The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi最新文献_第6页

Autonomic Nervous System Dysfunction in Achalasia. Achalasia 的自主神经系统功能障碍。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-02-25 DOI: 10.4166/kjg.2023.144

Min-Jae Kim, Eunha Cho, Zahid Hussain, Hyojin Park

{"title":"Autonomic Nervous System Dysfunction in Achalasia.","authors":"Min-Jae Kim, Eunha Cho, Zahid Hussain, Hyojin Park","doi":"10.4166/kjg.2023.144","DOIUrl":"10.4166/kjg.2023.144","url":null,"abstract":"Background/aims: Achalasia is an esophageal motility disorder characterized by dysphagia and noncardiac chest pain. Impairment of vagal function has been reported in achalasia. This study evaluated autonomic nervous system (ANS) dysfunctions in patients with achalasia to establish a correlation between an ANS dysfunction and the clinical symptoms of achalasia.Methods: Nineteen patients with achalasia (six males/13 females; mean age, 47.1±16.3 years) and 10 healthy controls (four males/six females; 34.8±10.7 years) were enrolled prospectively at Gangnam Severance Hospital between June 2013 and June 2014. All patients completed a questionnaire on ANS dysfunction symptoms and underwent a heart rate variability (HRV) test.Results: ANS dysfunction symptoms were present in 13 patients with achalasia (69%) and three controls (30%). The ANS dysfunction score was significantly higher in patients with achalasia than in the controls (p=0.035). There were no significant differences in the standard deviation of all normal R-R intervals, high frequency (HF), low frequency (LF), and LF/HF ratio in the HRV test. In subgroup analysis comparing female achalasia patients with controls, the cardiac activity was significantly higher in the female achalasia patients than in the controls (p=0.036). The cardiac activity (p=0.004) and endurance to stress (p=0.004) were significantly higher in the achalasia patients with ANS dysfunction symptoms than the achalasia patients without ANS dysfunction symptoms.Conclusions: ANS dysfunction symptoms are common in patients with achalasia. Female achalasia patients and those with ANS dysfunction symptoms showed increased cardiac activity. Hence, more attention should be paid to cardiac overload in achalasia patients who are female or have ANS dysfunction symptoms.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"83 2","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Giant Gastric Perforation Occurring in the Normal Mucosa during Endoscopy in a Patient with Advanced Gastric Cancer]. [一名晚期胃癌患者在内镜检查时在正常黏膜上发现巨大胃穿孔]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-02-25 DOI: 10.4166/kjg.2023.147

Cheol Min Lee, Su Jin Kim

引用次数: 0

Long-term Survivor of Unresectable Pancreatic Cancer Treated with Concurrent Chemoradiotherapy. 接受同期化疗和放疗的未切除胰腺癌长期存活者

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-01-25 DOI: 10.4166/kjg.2023.140

Yun Je Song, Jun-Ho Choi

引用次数: 0

Transcription Silencing and CpGs Hypermethylation as Therapeutic Gene Editing in Clinical Colorectal Adenocarcinoma Repression. 转录沉默和 CpGs 高甲基化作为治疗性基因编辑在临床大肠腺癌抑制中的应用。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-01-25 DOI: 10.4166/kjg.2023.132

Miqdam M Obaid Al-Jumaili

{"title":"Transcription Silencing and CpGs Hypermethylation as Therapeutic Gene Editing in Clinical Colorectal Adenocarcinoma Repression.","authors":"Miqdam M Obaid Al-Jumaili","doi":"10.4166/kjg.2023.132","DOIUrl":"10.4166/kjg.2023.132","url":null,"abstract":"Background/aims: Colorectal cancer is the most common cancer in oncopathology, with an increasing incidence among the elderly during the last decade. Various genetic and environmental factors play important roles in the emergence of colorectal adenocarcinoma. Non-coding RNAs, approximately 20-22 nucleotides, are transcribed irregularly in many cancer cells and play a critical role in many metabolic pathways in clinical cancer cases. DNA methylation is a critical epigenetic alteration that controls gene expression. In the current study, transcriptional silencing and CpG hypermethylation were developed as a therapeutic gene editing strategy for the clinical repression of colorectal adenocarcinoma.Methods: A human colorectal adenocarcinoma cell line (Caco2) and a normal lung fibroblast cell line (Wi38) were utilized as the paradigms in this research to examine the effect of mir155 molecule transfection and CpGs-island (CGI) methylation. Cell counting was achieved using six-well and 24-well plates before transfection using a hemocytometer. The two cell lines were transfected with the mir155 agomir and antagomir molecules. The transfection efficiency, cell viability, cell IC50, and target gene expression were measured, and CGIs-methylation was achieved by bisulfate conversion.Results: The outcomes revealed the downregulation of oncogenes (AKT1 and VCAM1 genes as cancer-associated genes) and the upregulation of tumor suppressor genes (TSGs, Tp53 and KEAP1). In addition, CpG-islands methylation showed significant blocking of the oncogene promoter regions, and the switch on of TSG promoter regions was continuous.Conclusions: miRNA-CGI-methylation led to the regression of Caco2 cell proliferation, suggesting the potential use of RNA silencing and DNA methylation in targeted gene therapy for colorectal cancer.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"83 1","pages":"6-16"},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Curious Case of Primary Gastric Mucosal Melanoma. 胃粘膜原发性黑色素瘤的奇特病例

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-01-25 DOI: 10.4166/kjg.2023.136

Zahabia Sohail, Mirza Rameez Samar, Neelam Jawed Qureshi, Sidra Arshad, Adeeba Zaki

{"title":"A Curious Case of Primary Gastric Mucosal Melanoma.","authors":"Zahabia Sohail, Mirza Rameez Samar, Neelam Jawed Qureshi, Sidra Arshad, Adeeba Zaki","doi":"10.4166/kjg.2023.136","DOIUrl":"10.4166/kjg.2023.136","url":null,"abstract":"Malignant melanoma is a neoplasm of melanin-producing cells predominantly of cutaneous origin, which uncommonly develops within gut mucosa. We present the case of a 58-year-old woman with complaints of abdominal pain, loss of appetite and weight. Esophagogastroduodenoscopy revealed a gastric mass and systemic imaging demonstrated widespread nodal and bilateral adrenal gland involvement. Histopathology of the gastric mass confirmed primary malignant mucosal melanoma of the stomach. The patient received three cycles of Nivolumab but did not respond, and thus, was then offered best supportive care. Although infrequent, mucosal melanoma can arise from the gastrointestinal tract, and in contrast to the cutaneous form, advanced disease usually has a dismal prognosis and responds poorly to immune checkpoint inhibitors. Primary gastric melanoma is an aggressive disease that is diagnosed by exclusion after the differential diagnosis of metastasis from a cutaneous or unknown primary site has been conducted. If available, patients with treatment-naïve mucosal melanoma should be considered for enrollment in clinical trials.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"83 1","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Cause of Hematochezia in Children: Solitary Rectal Ulcer, Single Center Experience. 儿童血尿的罕见病因：孤立性直肠溃疡，单中心经验。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-01-25 DOI: 10.4166/kjg.2023.093

Fatma İlknur Varol, Şükrü Güngör, Mukadder Ayşe Selimoğlu, Emine Şamdancı

{"title":"Rare Cause of Hematochezia in Children: Solitary Rectal Ulcer, Single Center Experience.","authors":"Fatma İlknur Varol, Şükrü Güngör, Mukadder Ayşe Selimoğlu, Emine Şamdancı","doi":"10.4166/kjg.2023.093","DOIUrl":"10.4166/kjg.2023.093","url":null,"abstract":"Background/aims: Solitary rectal ulcer syndrome (SRUS) can be overlooked, diagnosed late, or misdiagnosed, particularly in childhood. This study reviewed the 13-year experience of the authors' institution to increase clinicians' awareness of SRUS in the presence of symptoms. This paper reports the endoscopic and histopathological findings in children presenting with hematochezia.Methods: The clinical and laboratory findings of 22 patients diagnosed with biopsy-proven SRUS in the authors' clinic between 2007 and 2020 were evaluated retrospectively.Results: The mean age at diagnosis was 12.5±2.6 years, and 59.1% of the patients were male. The median time of diagnosis was 24 months. A single ulcer lesion was found by colonoscopy in 18 patients (81.8%), two ulcers in two patients (9%), and more than two ulcers in two patients (9%). The pathology reports of all biopsies taken from the lesions were consistent with a solitary rectal ulcer. In the first stage, the treatment was started with toilet training, a high-fiber diet, and laxatives. In 11 patients (50%) who did not respond to the initial treatment, a 5-ASA enema was added. A glucocorticoid enema was added to treatment in five patients (22%) whose complaints did not regress despite this treatment. Clinical remission was achieved in five of the patients (18.1%). The time to diagnosis was significantly shorter in those in remission than those not in remission (p=0.04).Conclusions: This study is the first large series on Turkish children. An increased awareness of SRUS in children will increase the rate of early diagnosis and treatment, allowing remission in more patients.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"83 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Type II Achalasia Occurring in a Nonagenarian Diagnosed with Acute Food Impaction]. [一位非高龄老人发生 II 型食道闭锁并被诊断为急性食物嵌塞的病例]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-01-25 DOI: 10.4166/kjg.2023.112

Seong Hyun Koh, Moo In Park, Woo Hyuk Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Seun Ja Park

引用次数: 0

[Microbiome and Biliary Tract Cancer]. [微生物组与胆道癌]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2024-01-25 DOI: 10.4166/kjg.2023.135

Jin-Seok Park

{"title":"[Microbiome and Biliary Tract Cancer].","authors":"Jin-Seok Park","doi":"10.4166/kjg.2023.135","DOIUrl":"10.4166/kjg.2023.135","url":null,"abstract":"Biliary tract cancers encompass a group of malignancies that affect the bile ducts and gallbladder and are associated with a poor prognosis, often due to late diagnosis and limited treatment options. The incidence of biliary tract cancer has been increasing gradually, underscoring the need for a better understanding of its pathogenesis and potential risk factors. Research suggests that biliary tract cancer may develop through a combination of genetic and epigenetic alterations, as well as environmental factors. The role of microbial exposure and the human microbiome in the pathogenesis of biliary tract cancer is an emerging area of interest. Traditionally, the biliary tree was considered sterile under normal conditions, but recent studies have identified associations between specific microbiological patterns and inflammatory biliary diseases and cancer. The human microbiome plays a crucial role in maintaining host homeostasis and interacting with the host's immune system. Dysbiosis, or an imbalance in the microbiome composition, has been implicated in the development of various diseases, including cancer. Hence, dysbiosis in the biliary tract might trigger the pathogenesis of biliary tract cancer. Advances in next-generation sequencing technology have provided researchers with a more comprehensive view of the microbiota and their potential roles in health and disease, providing more evidence of the relationship between the microbiota and biliary tract cancer. This review summarizes the latest evidence of the microbiome that would be associated with biliary tract cancer.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"83 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plug-Assisted Retrograde Transvenous Obliteration for the Treatment of Duodenal Variceal Bleeding - A Case Report and Literature Review. 用于治疗十二指肠静脉曲张出血的塞子辅助逆行经静脉阻断术--病例报告和文献综述。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2023-12-25 DOI: 10.4166/kjg.2023.105

Kyung Kyu Lee, Jae Yong Park, Woo Sun Choi, Young Youn Cho

引用次数: 0

Unique Case of Severe Sepsis and Acute Respiratory Failure in the Setting of Aseptic Epiploic Appendagitis of the Descending Colon. 降结肠无菌性外膜阑尾炎导致严重败血症和急性呼吸衰竭的独特病例。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2023-12-25 DOI: 10.4166/kjg.2023.111

Nathaniel J Leavitt, Usman S Kazi, Ryan Cromwell, Fagunkumar Modi

引用次数: 0