Arwa Jader, Barbara Buccilli, Danisha Kumar, Oday Atallah, Luqman Munir, Yasser F Almealawy, Michelle Ennabe, Neil Joshi, Urooj Imdad, Albert Alan, Martin Weinand
{"title":"Building a Stronger Backbone: 3D Printing's Role in Treating Spinal Cord Conditions.","authors":"Arwa Jader, Barbara Buccilli, Danisha Kumar, Oday Atallah, Luqman Munir, Yasser F Almealawy, Michelle Ennabe, Neil Joshi, Urooj Imdad, Albert Alan, Martin Weinand","doi":"10.1055/s-0044-1788916","DOIUrl":"10.1055/s-0044-1788916","url":null,"abstract":"<p><p>Spinal cord injuries (SCIs) pose significant challenges as complete nerve regeneration remains limited. The demand for improved technologies in SCI treatment is evident. One such emerging technology is three-dimensional printing (3DP), which, coupled with advancements in medical imaging and bioengineering, has significantly enhanced precision in surgical procedures. This systematic review aims to explore 3DP as a treatment option for SCIs, examining its cost, efficacy, safety, and the associated technological constraints. A systematic search of Medline was conducted through PubMed for literature published since 2019. The search results were exported to Rayyan for abstract and full-text screening following predefined criteria. The risk of bias in the selected studies was assessed using the RoB2 tool and the Newcastle-Ottawa Scale. From a total of 89 articles screened, 11 studies met the eligibility criteria, collectively assessing 237 individuals with various types of SCIs, including lumbar degeneration, en bloc resection of thoracolumbar metastasis, adult spinal deformity, and cervical degeneration. These studies examined the utilization of 3DP devices such as hand orthosis, interbody fusion cages, lamellar titanium cages, artificial vertebral bodies, and others. Most of the reviewed studies reported positive treatment outcomes, with the actual procedure costs varying from $65 to $5,000. Recent literature shows positive outcomes in the use of 3DP technologies for SCIs, highlighting its potential for enhancing both surgical and nonsurgical interventions. These advancements usher in a new era in SCI treatment, providing enhanced precision and a wider range of treatment options, ultimately leading to more comprehensive and effective patient care.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"587-597"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kugan Vijian, Bik Liang Lau, Davendran Kanesen, Swee San Lim, Donald L Ngian, Albert S Hieng Wong
{"title":"Improving Diagnostic Yield and Accuracy of Stereotactic Biopsies through Changes in Practice and Techniques: An 8-Year Single-Center Comparative Study.","authors":"Kugan Vijian, Bik Liang Lau, Davendran Kanesen, Swee San Lim, Donald L Ngian, Albert S Hieng Wong","doi":"10.1055/s-0044-1789593","DOIUrl":"10.1055/s-0044-1789593","url":null,"abstract":"<p><p><b>Background</b> Stereotactic biopsies are used to aid neurosurgeons in clinching the diagnosis of intracranial lesions that are difficult to access surgically. A published study of stereotactic biopsies in our center demonstrated a diagnostic yield of only 76% for biopsies from the year 2014 to 2019. A set of criteria/prerequisites was applied to increase yield. <b>Objective</b> The aim of the study was to identify the improvement in accuracy and yield after implementation of a set of criteria/prerequisites. <b>Materials and Methods</b> This was a retrospective and prospective analysis of all patients who underwent stereotactic biopsies from the year 2014 to 2022. This study was conducted at Sarawak General Hospital, Malaysia. A set of stereotactic criteria/prerequisites was introduced since 2020, which include preoperative careful, meticulous trajectory planning and target selection, regular checking and maintenance of equipment, larger burr holes, and good sampling techniques. <b>Results</b> A total of 83 patients underwent stereotactic biopsies from the year 2014 to 2022. Frameless and frame-based methods were used for 45 (54%) and 38 (46%) patients, respectively. The overall diagnostic yield of all biopsies was 84%. Fifty patients underwent stereotactic biopsies prior to implementation of good practice guidelines in 2020 with a positive histopathological yield and accuracy of 76 and 88%, respectively. Thirty-three biopsies done postimplementation demonstrated a yield and accuracy of 97% ( <i>p</i> < 0.05). There was also a shift of preference toward frame-based methods after 2019, with 85% of these biopsies being frame based. <b>Conclusion</b> This comparative study shows that adherence to specific stereotactic biopsy guidelines and techniques introduced in our center has successfully improved our biopsy yield and accuracy.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"701-706"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manikandan Sethuraman, Ajay Prasad Hrishi P, Neeraja Ajayan, Unnikrishnan Prathapadas, Smita Vimala, Ranganatha Praveen C S
{"title":"Evaluation of Cardiac Function in Patients with Supratentorial Tumors and Raised Intracranial Pressure: HABIT-ICP, a Prospective Observational Study Using Transthoracic Echocardiography.","authors":"Manikandan Sethuraman, Ajay Prasad Hrishi P, Neeraja Ajayan, Unnikrishnan Prathapadas, Smita Vimala, Ranganatha Praveen C S","doi":"10.1055/s-0044-1789262","DOIUrl":"10.1055/s-0044-1789262","url":null,"abstract":"<p><p><b>Objective</b> An acute increase in intracranial pressure (ICP) has been shown to affect cardiac function due to brain ischemia and the associated increased sympathetic activity. However, there is limited literature on the changes in cardiac function in clinical scenarios where there is a gradual and progressive increase in ICP, such as in brain tumors. We aimed to assess and compare the cardiac function in patients with primary supratentorial brain tumors presenting with and without raised ICP for neurosurgery. <b>Materials and Methods</b> In this prospective observational study, we included 60 patients; Group I (30 patients without features of raised ICP) and Group II (30 patients with features of raised ICP). Transthoracic echocardiography was performed on the day before the surgery and the seventh postoperative day. Hemodynamic, electrocardiographic, and echocardiographic parameters were obtained during pre-, intra-, and postoperative periods and were used for statistical analysis. <b>Results</b> We found an increased relative wall thickness and an increased incidence of systolic (22%) and diastolic dysfunction (33.3%) in Group II compared with Group I patients. There was an increased incidence of intraoperative adverse events such as postinduction hypotension and vasopressor use in Group II patients. In the postoperative period, there was an improvement in the systolic function; however, the chamber dimensions and diastolic dysfunction did not improve significantly. <b>Conclusion</b> Our study suggests that raised ICP might contribute to the pathophysiology of sympathetic overactivity and sympathetically driven cardiac dysfunction, which does not entirely revert in the immediate postoperative period.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"693-700"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kumar Vaibhav, Anurag Sahu, Ravi Shankar Prasad, Debabrata Deb, Devendra Kumar, Abjad Karimi
{"title":"Prediction of Postoperative Recurrence of Chronic Subdural Hematoma Using Preoperative Systemic Immune Inflammation Index and Eosinophils.","authors":"Kumar Vaibhav, Anurag Sahu, Ravi Shankar Prasad, Debabrata Deb, Devendra Kumar, Abjad Karimi","doi":"10.1055/s-0044-1789247","DOIUrl":"10.1055/s-0044-1789247","url":null,"abstract":"<p><p><b>Objective</b> Chronic subdural hematoma (CSDH) is a common neurological problem with significant recurrence after surgery. Risk considerations can vary, ranging from patient-related factors to those related to the surgical procedure. This study explores the association between preoperative eosinophil count and systemic immune inflammation (SII) with CSDH recurrence. <b>Materials and Methods</b> We conducted a prospective analysis of 105 patients with equal numbers of CSDHs who underwent surgery for CSDH between January 2023 and January 2024. The preoperative eosinophil counts, along with other differential leukocyte counts, were measured. The SII index was calculated using the standard formula (SII = neutrophil count × platelet count/lymphocyte count). Multivariate and univariate regression analyses were performed to assess the association between risk factors and CSDH recurrence. <b>Results</b> The preoperative eosinophil count showed a significant correlation with recurrence ( <i>p</i> < 0.001). The SII index was significantly higher in patients with recurrent CSDH ( <i>p</i> = 0.003). Neutrophils were found to be significantly associated with CSDH recurrence ( <i>p</i> = 0.038). Age ( <i>p</i> < 0.001) and SII ( <i>p</i> = 0.005) were found to be independent predictors of CSDH recurrence, whereas hematoma volume ( <i>p</i> < 0.001) and the antiplatelet regimen were a significant predictor of CSDH recurrence ( <i>p</i> = 0.047). Variables like male gender, diabetes mellitus, anticoagulants, and hematoma volume were associated with eosinophil-rich or eosinophil-poor status. <b>Conclusion</b> Preoperative eosinophil count, neutrophils, and the SII index may serve as potential predictors of CSDH recurrence. Further studies with larger sample sizes are needed to validate these findings.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"707-714"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Calvarial Tuberculosis: Shifting Paradigm from Surgical to Conservative Approach","authors":"Vivek Kumar, Varun Aggarwal, Gopal Krishna, Ishwar Singh, Vinay Vinay, Praveen S. Holkar","doi":"10.1055/s-0044-1788987","DOIUrl":"https://doi.org/10.1055/s-0044-1788987","url":null,"abstract":"\u0000 Background Tuberculosis (TB) is an endemic disease in developing countries like India. However, incidence of calvarial TB is very low and it presents in varied forms posing a diagnostic dilemma and delay in management.\u0000 Objectives This article reports a case series of 15 patients with varied presentations of calvarial TB from a tertiary care superspeciality center of Haryana state in India.\u0000 Material and Methods Study is a retrospective analysis of 15 patients with calvarial TB treated between 2018 and 2021 in a tertiary care hospital. Clinical features, radiological findings, surgical and medical management, and outcomes were reviewed.\u0000 Results Of the 15 patients, 9 were males and age ranged between 12 and 45 years. Mean duration of symptoms was 2.9 months (range 1–5 months). The most common presenting symptoms were scalp swelling, discharging sinus, and pain. Four patients were treatment defaulters of pulmonary TB and two patients were found human immunodeficiency virus positive. Brain imaging showed peripherally enhancing extradural collection with bone erosions in most cases. Eleven patients were managed conservatively with fine-needle aspiration cytology (FNAC) or local debridement/sinus excision. Four patients were managed surgically with drainage of collection, excision of necrotic bone, followed by antitubercular therapy. One patient needed cerebrospinal fluid diversion for associated hydrocephalous with tubercular meningitis which could not recover and succumbed.\u0000 Conclusion Calvarial TB is a rare occurrence of common prevalent diseases. Conservative management with FNAC and sinus excision followed by antitubercular treatment are the mainstay of treatment. Surgery should be reserved for extensive lesion or lesion with mass effect.","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"44 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141924204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metastatic Malignant Melanoma of Brain: A Rare Case Report.","authors":"Manoj Kumar Seervi, Surendra Jain, Ugan Singh Meena, Devendra Kumar Purohit","doi":"10.1055/s-0044-1788633","DOIUrl":"10.1055/s-0044-1788633","url":null,"abstract":"<p><p>Malignant melanoma is third most common cause of brain metastasis after lung and breast cancer. Most patients with brain metastases from malignant melanoma are diagnosed after treatment for known extracranial metastases and have a poor outcome despite various local and systemic therapeutic approaches. Here we discuss an unusual case of a 61-year-old male patient who presented with a brain metastasis as the initial disease presentation and the presumed primary lesion was later found in the gastrointestinal tract and the scalp. Treatment consisted of a surgical removal of the large intracranial lesion. Further evaluation for primary lesion was done by general physical examination, contrast-enhanced computed tomography (CECT) of the chest and whole abdomen. Apart from that, colonoscopy was done, and a biopsy was taken from a suspicious colonic lesion. The scalp pigmented lesion was also evaluated. Both biopsies were in favor of melanoma. Recently, management of metastatic melanoma of the brain is decided according to the number of lesions, accessibility, visceral metastasis, and resectability of the lesion. Various treatment options are surgical resection, whole brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS). Malignant melanoma is relatively radioresistant, so the results are debatable. In conclusion, the prognosis of intracranial malignant melanoma is determined by the following factors: (1) the type of lesion; (2) the involvement of the leptomeninges; (3) the extent of tumor excised; and (4) the molecular immunology borstel number 1 (MIB 1) antibody index, which is the most relevant factor for prognosis in this type of cancer.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"777-781"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac Arrest during Temporary Clipping for Ruptured Internal Carotid Artery Aneurysm: A Case Report.","authors":"Toshihiko Shimizu, Hiroshi Kosaka, Yuji Yamamoto","doi":"10.1055/s-0044-1788974","DOIUrl":"10.1055/s-0044-1788974","url":null,"abstract":"<p><p>Mechanical stimulation of the trigeminal nerve during craniofacial, skull base, or dental surgeries may cause bradycardia, hypotension, or cardiac arrest. This phenomenon is called trigeminal cardiac reflex (TCR). We encountered a rare case of a patient who experienced sinus arrest due to temporary clipping of the intracranial carotid artery during the clipping of a ruptured aneurysm. We discuss possible reasons for the occurrence of TCR in this case. A man in his 30s with no medical history presented with a sudden-onset headache. Computed tomography revealed a subarachnoid hemorrhage in the basal cistern and left Sylvian fissure. Angiography revealed a saccular aneurysm of the left internal carotid-anterior choroidal artery. A left frontotemporal craniotomy and dural incision were performed, followed by a trans-Sylvian approach. Cardiac arrest occurred twice during the temporary clipping of the intracranial carotid artery. After surgery, we performed a cardiac ultrasound echo and a 1-week Holter electrocardiogram. Neither showed abnormalities. No arrhythmia or cardiac events were observed over a one and half-year follow-up period. The cardiac arrest might have been triggered by the stimulation of the trigeminal nerve in the internal carotid artery. The repeated and anatomical features of this case suggest that TCR triggered cardiac arrest. The high probability that cardiac arrest was induced by trigeminal nerve stimulation should be considered during the temporary clipping of the internal carotid artery. However, the predisposing factors and exact underlying mechanisms for these arrhythmias remain unknown and require further investigation.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"787-790"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Are There Left-Right Differences in Ruptured Middle Cerebral Artery Bifurcation Aneurysms? A Single-Center Retrospective Study and Review of the Literature.","authors":"Joji Inamasu, Katsuya Saito","doi":"10.1055/s-0044-1788804","DOIUrl":"10.1055/s-0044-1788804","url":null,"abstract":"<p><p><b>Background</b> The left (Lt) and right (Rt) middle cerebral artery bifurcation (MCAB) aneurysms have mostly been regarded as identical. Considering substantial Lt-Rt differences in hemispheric infarction, however, the presence of Lt-Rt differences may not be denied totally in patients with ruptured MCAB aneurysms. We herein investigated whether such Lt-Rt differences existed by a single-center retrospective study. <b>Materials and Methods</b> Clinical data prospectively acquired between 2011 and 2021 on 99 patients with ruptured MCAB aneurysms were analyzed. They were dichotomized based on the laterality, and demographic and outcome parameters were compared. Additionally, a literature review was conducted to elucidate possible Lt-Rt differences in the frequency of ruptured MCAB aneurysms (Rt/Lt ratio). <b>Results</b> Among the 99 patients, 42 had Lt and 57 had Rt ruptured MCAB aneurysms, with the Rt/Lt ratio of 1.36. Neither demographic, radiographic, nor outcome variables differed significantly between the two groups. A total of 19 studies providing information on the laterality of the ruptured MCAB were retrieved by literature search. A sum total for the Lt and Rt MCAB aneurysms was 671 and 940, making the Rt/Lt ratio of 1.40. After adding our data, a sum total for the Lt and Rt MCAB aneurysms was 713 and 997, making the Rt/Lt ratio of 1.40. <b>Conclusion</b> The Rt ruptured MCAB aneurysms were 1.40 times more frequent than the Lt-sided counterpart. While there may be some Lt-Rt differences in the MCA anatomy, it remains to be seen whether such anatomical differences are truly responsible for the disproportionately higher frequency of Rt MCAB aneurysms.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"678-684"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endovascular Treatment of Ruptured Broad-Necked Intracranial Aneurysms with Double Microcatheter Technique: Case Series with Brief Review of Literature.","authors":"Mohan Karki, Girish Rajpal","doi":"10.1055/s-0044-1788803","DOIUrl":"10.1055/s-0044-1788803","url":null,"abstract":"<p><p><b>Objective</b> Treatment of ruptured broad-necked intracranial aneurysms by endovascular therapy is technically burdensome. It is commonly treated with stent- and balloon-assisted coils embolization. The aim of this study was to evaluate clinical and radiological outcomes following double micro-catheter (MC) technique. <b>Materials and Methods</b> A retrospective study was done on 16 broad-necked (neck diameter ≥ 4 mm and dome-to-neck ratio < 2) ruptured intracranial aneurysms in 16 patients treated with double MC technique at our center between December 2021 and December 2023. Clinical outcome was evaluated by modified Rankin Score, postcoiling radiological outcome was evaluated by Raymond-Roy occlusion grade, and treatment-related complications were assessed. <b>Results</b> There were 16 patients, 9 females and 7 males; with a mean age of 51.3 years (35-70 years). All the patients underwent dual MC coils embolization for all aneurysms. Raymond-Roy occlusion class I was achieved in 81.3% (13) cases and Raymond-Roy class II was achieved in 18.7% (3) cases immediately after the procedure. There were no serious postprocedure-related complications or recanalization of the aneurysm at the mean follow-up of 4.8 months (range 2-10 months). <b>Conclusion</b> Our study presents the safety and effectiveness of double MC system for treating ruptured broad-necked intracranial aneurysm. Large numbers of studies with longer follow-up period are required to secure validity of double MC technique.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"672-677"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shayan Huda, Souvik Singha, Ali Haidous, Phillip R Bukberg, Bidyut K Pramanik, Manju Harshan, Luis Medina Mora, Maria Devita, Amy McKeown, John A Boockvar
{"title":"Unraveling the Mystery of Rathke's Cleft Cyst Presenting with Hyponatremia: A Case Report with a Comprehensive Review of Literature.","authors":"Shayan Huda, Souvik Singha, Ali Haidous, Phillip R Bukberg, Bidyut K Pramanik, Manju Harshan, Luis Medina Mora, Maria Devita, Amy McKeown, John A Boockvar","doi":"10.1055/s-0044-1788618","DOIUrl":"10.1055/s-0044-1788618","url":null,"abstract":"<p><p>Rathke's cleft cyst (RCC) is a benign cystic lesion that is commonly discovered incidentally and remains asymptomatic in most cases. However, its association with the syndrome of inappropriate antidiuretic hormone (SIADH) secretion leading to hyponatremia (HN) is rare and has only been sporadically reported in the medical literature. In this article, we present a unique case of RCC manifesting with HN and discuss the diagnostic and management challenges encountered in a neurosurgical context. Additionally, we provide a comprehensive review of existing literature on RCC presenting with HN to enhance our understanding of this rare presentation. A 56-year-old woman with acute-onset blurry vision, headaches, and low fluid intake was diagnosed with euvolemic HN secondary to SIADH. Further evaluation revealed an intrasellar cystic lesion consistent with RCC, which was successfully resected through endoscopic transnasal transsphenoidal surgery, resulting in a complete recovery without the need for hormone replacement. The most likely explanation for the HN due to SIADH in this case is the release of accumulated antidiuretic hormone (ADH) due to compression by the cyst and the irritating effect of inflammation at this location. Accurate evaluation and classification of HN are essential for proper diagnosis and management, considering the rarity of RCC presenting with HN. A multidisciplinary approach to treatment can lead to favorable functional outcomes; however, further research is necessary to better comprehend this unique clinical entity and optimize neurosurgical approaches.</p>","PeriodicalId":94300,"journal":{"name":"Asian journal of neurosurgery","volume":"19 4","pages":"767-773"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}