The Journal of dermatology最新文献_第3页

Effectiveness of long-term bimekizumab treatment and predictive factors for responders in moderate-to-severe psoriasis: A 52-week real-world study. 中度至重度银屑病患者长期使用双美珠单抗治疗的疗效及应答者的预测因素：一项为期 52 周的真实世界研究。

The Journal of dermatology Pub Date : 2024-11-05 DOI: 10.1111/1346-8138.17532

Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda

{"title":"Effectiveness of long-term bimekizumab treatment and predictive factors for responders in moderate-to-severe psoriasis: A 52-week real-world study.","authors":"Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda","doi":"10.1111/1346-8138.17532","DOIUrl":"https://doi.org/10.1111/1346-8138.17532","url":null,"abstract":"Psoriasis is a chronic, inflammatory skin disease in which the interleukin (IL)-23/IL-17 axis plays a central role. Bimekizumab is a novel antibody that targets both IL-17A and IL-17F. This retrospective study aimed to assess the long-term effectiveness and safety of 52-week treatment with bimekizumab, and to identify predictive factors for short- (16 weeks) and long-term (52 weeks) responders (i.e., achievers of a Psoriasis Area and Severity Index (PASI) score of 100) to bimekizumab in Japanese patients with psoriasis. The study was conducted on 56 Japanese patients (aged ≥ 15 years) with moderate-to-severe psoriasis treated with bimekizumab from May 2022 to March 2024. The therapeutic effectiveness was evaluated by the transition of PASI scores during treatment. Baseline characteristics and clinical and laboratory indexes were compared between responders and poor responders. Treatment-emergent adverse events (TEAEs) were recorded to assess the safety of the treatment. At week 52, the achievement of PASI 100, static Physician's Global Assessment 0/1, and the Dermatology Life Quality Index 0/1 were 72.4%, 94.7%, and 93.3%, respectively. Short-term responders showed lower baseline values of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory response index compared to poor responders. Long-term responders showed younger age and lower MLR compared to poor responders. TEAEs were mild or moderate, without serious adverse events. Long-term treatment with bimekizumab is effective and safe for psoriasis patients. Lower MLR and younger age might predict long-term response to treatment with bimekizumab, aiding in personalized treatment strategies.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ingrown hairs in persistent kerion of children: A clinical study. 嵌毛在儿童顽固性角膜炎中的作用：临床研究。

The Journal of dermatology Pub Date : 2024-11-05 DOI: 10.1111/1346-8138.17523

Qi-Hao Yao, Hui-Lin Zhi, Xiu-Jiao Xia, Ze-Hu Liu

{"title":"The role of ingrown hairs in persistent kerion of children: A clinical study.","authors":"Qi-Hao Yao, Hui-Lin Zhi, Xiu-Jiao Xia, Ze-Hu Liu","doi":"10.1111/1346-8138.17523","DOIUrl":"https://doi.org/10.1111/1346-8138.17523","url":null,"abstract":"Tinea capitis, a common public health problem in developing countries, has severe forms such as kerion. However, the underlying mechanisms and standard treatments for persistent cases of tinea capitis or kerion remain controversial. In this work, we investigate the ingrown hairs and corresponding treatment in persistent kerion of children. Children with persistent kerion were enrolled among 312 cases of tinea capitis at the Department of Dermatology, Hangzhou Third People's Hospital from January 2020 to June 2024. The presence of fungal infection was ascertained by direct microscopic examination under calcofluor white staining and routine culture. The structure of the ingrown hairs was observed directly by a dermatoscope, which was subsequently extracted using sterile tools. A total of six cases of persistent kerion among 312 cases of tinea capitis were enrolled. Ingrown hairs were ascertained under dermatoscopy and extracted by minor operation. Except for one patient who continued oral terbinafine, the other five cases were cured by removal alone. Ingrown hairs, induced by fungal infection, may be an aggravating factor of persistent course of tinea capitis. Our study demonstrated that the presence of ingrown hairs could be confirmed through direct dermatoscopy, and patients experienced significant improvement following removal treatment under dermatoscopy.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of indeterminate cell histiocytosis with ETV3-NCOA2 translocation. 一例伴有 ETV3-NCOA2 易位的不定形细胞组织细胞增生症。

The Journal of dermatology Pub Date : 2024-11-04 DOI: 10.1111/1346-8138.17530

Norihito Suzuki, Takatoshi Shimauchi, Satoshi Baba, Yuka Nagakura, Juri Takahashi, Sayaka Ajima, Mizuho Tajima, Yurie Kitauchi, Reiko Kageyama, Tetsuya Honda

{"title":"A case of indeterminate cell histiocytosis with ETV3-NCOA2 translocation.","authors":"Norihito Suzuki, Takatoshi Shimauchi, Satoshi Baba, Yuka Nagakura, Juri Takahashi, Sayaka Ajima, Mizuho Tajima, Yurie Kitauchi, Reiko Kageyama, Tetsuya Honda","doi":"10.1111/1346-8138.17530","DOIUrl":"https://doi.org/10.1111/1346-8138.17530","url":null,"abstract":"Indeterminate cell histiocytosis (ICH) is a rare histiocytic disorder characterized by a proliferation of CD1a+ and CD207/langerin- cells. Recent molecular analyses have identified ETV3-NCOA2 translocation as a possible aetiopathogenesis of ICH. Herein, we describe the first Japanese case of ICH with ETV3-NCOA2 translocation. A 79-year-old Japanese man presented with a 1-year history of pruritic erythematous papules and nodules on his trunk and extremities. Histological examination revealed a dense and diffuse sheets-like infiltration of medium-sized histiocyte-like cells from the epidermis to the deep dermis. Immunohistochemically, the atypical cells were positive for CD1a but negative for CD207/langerin. Fluorescence in situ hybridization using NCOA2 break-apart probes confirmed a chromosomal break occurring on NCOA2 monoallele in the tumor cells. Furthermore, ETV3 exon 4-NCOA2 exon 14 translocation was identified in formalin-fixed paraffin-embedded skin samples using reverse transcription polymerase chain reaction and subsequent direct DNA sequencing. He also presented with interspersed eczematous plaques on his trunk and reactive dermatopathic lymphoadenopathy without any infiltration of ICH. He was treated with topical corticosteroids and narrowband UVB phototherapy. Four months later, his ICH skin eruptions, eczematous plaques, and lymphoadenopathy gradually regressed. Our case supports the notion that the detection of ETV3-NCOA2 translocation can be useful for diagnosis of ICH.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasculo-Behçet disease with venous thromboembolism successfully treated with direct oral anticoagulants: A literature review. 使用直接口服抗凝剂成功治疗伴有静脉血栓栓塞的血管-贝赫切特病：文献综述。

The Journal of dermatology Pub Date : 2024-11-04 DOI: 10.1111/1346-8138.17535

Souta Kobayashi, Yasuaki Ikuno, Akihiko Yamaguchi, Toshifumi Takahashi, Akiko Arakawa, Wataru Shioyama, Noriki Fujimoto

引用次数: 0

Pasteurella stomatis and Prevotella heparinolytica infection following dog bite. A case report and review of published works. 被狗咬伤后的口腔巴斯德氏菌和肝溶性普雷沃特氏菌感染。一份病例报告和对已发表作品的回顾。

The Journal of dermatology Pub Date : 2024-11-04 DOI: 10.1111/1346-8138.17472

Yuta Norimatsu, Taro Akatsuka, Akari Matsuoka-Nagashima, Sohshi Morimura, Toshihisa Hamada, Makoto Sugaya

引用次数: 0

Response to: "Potential sitosterolemia in necrobiotic xanthogranuloma: Comment on Extensive yellowish masses in bilateral orbit and neck" by Chen et al. 回应：对 "坏死性黄疽瘤潜在的坐骨神经胆固醇血症：对 Chen 等人发表的 "对双侧眼眶和颈部广泛淡黄色肿块的评论 "的回应

The Journal of dermatology Pub Date : 2024-11-01 DOI: 10.1111/1346-8138.17522

Qifeng Zang, Yinshan Zang

引用次数: 0

Is alopecia areata one of the atopic diseases? A two-sample Mendelian randomization analysis. 斑秃是特应性疾病之一吗？双样本孟德尔随机分析。

The Journal of dermatology Pub Date : 2024-11-01 DOI: 10.1111/1346-8138.17527

Zheng Chen, Xinquan Wang, Ji Li, Yan Tang

引用次数: 0

Multiple primary Merkel cell carcinomas on bilateral auricle diagnosed by Merkel cell polyomavirus detection: A literature review and utility of Sangar sequencing. 通过检测梅克尔细胞多瘤病毒确诊的双侧耳廓多发性原发性梅克尔细胞癌：文献综述和桑格测序的实用性。

The Journal of dermatology Pub Date : 2024-10-31 DOI: 10.1111/1346-8138.17531

Miwa Kato, Yasuaki Ikuno, Takahiro Koike, Yasuhiro Maeda, Shino Fujimoto, Akihiko Yamaguchi, Toshifumi Takahashi, Akiko Arakawa, Takeshi Kato, Noriki Fujimoto

引用次数: 0

The interleukin-1α stimulated expression of the wrinkle-inducing elastase neprilysin in adult human dermal fibroblasts is mediated via the intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1. 白细胞介素-1α通过细胞内ERK/JNK/c-Jun/c-Fos/AP-1信号轴介导，刺激成人真皮成纤维细胞中皱纹诱导弹性蛋白酶神经纤溶酶的表达。

The Journal of dermatology Pub Date : 2024-10-31 DOI: 10.1111/1346-8138.17520

Mariko Takada, Uma Chandula Pinnawala, Shinichi Hirano, Genji Imokawa

{"title":"The interleukin-1α stimulated expression of the wrinkle-inducing elastase neprilysin in adult human dermal fibroblasts is mediated via the intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1.","authors":"Mariko Takada, Uma Chandula Pinnawala, Shinichi Hirano, Genji Imokawa","doi":"10.1111/1346-8138.17520","DOIUrl":"https://doi.org/10.1111/1346-8138.17520","url":null,"abstract":"Neprilysin is a skin wrinkle-inducing membrane bound elastase that is expressed abundantly in UV-exposed and in aged dermal fibroblasts. The overexpression of neprilysin is closely associated with enhanced epithelial-mesenchymal cytokine interactions mainly via interleukin (IL)-1α, which has the distinct potential to stimulate the expression of neprilysin by human dermal fibroblasts (HDFs). The over-expression of neprilysin also accelerates the formation of wrinkles, accompanied by disruptions of the three-dimensional architecture of dermal elastic fibers that are responsible for the loss of skin elasticity. Because the signaling pathway(s) that lead to the IL-1α-stimulated expression of neprilysin in HDFs remain unclear, we characterized the signaling pathway involved, including their related transcription factors, in IL-1α-treated HDFs. Since qRT-PCR analysis revealed that the mRNA expression level of neprilysin is stimulated to a stronger extent in adult HDFs (aHDFs) by IL-1α than in neonatal HDFs, we used aHDFs for the signaling analysis. Western blotting analysis of the phosphorylation of signaling factors revealed that IL-1α significantly stimulated the phosphorylation of ERK1/2, RSK, JNK, p38, MSK1, NFkB, c-Jun, ATF-2, CREB, and STAT3. Analysis using various signaling inhibitors demonstrated that inhibiting ERK and JNK but not p38, MSK1, NFkB, or STAT3 significantly abrogated the IL-1α stimulated expression of neprilysin at the mRNA, protein, and enzyme activity levels. Furthermore, silencing c-Fos significantly down-regulated the IL-1α-increased expression of neprilysin at the protein and enzyme activity levels. These findings strongly suggest that the IL-1α-stimulated expression of neprilysin in aHDFs is mediated via the intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1.","PeriodicalId":94236,"journal":{"name":"The Journal of dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of bullous pemphigoid after nemolizumab administration. 一例服用奈莫珠单抗后出现的大疱性丘疹。

The Journal of dermatology Pub Date : 2024-10-29 DOI: 10.1111/1346-8138.17528

Yuriko Ishikawa, Ken Washio

引用次数: 0