{"title":"Reply to Letter to the Editor: Artificial Intelligence in Cardiac Rehabilitation: Evaluating ChatGPT's Knowledge Level and Responses to Clinical Scenarios-Uncorrected Proof.","authors":"Muhammet Geneş","doi":"10.5543/tkda.2025.77137","DOIUrl":"https://doi.org/10.5543/tkda.2025.77137","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koray Kalenderoğlu, Mert İlker Hayıroğlu, Tufan Çınar
{"title":"Reply to the Letter to the Editor: ''Would the Hemoglobin, Albumin, Lymphocyte, and Platelet Score Help Predict Atrial Fibrillation Recurrence After Cryoballoon Ablation?''-Uncorrected Proof.","authors":"Koray Kalenderoğlu, Mert İlker Hayıroğlu, Tufan Çınar","doi":"10.5543/tkda.2025.55305","DOIUrl":"https://doi.org/10.5543/tkda.2025.55305","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Meteorin-like Protein Infusion vs. Moderate-Intensity Exercise on Cardiac Mast Cell and Plasma Cell Dynamics and Musclin Levels in Female Rats.","authors":"Nazife Ülker Ertuğrul, Ebru Gökdere, Feyza Keskin, Nurcan Delice, Tuğrul Ertuğrul, Gökçen Sevilgen, Şerife Tütüncü, Sinan Canpolat","doi":"10.5543/tkda.2025.80886","DOIUrl":"https://doi.org/10.5543/tkda.2025.80886","url":null,"abstract":"<p><strong>Objective: </strong>Moderate-intensity exercise modulates the immunological response in cardiac tissue. Meteorin-like protein (metrnl) is a myokine secreted by muscle cells during exercise and is involved in immune response regulation. However, the effects of metrnl on mast cells and plasma cells in cardiac tissue are not fully understood. This study was designed to assess the effects of exogenous metrnl infusion on the cardiac mast cells and plasma cells. In addition, serum levels of musclin, an exercise-responsive factor, were evaluated during the effects of moderate-intensity exercise on cardiac immune cells.</p><p><strong>Method: </strong>Twenty-seven female rats were randomly divided into three groups (n=9 each): control (deionized water), exercise (moderate-intensity swimming exercise) and metrnl (1 µg/day). For histological studies, hematoxylin-eosin, toluidine blue and methyl green-pyronin staining were performed on heart tissues. Musclin levels were measured in serum samples using the ELISA method.</p><p><strong>Results: </strong>Metrnl infusion increased cardiac mast cell and plasma cell numbers in female rats like moderate-intensity exercise. In addition, the increase in cardiac mast cell count was greater in the exercise group, whereas musclin concentration decreased in female rats subjected to moderate-intensity exercise.</p><p><strong>Conclusion: </strong>Our data suggests that moderate-intensity exercise's effects on the cardiac immune system may be mediated, by downregulating musclin and metrnl-dependent upregulating cardiac mast cells and plasma cells. Thus, exercise-induced metrnl may affect the cardiac immune response by modulating cardiac immune cells.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suppression of Recurrent Ventricular Fibrillation Associated with J-Wave Syndrome Using Cilostazol.","authors":"Uğur Canpolat, Kudret Aytemir","doi":"10.5543/tkda.2025.48409","DOIUrl":"https://doi.org/10.5543/tkda.2025.48409","url":null,"abstract":"<p><p>Sudden cardiac death (SCD) survivors should be carefully evaluated for primary electrical diseases of the heart, including early repolarization syndrome (ERS). Early repolarization patterns in some patients may be hindered by depolarization or intermittent, making it difficult to diagnose. Besides implantable cardioverter defibrillator (ICD) implantation for secondary prevention, pharmacological agents like quinidine and phosphodiesterase-III inhibitors (e.g., cilostazol) are recommended to prevent or reduce recurrent VF episodes. We presented an SCD survivor, a young female patient with a documented VF and ICD implantation, who was admitted after Home Monitoring detected multiple short-coupled PVC-induced VF episodes and was successfully treated with cilostazol.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frontal QRS-T Angle as a Prognostic Marker of Long-Term Mortality in Hemodialysis Patients-Uncorrected Proof.","authors":"Çağlar Kaya, Mustafa Ebik, Cihan Öztürk, Merve Akbulut Çakır, Emirhan Çakır, İlhan Kılıç","doi":"10.5543/tkda.2025.98252","DOIUrl":"https://doi.org/10.5543/tkda.2025.98252","url":null,"abstract":"<p><strong>Objective: </strong>The electrocardiogram is a crucial, cost-effective, and noninvasive tool for assessing the risk of cardiac morbidity and mortality. The frontal QRS-T angle is a marker of ventricular repolarization. This study investigated whether the frontal QRS-T angle could predict mortality in hemodialysis patients over a seven-year follow-up period.</p><p><strong>Method: </strong>The study included 110 patients undergoing regular hemodialysis. Frontal QRS-T angles greater than 90 degrees were classified as wide. Patients were categorized based on the width of the QRS-T angle and the presence or absence of mortality. Electrocardiogram (ECG) parameters measured included the QRS, T axis, TP/QT ratio, fragmented QRS, TPe/QTc ratio, and the frontal QRS-T angle, defined as the absolute difference between the frontal QRS and T axes.</p><p><strong>Results: </strong>A total of 37 patients (34%) had a wide frontal QRS-T angle. The mean age was significantly higher in both the wide frontal QRS-T angle group and the mortality group. Ejection fraction was lower in the mortality group. The frontal QRS-T angle was wider in the mortality group (94 [31-113] vs. 33 [16-80], P < 0.001). In univariate and multivariate logistic regression analyses, having a wide QRS-T angle was associated with increased mortality (odds ratio [OR]: 8.08, confidence interval [CI]: 2.75-23.74, P < 0.001). Additionally, the presence of fragmented QRS also increased mortality risk (OR: 11.25, CI: 2.98-42.49, P < 0.001).</p><p><strong>Conclusion: </strong>Our findings demonstrate the independent prognostic value of the frontal QRS-T angle in patients undergoing hemodialysis, irrespective of ejection fraction status. This suggests that it may serve as a valuable tool in routine cardiovascular risk assessments, contributing to improved management strategies for this high-risk population.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Fici, Nicolas Roberto Robles, Istemihan Tengiz, Guido Grassi
{"title":"New Drugs for Resistant Hypertension: Pending Issue?","authors":"Francesco Fici, Nicolas Roberto Robles, Istemihan Tengiz, Guido Grassi","doi":"10.5543/tkda.2025.74304","DOIUrl":"https://doi.org/10.5543/tkda.2025.74304","url":null,"abstract":"<p><p>Antihypertensive pharmacological treatment, based on currently available drugs, has been shown to reduce the cardiovascular risk profile of the treated hypertensive patients by lowering elevated blood pressure values. However, the risk of the treated hypertensive patients remains elevated. This represents the rationale for developing new antihypertensive drugs capable to normalize cardiovascular risk related to uncontrolled high blood pressure. This paper is designed at reviewing new antihypertensive drugs for the treatment of drug-resistant hypertension. The review will focus in particular on the results obtained with non-steroidal mineralcorticoid receptors antagonists, aldosterone synthase inhibitors, brain renin-angiotensin blockers, hepatic angiotensinogen inhibitors, atrial natriuretic peptides and endothelin 1 receptors antagonists.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burcunur Karayiğit, Orhan Karayiğit, Ahmet Balun, Hamdi Temel
{"title":"Reply to the Letter to the Editor: 'Uric Acid/Albumin Ratio: Beyond Risk Stratification to Therapeutic Guidance in Hypertension'.","authors":"Burcunur Karayiğit, Orhan Karayiğit, Ahmet Balun, Hamdi Temel","doi":"10.5543/tkda.2025.30971","DOIUrl":"https://doi.org/10.5543/tkda.2025.30971","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}