P Deepalakshmi, Dharmendra Tripathi, G Shankar, O Anwar Bég, Sireetorn Kuharat, E P Siva
{"title":"Ureteral Peristaltic Flows in the Presence of Microliths: A Review.","authors":"P Deepalakshmi, Dharmendra Tripathi, G Shankar, O Anwar Bég, Sireetorn Kuharat, E P Siva","doi":"10.1615/CritRevBiomedEng.2025055048","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2025055048","url":null,"abstract":"<p><p>A detailed review is presented on research contributions in peristaltic transport in the human ureter in the presence of microliths. The studies reviewed are differentiated based on methodologies deployed, namely analytical, numerical and CFD simulation techniques and also experimental (clinical) investigations. Various 2D and 3D models are discussed along with more advanced fluid structure interaction (FSI) studies. The propagation of the incompressible urine flow results in reflux nephropathy. As such, the peristaltic waves spread near the outlet of the tube which manifests in a depletion in the flow rate. Due to the maximum pressure gradient, urine backflow occurs. A full understanding of ureter reflux has however not yet been achieved. This review surveys approximately 101 journals addressing the obstruction inside the ureter and the associated hydrodynamics. As such it consolidates many different efforts in the field in a single source which will serve as a guide to both clinical researchers (e.g., physicians) and also mathematical and engineering research groups and is hoped that it will assist in the development of new integrated approaches for robust treatments. The extensive survey of the scientific literature in this review article confirms that stones (monoliths) detected in the proximal part of the nephron are generally larger than those identified in distal parts. These papers defined the position and shapes of microliths. Due to bolus transport inside the ureter flow, varying pressure and velocity balances are also appraised. The more advanced FSI simulations provide much-needed insight into visualizing actual ureteral transport. Some future pathways for collaborative efforts in improving healthcare for patients are also suggested.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 3","pages":"23-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Implementation of Fractional Blood Alcohol Model by Numerical Approach.","authors":"Shyamsunder","doi":"10.1615/CritRevBiomedEng.2024055033","DOIUrl":"10.1615/CritRevBiomedEng.2024055033","url":null,"abstract":"<p><p>The current article discusses several innovative and intriguing aspects of the Caputo and modified Atangana-Baleanu derivative in the Caputo sense (MABC) based on a fractional blood alcohol model. The initial concentration of alcohol in the stomach after consumption, the rate at which alcohol is absorbed into the circulation, and the rate at which the liver metabolizes alcohol are the three factors that determine the model's resolution. Utilizing the Laplace transform method and the generalized Mittag-Leffler function method (GMLFM), the analytical results of stomach alcohol concentration and blood alcohol concentration are examined. Additionally, the study comprehensively analyzes the relationship between blood and stomach alcohol concentrations through an extended series representation. Graphical representations of the impact of fractional parameters on blood and stomach alcohol concentrations are provided. The comparison analysis for both concentrations reveals novel aspects of the studied model's entire fractional derivatives. The fractional blood alcohol models presented provide significant and beneficial outcomes that may be used to forecast future information forthe medical community.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 2","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovative Ultrasound Image Denoising Using Channel Attention and Variational Autoencoders.","authors":"Taher Slimi, Emna Ben Baoues, Anouar Ben Khalifa","doi":"10.1615/CritRevBiomedEng.2025058842","DOIUrl":"10.1615/CritRevBiomedEng.2025058842","url":null,"abstract":"<p><p>Speckle noise in ultrasound images compromises image quality and hinders diagnostic accuracy. Traditional ultrasound denoising methods often struggle to preserve anatomical details while effectively reducing noise, especially under high-noise conditions. In this study, we propose an innovative approach that integrates a lightweight channel attention mechanism (LCAM) within a convolutional variational autoencoder (CVAE) framework to enhance ultrasound image denoising. The proposed approach efficiently reduces speckle noise while maintaining essential anatomical features. Comprehensive evaluations across six diverse ultrasound datasets demonstrate that the LCAM-CVAE outperforms conventional denoising techniques in both subjective image quality and objective performance metrics, including peak signal-to-noise ratio (PSNR), structural similarity index measure (SSIM), standard deviation in PSNR (SD-PSNR), standard deviation in SSIM (SD-SSIM), PSNR statistical relevance tests, and computational efficiency (CE). The LCAM-CVAE approach demonstrates exceptional performance, particularly under high-noise conditions, ensuring the preservation of key anatomical structures for accurate diagnosis. These results highlight the LCAM-CVAE approach as a robust and promising solution for ultrasound image denoising, with significant clinical potential to improve diagnostic quality in noisy environments.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 3","pages":"47-76"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mathematical Model of Cancer Treatment with Virotherapy and Immune System.","authors":"Arvind Kumar Sinha, Ambika Sahu","doi":"10.1615/CritRevBiomedEng.2025055125","DOIUrl":"10.1615/CritRevBiomedEng.2025055125","url":null,"abstract":"<p><p>The global burden of cancer is rising, causing significant strain on individuals, families, and healthcare systems. Traditional treatments, such as chemotherapy and radiation, are effective but harm healthy cells and lead to side effects. In contrast, virotherapy specifically targets cancer cells, leaving healthy cells unharmed. This study presents a mathematical model of cancer treatment with viral therapy and the immune system. We show the non-negative and boundedness of the model's solution. Our findings identify five equilibrium points: free equilibrium point, two immune response-free equilibrium points, and two coexisting equilibrium points. The local and global stability of the equilibrium point is established. We show the tumor size reduction from 0.55 to 0.05 as an increase in the burst size from 0.8 to 9.0, respectively. We also explore that the proposed methodology reduces tumor size from 0.59 to 0.21 as the stimulation rate of immune response increases from 0.29 to 0.90. Thus, numerical simulations indicate that high immune response and viruses reduce tumor size. This study emphasizes the effectiveness of combining viral therapy with high immune responses in cancer patients. This study is helpful for oncologists and immunologists to understand the behavior of virotherapy and immune response to control the proliferation of different kinds of tumors.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 3","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Mathematical Model Evaluating the Impact of Asymptomatic COVID-19 Cases and Reinfection.","authors":"Arpita Devi, Asish Adak, Praveen Kumar Gupta","doi":"10.1615/CritRevBiomedEng.2024056294","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2024056294","url":null,"abstract":"<p><p>In this study, an epidemic model with a constant recruitment rate of susceptible individuals with a bilinear transmission rate of infection is considered. Vaccination-type treatment is inspected to minimize the impact of the disease. The asymptomatic infected and the vaccinated compartments are taken with regard to the circumstances of the coronavirus disease (COVID-19) pandemic 2020-2025. The impact of these two compartments is examined specifically to shed light on the behavioral dynamics. Local as well as the global stability of the disease-free equilibrium point and the endemic equilibrium point are examined by constructing Lyapunov functions. Hence, we prove that if the basic reproduction number is < 1, then there will be no disease in the system, and if the basic reproduction number is > 1, then the disease will persist. Sensitivity analysis is performed to identify the influential model parameters that have the greatest impact on the original reproduction number of the proposed model. The model is validated by fitting it to real data. Furthermore, we carried out numerical simulations of the model parameters and their accompanying theoretical results. To control or eliminate the effect of emerging diseases, we made several suggestions to control the most sensitive model parameters while using necessary preventive measures.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 4","pages":"77-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomechanics of Brachial Plexus Injuries Due to Shoulder Dystocia.","authors":"Gunter P Siegmund, Carolyn W Roberts","doi":"10.1615/CritRevBiomedEng.v53.i4.10","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.v53.i4.10","url":null,"abstract":"<p><p>Brachial plexus injuries during childbirth can be devastating injuries with lifelong consequences. Here we review the biomechanical literature related to this injury and integrate it with recent epidemiological and clinical literature to better understand how intrinsic and extrinsic factors contribute to this injury. Brachial plexus palsy is caused by excessive stretching, tearing, or avulsion of the nerve fibers of the brachial plexus and can lead to temporary or permanent injury to the motor and sensory functions of the upper extremity. Compared to other maternal and fetal factors, the highest risk factor for brachial plexus palsy is shoulder dystocia. The continuum of brachial plexus injuries, from temporary impairments of the C5 and C6 nerve roots to the permanent disruption of the entire brachial plexus, is consistent with a dose-response relationship whereby higher applied birthing forces cause greater degrees of injury. The current biomechanical models of shoulder dystocia and brachial plexus strain have not been validated against experimental data and their results should be treated cautiously. Endogenous forces (e.g., uterine contractions and maternal pushing) and exogenous forces (e.g., clinician-applied traction) generate strain in the brachial plexus, but the rarity of permanent, severe injuries and the reduction of these injuries after clinician training suggest that clinician-applied forces during shoulder dystocia increase the risk of permanent, severe brachial plexus injury. There are currently no reliable biomechanical methods for determining if maternal forces or clinician-applied forces are responsible for less severe types of brachial plexus injury.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 4","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Study of Cryosurgery of Prostate Cancer Using Mathematical Model.","authors":"Mukesh Kumar, K N Rai","doi":"10.1615/CritRevBiomedEng.2024052841","DOIUrl":"https://doi.org/10.1615/CritRevBiomedEng.2024052841","url":null,"abstract":"<p><p>In this study, a two-dimensional three-phase lag (TPL) bio-heat transfer model during cryosurgery of prostate cancer is developed. The cryoprobe, with a temperature that decreases linearly with time, is placed at the prostate tumor tissue. The mathematical model of this bio-heat transfer problem is a moving boundary value problem. Using finite differences, the boundary value problem is converted into the initial value problem of vector-matrix form. Further applying the Legendre wavelet Galerkin method, the problem has been converted into a generalized system of the Sylvester equation, which is solved by the Bartels-Stewart algorithm, where the idea of generalized inverse has been used. We found the temperature distribution using the TPL model and, using these in interface conditions, we obtained the moving layer thicknesses. We compared the present numerical study with the exact solution and see that the results are in good agreement. We have also seen the effects of τq (phase lag due to heat flux), τT (phase lag due to temperature gradient) and τν (phase lag due to temperature displacement gradient) on temperature distribution.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 2","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krishna Agrawal, Randhir Singh Baghel, Amit Parmar
{"title":"Magnetic Dipole Impact Involvement on Ferromagnetic Non-Newtonian Radiative MHD Blood Flow under Two Boundary Conditions Involving Applications, Biotechnology, and Medical Sciences.","authors":"Krishna Agrawal, Randhir Singh Baghel, Amit Parmar","doi":"10.1615/CritRevBiomedEng.2024056488","DOIUrl":"10.1615/CritRevBiomedEng.2024056488","url":null,"abstract":"<p><p>The primary focus of this research is the numerical analysis Casson flow behavior of ferromagnetic liquefied blood over an extended stretching region. The characteristics of the domain are influenced by factors such as radiation, blood flow velocity, thermal slip, and melting surface conditions. The governing equations for the impenetrable magneto-dynamic liquid blood are converted into the first-order ordinary differential equations by utilizing the alteration approach. The fourth-order R-K methodology is then used to solve these ODEs. The results show that the skin friction, Sherwood number, and Nusselt value get lower by increasing the ferromagnetic interface value. There is good concordance between the study's numerical approach and previously published studies. The magnitude of blood flow velocity and temperature are influenced by the Casson parameter, and the changes in these parameters are more noticeable with higher Casson parameter values. Furthermore, a drop in the Nusselt number and a strengthening of skin friction result from raising the Casson parameter.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"53 5","pages":"23-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madisyn Messmore, Alain J Kassab, Ray O Prather, David A Castillo Arceo, William DeCampli
{"title":"Cilia and Nodal Flow in Asymmetry: An Engineering Perspective.","authors":"Madisyn Messmore, Alain J Kassab, Ray O Prather, David A Castillo Arceo, William DeCampli","doi":"10.1615/CritRevBiomedEng.2024051678","DOIUrl":"10.1615/CritRevBiomedEng.2024051678","url":null,"abstract":"<p><p>Over the past several years, cilia in the primitive node have become recognized more and more for their contribution to development, and more specifically, for their role in axis determination. Although many of the mechanisms behind their influence remain undocumented, it is known that their presence and motion in the primitive node of developing embryos is the determinant of the left-right axis. Studies on cilial mechanics and nodal fluid dynamics have provided clues as to how this asymmetry mechanism works, and more importantly, have shown that direct manipulation of the flow field in the node can directly influence physiology. Although relatively uncommon, cilial disorders have been shown to have a variety of impacts on individuals from chronic respiratory infections to infertility, as well as situs inversus which is linked to congenital heart disease. After first providing background information pertinent to understanding nodal flow and information on why this discussion is important, this paper aims to give a review of the history of nodal cilia investigations, an overview of cilia mechanics and nodal flow dynamics, as well as a review of research studies current and past that sought to understand the mechanisms behind nodal cilia's involvement in symmetry-breaking pathways through a biomedical engineering perspective. This discussion has the additional intention to compile interdisciplinary knowledge on asymmetry and development such that it may encourage more collaborative efforts between the sciences on this topic, as well as provide insight on potential paths forward in the field.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"52 3","pages":"63-82"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vineet Srivastava, Dharmendra Tripathi, P K Srivastava, Sireetorn Kuharat, O Anwar Bég
{"title":"Mathematical Modeling of Oxygen Diffusion from Capillary to Tissues during Hypoxia through Multiple Points Using Fractional Balance Equations with Memory.","authors":"Vineet Srivastava, Dharmendra Tripathi, P K Srivastava, Sireetorn Kuharat, O Anwar Bég","doi":"10.1615/CritRevBiomedEng.2024053461","DOIUrl":"10.1615/CritRevBiomedEng.2024053461","url":null,"abstract":"<p><p>The diffusion of oxygen through capillary to surrounding tissues through multiple points along the length has been addressed in many clinical studies, largely motivated by disorders including hypoxia. However relatively few analytical or numerical studies have been communicated. In this paper, as a compliment to physiological investigations, a novel mathematical model is developed which incorporates the multiple point diffusion of oxygen from different locations in the capillary to tissues, in the form of a fractional dynamical system of equations using the concept of system of balance equations with memory. Stability analysis of the model has been conducted using the well known Routh-Hurwitz stability criterion. Comprehensive analytical solutions for the differntial equation problem in the new proposed model are obtained using Henkel transformations. Both spatial and temporal variation of concentration of oxygen is visualized graphically for different control parameters. Close correlation with simpler models is achieved. Diffusion is shown to arise from different points of the capillary in decreasing order along the length of the capillary i.e. for the different values of z. The concentration magnitudes at low capillary length far exceed those further along the capillary. Furthermore with progrssive distance along the capillary, the radial distance of diffusion decreases, such that oxygen diffuses only effectively in very close proximity to tissues. The simulations provide a useful benchmark for more generalized mass diffusion computations with commercial finite element and finite volume software including ANSYS FLUENT.</p>","PeriodicalId":94308,"journal":{"name":"Critical reviews in biomedical engineering","volume":"52 6","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}