{"title":"Do You Have a Backup Plan or Exit Strategy?","authors":"Kyle J Kramer","doi":"10.2344/725411","DOIUrl":"10.2344/725411","url":null,"abstract":"","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 3","pages":"107-108"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of Current Literature of Interest to the Office-Based Anesthesiologist.","authors":"Mark A Saxen","doi":"10.2344/466208","DOIUrl":"10.2344/466208","url":null,"abstract":"","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 3","pages":"158-160"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caroline M Sawicki, Daniel B McKim, Hongrui Wang, Morgan Vasas, Joshua J Blakeslee, Courtney A Jatana, Patrick Dib, Bryant W Cornelius, Spencer D Wade
{"title":"Stability of Epinephrine in a Normal Saline Solution.","authors":"Caroline M Sawicki, Daniel B McKim, Hongrui Wang, Morgan Vasas, Joshua J Blakeslee, Courtney A Jatana, Patrick Dib, Bryant W Cornelius, Spencer D Wade","doi":"10.2344/998301","DOIUrl":"10.2344/998301","url":null,"abstract":"<p><strong>Objective: </strong>Dilution of concentrated epinephrine prior to intravenous use during clinical emergencies can delay urgent interventions. The objective of this study was to determine whether diluted epinephrine remains stable and sterile over time in common hospital settings.</p><p><strong>Methods: </strong>Epinephrine samples were prepared by clinically relevant double dilution techniques. Samples were stored in 10-mL syringes and incubated under 1 of 4 simulated hospital environments with a mixture of lighting and temperature settings: 4°C/20°C, with or without fluorescent lighting. Samples were incubated for 0, 15, 30, 60, or 90 days. Capillary zonal electrophoresis was used to quantify the concentration of epinephrine and/or presence of any degradation products. All samples were tested for the presence of bacterial growth using blood agar cultures.</p><p><strong>Results: </strong>Diluted epinephrine samples remained stable for up to 90 days in all 4 simulated clinical storage conditions. No bacterial colony-forming units were detected in any of the environmental samples regardless of incubation duration, light, or temperature conditions.</p><p><strong>Conclusion: </strong>Diluted epinephrine for anticipated clinical emergencies may remain clinically useful for up to 90 days, thus improving patient safety, access to medications, and overhead costs by reducing waste.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 3","pages":"109-114"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anesthetic Management of a Pediatric Patient With Pfeiffer Syndrome.","authors":"Emiko Inoue, Chikako Owada, Ayumi Kiyohara, Tomoyuki Miyata, Hina Wajima, Yasuko Iwahori, Gentaro Tsujimoto, Asako Yasuda, Yoshiki Shionoya","doi":"10.2344/523400","DOIUrl":"10.2344/523400","url":null,"abstract":"<p><p>Pfeiffer syndrome (PS) is a rare inherited disorder that affects the craniofacial and extremity bones but can also include anomalies of the upper and lower airways. Among the 3 subtypes, PS types 2 and 3 are the most severe. We describe the anesthetic management of a 10-year-old boy with PS type 2 scheduled for dental treatment under general anesthesia. Because of his history of Chiari malformation, avoiding neck hyperextension was recommended to prevent worsening of his neurologic function. Preoperative computed tomography revealed significant nasal stenosis but no tracheal anomalies. Considering the difficulty of nasotracheal intubation, we planned for an oral intubation. General anesthesia was induced using sevoflurane, nitrous oxide, and oxygen along with an oropharyngeal airway. After lidocaine was topically applied to the oropharynx, fiber-optic orotracheal intubation was performed under spontaneous ventilation to minimize head and neck movement. Anesthesia was maintained using desflurane and remifentanil, and no postoperative complications were observed. General anesthesia for patients with PS requires careful planning, which should include preoperative assessment of the airway to determine the feasibility of nasotracheal intubation and identify airway irregularities.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 3","pages":"140-144"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dental Sedation and General Anesthesia Considerations for Patients Posthepatic Transplantation.","authors":"Tiffany Hoang, Alon Frydman, Regina A E Dowdy","doi":"10.2344/616992","DOIUrl":"10.2344/616992","url":null,"abstract":"<p><p>Hepatic compromise poses significant impacts upon the care of patients undergoing routine dental treatment. When sedation or general anesthesia is planned for dental treatment or oral and maxillofacial surgery, an understanding of basic liver function and clinical evaluation can assist in adapting treatment modifications for patients with limited function due to previous disease and resultant organ transplantation efforts. Beginning with a basic overview of hepatic physiology, this review will outline the specific functions of digestion, metabolism, synthesis, and detoxification involving the liver. Specific clinical considerations will be reviewed regarding comorbidities that develop prior to and after liver transplantation that often impact a patient's suitability for ambulatory and office-based care. Lastly, choices in both local anesthetics, sedative medications, general anesthetics, and postoperative analgesics utilized in dental treatment will be discussed.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 3","pages":"149-157"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anesthesia progressPub Date : 2024-07-08DOI: 10.2344/anpr-71-2_continuing_edu
Tiffany Hoang, Regina A E Dowdy
{"title":"Review of Inherited Coagulation Disorders.","authors":"Tiffany Hoang, Regina A E Dowdy","doi":"10.2344/anpr-71-2_continuing_edu","DOIUrl":"10.2344/anpr-71-2_continuing_edu","url":null,"abstract":"<p><p>Most invasive dental procedures elicit some degree of bleeding which ultimately leads to clotting and eventual hemostasis. However, patients with inherited coagulation disorders may exhibit prolonged or, in some cases, excessive bleeding requiring multiple perioperative interventions. Von Willebrand disease is the most common inherited coagulopathy and often manifests via easy bruising, epistaxis, or prolonged bleeding. Hemophilia A (factor VII) and B (factor IX) are factor deficiencies that are clinically indistinguishable and managed according to severity and the required dental treatment. Other coagulopathies are rare (ie, inheritance is autosomal recessive) and may only become evident in homozygotes or compound heterozygotes. Current lab values and medical consultation with the patient's hematologist are imperative prior to rendering invasive dental treatment. There are a myriad of sedation and general anesthesia considerations, including risks for epistaxis with nasal instrumentation and bruising with improper patient positioning. Preoperative treatment with desmopressin or factor replacement may be required and generally should facilitate normal hemostasis. Additional therapies should be considered to help ensure adequate postoperative hemostasis, including pressure dressings, resorbable clotting materials, laser therapy, and oral rinses.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 2","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Memoriam: Dr Stuart E. LieblichOctober 14, 1955-February 28, 2024.","authors":"Robert C Bosack","doi":"10.2344/anpr-566035","DOIUrl":"10.2344/anpr-566035","url":null,"abstract":"","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 2","pages":"106"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of Current Literature of Interest to the Office-Based Anesthesiologist.","authors":"Mark A Saxen","doi":"10.2344/809216","DOIUrl":"10.2344/809216","url":null,"abstract":"","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 2","pages":"96-98"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of Rocuronium and Sugammadex for a Patient With Controlled Polymyositis: A Case Report.","authors":"Hidetaka Kuroda, Tomomi Katayama, Atsuki Yamaguchi, Norika Katagiri, Shota Tsukimoto, Uno Imaizumi, Takuro Sanuki","doi":"10.2344/021627","DOIUrl":"10.2344/021627","url":null,"abstract":"<p><p>Muscle relaxants and their reverse drugs should be carefully administered to patients with acute polymyositis and/or dermatomyositis. However, the use of these drugs in controlled polymyositis and/or dermatomyositis is controversial. This case report describes the use of rocuronium and sugammadex in a 27-year-old female patient with controlled polymyositis who was scheduled for minor oral surgery under general anesthesia. General anesthesia was induced rapidly, and 0.66 mg/kg of rocuronium was administered prior to nasotracheal intubation. No additional muscle relaxants were administered during the surgery. At the end of surgery, approximately 2 hours after the rocuronium was administered, her train-of-four (TOF) ratio was still 49%. A dose of 3.3 mg/kg of sugammadex was administered, and it took 12 minutes for the TOF ratio to exceed 90%. The prolonged duration of muscle relaxation in patients with polymyositis may be due to a decrease in skeletal muscle and capillary volume. The slow onset of sugammadex may be caused by slow diffusion of rocuronium from the neuromuscular junction. Patients with polymyositis require close perioperative neuromuscular function monitoring, regardless of their disease control status.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 2","pages":"81-84"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}