors":"Sreedhara Rao Gunakala, Victor M Job, P V S N Murthy, S Umakanthan, Vikash Ramcharitar","doi":"10.1615/CritRevBiomedEng.2025055746","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025055746","url":null,"abstract":"<p><p>This study aims to compare the efficacy of magnetic nanoparticle hyperthermia for treating cancerous tissues in two distinct scenarios: breast and muscle/prostate tumors. Heat transfer dynamics during magnetic hyperthermia cancer therapy are explored using intravenously administered nanoparticles to a muscle/prostate tumor and intratumoral injection into a breast tumor. Utilizing non-Newtonian blood rheological models, we analyze a complex geometric domain for both tumor types and apply the mixed finite element technique for solving the governing equations. The impact of varying magnetic field frequencies and injected nanoparticle concentrations on heat transfer and nanoparticle transport within muscle/prostate, and breast tissues are examined numerically. Higher magnetic field frequencies and injected nanoparticle concentrations were found to increase localized heating in tumor regions, reduce therapy duration, and maximize thermal damage to cancer cells for both tumor configurations. This research provides valuable insights for optimizing magnetic hyperthermia parameters for different tumor types and also highlights the potential for personalized treatment strategies.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 6","pages":"61-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Preface: Mathematical Biology.","authors":"Dharmendra Tripathi, Kalpana Sharma, Rajashekhar Choudhari, Rajesh K Pandey, Sreedhara Rao Gunakala","doi":"10.1615/CritRevBiomedEng.2025058392","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025058392","url":null,"abstract":"","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 2","pages":"v-vi"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Herbal Drugs and Natural Product Nano Formulations for Cancer Treatment.","authors":"Ankit Monga, Sanya Jain, Ginpreet Kaur, Veeranjaneyuluu Addepalli, Bunty Sharma, Damandeep Kaur, Ujjawal Sharma, Hardeep Singh Tuli","doi":"10.1615/CritRevBiomedEng.2025056287","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025056287","url":null,"abstract":"<p><p>Nanomedicine has revolutionized the pharmaceutical and biological sciences industry by providing new frontiers and targets on the diagnosis and treatment of diseases. One promising development is the integration of natural products with nanoformulations, is emerging as a novel strategy in antitumor therapy. This combination has opened up new avenues for primary intervention and treatment due to targeted delivery of therapeutic agents against cancer. Researchers are trying to enhance and establish the safety and efficacy of naturally occurring bioactive compounds characterised by their anticancer potential. Polyphenols and other phytochemicals, along with functional foods, have high potency in circumventing tumors by the effective inhibition of the expansion of cancerous cells and induction of apoptosis. Incorporation of such natural products natural products through nanotechnology is therefore meant to enhance therapeutic efficacy with an improved safety profile. The aim will be to formulate these bioactive compounds as nanoformulations to achieve higher tumor site concentration, which would result in maximum anticancer effects and perhaps reduce the possible side effects associated with conventional therapies. This calls for collaboration among researchers and clinicians in establishing evidence-based guidelines and standardized protocols that ensure safety and efficacy in the use of such therapies.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 6","pages":"25-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the Practice for Medical Imaging Software Based on Open Source Repositories.","authors":"Spencer Smith, Ao Dong, Jacques Carette, Michael D Noseworthy","doi":"10.1615/CritRevBiomedEng.2025057015","DOIUrl":"10.1615/CritRevBiomedEng.2025057015","url":null,"abstract":"<p><p>We review the state of the practice for the development of medical imaging (MI) software based on data available in open-source repositories. We selected 29 projects from 48 candidates and assessed nine software qualities by answering 108 questions for each. Using the analytic hierarchy process (AHP) on the quantitative data, we ranked the MI software. The top five are 3D Slicer, ImageJ, Fiji, OHIF Viewer, and ParaView. This is consistent with the community's view, with four of these also appearing in the top five using GitHub metrics (stars per year). The quality and quantity of documentation present in a project correlate quite well with its popularity. Generally, MI software is in a healthy state: in the repositories, we observed 88% of the documentation artifacts recommended by research software development guidelines, and 100% of MI projects use version control tools. However, the current state of the practice deviates from existing guidelines as some recommended artifacts are rarely present (such as a test plan, requirements' specification, and code style guidelines), low usage of continuous integration (17% of the projects), low use of unit testing (~ 50% of projects), and room for improvement with documentation. From developer interviews, we identified seven concerns: lack of development time, lack of funding, technology hurdles, correctness, usability, maintainability, and reproducibility. We recommend increasing effort on documentation, increasing testing by enriching datasets, increasing continuous integration, moving to web applications, employing linters, using peer reviews, and designing for change.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 6","pages":"1-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Accelerated Magnetic Resonance Imaging Techniques: Parallel Imaging, Compressed Sensing, and Machine Learning.","authors":"Mitra Tavakkoli, Michael D Noseworthy","doi":"10.1615/CritRevBiomedEng.2024056909","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2024056909","url":null,"abstract":"<p><p>A concise overview of three major advancements in fast magnetic resonance imagine (MRI) reconstruction techniques is presented, focusing on their roles in enhancing image quality and reducing acquisition times. The first set of methods, parallel imaging techniques, includes sensitivity encoding (SENSE) and generalized autocalibrating partially parallel acquisitions (GRAPPA). SENSE utilizes spatial sensitivity information from multiple receiver coils to accelerate image acquisition by undersampling k-space data and reconstructing images using coil sensitivity profiles, allowing for faster scans. GRAPPA, another parallel imaging method, uses estimated weights from a calibration scan to fill in missing data in undersampled k-space and then reconstructs unaliased images. Additionally, this review explores sparse reconstruction techniques such as compressed sensing, which leverages the sparsity of images in a transformed domain to reconstruct high quality images from significantly fewer measurements, thus reducing scan times. The latest developments in machine learning applications for MRI acquisition are also discussed, highlighting how advanced algorithms are being used to improve image reconstruction, enhance diagnostic accuracy, and simplify workflow processes.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 5","pages":"71-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Blood Flow Simulation in Stenotically Diseased Arteries.","authors":"G Shankar, Dharmendra Tripathi, P Deepalakshmi, O Anwar Bég, Sireetorn Kuharat, E P Siva","doi":"10.1615/CritRevBiomedEng.2025055069","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025055069","url":null,"abstract":"<p><p>Heart diseases which can lead to stroke and heart attacks, affect numerous individuals worldwide due to disruptions in blood flow within the body. A common underlying cause for such hemodynamic disorders is a constriction in the artery, which is known as a stenosis, which is attributable to a range of causes including atherosclerosis or plaque accumulation. Many theoretical and computational studies have been presented in this area providing a useful compliment to experimental (clinical) studies. These studies have benefited clinical practice by providing insights into complex fluid dynamics associated with cardiovascular disease and identifying robust methodologies for mitigating such diseases. This review therefore aims to provide an overview of recent mathematical and numerical modelling advancements in understanding blood flow in stenosed arteries which have served to expand the current understanding of disease onset and mitigation for patients. Many diverse aspects of stenotic hemodynamics have been addressed in a large body of literature under various assumptions, such as different fluid material models, artery channel characteristics and diverse analytical and numerical solution techniques. These studies have also considered a variety of multi-physical effects including heat transfer, mass diffusion, nanoparticle effects in actual clinical treatments. In this review, over 100 recent articles from reputable journals are appraised. The primary objectives of this review paper are to emphasize the methodologies used for modelling, numerical simulation, and robust evaluation of hemodynamic characteristics in arterial blood flow which provide a more sophisticated insight into hemodynamics associated with diseases and possible mitigation strategies. The tabular format outlines different aspects of geometries and blood behavior (fluids) examined in the period 2015-2025. This organized presentation and crystallization of key contributions in a single article will also serve as a valuable resource for multi-disciplinary researchers including mathematicians, bioengineers, computer scientists in addition to medical researchers. Future pathways are also outlined.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 5","pages":"49-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave Imaging Systems for Tumor Detection: A Comprehensive Review of Antenna Designs and Imaging Algorithms.","authors":"Sujit Tripathy, Vishwajeet Mukherjee, Pranaba K Mishro","doi":"10.1615/CritRevBiomedEng.2024055777","DOIUrl":"10.1615/CritRevBiomedEng.2024055777","url":null,"abstract":"<p><p>In the past decade, microwave imaging (MWI), employing advanced antenna-based systems, has emerged as a cutting-edge, non-invasive approach for pathological diagnosis. Multiple experimental studies suggest that MWI proposes promising results for early-stage tumor diagnosis. Recent studies on MWI show the importance of antenna types and configuration. However, it is observed that a very limited research has focused on exploring the large classes of antennas used in detail. In this review, a systematic study and firsthand classification of the antennas used, as the most important aspect of an MWI system, is proposed. The classification includes fundamental antennas, microstrip antennas, metamaterial/metastructure antennas, specialized antennas, and 3D antennas. A cross-sectional study is performed to depict the potential relationship between antenna type and efficiency of the MWI systems. This goal is achieved by quantitatively analyzing the gain and operating bandwidth, antenna configuration, and application models. Further, a critical analysis is presented on different signal processing and imaging algorithms for synthetic image generation. This review presents a modular analysis of MWI systems and draws several conclusions on the effectiveness of each essential module for a reliable MWI system. It also addresses the challenges, scope of improvement in the MWI systems, and prospects for the technology's integration into clinical practice.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 4","pages":"25-53"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion Models for Oral Drug Delivery to the Colon Using Porous Materials.","authors":"Austin Evers, Symone L M Alexander","doi":"10.1615/CritRevBiomedEng.2025056706","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025056706","url":null,"abstract":"<p><p>Oral administration of drugs is patient-preferred due to ease of administration, less invasive procedures, and overall simplicity. However, traditional oral administration of drugs can lead to ineffective treatment and adverse side effects due to the physiological barriers of the gastrointestinal tract. Because of this, colon-specific drug delivery vehicles synthesized from polymeric, porous materials are being designed to control drug release to the colon. Specifically, these porous matrices include hydrogels, microgels/microparticles, and nanoparticle drug delivery systems. Furthermore, these formulations have been studied on their survivability and efficacy in delivery of the drugs to the colon. This review paper is focused on diffusion models for diffusion and drug release and how the choice of matrix material determines what drug release profiles are possible. Our goal is to provide a resource for identifying, applying, and advancing models for drug diffusion to the colon to help guide experimental design of drug delivery vehicles for intestinal pathologies.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 4","pages":"55-76"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteral Peristaltic Flows in the Presence of Microliths: A Review.","authors":"P Deepalakshmi, Dharmendra Tripathi, G Shankar, O Anwar Bég, Sireetorn Kuharat, E P Siva","doi":"10.1615/CritRevBiomedEng.2025055048","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025055048","url":null,"abstract":"<p><p>A detailed review is presented on research contributions in peristaltic transport in the human ureter in the presence of microliths. The studies reviewed are differentiated based on methodologies deployed, namely analytical, numerical and CFD simulation techniques and also experimental (clinical) investigations. Various 2D and 3D models are discussed along with more advanced fluid structure interaction (FSI) studies. The propagation of the incompressible urine flow results in reflux nephropathy. As such, the peristaltic waves spread near the outlet of the tube which manifests in a depletion in the flow rate. Due to the maximum pressure gradient, urine backflow occurs. A full understanding of ureter reflux has however not yet been achieved. This review surveys approximately 101 journals addressing the obstruction inside the ureter and the associated hydrodynamics. As such it consolidates many different efforts in the field in a single source which will serve as a guide to both clinical researchers (e.g., physicians) and also mathematical and engineering research groups and is hoped that it will assist in the development of new integrated approaches for robust treatments. The extensive survey of the scientific literature in this review article confirms that stones (monoliths) detected in the proximal part of the nephron are generally larger than those identified in distal parts. These papers defined the position and shapes of microliths. Due to bolus transport inside the ureter flow, varying pressure and velocity balances are also appraised. The more advanced FSI simulations provide much-needed insight into visualizing actual ureteral transport. Some future pathways for collaborative efforts in improving healthcare for patients are also suggested.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 3","pages":"23-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Breast Tumor Detection: A Miniature Antenna for Industrial, Scientific, and Medical (ISM) Band Implantation.","authors":"Saidi Amaria, Nouri Keltouma, Abes Turkiya, Damou Mehdi","doi":"10.1615/CritRevBiomedEng.v53.i6.30","DOIUrl":"10.1615/CritRevBiomedEng.v53.i6.30","url":null,"abstract":"<p><p>Breast cancer diagnosis using implantable biomedical antennas offers a promising alternative to conventional imaging techniques due to their potential for continuous monitoring and minimal invasiveness. This paper presents a miniaturized antenna with dimensions of 3 ȕ 3 ȕ 1.27 mm3, specifically designed for implantation in breast tissue to detect the presence of tumors. The objective is to evaluate the antenna's ability to detect breast tumors by first analyzing its reflection behavior (S11) in implanted conditions, both with and without tumors. Subsequently, a second external antenna is introduced in free space to assess transmission performance at varying distances. To further assess transmission performance, a second external antenna is introduced, and the system is tested at varying distances and orientations (face-to-face and side-by-side). The antenna operates at 2.45 GHz and is tested in both skin and breast tissue phantoms with embedded tumors of different sizes and positions. Key performance metrics such as S-parameters, gain, transmission coefficient, and group delay are analyzed. Simulation results show gain values of -31.28 dB in skin and -17.78 dB in breast tissue. Patient safety is confirmed through specific absorption rate (SAR) analysis, with a maximum input power of 2.3 mW. The proposed design shows strong potential for breast cancer detection due to its small size, consistent performance in various antenna positions, and compliance with SAR safety standards.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 6","pages":"47-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145368981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}