The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi最新文献_第2页

[Upper Gastrointestinal Involvement in Behcet's Disease]. [白塞氏病的上消化道受累]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.148

Hogyung Jun, Hyun Joo Song, Ji Hwan Mun, Heung Up Kim

{"title":"[Upper Gastrointestinal Involvement in Behcet's Disease].","authors":"Hogyung Jun, Hyun Joo Song, Ji Hwan Mun, Heung Up Kim","doi":"10.4166/kjg.2024.148","DOIUrl":"https://doi.org/10.4166/kjg.2024.148","url":null,"abstract":"Background/aims: Behcet's disease is an idiopathic, chronic, multisystemic vasculitis characterized by recurrent oral and genital ulcers, ophthalmologic inflammation, and skin lesions. This study sought to identify the involvement of the upper gastrointestinal (GI) tract in patients with Behcet's disease.Methods: We retrospectively analyzed 365 patients diagnosed with Behcet's disease at the Jeju National University Hospital from March 2009 to 2021. GI involvement in Behcet's disease was evaluated by endoscopy. Intestinal Behcet's disease was classified according to the presence of typical intestinal ulcers, systemic Behcet's disease, and oral ulcers.Results: A total of 365 patients with Behcet's disease were included; 128 patients underwent endoscopy, including colonoscopy (n=80), upper endoscopy (n=115), and colonoscopy with upper endoscopy (n=68). During colonoscopy (n=80), 17 (21.3%) patients were found to have typical ulcers, 13 (16.3%) atypical ulcers, and 50 (62.5%) had no ileocolic ulcers. During upper endoscopy (n=115), upper GI involvement was found in 14 (12.2%) patients: 21.4% (3/14) in the esophagus, 35.7% (5/14) in the stomach and 42.9% (6/14) in the duodenum. Overall, among those with Behcet's disease, 10.4% (38/365) had GI involvement, with lower GI in 8.2% (30/365) and upper GI in 3.8% (14/365).Conclusions: GI involvement in Behcet's disease in Jeju Island was approximately 10.4%; including lower GI involvement in 8.2% and upper GI in 3.8% of the subjects. The upper GI involvement in Behcet's disease showed typical and atypical ulcers, similar to those of the lower GI tract involvement.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"170-178"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorectal Neoplasia in Vietnamese Patients Under 50 Years of Age: A Cross-Sectional Study. 越南50岁以下患者的结肠直肠癌：一项横断面研究。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.146

Nhan Quang Le, Luan Minh Dang, Tien Manh Huynh, Chuong Dinh Nguyen, Diem Thi Ngoc Vo, Truc Le Thanh Tran, Vy Ly Thao Tran, An Duc Le, Tai Duy Nguyen, Hen Van Dao, Trung Duc Nguyen, Duc Trong Quach

{"title":"Colorectal Neoplasia in Vietnamese Patients Under 50 Years of Age: A Cross-Sectional Study.","authors":"Nhan Quang Le, Luan Minh Dang, Tien Manh Huynh, Chuong Dinh Nguyen, Diem Thi Ngoc Vo, Truc Le Thanh Tran, Vy Ly Thao Tran, An Duc Le, Tai Duy Nguyen, Hen Van Dao, Trung Duc Nguyen, Duc Trong Quach","doi":"10.4166/kjg.2024.146","DOIUrl":"https://doi.org/10.4166/kjg.2024.146","url":null,"abstract":"Background/aims: Few studies have examined the colonoscopic findings of Asian individuals under 50 years of age, with some focusing on specific age cohorts. The present study examined the prevalence, endoscopic characteristics, and histology findings of colorectal neoplasia in Vietnamese patients under 50 years of age and compared these results across age groups.Methods: A retrospective cross-sectional study was conducted at the University Medical Center, Ho Chi Minh City, Vietnam. Patients aged 18-49 years who underwent a colonoscopy and were diagnosed with colorectal neoplasia were included. The prevalence of colorectal neoplasia was analyzed across three age groups: 18-29, 30-39, and 40-49 years.Results: This study included 1,696 patients (52.9% male) with a median age of 41 years. The prevalence of colorectal neoplasia and advanced colorectal neoplasia was 13% and 3.7%, respectively. The prevalence of colorectal neoplasia increased significantly with age: 4.1% in the 18-29 age group, 9.9% in 30-39, and 16.6% in 40-49 (p<0.01). Adenomas were more prevalent than serrated polyps (10.7% vs. 0.5%, p<0.01), and the incidence increased with age (3.3%, 7.2%, and 14.3% in the 18-29, 30-39, and 40-49 year group, respectively; p<0.01). The overall prevalence of colorectal cancer was 1.6%, with no significant difference among the age groups (p=0.51).Conclusions: Colorectal neoplasia is not uncommon in Vietnamese individuals under 50 years, and the prevalence notably increases to 16.6% among those aged 40-49 years. These findings highlight the need for the prompt investigation and management of symptoms in this population. Nevertheless, further research in asymptomatic populations is needed to inform screening recommendations in Vietnam.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"185-193"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Metabolic Dysfunction-Associated Steatotic Liver Disease, Recent Revision of Terminology and Its Implications]. [代谢功能障碍相关的脂肪变性肝病，术语的最新修订及其含义]。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.027

Hyo Young Lee, Eileen L Yoon

引用次数: 0

[Case of Intraductal Papillary Neoplasm of Bile Duct with Invasive Carcinoma after Choledochoduodenostomy for Intrahepatic Duct Stones]. 胆管乳头状肿瘤合并浸润性癌胆总管十二指肠吻合术治疗肝内胆管结石1例。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.144

Gwang Hyo Yim, Jimin Han, Jae Hum Yun, Sun-Jae Lee, Chang Ho Cho, Joo Dong Kim, Han Taek Jeong

引用次数: 0

Rare Case of Spontaneous Regression in Primary Gastric Diffuse Large B Cell Lymphoma. 原发性胃弥漫性大B细胞淋巴瘤自发性消退的罕见病例。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.151

Cheolung Kim, Kyung Bin Kim, Bong Eun Lee, Gwang Ha Kim, Moon Won Lee, Dong Chan Joo

引用次数: 0

[Pharmacologic Treatment of Irritable Bowel Syndrome with Predominant Constipation]. 以便秘为主的肠易激综合征的药物治疗

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.002

Dong Hyun Kim, Hyo Yeop Song, Kwangwoo Nam

{"title":"[Pharmacologic Treatment of Irritable Bowel Syndrome with Predominant Constipation].","authors":"Dong Hyun Kim, Hyo Yeop Song, Kwangwoo Nam","doi":"10.4166/kjg.2025.002","DOIUrl":"https://doi.org/10.4166/kjg.2025.002","url":null,"abstract":"Irritable bowel syndrome with predominant constipation (IBS-C) is a functional gastrointestinal disorder characterized by abdominal pain with chronic constipation and abdominal bloating, which could significantly impair the quality of life of patients and bring substantial socio-economic burdens. Pharmacology treatment is central to managing patients with IBS-C, aiming to alleviate symptoms and improve patient treatment outcomes. Guanylate cyclase-C agonists (linaclotide and plecanatide) enhance intestinal fluid secretion and motility, normalize bowel movements, and reduce abdominal pain. Na+/H+ exchanger inhibitors (e.g., tenapanor) decrease sodium absorption, increase fluid secretion, and alleviate visceral pain. Lubiprostone activates the chloride channels to facilitate bowel movements, while polyethylene glycol laxatives regulate osmotic pressure to improve stool consistency and ease defecation. Highly selective 5-HT4 agonists, such as prucalopride, accelerate gastrointestinal and colonic transit and improve stool frequency and consistency without increasing the cardiovascular risks raised in earlier agents such as tegaserod. Neuromodulators, including selective serotonin reuptake inhibitors and tricyclic antidepressants, help manage visceral hypersensitivity and chronic abdominal pain in selected patients. These pharmacology agents have shown efficacy and safety in clinical studies, but drug availability, adverse effects, and variable patient responses are still challenging. Effective strategies to manage IBS-C require a personalized approach, considering the patient's symptom profile, treatment goals, and safety concerns.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Steatotic Donor Livers in Liver Transplantation. 脂肪变性供肝在肝移植中的应用。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.013

Xiang Li, Xiaodan Yin, Jun Xu, Lei Geng

{"title":"Application of Steatotic Donor Livers in Liver Transplantation.","authors":"Xiang Li, Xiaodan Yin, Jun Xu, Lei Geng","doi":"10.4166/kjg.2025.013","DOIUrl":"https://doi.org/10.4166/kjg.2025.013","url":null,"abstract":"The growing prevalence of fatty liver disease in donor livers has become a critical focus in liver transplantation due to the global shortage of viable grafts. This article reviews the challenges and advancements in utilizing steatotic donor livers, emphasizing their increased risk of post-transplant complications, such as primary non-function and early allograft dysfunction. Mechanistically, macrovesicular and microvesicular steatosis differentially impair lipid metabolism, exacerbate ischemia-reperfusion injury (IRI), and disrupt hepatic microcirculation, contributing to graft failure. Innovations in donor assessment, including magnetic resonance imaging-proton density fat fraction and AI-enhanced imaging, have improved fat quantification accuracy, while machine perfusion techniques (e.g., hypothermic oxygenated perfusion and normothermic machine perfusion) show promise in mitigating IRI and enhancing preservation, particularly for marginal steatotic livers. However, controversies persist regarding standardized fat-content thresholds, ischemia tolerance limits, and heterogeneity in risk stratification. Future research highlights the need for non-invasive subtyping technologies, dynamic preservation strategies guided by real-time biomarkers, and multi-omics approaches to unravel steatosis-related molecular pathways. Addressing these challenges may expand the safe use of steatotic grafts and alleviate organ shortages.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"160-169"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dramatic Extrahepatic Cholestasis Improvement after Steroid Therapy. 类固醇治疗后肝外胆汁淤积显著改善。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2024.138

Bagus Setyoboedi, Rendi Aji Prihaningtyas, Sjamsul Arief

{"title":"Dramatic Extrahepatic Cholestasis Improvement after Steroid Therapy.","authors":"Bagus Setyoboedi, Rendi Aji Prihaningtyas, Sjamsul Arief","doi":"10.4166/kjg.2024.138","DOIUrl":"https://doi.org/10.4166/kjg.2024.138","url":null,"abstract":"Biliary atresia remains a health concern and the leading cause of liver transplantation despite the establishment of Kasai surgery. This case report describes an infant with extrahepatic cholestasis leading to biliary atresia that improved with steroids. A one-month-24-day-old girl presented with the chief complaint of jaundice accompanied by pale stools, dark urine, and a distended abdomen since she was two weeks of age. The laboratory findings showed elevated liver function tests (AST 99 U/L, ALT 87 U/L, GGT 100.9 U/L, and ALP 968 U/L) and cholestasis (total bilirubin 10.02 mg/dL and direct bilirubin 7.34 mg/dL) with anemia (Hb 9.0 g/dL), accompanied by reactive CMV IgG and reactive CMV IgM. A two-phase abdominal ultrasound examination revealed a gallbladder length of ±2.54 cm, increased HA/PV, and a gallbladder contractility index of ±76%. A percutaneous liver biopsy revealed extrahepatic cholestasis. After eight weeks of steroid and ursodeoxycholic acid treatment, improvements were observed in her clinical condition, laboratory biomarkers (AST 41 U/L, ALT 77 U/L, GGT 115 U/L, ALP 383 U/L, total bilirubin 0.3 mg/dL, direct bilirubin 0.1 mg/dL, and Hb 13.8 g/dL) and gallbladder contractility index. Hence, steroid administration in extrahepatic cholestasis leading to biliary atresia may improve inflammation in the biliary system and prevent the progression of biliary obstruction to biliary atresia.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"207-215"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Management of Colorectal Subepithelial Lesions: Differential Diagnosis and Follow-up]. 结直肠上皮下病变的处理：鉴别诊断和随访。

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-04-25 DOI: 10.4166/kjg.2025.004

Jun Lee

{"title":"[Management of Colorectal Subepithelial Lesions: Differential Diagnosis and Follow-up].","authors":"Jun Lee","doi":"10.4166/kjg.2025.004","DOIUrl":"https://doi.org/10.4166/kjg.2025.004","url":null,"abstract":"The use of colonoscopy as a screening tool for colorectal cancer has increased, leading to the increasing detection of colorectal subepithelial lesions (SELs). These lesions are typically asymptomatic at diagnosis, appearing as small, protruding growths covered by normal mucosa. Colorectal SELs represent a diverse spectrum of lesions, and their differentiation based solely on their endoscopic appearance, endoscopic ultrasound, or radiology imaging remains challenging. Although many lesions are benign, certain types, including neuroendocrine tumors, gastrointestinal stromal tumors, and lymphomas, have malignant potential and warrant thorough evaluation and management. Current research, treatment, and follow-up strategies for these lesions are limited, often relying on the guidelines developed for upper gastrointestinal SELs. Unlike upper gastrointestinal SELs, colonoscopy is essential for the follow-up of colorectal SELs. However, it is time-consuming and costly, and obtaining tissue biopsies through endoscopic ultrasound can be technically challenging. This review aims to provide clinicians with foundational insights into managing colorectal SELs, and facilitating optimal patient care through a comprehensive analysis of the existing literature.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 2","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[How to Achieve Diversity, Equity, and Inclusion in The Korean Society of Gastroenterology?] 如何实现韩国消化内科学会的多样性、公平性和包容性？］

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2025-01-25 DOI: 10.4166/kjg.2024.092

Nayoung Kim, Kwangwoo Nam, Ki-Nam Shim, Hyo Jung Kim, Su Youn Nam, Sae Kyung Joo, Seun Ja Park, Yonghoon Choi, Yoon Ju Jung, Yong Sung Kim, Ja Kyung Kim, Seon Mee Park

{"title":"[How to Achieve Diversity, Equity, and Inclusion in The Korean Society of Gastroenterology?]","authors":"Nayoung Kim, Kwangwoo Nam, Ki-Nam Shim, Hyo Jung Kim, Su Youn Nam, Sae Kyung Joo, Seun Ja Park, Yonghoon Choi, Yoon Ju Jung, Yong Sung Kim, Ja Kyung Kim, Seon Mee Park","doi":"10.4166/kjg.2024.092","DOIUrl":"10.4166/kjg.2024.092","url":null,"abstract":"With the increasing emphasis on diversity, equity, and inclusion (DEI) in organizations and institutions, academic societies in gastroenterology and hepatology are beginning to take actionable steps toward achieving DEI. The successful implementation of DEI initiatives leads to excellence in the field, improved patient outcomes, particularly in areas where health disparities are prevalent, and advances in the gastrointestinal discipline. Such implementation also results in a workforce that better reflects the growing diversity of the population. This review defines DEI and introduces the DEI policies and strategies adopted by the academic societies of gastroenterology in other countries. This paper proposes strategies to integrate DEI better into the Korean Society of Gastroenterology, emphasizing the importance of embedding DEI into the culture and strategic framework. The key strategies include establishing a DEI committee, setting clear targets, and conducting formal assessments to measure DEI progress. This study focused on enhancing workforce diversity, particularly among women and young doctors, and advocates for the need to support their academic development through male allyship and the promotion of equitable and inclusive academic cultures.","PeriodicalId":94245,"journal":{"name":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi","volume":"85 1","pages":"22-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0