Cardiology Research最新文献

{"title":"<i>De Novo</i> Acute Heart Failure Versus Acute Decompensated Chronic Heart Failure: Are There Differences in In-Hospital Outcomes and Mortality?","authors":"Juan David Pelaez-Martinez, Daniel Castillo, Jackelin Mainguez, Sebastian Seni-Molina, Yorlany Rodas, Hoover O Leon-Giraldo, Diana Cristina Carrillo, Juan David Lopez-Ponce de Leon, Noel Alberto Florez, Pastor Olaya, Edilma Lucy Rivera, Nancy Olaya, Juan Esteban Gomez-Mesa","doi":"10.14740/cr2135","DOIUrl":"10.14740/cr2135","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is a major cause of global morbidity and mortality. Patients with acute decompensated chronic HF (ad-CHF) usually have more comorbidities, whereas those with <i>de novo</i> acute HF (dn-AHF) may have a more severe clinical presentation. Despite extensive research on HF, comparative data on in-hospital outcomes and mortality between these groups are scarce in Latin American countries. The aim of this study was to evaluate differences in in-hospital complications and mortality among patients hospitalized with either dn-AHF or ad-CHF.</p><p><strong>Methods: </strong>An ambispective study was conducted at a tertiary hospital in Colombia, including 780 patients hospitalized for acute HF. Patients were classified as dn-AHF or ad-CHF, and sociodemographic, clinical, and in-hospital outcomes were compared using bivariate analysis. A Firth penalized logistic regression model was used to assess the association between dn-AHF and in-hospital mortality.</p><p><strong>Results: </strong>Of these patients, 39.2% had dn-AHF, and 60.8% had ad-CHF. Median ages were 67 (interquartile range (IQR): 56 - 76) and 66 (IQR: 55 - 79) years, respectively. Both groups had a predominance of reduced left ventricular ejection fraction, with median values of 30% in ad-CHF and 34% in dn-AHF. Ad-CHF patients had more comorbidities, whereas dn-AHF patients showed higher rates of cardiac and non-cardiac complications. Intensive care unit (ICU) admission rates were similar, the need for invasive mechanical ventilation (P < 0.001) and the occurrence of infections (P = 0.049) were significantly more frequent in patients with dn-AHF. In-hospital mortality was higher in dn-AHF than ad-CHF (9.8% vs. 5.5%, P = 0.023). After adjustment, dn-AHF remained independently associated with greater in-hospital mortality (odds ratio (OR): 1.87; 95% confidence interval (CI): 1.07 - 3.31; P = 0.029).</p><p><strong>Conclusions: </strong>Patients with dn-AHF experienced more in-hospital complications and higher mortality than those with ad-CHF, despite similar ICU admission rates and fewer comorbidities. These results highlight the prognostic importance of dn-AHF and underscore the need for early identification, vigilant monitoring, and phenotype-specific management from admission to improve outcomes, particularly among patients with reduced ejection fraction.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 6","pages":"507-517"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Patent Foramen Ovale on In-Hospital Outcomes in Acute Pulmonary Embolism.","authors":"Ahmad Jabri, Sant Kumar, Mohamed Zghouzi, Mohamed Farhan Nasser, Anand Maligireddy, Raef Fadel, Brian O'Neill, Pedro Villablanca, Pedro Engel-Gonzalez, Tiberio Frisoli, Herbert D Aronow, Mohammad Alqarqaz, Gennaro Giustino, Herman Kado, Amr Abbas, Vikas Aggarwal","doi":"10.14740/cr2130","DOIUrl":"10.14740/cr2130","url":null,"abstract":"<p><strong>Background: </strong>Patent foramen ovale (PFO) may complicate acute pulmonary embolism (PE) by enabling paradoxical embolism, but its clinical impact remains unclear. We evaluated the characteristics, management, and outcomes of patients hospitalized with PE with or without PFO.</p><p><strong>Methods: </strong>Using the National Inpatient Sample database, adult patients admitted with acute PE between 2016 and 2020 were identified via ICD-10 codes. Patients were grouped based on whether they had concomitant PFO. Clinical characteristics, advanced therapies, and in-hospital outcomes were compared between patients with and without PFO. Multivariable logistic regression analyses were adjusted for demographics and comorbidities, with outcomes reported as adjusted odds ratios (aORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>We identified 903,230 adult patients hospitalized with acute PE, among whom 4,860 (0.54%) had a PFO. Patients with concomitant PE and PFO were younger (59.4 ± 15.9 vs. 63 ± 16.5 years, P < 0.001) and presented with more severe clinical features, including higher rates of saddle PE (17.7% vs. 9%, P < 0.001) and cor pulmonale (17.9% vs. 8.3%, P < 0.001). They required significantly more frequent interventions, such as catheter-directed thrombolysis (7.4% vs. 3.8%, P < 0.001). After multivariable adjustment, PFO presence was associated with significantly increased odds of stroke (aOR 25.5, 95% CI 19.8 - 32.8; P < 0.001) and peripheral embolism (aOR 13.7, 95% CI 10.5 - 18.0; P < 0.001) but not increased in-hospital mortality (aOR 0.9, 95% CI 0.6 - 1.3; P = 0.702).</p><p><strong>Conclusion: </strong>In this nationwide study, PFO in patients with acute PE was linked to greater clinical severity and more frequent advanced interventions. Prospective studies are needed to define optimal screening strategies.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 6","pages":"499-506"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Oscillatory Ventilation: A Potential New Risk Factor for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.","authors":"Stefanos G Sakellaropoulos, Muhemin Mohammed, Panagiotis Sakellaropoulos, Muhammad Ali, Athanasios Papadis, Ilias Piperopoulos, Eugenia Kloufetou, Benedict Schulte Steinberg, Claire Rogers, Andreas Mitsis","doi":"10.14740/cr2131","DOIUrl":"10.14740/cr2131","url":null,"abstract":"<p><p>Other than the traditional risk factors for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) - detected by means of anamnesis, Holter monitoring, exercise testing, echocardiography and cardiac magnetic resonance imaging - exercise oscillatory ventilation (EOV), detected by cardiopulmonary exercise testing (CPET), has recently been observed in patients with HCM. EOV is considered as one of the most important independent risk factors for morbidity, mortality and SCD in patients with reduced, as well as with preserved ejection fraction. Considering HCM as a prototype of heart failure with preserved ejection fraction, we would like to present a short, specific review concerning EOV as a potential new risk factor for SCD in HCM.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 6","pages":"475-478"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Observations on Discordance Between Coronary Artery Calcium Score of Zero and Coronary Computed Tomography Angiography Findings in Asymptomatic Adults.","authors":"Farhan Ashraf, Mohammad Raza Qureshi, Masoud Alam, Sushma Umroa, Shafaath Husain, Faiz Ul Amin, Munir Khan","doi":"10.14740/cr2151","DOIUrl":"10.14740/cr2151","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery calcium (CAC) scoring is widely used to screen for coronary artery disease (CAD) in asymptomatic individuals. However, it detects calcified plaques and may miss non-calcified or soft plaques. This study compared the diagnostic accuracy of CAC scoring with coronary computed tomography angiography (CCTA) for detecting CAD in asymptomatic individuals with risk factors.</p><p><strong>Methods: </strong>Eighteen asymptomatic adults with a CAC score of 0 underwent CCTA to evaluate for subclinical CAD. Clinical, biochemical, and lifestyle risk factors were assessed. Diagnostic agreement between CAC and CCTA was analyzed using the Wilcoxon signed rank test.</p><p><strong>Results: </strong>The cohort had a mean age of 51.4 ± 10.6 years, 88.8% were male, and mean body mass index (BMI) was 27.7 ± 3.6 kg/m². Smoking (70.5%) and family history of CAD (56.25%) were prevalent. Biochemical analyses showed preserved renal function and non-diabetic glycemic profiles. Despite the absence of calcification on CAC, CCTA revealed CAD in 72.2% (13/18) of participants, detecting non-calcified plaques missed by CAC scoring. Elevated cardiac and inflammatory markers, including high-sensitivity cardiac troponin T, apolipoprotein B (apoB), and lipoprotein(a) (Lp(a)), were observed in those with positive CCTA findings. The Wilcoxon signed rank test indicated a significant difference between the modalities (Z = -3.606, P < 0.001).</p><p><strong>Conclusions: </strong>CCTA detected non-calcified atherosclerosis missed by CAC and demonstrated superior sensitivity for early CAD detection in asymptomatic individuals.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 6","pages":"518-524"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic Evaluation of Right Heart and Hemodynamic Changes After Transcatheter Secundum Atrial Septal Defect Closure in Adults: A Single-Center Retrospective Study.","authors":"Jamilah S AlRahimi, Almas S AlSolami, Renad S Alghamdi, Ritaj S AlZahrani, Aryam M Bawazeer, Nawal W Kutob, Rana A O Madi, Amjad A SaemAldahar, Waad A AlSulami, Alhanouf AlOtaibi","doi":"10.14740/cr2116","DOIUrl":"10.14740/cr2116","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter closure of secundum atrial septal defects (ASDs) is a widely accepted intervention in adults with left-to-right shunting and right heart volume overload. However, the time course and magnitude of cardiac remodeling and functional improvement after closure remain incompletely defined. This study evaluated serial echocardiographic changes in right heart structure and hemodynamics following ASD closure.</p><p><strong>Methods: </strong>In this single-center retrospective cohort, adults who underwent transcatheter secundum ASD closure between January 2020 and December 2023 were included. Echocardiography was performed at baseline, immediately post-procedure, at 3 to 6 months, and at 1 year. Parameters included right atrial (RA) area and volume index (RAVI), right ventricular (RV) dimensions, pulmonary valve velocities, RV systolic pressure (RVSP), mean pulmonary artery pressure (mPAP), tricuspid annular plane systolic excursion (TAPSE), and tricuspid regurgitation (TR) severity. Analyses used Wilcoxon signed-rank tests, Chi-square tests, repeated-measures analysis of variance (ANOVA)/multivariate ANOVA (MANOVA), and mixed-effects models.</p><p><strong>Results: </strong>Eighty patients were included (mean age: 42.3 ± 15.0 years; 72.5% female). Immediately after closure, significant reductions were observed in TR Vmax (-20.8 cm/s, P = 0.0005), pulmonary valve Vmax (-32.1 cm/s, P < 0.0001), Vmean (-18.6 cm/s, P < 0.0001), velocity time integral (VTI) (-6.9 cm, P < 0.0001), RA area (-2.6 cm², P < 0.0001), RAVI (-7.0 mL/m², P < 0.0001), RVSP (-7.7 mm Hg, P < 0.0001), QP:QS (-0.8, P ≤ 0.0001), and mPAP (-10.0 mm Hg, P = 0.0007). Improvements were sustained at 3 - 6 months (n = 54) and at 1 year (n = 19).</p><p><strong>Conclusions: </strong>Transcatheter ASD closure in adults results in early and sustained improvements in RA and ventricular remodeling, pulmonary pressures, and TR severity. These findings underscore the role of echocardiography in longitudinal surveillance and support timely intervention in patients with significant shunting (QP:QS > 1.5). Larger multicenter studies with extended follow-up and correlation to clinical outcomes are warranted.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 5","pages":"421-432"},"PeriodicalIF":1.4,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Care of a Patient With Carney Complex.","authors":"Dillon Froass, Katherine Manupipatpong, Brittany L Willer, Joseph D Tobias","doi":"10.14740/cr2127","DOIUrl":"10.14740/cr2127","url":null,"abstract":"<p><p>Carney complex is a multiple endocrine neoplasia syndrome, commonly affecting the thyroid, adrenal, and pituitary glands. In addition to endocrine involvement, tumors and myxomas may develop including cardiac myxomas and schwannomas. Approximately 70% of cases result from autosomal dominant germline mutation, with the remaining 30% representing <i>de novo</i> spontaneous mutations. Carney complex remains extremely rare, with only approximately 750 cases reported worldwide since 1985. We present an adolescent with Carney complex who underwent left atrial myxoma resection, followed by bilateral adrenalectomy a few years later. The perioperative implications of Carney complex are presented, previous reports of anesthetic care in these patients reviewed, and options for anesthetic management discussed.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 5","pages":"462-466"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BEAT-HTN India: Burden, Epidemiology, and Trends of Hypertension - A Nationwide Survey.","authors":"H K Chopra, Navin C Nanda, A K Das, Ashok Kripalani, Uday Jadhav, G S Wander, Mangesh Tiwaskar, Umapati Hegde, Niteen Deshpande, Suhas Hardas, Ajit Mullasari, Ajit Bhagwat, Soumitra Ray, Vikas Singh, S Chandrasekhar, Rajasekar Chakravarthi, Dharmesh Solanki, Sarita Bajaj, Tiny Nair, C K Ponde, Dinesh Khullar, Viveka Kumar, Satyendra Tiwari, Vidyut Jain, A K Pancholia, J P S Sawhney, Rajeev Agarwala, Aparna Jaswal, Aditya Kapoor, Roopali Khanna, A K Bhalla, Sarita Rao, Shibba Takkar Chhabra, Kavita Tyagi, Namrata Gaur, Anu Grover","doi":"10.14740/cr2110","DOIUrl":"10.14740/cr2110","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a growing public health concern in India, increasingly interlinked with metabolic disorders such as diabetes and characterized by significant regional and demographic variation. Despite advancements in diagnosis and treatment, control rates remain unsatisfactory. Elevated resting heart rate (HR), an emerging marker of sympathetic overactivity, may offer additional insight into the underlying pathophysiology of Indian hypertensives. The objective of the study was to assess the prevalence of hypertension across India, explore its association with diabetes, elevated HR, and regional variation, and evaluate the potential role of sympathetic overdrive as a common pathophysiological thread.</p><p><strong>Methods: </strong>A nationwide, cross-sectional survey was conducted among 41,370 adults across 31 Indian regions. Data on systolic and diastolic blood pressure, resting HR, diabetes history, age, gender, and region were collected and analyzed to identify patterns of comorbidity and demographic distribution.</p><p><strong>Results: </strong>Overall hypertension prevalence was 29.8% (95% confidence interval (CI): 29.4 - 30.2), higher among males, 33.2% (95% CI: 32.6 - 33.8) than females, 27.2% (95% CI: 26.6 - 27.8). A notable proportion (14.6%, 95% CI: 14.2 - 15.0) of hypertensives also had diabetes, with this comorbidity more prevalent in males (15.8%, 95% CI: 15.2 - 16.4) than females (13.3%, 95% CI: 12.8 - 13.8). The mean resting HR was 83.9 bpm across all participants, exceeding 80 bpm even among normotensives, and was highest in diabetic hypertensives (85.9 vs. 82.2 bpm in non-diabetics; P < 0.05). Hypertension was more common in older adults, males, and those residing in urbanized or rapidly transitioning regions. Though obesity data were not captured, the strong associations between hypertension, diabetes, and elevated HR point toward underlying metabolic dysfunction and sympathetic overactivity.</p><p><strong>Conclusion: </strong>This large-scale survey reinforces the complex cardiometabolic burden in India and highlights elevated resting HR as a potential surrogate marker of sympathetic overactivity in hypertensives, especially those with diabetes. Regional and demographic disparities underscore the need for integrated, population-specific approaches that go beyond blood pressure control to address the broader spectrum of metabolic and autonomic dysfunction.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 5","pages":"403-412"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Cardiac Myxoma With Multiple Feeding Vessels From the Right Coronary Artery and the Left Circumflex Artery.","authors":"Tomo Komaki, Natsuki Onishi, Kohei Tashiro, Yuko Teratani, Yuta Sukehiro, Hideichi Wada, Shin-Ichiro Miura, Masahiro Ogawa","doi":"10.14740/cr2113","DOIUrl":"10.14740/cr2113","url":null,"abstract":"<p><p>An 80-year-old woman with persistent atrial fibrillation was referred to our hospital for evaluation of a left atrial mass. Transthoracic and transesophageal echocardiography revealed a well-defined, sessile, and immobile mass attached to the interatrial septum. Computed tomography (CT) coronary angiography revealed a cardiac tumor fed by two vessels: one from the right coronary artery and one from the left circumflex artery. Based on these findings and cardiac magnetic resonance imaging, the mass was diagnosed as a left atrial myxoma, and excision was performed. Although some atrial myxomas are highly vascular, identification of multiple feeding vessels on CT coronary angiography is rare. Preoperative evaluation of feeding vessels is helpful in distinguishing myxomas from left atrial thrombi, especially in patients with hypercoagulability.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 5","pages":"457-461"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Point-of-Care N-Terminal Pro-Brain Natriuretic Peptide Assay for Heart Failure Management.","authors":"Florian Belik, Meryem Benamour, Antoine Laffalize, Thibault Lavalleye, Louisa Van Belle, Anne-Catherine Pouleur, Damien Gruson","doi":"10.14740/cr2117","DOIUrl":"10.14740/cr2117","url":null,"abstract":"<p><strong>Background: </strong>N-terminal pro-brain natriuretic peptide (NT-proBNP) is a key biomarker in heart failure (HF) diagnosis and management. This study aimed to evaluate performances of the LumiraDx^® NT-proBNP, a point-of-care testing (POCT) device, focusing on imprecision, method comparison, and clinical practicability.</p><p><strong>Methods: </strong>The LumiraDx^® NT-proBNP test was assessed for imprecision across two reagent lots and compared with a reference laboratory method (Cobas e601) using 81 plasma samples. Method concordance was analyzed using Bland-Altman and Passing-Bablok regression. A user satisfaction survey evaluated its practicality in a clinical setting.</p><p><strong>Results: </strong>For the first reagent lot, a coefficient of variation (CV) of 2.81% was observed, while for the second reagent lot, the CV was 5.4%. Method comparison revealed strong concordance with the reference method for NT-proBNP values < 1,000 ng/L. However, a significant bias was observed for values > 1,000 ng/L in the first lot, resolved in the second. User satisfaction surveys highlighted ease of use. Additionally, implementing the LumiraDx^® NT-proBNP Platform resulted in a significant reduction in turnaround time, with an estimated 49 min saved in result reporting.</p><p><strong>Conclusion: </strong>The LumiraDx^® NT-proBNP POCT device demonstrates strong potential for HF management by combining rapid results, user-friendly operation, and sampling versatility. While biases at higher NT-proBNP levels warrant further standardization, this system represents a practical tool for decentralized HF care.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 5","pages":"447-452"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Alternative Access Site Versus Lithotripsy-Assisted Transfemoral Transcatheter Aortic Valve Replacement: A Single-Center Retrospective Study.","authors":"Gabriel Ramos, Grant DeLozier, Ryan Ullibarri, Alden Mileto, Nicholas Ierovante, Yassir Nawaz","doi":"10.14740/cr2115","DOIUrl":"10.14740/cr2115","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve replacement (TAVR) has emerged as a primary therapeutic option for patients with severe aortic stenosis across all surgical risk categories. Alternative access site (AAS) routes are often used in patients unsuitable for standard transfemoral (TF) approach, though intravascular lithotripsy (IVL) provides novel remedies to traditionally \"unsuitable\" patients. The objectives of our study were to compare outcomes between AAS TAVR placement and lithotripsy-assisted TF TAVR.</p><p><strong>Methods: </strong>The authors analyzed 60 patients who underwent TAVR between 2019 and 2022 (41 with alternative access, 19 with lithotripsy) at a single US site. Primary outcomes included procedural success, adverse events at 1 month and 1 year, length of stay, and 3-year mortality.</p><p><strong>Results: </strong>The data trended towards higher 1-month adverse outcomes in the alternative access patients compared to TF lithotripsy patients (17.1% (95% confidence interval (CI): 8.5% - 31.3%) vs. 0% (95% CI: 0.0% - 16.8%); P = 0.09), while 1-year adverse outcomes were similar (AAS 12.2% (95% CI: 5.3% - 25.5%) vs. IVL 15.8% (95% CI: 5.5% - 37.6%); P = 0.70), and 3-year mortality (19.5% vs. 21.1%) were similar between groups. Median length of stay was 3 days for both groups.</p><p><strong>Conclusions: </strong>Lithotripsy-assisted TF TAVR demonstrated a statistically insignificant trend toward short-term major adverse events with comparable 1-year morbidity and 3-year mortality to alternative access approaches. These findings may support lithotripsy as a viable option for patients with challenging vascular anatomy rather than the more traditional use of AAS in these settings. However, more extensive research is necessary for appropriate statistical power to prove superiority rather than equivocality alone.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"16 5","pages":"413-420"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}