Actas urologicas espanolas最新文献

{"title":"The future of prostate cancer screening in the European Union: PRAISE-U project","authors":"J. Gómez Rivas ,&nbsp;P. Gómez Dávila ,&nbsp;A.M. Tarrazo Antelo ,&nbsp;M. Corujo Quinteiro ,&nbsp;Á. Gómez Amorín ,&nbsp;A. Rodríguez Alonso ,&nbsp;J.M. Vilaseca ,&nbsp;H. López ,&nbsp;J.P. Salazar ,&nbsp;Á. Borque-Fernando ,&nbsp;J. Moreno-Sierra ,&nbsp;S. Collen ,&nbsp;K. Beyer ,&nbsp;J. Helleman ,&nbsp;M.J. Roobol ,&nbsp;H. van Poppel ,&nbsp;en representación de PRAISE-U Consortium","doi":"10.1016/j.acuroe.2026.501919","DOIUrl":"10.1016/j.acuroe.2026.501919","url":null,"abstract":"<div><h3>Introduction</h3><div>Prostate cancer (PCa) remains one of the leading public health challenges among European men. Despite technological advances, its early detection continues to be controversial due to the risk of overdiagnosis and the limited adoption of organized screening programs.</div></div><div><h3>Materials and methods</h3><div>A review was conducted of scientific literature, institutional reports, and technical documentation from the PRAISE-U project. We describe the key components of its design, implementation and lessons learned at two pilot sites in Spain (Galicia and Manresa), with a focus on personalized strategies and operational efficiency.</div></div><div><h3>Results</h3><div>Based on the European Union recommendation of 2022, the PRAISE-U project promotes a risk-based screening program that incorporates prostate-specific antigen (PSA), magnetic resonance imaging (MRI) and risk calculators (RC). Galicia and Manresa have developed screening circuits adapted to their health systems. Galicia has managed to invite 7000 of the 12,000 target men in less than a year, integrating digital tools and direct contact strategies. Manresa, from primary care, has developed a coordinated approach focused on accessibility and traceability. Both models prioritize equity, adherence and minimization of overtreatment.</div></div><div><h3>Conclusions</h3><div>The PRAISE-U project offers an innovative and adaptable framework for PCa screening in Europe. The Spanish experience demonstrates that it is possible to implement effective and risk-focused early detection programs, provided that there is sound planning, technological tools and a collaborative approach between levels of care.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501919"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection and inflammation of the seminal tract: A review of its relationship to male fertility","authors":"Á. Vives Suñé ,&nbsp;M. Cosentino","doi":"10.1016/j.acuroe.2026.501899","DOIUrl":"10.1016/j.acuroe.2026.501899","url":null,"abstract":"<div><h3>Introduction</h3><div>In 1997, the WHO established the role of genital tract infections in human infertility, currently responsible for 15% of the causes of infertility in men. The WHO classifies urethritis, prostatitis, vesiculitis, orchitis, and epididymitis as infections of the male accessory gland. This paper represents the state of the art on inflammation and infection of seminal tract. Objective of the study is to revise literature and to discuss regarding association to fertility.</div></div><div><h3>Methods</h3><div>A literature search was performed on PubMed database (<span><span>http://www.pubmed.gov</span><svg><path></path></svg></span>) for peer-reviewed journal articles relating to STD, UTI, Diagnosis and Treatment and Fertility. We carefully evaluated the most representative reports published in literature and all papers results were supported by European and American guidelines results on theme.</div></div><div><h3>Results</h3><div>Seminal tract infections may cause infertility by different mechanisms. Traditionally, the most common infectious causes of male infertility were sexually transmitted infections, especially <em>Neisseria gonorrhoeae</em>. However, the most frequent causes of infection of the seminal tract are <em>Chlamydia</em> trachomatis, <em>Microplasma</em> spp., especially <em>Ureaplasma urealyticum</em> and the gram-negative bacteria typical of urogenital infections. When classifying seminal tract infections, it must be considered whether or not these are sexually transmitted, and treat both partners for Sexual Transmitted Diesase if necessary (STI). There is evidence that treating STIs leads to improved semen parameters. Although antibiotics can improve sperm quality and reduce DNA fragmentation values, there is no evidence that they increase the probability of natural conception.</div></div><div><h3>Conclusions</h3><div>Taking into account the highly prevalence of infective or inflammatory affections of the male genital tract, its clearly stablished association with infertility and that a remarkable percentage of sexual transmitted infections (STI) are asymptomatic, we believe that these infections must be ruled out during the initial andrological evaluation in couples seeking fertility.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501899"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urachal adenocarcinoma: Case report, literature review, and therapeutic algorithm proposal","authors":"P. Guedes Oliva ,&nbsp;P. Jiménez Marrero ,&nbsp;R. Espino Espino ,&nbsp;R. Marrero Domínguez ,&nbsp;E. Perera Gordo","doi":"10.1016/j.acuroe.2026.501916","DOIUrl":"10.1016/j.acuroe.2026.501916","url":null,"abstract":"<div><div>Urachal adenocarcinoma is an extremely rare malignancy, accounting for less than 1% of all bladder tumors. Diagnosis is often delayed due to nonspecific symptoms and low clinical suspicion. We report the case of a 52-year-old male with no relevant medical history who presented with lower urinary tract symptoms. Cystoscopy revealed a cystic lesion at the bladder dome. Transurethral resection confirmed mucinous urachal adenocarcinoma. CT imaging showed no locoregional or distant spread, and tumor markers were within normal limits. The patient underwent laparoscopic partial cystectomy with en bloc excision of the urachus and umbilicus plus bilateral pelvic lymphadenectomy. Final pathology confirmed a Sheldon stage IIIA mucinous cystadenocarcinoma. At 25 months of follow-up, the patient remains free of disease recurrence. Given its low prevalence and aggressive nature, accurate diagnosis and appropriate surgical management are critical. While surgery remains the cornerstone in localized disease, the role of systemic therapy remains unclear. Immunotherapy and targeted therapies are emerging as promising options in advanced stages. This case illustrates the diagnostic challenges and emphasizes the importance of surgical planning and long-term surveillance in the absence of standardized treatment guidelines. Midline bladder lesions should prompt suspicion of urachal adenocarcinoma. Complete surgical excision is essential, with lymphadenectomy and systemic therapy considered on a case-by-case basis. Long-term follow-up is necessary due to the high risk of recurrence.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501916"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urology week under the MEDIUVer-UROLATAM model for the development of university-led actions with social impact","authors":"J.C. Viñas Dozal ,&nbsp;R. Edel Navarro ,&nbsp;A.M. Autrán Gómez ,&nbsp;F. Ruiz García ,&nbsp;V.G. Rojas Hernández ,&nbsp;J.M. Hurtado Capetillo ,&nbsp;C. Palmeros Exsome ,&nbsp;E. Castellanos Contreras ,&nbsp;A. Báez Jiménez ,&nbsp;J.E. Villegas Dominguez","doi":"10.1016/j.acuroe.2026.501913","DOIUrl":"10.1016/j.acuroe.2026.501913","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>uROLOGIC health is a global priority, particularly in Latin America, where access to quality services remains limited. This underscores the importance of collaboration among key societal sectors, including the public, private, and academic domains. The MEDIUVer-UROLATAM model emerges as a university-led urological health strategy aimed at promoting socially impactful health initiatives. It is grounded in core university functions, collaborative work, and a targeted approach to specific social needs. The objective was to demonstrate the utility of the MEDIUVer-UROLATAM model as a framework for facilitating prostate cancer (PCa) detection and prevention actions.</div></div><div><h3>Material and methods</h3><div>The MEDIUVer model was implemented in three stages through a urological campaign coordinated by the Latin American Institute of Urology (UROLATAM) and the Faculty of Medicine at Universidad Veracruzana. The initiative involved collaboration with the private sector, government agencies, and the community to facilitate the early detection of prostate cancer. Medical evaluations, diagnostic tests, and educational activities were conducted.</div></div><div><h3>Results</h3><div>A total of 1656 individuals were attended, with 1352 urological evaluations performed. The first stage focused on social action, the second strengthened inter-institutional collaboration, and the third incorporated educational research and healthcare services for the transgender population. This approach led to greater stakeholder integration and an expanded social impact.</div></div><div><h3>Conclusions</h3><div>The MEDIUVer–UROLATAM model is an educational, training, and care-oriented tool for both the general population and healthcare professionals in terms of timely prostate cancer (PCa) detection and prevention.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501913"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial comment on the article «Perioperative and periprocedural management of antithrombotic therapy: 2025 consensus document of SEC, SEDAR, SEACV, SECCE, AEC, SECOM CYC, SECPRE, SEPD, SEGG, SEGO, SEHH, SETH, SEMERGEN, SEMFYC, SEMG, SEMICYUC, SEMI, SEMES, SEN, S.E.N., SENEC, SEPAR, SEO, SEORL-CCC, SEPA, SERVEI, SECOT, and AEU»","authors":"L. Ibáñez Vázquez,&nbsp;J.F. Hermida Gutiérrez,&nbsp;J. Moreno Sierra","doi":"10.1016/j.acuroe.2026.501931","DOIUrl":"10.1016/j.acuroe.2026.501931","url":null,"abstract":"","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501931"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping open surgical skills: Eight years of reconstructive urology simulation training in the UK","authors":"S. Rahman ,&nbsp;H. wen Ho ,&nbsp;C. Shekhar Biyani ,&nbsp;M. Hamid Elmamoun ,&nbsp;V. Hanchanale ,&nbsp;S. Jain ,&nbsp;B. Hickerton ,&nbsp;A. Hoyle ,&nbsp;A. Turner","doi":"10.1016/j.acuroe.2026.501920","DOIUrl":"10.1016/j.acuroe.2026.501920","url":null,"abstract":"<div><h3>Objective</h3><div>The Urology Simulation Bootcamp Course (USBC) was developed to address the lack of a structured national programme for practical urological skills training. Feedback from urology colleagues and trainees highlighted the need for focused procedural teaching, particularly in reconstructive urology. In response, a dedicated reconstructive skills module was established within the USBC in 2015. A descriptive report of a structured educational module is presented.</div></div><div><h3>Methods</h3><div>The module concentrated on four key reconstructive procedures: small bowel anastomosis, stoma formation, uretero-ileal anastomosis, and repair of ureteric and bladder injuries. This hands-on training was delivered with a high faculty-to-trainee ratio, allowing one-to-one mentorship. Faculty recruitment was based on subspecialist expertise and enthusiasm for medical education, ensuring high-quality instruction and one-to-one training. Continuous evaluation and feedback from participants shaped iterative improvements to course content and delivery. Feedback was collated from 2016 onwards, which facilitated the revision of the course over subsequent iterations.</div></div><div><h3>Results</h3><div>Over eight years, 378 trainees participated in the course. Delegates consistently praised the programme, particularly the individualised mentoring and the quality of tissue models used. The evolving curriculum, informed by systematic feedback, ensured relevance and sustainability. One notable adaptation was reducing the time devoted to small bowel anastomosis in order to expand training on ureteric reimplantation and bladder repair, reflecting delegate preferences and clinical relevance.</div></div><div><h3>Conclusion</h3><div>Our simulation-based approach to teaching reconstructive urological skills has demonstrated extremely positive results from the delegates consistently over the eight-year period. Focused mentorship and amendments based on feedback have been vital in ensuring a high degree of satisfaction throughout the evolution of the course.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501920"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective pelvic radiotherapy in prostate cancer: The sunset of a historical practice","authors":"A. Ocanto ,&nbsp;F. López-Campos ,&nbsp;P. Ost ,&nbsp;F. Couñago","doi":"10.1016/j.acuroe.2026.501923","DOIUrl":"10.1016/j.acuroe.2026.501923","url":null,"abstract":"","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501923"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current landscape of surgical training and simulation in urology: A multinational study of residency programs in the American Confederation of Urology","authors":"G. Gentili ,&nbsp;N. Paesano ,&nbsp;M. Barreto ,&nbsp;G. Castillo ,&nbsp;T. Mierzwa ,&nbsp;A. Hernández Méndez ,&nbsp;M. Falcioni ,&nbsp;F. Santomil ,&nbsp;A.M. Autrán Gómez ,&nbsp;I. Tobia-González ,&nbsp;A. Rodríguez ,&nbsp;en nombre del Grupo de Trabajo del Proyecto PRYUS-CAU","doi":"10.1016/j.acuroe.2026.501915","DOIUrl":"10.1016/j.acuroe.2026.501915","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical training in urology has undergone significant transformation due to the increasing complexity of procedures and the integration of advanced technologies. Simulation-based education is recognized as a fundamental component of residency programs. This study aimed to evaluate the current status of surgical training and the availability of simulation resources for urology residents and early-career urologists in the countries represented by the American Confederation of Urology.</div></div><div><h3>Methods</h3><div>A descriptive, cross-sectional survey was conducted with 402 participants from 19 countries. The questionnaire included multiple-choice questions addressing demographics, access to surgical procedures, simulation tools, evaluation methods, mentorship, and the impact of the COVID-19 pandemic.</div></div><div><h3>Results</h3><div>The study revealed significant heterogeneity in surgical training. Only 17.9% had access to robotic surgery and 32.8% to prostate enucleation. Over 80% reported the absence of virtual or wet labs at their institutions. Training was based on step-by-step instruction (89.9%), in laparoscopic (45%) and endoscopic (50.7%). However, 15.7% used simulators during surgical procedures. Additionally, 50.6% reported the absence of formal assessment or mentorship. Fellowship training was considered in 84.7%. The COVID-19 pandemic negatively impacted academic (50.3%) and surgical (66.9%) training.</div></div><div><h3>Conclusions</h3><div>The findings highlight considerable variability in surgical training, limited access to simulation resources, and a general absence of standardized evaluation and mentorship systems. These results emphasize the need to implement structured and equitable training that incorporate simulation, these offer a safe and effective environment for developing surgical skills.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501915"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANCOIT study: Pilot study on the prevention of recurrent postcoital urinary tract infection in women with d-mannose plus proanthocyanidins (PAC)","authors":"E. López Pérez ,&nbsp;V. García-Astillero Vallecillo ,&nbsp;J.M. Gómez de Vicente ,&nbsp;S. Bravo Marín ,&nbsp;Á. Yebes ,&nbsp;C. de Castro Guerín ,&nbsp;M.J. García-Matres y Cortés ,&nbsp;J.A. Maínez Rodríguez ,&nbsp;N. Cámara Llorente ,&nbsp;C. Iglesias García ,&nbsp;L. Martínez-Piñeiro Lorenzo","doi":"10.1016/j.acuroe.2026.501911","DOIUrl":"10.1016/j.acuroe.2026.501911","url":null,"abstract":"<div><h3>Introduction</h3><div>Urinary tract infections (UTIs) are common among women, and approximately 20–30% experience recurrent episodes (rUTIs). The increasing prevalence of antimicrobial resistance highlights the need for non-antibiotic preventive strategies. <span>d</span>-mannose and proanthocyanidins (PAC) have shown potential in reducing rUTIs. The aim of this study was to evaluate the efficacy of a combination of <span>d</span>-mannose and PAC in preventing postcoital UTIs over a 6-month period.</div></div><div><h3>Materials and methods</h3><div>We conducted a prospective, single-center pilot study including 26 women aged 18–45 years with a history of recurrent postcoital UTIs. Participants received a daily prolonged-release formulation containing <span>d</span>-mannose (2000 mg) and PAC (140 mg) for 6 months. The primary outcome was the incidence of postcoital UTI episodes. Secondary outcomes included treatment adherence, episode severity, microbiological findings, safety, quality of life, and patient-reported improvement. Analyses were performed on both the intention-to-treat (ITT) and per-protocol (PP) populations.</div></div><div><h3>Results</h3><div>At 6 months, 53.6% of participants had no new UTI episodes. A total of 24 episodes were recorded in 12 women, with more than two-thirds concentrated in a small subgroup. Overall, UTI incidence decreased significantly (<em>p</em> = 0.01), and 76.2% of participants remained infection-free at the final visit. Adherence was high (90.9% at 3 months and 85.7% at 6 months). Positive urine cultures most frequently identified <em>Klebsiella aerogenes</em> and <em>Escherichia coli</em>. Sexual function remained stable, and 80.9% of women reported subjective improvement. Only one withdrawal occurred due to vaginal dryness.</div></div><div><h3>Conclusions</h3><div>The combination of <span>d</span>-mannose and PAC in a prolonged-release formulation appears to be a promising, safe, and well-tolerated strategy for the prevention of postcoital rUTIs in young women. Larger randomized controlled trials are warranted to confirm these preliminary findings.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501911"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local prostate cancer recurrence after radiotherapy or brachytherapy. What now? Retrospective analysis of salvage prostatectomy and salvage cryoablation","authors":"C. Martínez Osorio ,&nbsp;P. de Pablos-Rodríguez ,&nbsp;N. Valdés Figueroa ,&nbsp;M. Beamud Cortés ,&nbsp;C. Gutiérrez Castañé ,&nbsp;Á. Gómez-Ferrer Lozano ,&nbsp;A. Wong Gutiérrez ,&nbsp;Y. Murria Pérez ,&nbsp;B. Sanvictor Beneito ,&nbsp;A. Calatrava Fons ,&nbsp;J. Patiño Aliaga ,&nbsp;Á. García Cortés ,&nbsp;J.A. López González ,&nbsp;V. Rodríguez-Part ,&nbsp;P. Pelechano Gómez ,&nbsp;J.L. Casanova Ramón-Borja","doi":"10.1016/j.acuroe.2026.501914","DOIUrl":"10.1016/j.acuroe.2026.501914","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Local recurrence after radiotherapy for prostate cancer poses a significant clinical challenge, and the lack of robust comparative evidence limits clear therapeutic guidance. This study aimed to assess oncological outcomes of salvage radical prostatectomy (SRP) versus salvage cryoablation (SCA) in patients with localized radio-recurrent disease.</div></div><div><h3>Materials and methods</h3><div>A retrospective, single-centre cohort study was conducted including hormone-sensitive prostate cancer patients with local recurrence after external beam radiotherapy or brachytherapy, treated between 2007 and 2024. The primary endpoint was biochemical recurrence-free survival (BCR-FS) at 3 and 5 years. Secondary endpoints included additional treatment-free survival (AT-FS), metastasis-free survival (MFS), and recurrence predictors. Kaplan-Meier and multivariate logistic regression analyses were performed.</div></div><div><h3>Results</h3><div>A total of 56 patients were included: 32 treated with SRP and 24 with SCA. Median follow-up was significantly longer in the SCA group (8.2 vs. 3.8 years, <em>P</em> &lt; .05). BCR-FS at 3 and 5 years was 47% and 37% in the SCA group and 43% and 32% in the SRP group (<em>P</em> &gt; .05). Five-year AT-FS was 40% (SCA) vs. 55% (SRP; <em>P</em> = .32), and MFS was 85% (SCA) vs. 83% (SRP; <em>P</em> = .92). A Gleason score ≥ 8 at recurrence was independently associated with higher risk of recurrence (OR 7.7; 95% CI: 1.3–47; <em>P</em> = .02).</div></div><div><h3>Conclusions</h3><div>SRP and SCA showed similar oncological outcomes. Gleason ≥ 8 was the only factor related to poor outcomes. Given the low chance of cure after salvage therapies, SCA may be an adequate option in these patients.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501914"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}