WMJ : official publication of the State Medical Society of Wisconsin最新文献

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Lung Adenocarcinoma in Primary Ciliary Dyskinesia: A Case Report of Metastatic Disease and Successful Multimodal Treatment. 原发性纤毛运动障碍的肺腺癌:一例转移性疾病和成功的多模式治疗。
Vishnu Kommineni, Rathnamitreyee Vegunta, Venkata Rokkam, Gurusaravanan Kutti Sridharan
{"title":"Lung Adenocarcinoma in Primary Ciliary Dyskinesia: A Case Report of Metastatic Disease and Successful Multimodal Treatment.","authors":"Vishnu Kommineni, Rathnamitreyee Vegunta, Venkata Rokkam, Gurusaravanan Kutti Sridharan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired mucociliary clearance. To our knowledge, no cases of lung adenocarcinoma in patients with PCD have been previously reported.</p><p><strong>Case presentation: </strong>A 43-year-old White man with PCD presented with persistent cough and dysphonia. Chest imaging revealed a 4-cm mass in the left upper lobe, and positron emission tomography/computed tomography (PET/CT) demonstrated increased uptake in the mass, hilar lymph nodes, and sternum, suggesting metastatic disease. Biopsy of the lung mass confirmed adenocarcinoma, and magnetic resonance imaging of the brain identified a metastatic lesion. He was treated initially with pembrolizumab and stereotactic radiation therapy for a brain metastasis and had a mixed response. Consequently, chemotherapy with carboplatin and pemetrexed was added, resulting in complete response, with no fluorodeoxyglucose-avid lesions on follow-up PET imaging.</p><p><strong>Discussion: </strong>With only 8 reported cases of lung cancer in patients with PCD, this is, to our knowledge, the first report of lung adenocarcinoma in a patient with PCD successfully treated with chemoimmunotherapy.</p><p><strong>Conclusions: </strong>Although rare, clinicians should consider lung cancer in patients with PCD who present with persistent symptoms refractory to standard treatment.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 3","pages":"410-413"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Racial, Ethnic, and County-Level Disparities in Invasive Cervical Cancer Incidence in Wisconsin, 1998-2022. 1998-2022年威斯康星州浸润性宫颈癌发病率的持续种族、民族和县级差异
Madelyn Frey, Laurie Lapp, Lena Swander, Ran C Zhang, Laura Jacques
{"title":"Persistent Racial, Ethnic, and County-Level Disparities in Invasive Cervical Cancer Incidence in Wisconsin, 1998-2022.","authors":"Madelyn Frey, Laurie Lapp, Lena Swander, Ran C Zhang, Laura Jacques","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Invasive cervical cancer continues to disproportionately affect racially and ethnically minoritized populations and individuals living in rural areas. We analyzed trends in cervical cancer incidence by race, ethnicity, and geography in Wisconsin from 1998 through 2022.</p><p><strong>Methods: </strong>Cervical cancer incidence rates (per 100 000 individuals with a cervix) were analyzed by race/ethnicity and county using data from the Wisconsin Cancer Reporting System.</p><p><strong>Results: </strong>Overall incidence declined 28%, from 8.2 to 5.9 cases per 100 000, but declines were not evenly distributed across populations. Compared with non-Hispanic White individuals, non-Hispanic Black individuals had nearly twice the incidence rate throughout the study period. Although Hispanic individuals experienced the largest relative decline (40.8%, 15.7 to 9.3 per 100 000), incidence remained higher among non-Hispanic White individuals. Milwaukee County, Wisconsin's most socially vulnerable county, had among the highest incidence rates and slowest decline over time (19.8%).</p><p><strong>Discussion: </strong>Because cervical cancer is largely preventable, the persistence of substantial disparities in Wisconsin highlights structural inequities that warrant urgent attention.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 3","pages":"383-387"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purple Fentanyl: A New Face on an Old Enemy. 紫色芬太尼:老敌人的新面孔。
Jennifer Esch, Matthew Bougie, Alexis Vandehey
{"title":"Purple Fentanyl: A New Face on an Old Enemy.","authors":"Jennifer Esch, Matthew Bougie, Alexis Vandehey","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Overdoses due to novel potent opioids continue to increase across the United States. The availability of colored fentanyl products that may appeal to younger patients is concerning.</p><p><strong>Case presentation: </strong>We present the case of an adult male with an unknown ingestion subsequently identified as purple fentanyl. Brorphine is a common component of purple fentanyl and is considered an emerging novel potent opioid.</p><p><strong>Discussion: </strong>Only limited number of case reports describing brorphine exposure are available, and many clinicians remain unfamiliar with this substance. It is a potent opioid with a presumed long half-life. Clinical presentation is similar to that of other opioid toxidromes, including respiratory depression, miosis, and sedation, and is managed similarly. Patients may require extended monitoring after exposure to brorphine.</p><p><strong>Conclusions: </strong>Awareness of emerging substances of abuse will enable clinicians to diagnose and treat affected patients more readily.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 3","pages":"424-426"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Considering 'Big Questions' About the Human Being in Medical Education. 医学教育中关于人的“大问题”的思考
Victoria Toledo, Raudah Yunus, Lauren Nickel, Fabrice Jotterand, Aasim I Padela
{"title":"Considering 'Big Questions' About the Human Being in Medical Education.","authors":"Victoria Toledo, Raudah Yunus, Lauren Nickel, Fabrice Jotterand, Aasim I Padela","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 1","pages":"109-110"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When the Jar Keeps Growing. 当罐子不断增长。
Jayshil J Patel, Michael J Malinowski, Manpreet S Mundi
{"title":"When the Jar Keeps Growing.","authors":"Jayshil J Patel, Michael J Malinowski, Manpreet S Mundi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 3","pages":"333"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Development and Evolution of Group Medical Visits at UW Health. 西澳大学健康中心团体医疗探访的发展与演变。
Sarah Walters, Isabella Rodriguez Cardenas, Karina Viloria Rodrigues, Lisa Simpson, Magnolia Larson, Greta Kuphal, Katherine Eby, Melissa Stiles, Lisa Grant, Bruce Barrett
{"title":"The Development and Evolution of Group Medical Visits at UW Health.","authors":"Sarah Walters, Isabella Rodriguez Cardenas, Karina Viloria Rodrigues, Lisa Simpson, Magnolia Larson, Greta Kuphal, Katherine Eby, Melissa Stiles, Lisa Grant, Bruce Barrett","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic disease management presents substantial challenges for both patients and health care providers, often limited by time, resources, and operational complexities. Group medical visits (GMVs) at UW Health have evolved as a collaborative intervention, combining clinician-led care with peer support to address chronic conditions such as chronic pain, heart disease, anxiety, and more.</p><p><strong>Methods: </strong>This program evaluation explores the development and characteristics of GMVs at UW Health through a qualitative approach, utilizing interviews, observations, and questionnaires to analyze GMV practices across multiple UW Health clinics.</p><p><strong>Results: </strong>The findings highlight key themes, including a sense of community through group support, clinician satisfaction, the innovative structure of GMVs, wellness-based content, integrative facilitation of care, and areas for improvement.</p><p><strong>Conclusions: </strong>As GMVs continue to evolve, enhancing support mechanisms, refining recruitment strategies, and expanding access will be crucial for optimizing their impact on chronic disease management. These insights offer valuable learnings for UW Health and other institutions seeking to refine and expand GMVs.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 3","pages":"371-377"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thinking Beyond Common Diagnoses: A Case Report of Creutzfeldt-Jakob Disease. 超越常见诊断的思考:克雅氏病1例报告。
Thomas Licata, Won Huh, Michael Bolan
{"title":"Thinking Beyond Common Diagnoses: A Case Report of Creutzfeldt-Jakob Disease.","authors":"Thomas Licata, Won Huh, Michael Bolan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Prion diseases are rare neurodegenerative disorders characterized by abnormal folding of prion proteins in the brain. Creutzfeldt-Jakob disease (CJD), is the most common prion disease in humans, typically presenting with neuropsychiatric manifestations, including dementia, behavioral abnormalities, and motor dysfunction. Diagnosis can be challenging because its nonspecific presentation overlaps with numerous other potential causes.</p><p><strong>Case presentation: </strong>A 60-year-old man presented with altered mental status and progressive neurologic decline. After an extensive diagnostic evaluation, he was diagnosed with probably CJD. Management was primarily supportive and focused on symptom relief and patient comfort. The patient died shortly after the diagnosis was confirmed.</p><p><strong>Conclusions: </strong>This case highlights the challenges of diagnosing CJD and underscores the value of System 1 and System 2 reasoning in navigating a broad differential diagnosis in patients presenting with altered mental status and rapidly progressive neurologic symptoms.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 3","pages":"402-406"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardizing the Educational Experience of Medical Students Rotating With the Orthopedic Department Regardless of Subspecialty Assignment. 规范医学生在骨科轮转的教育经验。
Quinn Steiner, Alex Lasinski, Pamela Lang, Lindsey Boyke
{"title":"Standardizing the Educational Experience of Medical Students Rotating With the Orthopedic Department Regardless of Subspecialty Assignment.","authors":"Quinn Steiner, Alex Lasinski, Pamela Lang, Lindsey Boyke","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Musculoskeletal (MSK) conditions are frequently encountered by physicians in emergency and primary care settings. An orthopedic surgery elective provides an opportunity for medical students to develop knowledge and skills in evaluating and managing these conditions; however, increasing subspecialization and limited curricular time may restrict exposure to the breadth of MSK pathology.</p><p><strong>Methods: </strong>A standardized video lecture series covering common orthopedic conditions was developed for use during 2-week orthopedic surgery elective for third-year medical students at a single academic institution. Students completing the elective during May 2023 to April 2024 completed a 50-question pre-rotation knowledge assessment and were instructed to complete the video curriculum during the rotation. The same 50 question assessment was administered at the end of the rotation. Students also completed a 4 item qualitative survey evaluating the perceived educational value of the lecture series.</p><p><strong>Results: </strong>All 24 students (100%) completed the pre- and post-rotation assessments. Post-rotation scores were 4.96 points higher (9.9%) than pre-rotation scores (P = .0052). Nineteen students (79%) completed the post-rotation survey; 89.5% agreed or strongly agreed that the lectures improved their general knowledge of orthopedic topics, and 52.6% agreed or strongly agreed that the lectures adequately prepared them for the post-rotation assessment.</p><p><strong>Conclusions: </strong>Students demonstrated significant improvement in MSK knowledge after completing a 2-week orthopedic surgery rotation that incorporated a standardized video curriculum. Survey findings suggest the curriculum enhanced students' confidence in understanding MSK pathology and may help address educational gaps resulting from subspecialty based clinical assignments.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact and Description of a Training Program With a Novel Landmark Device for Needle Thoracostomy. 一种新型胸廓针切开术标志性器械训练方案的影响与描述。
Justin T Chu, Thomas Engel, Matthew Chinn, Benjamin W Weston
{"title":"The Impact and Description of a Training Program With a Novel Landmark Device for Needle Thoracostomy.","authors":"Justin T Chu, Thomas Engel, Matthew Chinn, Benjamin W Weston","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Needle thoracostomy (NT) is a lifesaving procedure for patients with tension pneumothorax but requires correct anatomical placement to ensure effectiveness and minimize complications. We describe a novel emergency medical services (EMS) training using a lateral NT landmark device, the SAM ThoraSite, and report provider feedback on the training.</p><p><strong>Methods: </strong>A 90-minute training was delivered to EMS providers. Providers completed pre- and post-training surveys regarding confidence in procedural performance, concerns about complications, and overall educational experience.</p><p><strong>Results: </strong>The response rate was 79.4%. Post-training confidence in correctly performing NT increased significantly (7.1 vs 9.0, P  < .001). Participants also reported higher satisfaction with this training compared with prior needle thoracostomy education (6.9 vs 9.3, P  < .001).</p><p><strong>Conclusions: </strong>A novel EMS educational session incorporating the ThoraSite landmark device improved provider confidence in NT performance and increased satisfaction with training.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 1","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Physician Ethic. 医生伦理。
Joseph Edward Fojtik
{"title":"The Physician Ethic.","authors":"Joseph Edward Fojtik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"125 2","pages":"241-242"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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