{"title":"Spontaneous Recanalization of a Post-operative Acute Internal Carotid Artery Occlusion.","authors":"Simone Cuozzo, Francesca Miceli, Xavier Berard, Eric Ducasse, Enrico Sbarigia, Vincenzo Brizzi","doi":"10.1177/15385744251377686","DOIUrl":"https://doi.org/10.1177/15385744251377686","url":null,"abstract":"<p><p>Spontaneous recanalization (SR) of an internal carotid artery (ICA) is a rare phenomenon. Cases reported in literature described the evolution of dissection or atherothrombotic / cardioembolic acute occlusions. No case of post-endarterectomy ICA occlusion resolved by SR has never been reported. Herein, we describe the case of a 64-year old male patient who presented an ipsilateral ischemic stroke due to the ICA occlusion in the second post-operative day of a carotid endarterectomy (CEA) and SR 6 months later, without anticoagulant therapy administration. The aim of this report was to increase awareness of this unusual entity and to highlight the usefulness of duplex ultrasound (DUS) surveillance of ICA eventual postoperative occlusions in order to detect accidental recanalization and to propose an adjunctive treatment whenever needed.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251377686"},"PeriodicalIF":0.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Susan Fields, Taylor Pigg, Anastasia Navitski, Shauna Summers, Arthur Freedman, Padmashree Woodham
{"title":"Successful Antenatal Embolization of a Complex Pulmonary Arteriovenous Malformation in the Third Trimester of Pregnancy: A Case Report.","authors":"Susan Fields, Taylor Pigg, Anastasia Navitski, Shauna Summers, Arthur Freedman, Padmashree Woodham","doi":"10.1177/15385744251375349","DOIUrl":"https://doi.org/10.1177/15385744251375349","url":null,"abstract":"<p><p><b>Background:</b> A pulmonary arteriovenous malformation (PAVM) is an abnormal connection between the pulmonary arterial and venous systems, resulting in a pathologic right-to-left shunt. PAVMs worsen during pregnancy due to physiologic changes, yet no treatment guidelines exist for newly diagnosed PAVMs in pregnancy.<b>Case:</b> We report a case of a previously asymptomatic 19-year-old G1 who was incidentally found to have a low oxygen saturation during routine prenatal care at 34 5/7 weeks of gestation. She was diagnosed with a complex, left-sided PAVM. Through the close collaboration of the interventional radiology and high-risk obstetric teams, antenatal embolization was successfully performed, allowing for the prolongation of pregnancy. The patient experienced spontaneous rupture of membranes at 36 1/7 weeks and underwent a successful Cesarean delivery at this time.<b>Conclusion:</b> Embolization of a complex PAVM in the third trimester of pregnancy was successfully and safely achieved by a skilled multidisciplinary team. In comparable clinical scenarios, clinicians should carefully assess maternal and fetal risks-such as neonatal prematurity, radiation exposure, and PAVM-related complications-to guide optimal management.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251375349"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety & Effectiveness of the Obtura 8F Vascular Closure Device in Neuro-Interventional Practice: A Retrospective Analysis.","authors":"Rasmiranjan Padhi, Virag Sanjay Shethna, Jagadeesan Dhanasekaran, Kiran Kumar Shetty","doi":"10.1177/15385744251375265","DOIUrl":"https://doi.org/10.1177/15385744251375265","url":null,"abstract":"<p><p>ObjectiveVascular closure devices (VCDs) are essential in modern neuro-interventional procedures, offering advantages over manual compression by accelerating hemostasis, reducing complications, and enabling early ambulation. The Obtura 8F VCD is a novel bioabsorbable closure device designed to enhance safety and procedural efficiency. This study evaluates its efficacy and safety in achieving hemostasis and preventing vascular complications following femoral artery access.MethodThis retrospective, single-center study analyzed patients who underwent femoral artery closure with the Obtura 8F VCD. The primary performance endpoint was a successful hemostasis without additional intervention. The primary safety endpoint was the incidence of vascular complications within 30 days and 3 months. Secondary outcomes included time to ambulation and length of hospital stay.ResultsA total of 100 patients (mean age: 59.48 ± 13.03 years, 64% male) were included. Hemostasis was successfully achieved in 96% of cases, and all patients were able to move the limb within 8 hours post-procedure. During hospitalization, hematoma/pseudoaneurysm occurred in 6% of patients, with age ≥65 years, hypertension, and diabetes identified as significant risk factors. No evidence of infection was reported at either 30 days or 3 months. The majority of patients (80%) were discharged within 4-7 days.ConclusionsThe Obtura 8F VCD demonstrated high efficacy in achieving hemostasis with a strong safety profile with no major vascular complications. These findings support its use as a reliable alternative to manual compression, facilitating faster patient recovery and potentially reducing hospital resource utilization.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251375265"},"PeriodicalIF":0.7,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Róbert Bobák, Martin Ferkodič, Dominik Maduda, Tomáš Novotný, Luboš Kubíček, Ernest Biroš, Robert Staffa
{"title":"Effectiveness and Cost-Benefit Evaluation of Closed Incision Negative Pressure Therapy (ciNPT) in Patients After Major Revascularization Procedures.","authors":"Róbert Bobák, Martin Ferkodič, Dominik Maduda, Tomáš Novotný, Luboš Kubíček, Ernest Biroš, Robert Staffa","doi":"10.1177/15385744251375389","DOIUrl":"https://doi.org/10.1177/15385744251375389","url":null,"abstract":"<p><p>IntroductionWound healing complications (WHC) of groin incisions are frequently discussed in vascular surgery. Various preventive measures are often applied to reduce their rates, but not all have the desired effect, and all these measures have their respective costs. The main aim of this study is to determine the effectiveness of closed incision negative pressure therapy (ciNPT) in reducing WHCs in high-risk patients after major revascularization procedures compared to the conventional adhesive dressing and to investigate the cost-benefit of its routine use.Material and methodsFrom April 2023 to October 2024, 30 patients with 60 groin wounds who underwent aortic-bifemoral bypass surgery had their right groin wound treated with ciNPT and left groin wound with a conventional surgical adhesive dressing. The ciNPT system was removed after 7 days postoperatively. Both wounds were examined on the 7<sup>th</sup> and 30<sup>th</sup> postoperative day and any WHCs were marked and graded by the Szilagyi classification. Hospitalization costs and hospital stay periods of all patients were also analyzed.ResultsThe ciNPT-treated wound showed a statistically significant reduction in WHCs against the conventionally treated contralateral groin (<i>P</i> = 0.025). None of the ciNPT-treated wounds prolonged hospital stay and a significant increase in hospitalization costs (<i>P</i> < 0.001) has been observed in patients who developed WHCs, prolonging hospital stay (<i>P</i> = 0.007).ConclusionHigh-risk vascular surgery patients are very likely to benefit from ciNPT and the routine use of this method may also be considered economically, however, additional research must be conducted to evaluate indications better.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251375389"},"PeriodicalIF":0.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Etiology is a Factor when Choosing Endovascular or Open Treatment for Acute Mesenteric Ischemia.","authors":"Tejas S Nandurkar, Olivia H Millay, Eric D Endean","doi":"10.1177/15385744251375257","DOIUrl":"https://doi.org/10.1177/15385744251375257","url":null,"abstract":"<p><p>BackgroundThe role of endovascular therapy for patients presenting with AMI continues to be debated. This study was undertaken to compare open and endovascular treatment of AMI.MethodsAll patients who presented with AMI between 2010 and 2022 were identified. Patient demographics, baseline laboratory studies, length of stay (LOS), and outcomes were recorded. Student's t-test was used for quantitative data and Fisher's exact test for qualitative data.ResultsSixty-five patients were treated for AMI: 47 with an open procedure; 18 with endovascular techniques. Of the 18 patients in the endovascular group, 8 (45%) underwent laparotomy/laparoscopy; four (22%) requiring bowel resection. Patients treated with an endovascular approach were more likely to be male (87% vs 45%, <i>P</i> = .025), be caused by thrombosis (78% vs 55%, <i>P</i> = .005), have lower incidence of other vascular disease (56% vs 87%, <i>P</i> = .015) and have a lower initial WBC (11.9 ± 3.9 vs 18.5 ± 8.4, <i>P</i> = .0017). There was shorter ICU LOS in the endovascular group (5.5 ± 5.7 vs 13.5 ± 13.8, <i>P</i> = .025). A trend for decreased bowel resection was seen in the endovascular group compared the open group [4 (22%) vs 19 (40%), <i>P</i> = .25]. A trend for lower mortality was seen in the endovascular group compared to the open group (22% vs 40%, <i>P</i> = .25). In the 23 patients that died, the cause of death was directly related to bowel ischemia in 16 (70%), cardiac in 5 (22%) and stroke in 2 (9%).ConclusionEndovascular treatment of AMI has potentially lower mortality and lengths of stay. When choosing endovascular vs open treatment, the status of the bowel should be an important initial determinate. We recommend that the underlying etiology (thrombosis vs embolic) also be a consideration with a low threshold for conversion to an open procedure if endovascular treatment does not rapidly restore mesenteric flow in patients with embolic disease.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251375257"},"PeriodicalIF":0.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Hassan, Ahmed Elshiekh, Nick Matharu, Alexander Sergiou, Ashraf Elsharkawy, Asif Mahmood
{"title":"The Impact of Introducing a Surgeon-Led Emergency EVAR Service on Outcomes and Cost Efficiency in Ruptured Aortic Aneurysm Management: A UK Single-Center Experience.","authors":"Ahmed Hassan, Ahmed Elshiekh, Nick Matharu, Alexander Sergiou, Ashraf Elsharkawy, Asif Mahmood","doi":"10.1177/15385744251375278","DOIUrl":"https://doi.org/10.1177/15385744251375278","url":null,"abstract":"<p><p>ObjectiveTo evaluate the impact of introducing a surgeon-led emergency endovascular aneurysm repair (EVAR) service on patient outcomes and cost efficiency in the management of ruptured abdominal aortic aneurysms (rAAA) at a UK tertiary vascular center.MethodsA retrospective cohort study was conducted, including all patients presenting with rAAA between January 2019 and December 2023. Patients were categorized into two time periods: before (<b>Period A</b>: 2019-2020) and after (<b>Period B</b>: 2021-2023) the introduction of the emergency EVAR service. Outcomes assessed included 30-day and one-year mortality, length of hospital stay, complication rates, and return-to-theatre rates. Cost-effectiveness analysis was conducted using incremental cost-effectiveness ratio (ICER) calculations based on Quality-Adjusted Life Years (QALYs).ResultsA total of 71 patients with ruptured abdominal aortic aneurysm were identified, of whom 58 underwent surgical repair (OSR or EVAR). In Period A, all patients (n = 17) underwent open surgical repair. In Period B, 24 received OSR (58.5%) and 17 received EVAR (41.5%). The 30-day mortality rate was significantly lower in the EVAR group (5.9%) compared to OSR in both periods (63.3% and 50%, respectively; <i>P</i> = .001). The one-year mortality rate remained unchanged for EVAR but increased for OSR (<i>P</i> = .00075). Return-to-theatre rates were significantly higher in OSR patients (<i>P</i> = .044). ICER calculations showed EVAR to be cost-effective (-£202 526 per QALY within one year).ConclusionThe introduction of a surgeon-led emergency EVAR service significantly improved early survival rates and reduced reintervention rates in rAAA patients while demonstrating cost-effectiveness compared to OSR.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251375278"},"PeriodicalIF":0.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megan Power Foley, Daniel Westby, Oisín Brennan, Emily Boyle, Stewart R Walsh
{"title":"Comparison of Caprini and Worcester Scores for Venous Thromboembolism Risk Stratification in the Setting of Ambulatory Endovenous Surgery.","authors":"Megan Power Foley, Daniel Westby, Oisín Brennan, Emily Boyle, Stewart R Walsh","doi":"10.1177/15385744251375263","DOIUrl":"https://doi.org/10.1177/15385744251375263","url":null,"abstract":"<p><p>IntroductionPost-operative venous thromboembolism (VTE) remains a significant concern after endovenous ablation (EVA) for varicose veins. Risk stratification tools aid identifying which patients have an increased VTE risk. There is no consensus on which currently utilised score is most appropriate for daycase surgery. The aim of this observational study was to compare how 2 institutions utilised the Caprini and Worcester Scores to risk stratify ambulatory EVA patients in real-world practice.MethodsA retrospective review of consecutive patients undergoing truncal ablation under local anaesthetic in 2 separate vascular centres between 2022-23 was performed. Each patient was scored prospectively using either the Caprini and Worcester Score for perioperative VTE risk assessment, and then retrospectively using the alternate tool. Demographics and risk factors were documented and compared between patients categorised as \"at risk\" by each score. Categorical variables were analysed using Chi-Square and continuous using Mann-Whitney U Tests.ResultsTwo hundred patients undergoing endovenous ablation were included. Over half the cohort were female (n = 122, 61%) and the median age was 53.0 years (range 23-87). Twenty-one percent (n = 42) had a Body Mass Index (BMI) > 30. Overall, 90 patients were flagged as high-risk by either score. Fifty-three patients (26.5%) were flagged by the Worcester Score as either 'moderate' (n = 42, 21%) or 'high risk' (n = 11, 5.5%). Fifty-eight patients (29%) were identified as 'high risk' by the Caprini tool. A significant discrepancy in which patients were categorised as \"at risk\" by each score was noted, with only 21 patients stratified as \"at risk\" by both (<i>P</i> = 0.047).ConclusionsA similar proportion of patients were stratified as high risk by each score, however the lack of overlap between the 2 risk assessment tools suggests a discrepancy in what variables are scored for. Further well-powered studies are needed to validate which score is most appropriate for ambulatory EVA.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251375263"},"PeriodicalIF":0.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kausik Chatterjee, Jack Hood, Abhijit Das, Ragai R Makar, Bhavana Selvarajah, Andrew Irwin Khallaf, Kumar Pulupula, Parthasarathy Karunakarana, Joanna Heyworth, Georgia Farrag, Allam Harfoush, Alakendu Sekhar
{"title":"POSToperative CerebrovascUlar Accident Following Symptomatic Carotid EndarterectoMy (OSTIUM): A Retrospective Case-Control Study.","authors":"Kausik Chatterjee, Jack Hood, Abhijit Das, Ragai R Makar, Bhavana Selvarajah, Andrew Irwin Khallaf, Kumar Pulupula, Parthasarathy Karunakarana, Joanna Heyworth, Georgia Farrag, Allam Harfoush, Alakendu Sekhar","doi":"10.1177/15385744251367540","DOIUrl":"https://doi.org/10.1177/15385744251367540","url":null,"abstract":"<p><p>BackgroundAlthough carotid endarterectomy (CEA) is effective for moderate to severe symptomatic carotid artery stenosis, it carries a risk of postoperative cerebrovascular accident (POCVA). Currently, there is insufficient evidence on the relationship between cranial vascular integrity and intraoperative hemodynamic fluctuations.MethodsIn this retrospective case-control study, we utilised data collected from patients undergoing CEA for symptomatic carotid artery disease between December 2005 and October 2019 in the South Mersey Arterial Centre, UK. Patients with three-dimensional CT angiogram data and evidence of postoperative stroke were considered as cases and matched with those without such evidence considered as controls. 3D-CTA data were analysed following a structured pro-forma and data regarding haemodynamic changes were obtained from operative notes. Variables that showed statistical significance in univariate analysis were included in multivariate logistic regression analysis.ResultsA total of 21 cases and 55 matched controls were identified. Presence of atherosclerotic disease in the vertebral arteries on either side, intracranial atherosclerosis and a drop in the systolic blood pressure were significantly different between cases and controls. Our multivariate logistic regression models indicated that the likelihood of stroke was higher with vertebral artery (V1-V4) stenosis on either side (OR 6.5, 95% CI 1.7-24.6) and an intraoperative systolic blood pressure drop greater than 44 mmHg (OR 6.6, 95% CI 1.6-27.6).ConclusionsThese findings highlight the importance of evaluating posterior circulation abnormalities in POCVA. Moreover, careful intraoperative blood pressure management is crucial in perioperative care. This may aid in developing personalised risk stratification and enhancing intraoperative monitoring during CEA.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"15385744251367540"},"PeriodicalIF":0.7,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergio Asensio, Jose Antonio Brizuela, Alvaro Revilla, Sergio Fernández-Bello, James Henry Taylor, Enrique Maria San Norberto
{"title":"Endovascular Treatment of Common Iliac Aneurysm After Aortobifemoral Bypass: Banana Technique and Shape Memory Polymer Plug Embolization.","authors":"Sergio Asensio, Jose Antonio Brizuela, Alvaro Revilla, Sergio Fernández-Bello, James Henry Taylor, Enrique Maria San Norberto","doi":"10.1177/15385744251326310","DOIUrl":"10.1177/15385744251326310","url":null,"abstract":"<p><p><b>Objective:</b> This case report aims to present a new endovascular technique for arterial embolization using a relatively recently developed endovascular device, Shape Memory Polymer (SMP) Embolization Plug (IMPEDE, Shape Memory Medical). <b>Methods:</b> A 66-year-old man presented an asymptomatic common iliac aneurysm with a maximun diameter of 4.4 cm and a previous aorto-bifemoral bypass. <b>Results:</b> An embolization of the common iliac artery aneurysm with 5 units of IMPEDE-FX Rapid Fill (12 mm, Shape Memory Medical) and revascularization from external iliac artery to internal iliac artery through a banana technique with an auto-expandable covered stent (Viabahn 10 × 100 mm, Gore) was performed. <b>Conclusion:</b> The experience obtained after the use of this device has allowed us to increase the therapeutic arsenal for high volume aneurysm embolization.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"667-670"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic Diagnosis and Combinational Treatment With Pharmacomechanical Thrombectomy and Transjugular Intrahepatic Portosystemic Shunt for Non-cirrhotic and Non-malignant Portal Vein Thrombosis.","authors":"Feng Chen, Qing Gen Xiong, Fei Lu, Zhi Jian Luo, Wei Luo, Wei Zhou","doi":"10.1177/15385744251334793","DOIUrl":"10.1177/15385744251334793","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the potential role of the whole-exome sequencing (WES) technique in screening pathogenic genes of non-cirrhotic and non-malignant portal vein thrombosis (PVT) and the clinical efficacy of AngioJet-assisted pharmacomechanical thrombectomy (PMT) with transjugular intrahepatic portosystemic stent shunt (TIPS) to treat this disease.Methods16 patients with acute non-cirrhotic and non-malignant PVT were retrospectively analyzed. 14 patients received genetically diagnosed using the WES technique, ten patients received PMT with or without TIPS and 6 cases received anticoagulation alone. Changes in clinical symptoms, and recanalization of the portal vein (PV) were also recorded.Results4 patients (28.6%) had JAK2 V617 F mutation, 4 patients (28.6%) had PROC mutations, 3 patients (21.4%) had SERPINC1mutations. Among patients treated with anticoagulation alone, 5 patients (83.3%, 5/6) developed cavernous transformation of PV and one patient with JAK2 V617 F mutation achieved complete recanalization of PV. One patient treated with PMT without TIPS developed PV cavernous transformation, eight patients (80%) treated with PMT and TIPS achieved complete or partial recanalization of PV. Three patients who developed intestinal necrosis all had SERPINC1 mutations and one of them died of intestinal necrosis. No recurrence was found during follow-up (1-36 months).ConclusionsThe WES technique offers a promising way to screen for thrombophilia in patients with non-cirrhotic and non-malignant PVT. Patients with SERPINC1 mutations are more inclined to develop intestinal necrosis than others. PMT combined with TIPS provides a safe and effective therapeutic alternative.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"631-640"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}