The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi最新文献

[Drug Therapy for Gastroesophageal Reflux Disease]. [胃食管反流病的药物治疗]

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.145

Seung Young Kim

{"title":"[Drug Therapy for Gastroesophageal Reflux Disease].","authors":"Seung Young Kim","doi":"10.4166/kjg.2024.145","DOIUrl":"https://doi.org/10.4166/kjg.2024.145","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is a common condition primarily treated with acid-suppressive therapies such as proton pump inhibitors (PPIs) or potassium competitive acid blockers (P-CABs). However, many patients experience a suboptimal response to PPIs or symptom recurrence upon discontinuation, leading to an increased economic burden and reduced quality of life. For patients unresponsive to PPIs, objective tests such as reflux monitoring are essential to differentiate GERD from other conditions or to understand the underlying mechanisms causing the reflux. Strategies like optimizing adherence, dose escalation, switching to other PPIs, or transitioning to P-CABs can improve treatment outcomes. Use of neuromodulators may benefit patients with functional heartburn or reflux hypersensitivity. For those requiring maintenance therapy, explaining the advantages and disadvantages of continuous versus on-demand treatment and providing clear guidance can help achieve effective symptom control with the minimal necessary dosage of the medication. Sequential maintenance therapy, which begins with daily medication and transitions to on-demand therapy, is effective in improving patient satisfaction while minimizing drug exposure.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"146-152"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Dietary Therapy in Irritable Bowel Syndrome]. [肠易激综合征的饮食治疗]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.009

Seung Joo Kang

引用次数: 0

Rare Case Report of Ticagrelor-Induced Hepatotoxicity. 替格瑞洛致肝毒性罕见病例报告。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.153

Dong Wook Kim, Song-Hee Han, Yeo Wool Kang, Saing Yi Moon, Yang Hyun Baek

{"title":"Rare Case Report of Ticagrelor-Induced Hepatotoxicity.","authors":"Dong Wook Kim, Song-Hee Han, Yeo Wool Kang, Saing Yi Moon, Yang Hyun Baek","doi":"10.4166/kjg.2024.153","DOIUrl":"https://doi.org/10.4166/kjg.2024.153","url":null,"abstract":"Ticagrelor, a potent P2Y12 receptor inhibitor, is used widely to manage acute coronary syndrome owing to its superior efficacy in reducing cardiovascular events compared to clopidogrel. Despite its favorable safety profile, this paper reports a case of ticagrelor-induced hepatotoxicity. A 66-year-old male with a history of pituitary macroadenoma presented with elevated liver enzymes during a preoperative assessment for tumor removal. The patient was asymptomatic. Ultrasonography revealed diffusely decreased parenchymal echogenicity with prominent portal venular wall echogenicity, suggesting acute hepatopathy, while no significant findings were observed on the computed tomography image. All viral markers were negative; only the anti-nuclear antibody was positive. A biopsy was performed to discriminate autoimmune hepatitis. The specimen showed a lymphocytic infiltrate, with eosinophils and plasma cells mainly affecting the hepatic parenchyma in zone 3. The liver enzyme levels improved when the anti platelet drugs for biopsy were discontinued, but they worsened again after the biopsy. Hence, ticagrelor, an anti-platelet agent, was suspected as the causative drug. Ticagrelor was discontinued, and the subsequent liver enzyme levels gradually returned to normal. This case highlights the need for careful monitoring of the liver function in patients receiving ticagrelor.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"226-230"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ileocecal Tuberculosis was Incidentally Diagnosed after Ingesting a Blister Pill Pack. 回肠盲区结核是偶然诊断后，摄入水泡药片包。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.121

Kiet Gia Le Nguyen, Nang Van Pham, Tuan Van Nguyen, Doi Van Mai, Hien Van Nguyen, Huan Hoang Lam, Tuan Thanh Tran, Phu Thien Diep Duong, Trinh Anh Thi Vo

引用次数: 0

[Emerging Diagnostic Techniques and Therapies for Upper Gastrointestinal Bleeding]. [新兴的上消化道出血诊断技术和治疗方法]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.147

Hyung Seok Lee, Dong-Kyu Lee

引用次数: 0

[Treatment of Irritable Bowel Syndrome with Predominant Diarrhea]. 以腹泻为主的肠易激综合征的治疗

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.011

Min Cheol Kim, Yehyun Park, Hong Sub Lee

{"title":"[Treatment of Irritable Bowel Syndrome with Predominant Diarrhea].","authors":"Min Cheol Kim, Yehyun Park, Hong Sub Lee","doi":"10.4166/kjg.2025.011","DOIUrl":"https://doi.org/10.4166/kjg.2025.011","url":null,"abstract":"Irritable bowel syndrome with predominant diarrhea (IBS-D) is a subtype of irritable bowel syndrome that causes frequent loose stools. Although the precise pathophysiology remains unclear, factors, such as gut microbiota imbalance, visceral hypersensitivity, intestinal permeability changes, and stress, play significant roles. Recent studies have suggested that dysbiosis is a key contributor to IBS-D pathogenesis, emphasizing the need for targeted therapeutic strategies. The treatment of IBS-D involves pharmacological and non-pharmacological approaches. Pharmacological treatments include antidiarrheal agents, such as loperamide, which reduce stool frequency but have limited effects on pain relief. Antispasmodics, such as octylonium bromide and hyoscine butylbromide, alleviate abdominal pain by modulating intestinal motility. Rifaximin, a non-absorbable antibiotic, has shown efficacy in symptom reduction by altering the gut microbiota. Selective serotonin receptor antagonists, such as ramosetron, have benefits in symptom control, particularly in male patients. In addition, low-dose tricyclic antidepressants help manage pain and stool irregularities by modulating the gut-brain interactions. Non-pharmacological strategies include dietary modifications, with the low-FODMAP diet showing potential benefits despite concerns about long-term nutritional adequacy. Psychological interventions, such as cognitive behavioral therapy and gut-directed hypnotherapy, are recommended for patients with persistent symptoms unresponsive to medication. Mild physical activities, such as yoga and walking, relieve symptoms by improving gut motility and reducing stress. Personalized treatment approaches are essential because IBS-D presents a wide spectrum of symptoms. Clinicians should tailor therapeutic plans based on individual patient characteristics, balancing the benefits and risks of each intervention to optimize symptom control and improve the quality of life.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Parenteral Nutrition and Citrulline Levels of Pediatric Patients Who Underwent Surgery for Intestinal Disorders in Indonesia. 印度尼西亚接受肠道疾病手术的儿科患者肠外营养与瓜氨酸水平的相关性

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.122

Soehalino, Alpha Fardah Athiyyah, Reza Gunadi Ranuh, Andy Darma, Subijanto Marto Sudarmo, Khadijah Rizky Sumitro

{"title":"Correlation Between Parenteral Nutrition and Citrulline Levels of Pediatric Patients Who Underwent Surgery for Intestinal Disorders in Indonesia.","authors":"Soehalino, Alpha Fardah Athiyyah, Reza Gunadi Ranuh, Andy Darma, Subijanto Marto Sudarmo, Khadijah Rizky Sumitro","doi":"10.4166/kjg.2024.122","DOIUrl":"https://doi.org/10.4166/kjg.2024.122","url":null,"abstract":"Background/aims: Parenteral nutrition is often administered after a small bowel resection, but it can increase the risk of complications such as sepsis and organ disorders. Citrulline has been identified as a potential biomarker that correlates with intestinal adaptation, affects the tolerance to enteral nutrition, and predicts the duration of parenteral nutrition. This study examined the correlation between parenteral nutrition and the plasma citrulline levels of pediatric patients who underwent surgery for small bowel disorders.Methods: This cross-sectional study compared the citrulline levels before and after administering parenteral nutrition to infants and children with small bowel disorders who required surgery at the Pediatric and Surgery Inpatient Ward of Dr. Soetomo General Hospital, Surabaya, Indonesia, between April and July 2023.Results: The mean citrulline level before parenteral nutrition administration was 1.44 nmol/mL (±0.48 nmol/mL) and increased to 1.89 nmol/mL (±1.73 nmol/mL) after (no significant difference; p=0.231). No significant changes in the citrulline levels in any of the samples, intestinal resection, or the presence of the ileocecal junction were observed before and after administering parenteral nutrition. Positive correlations were observed between the citrulline level and hospital length of stay (moderate strength; r=0.451; p=0.024) and between the citrulline level and parenteral nutrition duration (moderate strength; r=0.439; p=0.028).Conclusions: The citrulline levels before and after parenteral nutrition administration were similar.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"179-184"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Novel Insights into Pathophysiology and Treatment of Functional Dyspepsia Management]. [功能性消化不良管理病理生理学和治疗的新见解]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.024

Sang Hoon Kim

引用次数: 0

Angiotensin-Converting Enzyme Inhibitor-Drug Induced Liver Injury: Clinical Features and Diagnostic Features - A Systematic Review of Current Reported Cases. 血管紧张素转换酶抑制剂-药物引起的肝损伤：临床特征和诊断特征-对当前报告病例的系统回顾。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.008

Thanathip Suenghataiphorn, Narisara Tribuddharat, Pojsakorn Danpanichkul, Narathorn Kulthamrongsri

{"title":"Angiotensin-Converting Enzyme Inhibitor-Drug Induced Liver Injury: Clinical Features and Diagnostic Features - A Systematic Review of Current Reported Cases.","authors":"Thanathip Suenghataiphorn, Narisara Tribuddharat, Pojsakorn Danpanichkul, Narathorn Kulthamrongsri","doi":"10.4166/kjg.2025.008","DOIUrl":"https://doi.org/10.4166/kjg.2025.008","url":null,"abstract":"Background/aims: Angiotensin-converting enzyme Inhibitor induced liver injury (ACEi-ILI) is a rare and frequently underrecognized condition. Its nonspecific gastrointestinal symptoms could lead to missed diagnoses, unnecessary procedures, and inappropriate treatments. Due to the scarcity of studies, we conducted a systematic review to summarize the clinical characteristics, diagnostic approach, and factors predicting delayed recovery.Methods: Electronic databases including MEDLINE, OVID, and EMBASE were used to identified eligible studies from inception to January 2025. Eligible cases were required to have a clear diagnosis of ACEi-ILI. Descriptive analysis and Kaplan Meier analysis were used to identify factors, outcomes and recovery time. The protocol was preregistered (PROSPERO: 640521).Results: Our systematic review included 54 eligible studies, comprising 60 ACEi-IAE cases with a mean age of 58 years old, and 43% were male. The majority came from the United States (27%). Patients were presented with 61% of jaundice. The median recovery time was 6 weeks after discontinuing ACEi. Diagnostic criteria were proposed and summarized based on the findings.Conclusions: Clinicians should be aware of ACEi-induced liver injury, particularly in ACEi users with non-specific jaundice. Implementing our proposed diagnostic criteria is recommended to prevent unnecessary investigation and inappropriate treatment.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"194-200"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Role of Artificial Intelligence in Improving Quality of Colonoscopy]. 【人工智能在提高结肠镜检查质量中的作用】。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.126

Ji Hyun Kim, Sung Chul Park, Hyun-Soo Kim

{"title":"[Role of Artificial Intelligence in Improving Quality of Colonoscopy].","authors":"Ji Hyun Kim, Sung Chul Park, Hyun-Soo Kim","doi":"10.4166/kjg.2024.126","DOIUrl":"https://doi.org/10.4166/kjg.2024.126","url":null,"abstract":"Colorectal cancer is a common malignancy and a major health concern in Korea. Although colonoscopy is an effective tool for screening and preventing colorectal cancer through the early detection of pre-cancerous lesions, many factors influence the quality of colonoscopy, including fatigue, experience, inter-observer variation, and human error. Minimizing errors and providing consistent performance improves the quality of colonoscopy, which can lower cancer-related mortality. Advances in artificial intelligence (AI) have led to the application of computer-aided detection (CADe) and computer-aided diagnosis (CADx) of neoplastic polyps, such as adenomas, and computer-aided quality assessment (CAQ), which involves monitoring withdrawal time, assessing cecal insertion, and ensuring sufficient colonic surface observation. Many AI models have been developed, and some CADe and CADx systems have become commercially available, demonstrating their usefulness in detection of adenomas and characterization of polyps. Additionally, clinical studies on the usefulness of CAQ have been published. This innovative technology holds great potential to assist endoscopists and benefit the general population. In the future, an evaluation of the practical benefits and cost-effectiveness of applying AI models to colonoscopy in clinical practice seems necessary.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"137-145"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0