Vaccine最新文献

{"title":"Population effects of influenza vaccination in children and adolescents: Systematic review.","authors":"Mona Askar, Karam Adel, Madeleine Batke, Yuan Chi, Lea Gorenflo, Anna Hayman Robertson, Kari Johansen, Jorgen de Jonge, Philipp Kapp, Tyra Grove Krause, Elizabeth Lynch, Joerg J Meerpohl, Angeliki Melidou, Hanna Nohynek, Carmen Olmedo, Kate Olsson, Ioanna Pavlopoulou, Jaime Jesús Pérez, Vanessa Piechotta, Catalina Hamon Pinilla, Johanna Rubin, Veronika Učakar, Julia Wilhelm, Ole Wichmann, Thomas Harder","doi":"10.1016/j.vaccine.2025.128040","DOIUrl":"10.1016/j.vaccine.2025.128040","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate indirect vaccine effectiveness (indirVE) of vaccination of children and adolescents with seasonal influenza vaccines against influenza-related outcomes occurring in other population groups.</p><p><strong>Methods: </strong>We performed a systematic review of studies (randomized and non-randomized) on indirVE of vaccination of participants aged 6 months-17 years with tri- or quadrivalent seasonal influenza vaccines against influenza (lab-confirmed; non-lab-confirmed) occurring in contacts of vaccinated persons or members of the wider community (last search: 17th March 2024). GRADE certainty of evidence (CoE) was evaluated (PROSPERO: CRD42024546400).</p><p><strong>Results: </strong>We identified 28 studies (5 randomized; 23 non-randomized). In community-based studies, indirect protection against laboratory-confirmed influenza (LCI) ranged from -38 % [95 % CI: -574 to 72] to 61 % [95 % CI: 8-83] (very low CoE). In household-based settings, indirVE against LCI varied between -151.2 % [95 % CI: -1194.6 to 51.3] and 39.4 % [95 % CI: 7.4 to 60.3] (very low CoE). In school-based settings, highly variable indirect effects were observed on LCI, hospitalization, emergency department visits and school/work absenteeism (very low CoE).</p><p><strong>Conclusions: </strong>There is no clear evidence of indirect effects from influenza vaccination in children. While plausible, effect size is uncertain and varies by study design, population, and vaccine type. Stronger indirect effects appeared only when direct VE was high.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"71 ","pages":"128040"},"PeriodicalIF":3.5,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvanted recombinant zoster vaccine and live attenuated zoster vaccine are vastly different.","authors":"Emily Jane Woo","doi":"10.1016/j.vaccine.2026.128272","DOIUrl":"https://doi.org/10.1016/j.vaccine.2026.128272","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"128272"},"PeriodicalIF":3.5,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Anticipated impact of novel adult-specific pneumococcal conjugate vaccine by Joshi et al.","authors":"J M McLaughlin, J Wassil","doi":"10.1016/j.vaccine.2025.127988","DOIUrl":"https://doi.org/10.1016/j.vaccine.2025.127988","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127988"},"PeriodicalIF":3.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value profile for Malaria vaccines and monoclonal antibodies.","authors":"Ashley J Birkett, Evelyn Ansah, Scott Gordon, Margaret Gyapong, Shanelle Hall, Sherrie L Kelly, Matthew Laurens, Melissa A Penny, Meredith Shirey, Laurence Slutsker, Erin Sparrow, Sally Ethelston, Nelli Westercamp, Lindsey Wu, Mary J Hamel","doi":"10.1016/j.vaccine.2025.127971","DOIUrl":"10.1016/j.vaccine.2025.127971","url":null,"abstract":"<p><p>Malaria remains a leading cause of morbidity and mortality and is responsible for over 0.5 million annual deaths globally. During the first two decades of this century, scale-up of a range of tools was associated with significant reductions in malaria mortality in the primary risk group, young African children. However, in recent years progress has stalled and even reversed in some high-burden countries, highlighting the urgent need for new interventions. Since 2021, two malaria vaccines have received World Health Organization (WHO) recommendations and Gavi, the Vaccine Alliance financing and are now in high demand across sub-Saharan Africa. Despite their promise, including a 13 % decline in all-cause mortality and a 22 % drop in severe malaria hospitalizations following pilot introduction, there remains keen interest in developing improved vaccines in alignment with WHO's preferred product characteristics (PPCs), revised in 2022 (see https://www.who.int/publications/i/item/9789240057463). Further, monoclonal antibody (mAb) prophylaxis has emerged as a promising new intervention, which led to WHO's developing a new guidance document to inform PPCs for malaria mAbs (see https://www.who.int/publications/i/item/9789240070981). The priority focus for these aspirational tools is on prevention of disease and death in young African children; however, there is increasing focus on tools that could be deployed across entire populations to break the cycle of parasite transmission and accelerate elimination. Further, accelerated impact of next-generation vaccines is emerging thanks to the pioneering introduction of current vaccines into established national immunization programs and strong coordination with national malaria programs. This vaccine value profile (VVP) for malaria-developed by a working group of subject matter experts from academia, nonprofit and multilateral organizations, and public-private partnerships-provides a high-level, holistic assessment of current, existing information and data that are publicly available to inform the potential public health, economic, and societal value of vaccines and prophylactic mAbs in the development pipeline.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127971"},"PeriodicalIF":3.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"COVID-19 vaccine attitudes, beliefs, intentions and behaviors among pregnant women within the context of dynamic national policy recommendations in Brazil, Ghana, Kenya, and Pakistan\" [Vaccine (2025) 127595].","authors":"Jessica L Schue, Emily S Miller, Berhaun Fesshaye, Prachi Singh, Renato T Souza, Caroline Dinam Badzi, Emefa Modey Amoah, Saleem Jessani, Muhammad Asim, Ingrid Gichere, Maria Laura Costa, Jose G Cecatti, Kwasi Torpey, Sarah Saleem, Marleen Temmerman, Sami L Gottlieb, Rupali J Limaye","doi":"10.1016/j.vaccine.2025.127768","DOIUrl":"10.1016/j.vaccine.2025.127768","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127768"},"PeriodicalIF":3.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase of Haemophilus influenzae type b meningitis, beyond initial findings.","authors":"Corinne Levy, Emmanuelle Varon, Stéphane Béchet, Stéphane Bonacorsi, Robert Cohen","doi":"10.1016/j.vaccine.2025.127764","DOIUrl":"https://doi.org/10.1016/j.vaccine.2025.127764","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127764"},"PeriodicalIF":3.5,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the role of influence and trust in information sources on the COVID-19 vaccine decision-making process for pregnant and postpartum women in Brazil, Ghana, Kenya, and Pakistan: A mixed methods study.","authors":"Jessica L Schue, Berhaun Fesshaye, Emily S Miller, Prachi Singh, Ruth A Karron, Saleem Jessani, Muhammad Asim, Ferdinand Okwaro, Caroline Dinam Badzi, Emefa Modey Amoah, Renato T Souza, Maria Laura Costa, Marleen Temmerman, Kwasi Torpey, Jose G Cecatti, Sarah Saleem, Grace Belayneh, Vanessa Brizuela, Sami L Gottlieb, Rupali J Limaye","doi":"10.1016/j.vaccine.2025.127721","DOIUrl":"10.1016/j.vaccine.2025.127721","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined associations between information sources and COVID-19 vaccination behavior among pregnant and postpartum women in Brazil, Ghana, Kenya, and Pakistan.</p><p><strong>Methods: </strong>This mixed methods study involved concurrent in-depth interviews and cross-sectional surveys.</p><p><strong>Results: </strong>A total of 1797 women participated in the study. Overall, participants were more likely to be vaccinated if they believed that they knew enough about safety to make a decision (aOR: 1.51; CI: 1.04-2.20) and trusted the information they received from healthcare providers (aoR: 1.74; CI: 1.19-2.54). Odds of vaccination were higher among those who trusted information provided by scientists (aoR:1.86; CI: 1.31-2.63) and among those who believed that leaders in their community recommended the COVID-19 vaccine (aOR: 1.4; CI: 1.01-1.92). Higher odds of vaccination were observed among participants in Pakistan who had the information they needed to make a decision (aOR: 2.58; CI: 1.35-4.94), knew enough about safety to make a decision (aOR: 3.82; CI: 1.85-7.89), trusted the information they received from healthcare providers (aOR: 3.20; CI: 1.39-7.34), and believed that community leaders recommended the COVID-19 vaccine (aOR: 2.53; CI: 1.22-5.25). Participants in Brazil who trusted information provided by scientists (aOR: 4.70; CI: 1.23-18.05); participants in Kenya who trusted information from the media (aOR: 1.94; CI: 1.10-3.44); and participants in Ghana who trusted recommendations from their government (aOR: 2.66; CI: 1.42-5.0) had higher odds of vaccination. Interviewed women noted that they felt overwhelmed with the amount of information and misinformation related to COVID-19 and the vaccine specifically.</p><p><strong>Discussion: </strong>Trusted COVID-19 vaccine information sources reported by pregnant and postpartum women vary by country, suggesting the need to identify sources across different target populations to improve vaccine acceptability and uptake with the goal of realizing the population level benefits of vaccination.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127721"},"PeriodicalIF":3.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myths, mandates, and decision-making: A qualitative exploration of COVID-19 vaccine hesitancy among pregnant and postpartum women in Pakistan.","authors":"Muhammad Asim, Saleem Jessani, Sarah Saleem, Haleema Yasmeen, Sidrah Nausheen, Jessica L Schue, Prachi Singh, Berhaun Fesshaye, Vanessa Brizuela, Rupali J Limaye","doi":"10.1016/j.vaccine.2025.127722","DOIUrl":"10.1016/j.vaccine.2025.127722","url":null,"abstract":"<p><strong>Background: </strong>Among pregnant and postpartum women, decision-making for receiving the COVID-19 vaccine is influenced by vaccine safety concerns, misconceptions, shifting vaccine policies, and exclusion in the initial vaccine rollout. This caused confusion and vaccine hesitancy among many groups including pregnant and postpartum women.</p><p><strong>Objective: </strong>The objective of this study was to understand the multilevel factors that influence vaccine decision-making among pregnant and postpartum women in Pakistan, which is crucial for improving vaccine demand among the vulnerable group-pregnant and postpartum women.</p><p><strong>Methods: </strong>This study is part of a multi-country mixed method study conducted in Brazil, Ghana, Kenya, and Pakistan. In Pakistan, fifty in-depth interviews were conducted with pregnant and postpartum women from two hospitals in Karachi. A grounded theory analysis approach was used, and a socio-ecological framework encompassing four levels of influence was applied to synthesize the study findings.</p><p><strong>Results: </strong>At the individual level, influences included concerns about vaccine safety, particularly regarding the health of the women and their babies due to potential side effects. Strong religious beliefs and trust in God also deterred some women from receiving the COVID-19 vaccine, as they relied on their faith practices. However, women with confidence in the vaccine had a positive attitude toward vaccination. At the interpersonal level, factors influencing vaccine decisions included the strong influence of observing others and recommendations from family and healthcare providers. Community-level factors included misconceptions about the vaccine's purpose and effects, and religious leaders' recommendations either supporting or discouraging vaccination. Policy-level factors involved mandatory vaccination for accessing public spaces, employment, and healthcare services. Coercive vaccination policies led some women to obtain vaccine cards without getting vaccinated.</p><p><strong>Conclusions: </strong>Efforts to promote vaccination among pregnant and postpartum women in Pakistan should engage family members, healthcare providers, and religious leaders, and implement evidence-based vaccine mandates to increase demand and to support uptake of maternal COVID-19 vaccination.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"127722"},"PeriodicalIF":3.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring off-label vaccine use: a survey of the global national immunization technical advisory group network.","authors":"Candace Roberts, Karina A Top, Louise Henaff, Matthew Tunis, Awnish Singh, Judith van Holten, Simona Ruta, Shalini Desai","doi":"10.1016/j.vaccine.2025.127581","DOIUrl":"10.1016/j.vaccine.2025.127581","url":null,"abstract":"<p><strong>Background: </strong>National Immunization Technical Advisory Groups (NITAGs) are crucial for enhancing vaccine use in immunization programs, particularly through off-label recommendations. This study sought to assess the adoption and trends of off-label vaccine recommendations made by NITAGs across low-, middle-, and high-income countries since the COVID-19 pandemic.</p><p><strong>Methods: </strong>An online survey was distributed to NITAG representatives in World Health Organization (WHO) member states, asking questions related to off-label use of vaccines including policies, procedures, legislation, and regulations for NITAGs in participants' countries. Respondents across all six WHO regions were invited to participate.</p><p><strong>Results: </strong>Respondents from 76 countries participated in the survey (55 %) were NITAG representatives, and 45 % were immunization program managers or from the NITAG secretariat). Most respondents 52 (68 %) reported their NITAG makes off-label recommendations, 18 (24 %) indicated their NITAG does not make off-label recommendations, and 6 (8 %) were unsure of their NITAG's role. There was a noticeable shift relating to off-label vaccine recommendations observed pre, during, and post-pandemic period. Prior to 2022, 25 (48 %) respondents indicated their country recommended off-label vaccines, 11 (21 %) specified off-label recommendations were limited to emergencies as temporary or conditional expansions, and 6 (12 %) were unsure. After 2022, 30 (58 %) respondents indicated their country recommended off-label vaccines, 4 (8 %) specified off-label recommendations were limited to emergencies as temporary or conditional expansions, 18 (35 %) selected no, and 0 (0%) were unsure. While most countries make off-label recommendations, few (15 %) have policies and procedures to support implementation.</p><p><strong>Conclusions: </strong>Although WHO broadly provides guidance on the mandate and core functions of NITAGs, globally, they have differing mandates and operational capacities related to off-label vaccine use. These findings suggest the need for increased awareness of off-label vaccine recommendations and strengthened dialogue around implementation of off-label recommendations.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"62 ","pages":"127581"},"PeriodicalIF":3.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving trends in HPV vaccination coverage among women aged 9-45 in Chengdu, China: insights from 2017 to 2023.","authors":"Jing Li, Dandan Zhao, Tongtong Zi, Rongna Huang, Fan Zhao, Lei Li, Jinghuan Zheng, Liang Wang","doi":"10.1016/j.vaccine.2025.127579","DOIUrl":"10.1016/j.vaccine.2025.127579","url":null,"abstract":"<p><strong>Background: </strong>Chengdu, China, is facing an increasing burden of cervical cancer. Although human papillomavirus (HPV) vaccines have been introduced in China since 2016, vaccination coverage remains suboptimal, and data on regional disparities are limited. In 2021, Chengdu implemented a subsidized HPV vaccination program targeting girls aged 13-14 years. This study aims to evaluate HPV vaccination coverage among females aged 9-45 years in Chengdu from 2017 to 2023, stratified by age group, geographic area, and vaccine type, and to examine changes in vaccination coverage among girls aged 13-14 years following the city's enrollment in the pilot subsidy program.</p><p><strong>Methods: </strong>HPV vaccination data were sourced from the Sichuan Provincial Immunization Information System. Descriptive analyses assessed annual and cumulative vaccination coverage from 2017 to 2023 among females aged 9-45 years in Chengdu. An interrupted time series (ITS) analysis using a segmented regression model (SRM) was conducted to quantify changes in vaccination rates following program implementation among girls aged 13-14 years.</p><p><strong>Results: </strong>From 2017 to 2023, first- and full-dose HPV vaccination coverage among females aged 9-45 years in Chengdu showed significant upward trends across age groups, geographic areas, and vaccine types. By 2023, cumulative first-dose coverage reached 34.17 %, with full-dose coverage at 24.40 %. Notably, vaccination rates for girls aged 13-14 years exhibited markedly higher first- and full-dose coverage compared to pre-program levels (β = 1.899, p-value = 0.002; β = 4.859, p-value <0.001, respectively).</p><p><strong>Conclusions: </strong>Following the HPV vaccination program in Chengdu, the vaccination rate for girls aged 13-14 years significantly increased. However, the overall vaccination rate for women aged 9-45 years remains relatively low, particularly among certain subpopulations. To enhance overall vaccination rates, strategic priorities should include targeted interventions for subpopulations with suboptimal coverage, expansion of pilot programs, and stronger political commitment to integrating the HPV vaccine into the National Immunization Program.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"62 ","pages":"127579"},"PeriodicalIF":3.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}