CHEST pulmonary最新文献

{"title":"Bronchoscopy Without Sedation in Healthy Volunteers","authors":"Dean Kellogg III MD , Diego Maselli MD , Kevin Proud MD , Eusondia Arnett PhD , Larry S. Schlesinger MD , Jay I. Peters MD","doi":"10.1016/j.chpulm.2024.100075","DOIUrl":"10.1016/j.chpulm.2024.100075","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"2 4","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141711904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 53-year-old woman with stage IV non-small cell lung cancer presenting with progressive paratracheal lymphadenopathy.","authors":"A. Goizueta, Aileen Anglin, Bruce F. Sabath","doi":"10.1016/j.chpulm.2024.100081","DOIUrl":"https://doi.org/10.1016/j.chpulm.2024.100081","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"8 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141716748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pirfenidone on Patient-Reported Outcomes in Patients With Idiopathic Pulmonary Fibrosis From the Pulmonary Fibrosis Foundation Patient Registry","authors":"Mohleen Kang, Sachin Gupta, Yi-Hsuan Tu, Karina Raimundo, Anisha M. Patel, Kevin R. Flaherty","doi":"10.1016/j.chpulm.2024.100082","DOIUrl":"https://doi.org/10.1016/j.chpulm.2024.100082","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"49 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic mutations conferring alpha-1 antitrypsin deficiency are accurately identified by a novel multiplexed molecular assay","authors":"E. Decurtis, S. Kuss-Duerkop, Iara M.P. Machado, Zoe P. Stewart, Matt Jackson, E. Hasenohr, Jessica L. Crumby, S.D. Groshong, C. Coeshott, R. Harbeck, James Woodrow, R. Sandhaus, Yongbao Wang","doi":"10.1016/j.chpulm.2024.100076","DOIUrl":"https://doi.org/10.1016/j.chpulm.2024.100076","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"143 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to improve quality of life and knowledge in Hypersensitivity Pneumonitis, a survey of clinician practices and perspectives.","authors":"Kerri I. Aronson, N.M. Holbrook, A. Edgar, Michael Anderson, Jamuna K. Krishnan, R. Kaner, A. Podolanczuk, F.J. Martinez, Johnathan N. Tobin, M.M. Safford","doi":"10.1016/j.chpulm.2024.100083","DOIUrl":"https://doi.org/10.1016/j.chpulm.2024.100083","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"39 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Efficacy of Dupilumab in Moderate-to-Severe Asthma Phenotyped by Blood Eosinophils and Exhaled Nitric Oxide","authors":"Michael E. Wechsler, Ian D. Pavord, A. Papi, Kenneth R. Chapman, A. Altincatal, N. Pandit-Abid, J. Jacob-Nara, Paul J Rowe, Y. Deniz, E. Laws, B. Akinlade, Nikhil Amin, H. Staudinger, D. Lederer, M. Hardin","doi":"10.1016/j.chpulm.2024.100072","DOIUrl":"https://doi.org/10.1016/j.chpulm.2024.100072","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"348 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Lung Function in Asthma Across the Ages","authors":"Celine Chedraoui MD , Battoul Fakhry MD , Joelle Sleiman MD , Bo Hu PhD , Amy Attaway MD , Peter Bazeley MD , Hyun Jo Kim MS , Peng Zhang MD , Joe G. Zein MD, PhD","doi":"10.1016/j.chpulm.2024.100047","DOIUrl":"10.1016/j.chpulm.2024.100047","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"2 2","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949789224000138/pdfft?md5=75b83b575f4ae0481188e80fe2d808cb&pid=1-s2.0-S2949789224000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Yield of Cone Beam CT Combined With Radial-Endobronchial Ultrasound for the Diagnosis of Peripheral Pulmonary Nodules","authors":"Michael V. Brown ,&nbsp;Arash Badiei ,&nbsp;Matthew Arnold ,&nbsp;Hubertus Jersmann ,&nbsp;Thomas Sullivan ,&nbsp;David Fielding ,&nbsp;Phan Nguyen","doi":"10.1016/j.chpulm.2024.100037","DOIUrl":"10.1016/j.chpulm.2024.100037","url":null,"abstract":"<div><h3>Background</h3><p>Identification of peripheral pulmonary nodules (PPNs) is becoming increasingly common with modern imaging and lung cancer screening programs. Navigational bronchoscopy has been developed to augment the diagnostic yield of sampling these nodules. Cone beam CT (CBCT) scan is one navigational tool which can be used alongside the historical criterion standard of fluoroscopy and radial endobronchial ultrasound (r-EBUS).</p></div><div><h3>Research Question</h3><p>What is the diagnostic yield and safety profile of combining CBCT scan with r-EBUS for the diagnosis of PPNs?</p></div><div><h3>Study Design and Methods</h3><p>Embase, PubMed, and Cochrane Central Register of Controlled Trials were searched in March 2023. Eligible studies used CBCT scan with r-EBUS as the primary navigation technique. The primary outcome, diagnostic yield, was analyzed using random effects meta-analysis. Additional subgroup analysis was based on the use of additional navigational technologies. Risk of bias was assessed using the Critical Appraisal Skills Programme tool for diagnostic studies. The Grading of Recommendations Assessment, Development, and Evaluation tool was used to assess the quality of outcomes.</p></div><div><h3>Results</h3><p>Fourteen studies (865 patients and 882 lesions) were included. The risk of bias was significant as assessed using the Critical Appraisal Skills Programme tool, which identified multiple confounders. The pooled diagnostic yield of combined CBCT scan and r-EBUS-guided biopsy for the diagnosis of PPNs was 80% (95% CI, 76%-84%). Subgroup analysis of diagnostic yield for CBCT scan and r-EBUS alone was 80% (95% CI, 76%-83%). The diagnostic yield of CBCT scan and r-EBUS combined with additional navigational technology (electromagnetic navigational bronchoscopy, virtual bronchoscopic navigation, and robotic-assisted bronchoscopy) was 80% (95% CI, 73%-87%). The quality of outcomes was assessed as low to very low using the Grading of Recommendations Assessment, Development, and Evaluation tool. There was a 2.01% pneumothorax rate and 1.08% bleeding rate. Although heterogeneously reported, the total radiation dose was between 19.59 and 85.9 Gy.cm², resulting in an approximate effective dose range of 3.1 to 13.8 mSv.</p></div><div><h3>Interpretation</h3><p>CBCT scan and r-EBUS for the diagnosis of PPNs has a high diagnostic yield and acceptable safety profile. Studies showed moderate heterogeneity with significant bias; hence, generalizability of the study is limited and further prospective trials are required.</p></div><div><h3>Clinical Trial Registration</h3><p>PROSPERO; No.: CRD42023410221; URL: <span>https://www.crd.york.ac.uk/prospero/</span><svg><path></path></svg>.</p></div>","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"2 2","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949789224000035/pdfft?md5=bc2aa3bf83825252aa53afcfceb99568&pid=1-s2.0-S2949789224000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139635622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Is Life After Severe COVID-19?","authors":"Maurizio Bernasconi MD ,&nbsp;Camelia Voinea MD ,&nbsp;Luca Sardella MD ,&nbsp;Alessandro Felice Chiesa MD ,&nbsp;Marco Previsdomini MD ,&nbsp;Andreas Perren MD ,&nbsp;Claudia Gamondi MD ,&nbsp;Adam Ogna MD","doi":"10.1016/j.chpulm.2024.100056","DOIUrl":"10.1016/j.chpulm.2024.100056","url":null,"abstract":"<div><h3>Background</h3><p>Data on long-term outcomes of COVID-19-related ARDS are scarce and rely largely on patient-reported outcomes. This study aimed to study cardiopulmonary function combined with psychosocial sequelae in a cohort of patients with severe COVID-19 requiring ICU management and intubation, with a follow-up of 12 months.</p></div><div><h3>Research Question</h3><p>What are the functional and psychosocial sequelae 1 year after severe COVID-19 requiring ICU management and intubation?</p></div><div><h3>Study Design and Methods</h3><p>We studied a longitudinal cohort of 39 mechanically ventilated patients with COVID-19 from the early phase of the pandemic. Pulmonary function test results, cardiopulmonary exercise testing findings, and subjective health perception data from 6 and 12 months after ICU admission were collected.</p></div><div><h3>Results</h3><p>Twelve months after COVID-19, 19.3% of participants showed at least moderate alteration in pulmonary function test findings, and 35.7% of participants showed a pathologically reduced effort capacity by cardiopulmonary exercise testing. A considerable impact on daily activities was reported, with only 41.7% of participants being able to resume work entirely and 71% reporting a relevant health impairment resulting from residual respiratory symptoms. The health perception scores did not correlate significantly with the measured cardiopulmonary performance or lung function.</p></div><div><h3>Interpretation</h3><p>A persistent objective limitation in physical activity was observed in this population of unvaccinated patients from the early phase of the pandemic, studied for 12 months after recovery from COVID-19-related ARDS. Patients also reported a profound impact on functional autonomy, daily activities, professional life, and health perception. Despite being attributed primarily to residual respiratory symptoms, the observed health impairment is probably multifactorial, with physical and psychological factors playing a role. The prolonged course of the symptoms and the underlying complexity should be considered in future programs for the care of patients who have recovered from COVID-19.</p></div>","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"2 2","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949789224000229/pdfft?md5=f1de51350138f46b2577d19100492a62&pid=1-s2.0-S2949789224000229-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone-Beam CT Scan-Guided Peripheral Bronchoscopy","authors":"Matthew Aboudara MD, FCCP, DAABIP ,&nbsp;James Katsis MD, DAABIP","doi":"10.1016/j.chpulm.2024.100045","DOIUrl":"10.1016/j.chpulm.2024.100045","url":null,"abstract":"","PeriodicalId":94286,"journal":{"name":"CHEST pulmonary","volume":"2 2","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949789224000114/pdfft?md5=5e788aa969ce3cb5e382ce215c5ec9d9&pid=1-s2.0-S2949789224000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140277625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}