The Journal of dermatological treatment最新文献

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The efficacy and safety of low-dose rituximab in the treatment of pemphigus vulgaris: a cohort study. 低剂量利妥昔单抗治疗寻常型天疱疮的疗效和安全性:一项队列研究。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-01-22 DOI: 10.1080/09546634.2024.2302071
Xingli Zhou, Tongying Zhan, Xiaoxi Xu, Tianjiao Lan, Hongxiang Hu, Yuxi Zhou, Dengmei Xia, Jinqiu Wang, Yiyi Wang, Yue Xiao, Wei Li
{"title":"The efficacy and safety of low-dose rituximab in the treatment of pemphigus vulgaris: a cohort study.","authors":"Xingli Zhou, Tongying Zhan, Xiaoxi Xu, Tianjiao Lan, Hongxiang Hu, Yuxi Zhou, Dengmei Xia, Jinqiu Wang, Yiyi Wang, Yue Xiao, Wei Li","doi":"10.1080/09546634.2024.2302071","DOIUrl":"10.1080/09546634.2024.2302071","url":null,"abstract":"<p><strong>Background: </strong>Rituximab (RTX) is considered the first-line treatment for pemphigus vulgaris (PV), which is a B-cell-mediated acquired autoimmune disease. However, no consensus on the optimum dosage has been achieved.</p><p><strong>Objectives: </strong>To investigate the efficacy and safety of low-dose RTX (a single infusion of 500 mg) for the treatment of PV, a cohort study was conducted for patients with PV, along with a 12-month follow-up following the administration of RTX.</p><p><strong>Methods: </strong>Patients with moderate or severe PV were divided into group A (low-dose RTX combined with corticosteroids) and group B (corticosteroids alone). Data on complete remission (CR) rates, doses of corticosteroids, cumulative doses of corticosteroids at the third, sixth, and twelfth months, pemphigus disease area index and adverse effects (AEs) were collected.</p><p><strong>Results: </strong>Forty-four patients with moderate or severe PV were enrolled in this study (19 in group A and 25 in group B). Patients treated with low-dose RTX had higher CR rates, lower doses of corticosteroids at the third, sixth, and twelfth months, lower cumulative doses of corticosteroids at the sixth and twelfth months, and fewer AEs than those who received corticosteroids alone.</p><p><strong>Conclusions: </strong>This study indicated that low-dose RTX may be a beneficial and secure therapy option for patients with moderate to severe PV.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2302071"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib for the management of bullous pemphigoid coexisting with psoriasis vulgaris: a case report and literature review. 乌达帕替尼治疗与寻常型银屑病并存的大疱性类天疱疮:病例报告和文献综述。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-01-23 DOI: 10.1080/09546634.2024.2302394
Fangying Su, Tai Wang, Qunshi Qin, Zhi Xie
{"title":"Upadacitinib for the management of bullous pemphigoid coexisting with psoriasis vulgaris: a case report and literature review.","authors":"Fangying Su, Tai Wang, Qunshi Qin, Zhi Xie","doi":"10.1080/09546634.2024.2302394","DOIUrl":"10.1080/09546634.2024.2302394","url":null,"abstract":"<p><p>Both bullous pemphigoid (BP) and psoriasis are common immune-related dermatological conditions in clinical practice, but the co-occurrence of these two diseases is rare. Currently, there is no consensus on the long-term safe and effective treatment for patients with both BP and psoriasis. JAK inhibitors are emerging as targeted therapeutic drugs that act by inhibiting Janus kinase activity, regulating the JAK/STAT pathway, blocking the transduction pathway of key proinflammatory cytokines, and influencing T-cell differentiation. These cytokines upstream of the JAK/STAT pathway play a pivotal role in the pathogenesis of numerous inflammatory and autoimmune disorders. Upadacitinib, a second-generation JAK inhibitor with high selectivity, demonstrates promising potential.This case report aims to provide a description of the successful treatment of bullous pemphigoid (BP) and psoriasis vulgaris by using upadacitinib, highlighting significant clinical outcomes. Additionally, we aim to analyze the underlying mechanism of upadacitinib in treating these two comorbidities by reviewing relevant literature from both domestic and international sources. Based on our clinical observations, upadacitinib appears to be a promising and well-tolerated therapeutic option for patients with concurrent BP and psoriasis, offering valuable insights for developing appropriate treatment strategies in clinical practice.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2302394"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expression of CD200 and CD23 on B lymphocytes in the pollen season and outside the pollen season in atopic dermatitis patients with and without dupilumab therapy. 接受和未接受杜匹单抗治疗的特应性皮炎患者花粉季节和非花粉季节 B 淋巴细胞上 CD200 和 CD23 的表达。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-01-23 DOI: 10.1080/09546634.2024.2305832
Jarmila Čelakovská, Eva Čermáková, Ctirad Andrýs, Petra Boudkova, Jan Krejsek
{"title":"The expression of CD200 and CD23 on B lymphocytes in the pollen season and outside the pollen season in atopic dermatitis patients with and without dupilumab therapy.","authors":"Jarmila Čelakovská, Eva Čermáková, Ctirad Andrýs, Petra Boudkova, Jan Krejsek","doi":"10.1080/09546634.2024.2305832","DOIUrl":"10.1080/09546634.2024.2305832","url":null,"abstract":"","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2305832"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The changes of leukocytes and T lymphocytes in atopic dermatitis patients with and without dupilumab therapy and in control group in pollen season compared to out of pollen season. 接受和未接受杜立单抗治疗的特应性皮炎患者以及对照组的白细胞和 T 淋巴细胞在花粉季节与非花粉季节的变化。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-02-25 DOI: 10.1080/09546634.2024.2318351
Jarmila Čelakovská, Eva Čermáková, Petra Boudkova, Jan Krejsek
{"title":"The changes of leukocytes and T lymphocytes in atopic dermatitis patients with and without dupilumab therapy and in control group in pollen season compared to out of pollen season.","authors":"Jarmila Čelakovská, Eva Čermáková, Petra Boudkova, Jan Krejsek","doi":"10.1080/09546634.2024.2318351","DOIUrl":"https://doi.org/10.1080/09546634.2024.2318351","url":null,"abstract":"","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2318351"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of pruritus and chronic cough: an all of us database study. 瘙痒症与慢性咳嗽的关系:我们所有人的数据库研究。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-05-26 DOI: 10.1080/09546634.2024.2355976
Divija Sharma, Juliana Pulsinelli, Joel Correa da Rosa, Zhen Wang, Brian Kim, Benjamin Ungar
{"title":"Association of pruritus and chronic cough: an all of us database study.","authors":"Divija Sharma, Juliana Pulsinelli, Joel Correa da Rosa, Zhen Wang, Brian Kim, Benjamin Ungar","doi":"10.1080/09546634.2024.2355976","DOIUrl":"10.1080/09546634.2024.2355976","url":null,"abstract":"<p><strong>Purpose: </strong>Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus and chronic cough (CC), this study, leveraging the <i>All of Us</i> database, examines the association between the two conditions.</p><p><strong>Materials and methods: </strong>A nested case-control comparison was used to examine the association, identifying cases with SNOMED codes 418363000 (pruritus) and 68154008 (CC). Matching was performed on a 1:4 ratio by age, sex, and ethnicity using the MatchIt package in R, followed by maximum likelihood method to estimate odds ratios (ORs) and 95% confidence intervals from 2x2 contingency tables.</p><p><strong>Results: </strong>CC patients (<i>n</i> = 2,388) were more than twice as likely to be diagnosed with pruritus (OR: 2.65) and pruritus patients (<i>n</i> = 22,496) were more than twice as likely to be diagnosed with CC (OR: 2.57), than respective matched controls.</p><p><strong>Conclusions: </strong>These results highlight the potential bidirectional relationship between CC and pruritus, suggesting possible shared immune and neural pathways. Treatments like difelikefalin and nalbuphine that modulate these pathways, alongside P2X3 targeting agents, are emerging as potential therapeutic approaches for itch and chronic cough given the possible interconnected pathophysiology. This study's insights into the associations between pruritus and CC may pave the way for targeted therapeutic strategies that address their shared mechanisms.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2355976"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141156039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term effectiveness and potential factors of ustekinumab based on real-world data in Chinese psoriasis patients. 基于中国银屑病患者真实世界数据的乌司替尼短期疗效和潜在因素。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-03-26 DOI: 10.1080/09546634.2024.2321188
Xingyu Li, Xiaowen Xie, Jiashuai Li, Jingjin Hu, Kun Hu, Minjia Tan, Jing Yang, Sichun Deng, Yijie Liu, Mi Zhang, Yehong Kuang, Junchen Chen, Liqiu Liao, Wu Zhu
{"title":"Short-term effectiveness and potential factors of ustekinumab based on real-world data in Chinese psoriasis patients.","authors":"Xingyu Li, Xiaowen Xie, Jiashuai Li, Jingjin Hu, Kun Hu, Minjia Tan, Jing Yang, Sichun Deng, Yijie Liu, Mi Zhang, Yehong Kuang, Junchen Chen, Liqiu Liao, Wu Zhu","doi":"10.1080/09546634.2024.2321188","DOIUrl":"10.1080/09546634.2024.2321188","url":null,"abstract":"<p><strong>Background: </strong>As one of the most effective biologic treatments for psoriasis, the short-term effectiveness of ustekinumab has yet to be studied extensively.</p><p><strong>Objective: </strong>The purpose of this study was to evaluate the short-term effectiveness and potential factors within four weeks after the first-dose ustekinumab treatment based on real-world data.</p><p><strong>Methods: </strong>The study enrolled 98 patients with moderate-to-severe psoriasis, given ustekinumab 45 mg at week 0, week 4, and then every 12 weeks. Based on clinical data collected at baseline and week 4, we investigated the short-term effectiveness of ustekinumab after the first dose and potential factors associated with the treatment. For evaluation, we collected demographic information, body data, medical history, laboratory examination results, Psoriasis Area and Severity Index (PASI), body surface area (BSA), and dermatology life quality index (DLQI). Response rates were calculated based on the number of patients that achieved a 75/90/100% reduction in PASI (PASI 75/90/100), and the primary treatment goal was to achieve PASI 75.</p><p><strong>Results: </strong>The response rates for PASI 75/90/100 at week 4 were 30.5%, 18.9%, and 16.8%, respectively. For PASI 75, the response rate was higher in patients without metabolic syndrome (MS) (without MS vs. with MS: 36.9% vs. 5.9%, <i>p</i> = 0.013); the serum triglyceride (TG) level was significantly lower in patients achieving PASI 75 (expressed as mean ± standard deviation, achieved vs. unachieved: 1.82 ± 1.79 vs. 3.59 ± 8.89, <i>p</i> = 0.010). For PASI 100, the response rates were higher in female patients (female vs. male: 26.3% vs. 10.5%, <i>p</i> = 0.044) and patients with a family history of psoriasis (with family history vs. without family history: 44.4% vs. 13.9%, <i>p</i> = 0.042). In addition, the possibility of achieving PASI 75/90/100 went up along with the serum high-density lipoprotein cholesterol (HDL-C) level (expressed as adjusted odds ratio < 95% confidence interval>: PASI 75: 28.484 < 2.035-248.419>, <i>p</i> = 0.011; PASI 90: 28.226 < 2.828-281.729>, <i>p</i> = 0.004; PASI 100: 12.175 < 1.876-79.028>, <i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>In this study, nearly one-third of patients achieved PASI 75 after only the first-dose ustekinumab treatment. Sex, family history of psoriasis, MS, serum TG level might affect the short-term effectiveness, and serum HDL-C level may be a potential factor. The possibility of achieving treatment goals (PASI 75/90/100) at week 4 increased along with serum HDL-C levels.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2321188"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paradoxical skin lesions induced by IL-17 inhibitors in SAPHO syndrome. SAPHO综合征中IL-17抑制剂诱发的矛盾性皮肤损伤。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2023-12-28 DOI: 10.1080/09546634.2023.2295239
Yuan Li, Fanzhang Meng, Haixu Jiang, Qiuwei Peng, Jingyuan Fu, Dan Yin, Xiujuan Hou, Chen Li
{"title":"Paradoxical skin lesions induced by IL-17 inhibitors in SAPHO syndrome.","authors":"Yuan Li, Fanzhang Meng, Haixu Jiang, Qiuwei Peng, Jingyuan Fu, Dan Yin, Xiujuan Hou, Chen Li","doi":"10.1080/09546634.2023.2295239","DOIUrl":"10.1080/09546634.2023.2295239","url":null,"abstract":"","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2295239"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139050032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review and meta-analysis of efficacy and safety of compound glycyrrhizin combined with second-generation non-sedated antihistamine for the treatment of chronic urticaria. 复方甘草酸苷联合第二代非镇静抗组胺药治疗慢性荨麻疹的疗效和安全性的系统综述和荟萃分析。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-01-03 DOI: 10.1080/09546634.2023.2299597
Sijue Chen, Wei Cao, Xianjun Xiao, Lu Wang, Renhong Wan, Zihao Zou, Qian Yang, Ying Li
{"title":"A systematic review and meta-analysis of efficacy and safety of compound glycyrrhizin combined with second-generation non-sedated antihistamine for the treatment of chronic urticaria.","authors":"Sijue Chen, Wei Cao, Xianjun Xiao, Lu Wang, Renhong Wan, Zihao Zou, Qian Yang, Ying Li","doi":"10.1080/09546634.2023.2299597","DOIUrl":"10.1080/09546634.2023.2299597","url":null,"abstract":"<p><strong>Background: </strong>Chronic urticaria (CU) is a prevalent dermatologic disease that negatively affects life, current therapies remain suboptimal. Hence, there is an urgent need to identify effective and safe treatment.</p><p><strong>Objective: </strong>Assess the efficacy and safety of compound glycyrrhizin (CG) combined with second-generation nonsedated antihistamine for the treatment of CU.</p><p><strong>Methods: </strong>Nine databases were queried to screen RCTs related. Two reviewers independently assessed the risk of bias using Cochrane Collaboration. Primary objective was the total efficiency rate, while secondary was rate of recurrence, adverse events, and cure. Statistical analyses using Review Manager 5.4 and Stata17.</p><p><strong>Results: </strong>Twenty-four RCTs were identified. Significant differences were noted in rate of total efficiency (<i>n</i> = 2649, RR = 1.36, 95%CI:1.30-1.43, <i>p</i> < 0.00001), cure (<i>n</i> = 2649, RR = 1.54, 95%CI:1.42-1.66, <i>p</i> < 0.00001) and recurrence (<i>n</i> = 446, RR = 0.34, 95%CI:0.20-0.58, <i>p</i> < 0.00001) between the combination of CG with second-generation non-sedated antihistamine and antihistamine monotherapy. Contrastingly, adverse events rate (<i>n</i> = 2317, RR = 0.76, 95% CI:0.59-0.97, <i>p</i> = 0.03) was comparable between the two groups. Our results indicated that CG combined with second-generation non-sedated antihistamine could significantly mitigate the symptoms in CU compared with antihistamine monotherapy. No serious adverse events were reported.</p><p><strong>Conclusions: </strong>CG combined with second-generation nonsedated antihistamine is effective for CU. Nevertheless, higher-quality studies are warranted to validate our results.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2299597"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost per response analysis of deucravacitinib versus apremilast and first-line biologics among patients with moderate to severe plaque psoriasis in the United States. 美国中重度斑块状银屑病患者服用 deucravacitinib 与 apremilast 和一线生物制剂的每次应答成本分析。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-06-24 DOI: 10.1080/09546634.2024.2366503
Sang Hee Park, Mark Lambton, Jordana Schmier, Sara Hovland, Keith Wittstock, Vardhaman Patel
{"title":"Cost per response analysis of deucravacitinib versus apremilast and first-line biologics among patients with moderate to severe plaque psoriasis in the United States.","authors":"Sang Hee Park, Mark Lambton, Jordana Schmier, Sara Hovland, Keith Wittstock, Vardhaman Patel","doi":"10.1080/09546634.2024.2366503","DOIUrl":"https://doi.org/10.1080/09546634.2024.2366503","url":null,"abstract":"<p><strong>Background: </strong>Understanding the economic value of deucravacitinib and apremilast could assist treatment decision-making for patients with moderate to severe plaque psoriasis.</p><p><strong>Objective: </strong>This study compared the cost per response (CPR) for US patients initiating deucravacitinib versus apremilast for moderate to severe plaque psoriasis.</p><p><strong>Methods: </strong>A CPR model using pharmacy and administration costs was developed from a US payer perspective. Response was defined as a 75% reduction from baseline in Psoriasis Area and Severity Index (PASI 75) at weeks 16 and 24. Long-term response was defined as the cumulative benefit over 52 weeks, measured as area under the curve; subsequent treatment was included. Scenario analyses explored varying the efficacy measure or choices of subsequent treatments and limiting discontinuation.</p><p><strong>Results: </strong>The CPR for deucravacitinib versus apremilast was lower at 16 weeks (difference: -$3796 [95% confidence interval (CI): -$6140 to -$1659]) and 24 weeks (difference: -$12,784 [95% CI: -$16,674 to -$9369]). At 52 weeks, the cost per cumulative benefit was lower for patients who initiated deucravacitinib, regardless of initial treatment period duration (16 or 24 weeks).</p><p><strong>Conclusions: </strong>Scenario analyses found mainly consistent results. This study showed that the CPR is lower when initiating deucravacitinib versus apremilast in moderate to severe plaque psoriasis.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2366503"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency and outcomes of treatment dose escalation with biologics in moderate-to-severe psoriasis: a Swedish register study. 中度至重度银屑病患者使用生物制剂进行剂量升级治疗的频率和结果:一项瑞典登记研究。
The Journal of dermatological treatment Pub Date : 2024-12-01 Epub Date: 2024-09-04 DOI: 10.1080/09546634.2024.2398170
Axel Svedbom, Christina Wennerström, Fredrik Hjelm, Anna Tjärnlund, Mona Ståhle
{"title":"Frequency and outcomes of treatment dose escalation with biologics in moderate-to-severe psoriasis: a Swedish register study.","authors":"Axel Svedbom, Christina Wennerström, Fredrik Hjelm, Anna Tjärnlund, Mona Ståhle","doi":"10.1080/09546634.2024.2398170","DOIUrl":"https://doi.org/10.1080/09546634.2024.2398170","url":null,"abstract":"<p><strong>Background: </strong>The advent of biosimilars may increase the frequency of dose escalation with biologics in psoriasis.</p><p><strong>Objective: </strong>To explore the frequency and outcomes of dose escalation with adalimumab etanercept, and ustekinumab.</p><p><strong>Methods: </strong>Data were extracted from DermaReg-Pso, a psoriasis register in Stockholm, Sweden. The main exposure was treatment, and the main outcome was dose escalation. We describe outcomes with dose escalation by estimating drug survival and changes in the Psoriasis Area and Severity Index (PASI).</p><p><strong>Results: </strong>554 patients had 946 treatment episodes with adalimumab, etanercept, or ustekinumab. The cumulative incidence of dose escalation was 4.1 per 100 treatment years. The Hazard Ratios (HRs) for dose escalation with ustekinumab vs adalimumab and ustekinumab vs etanercept were 1.93 (95% CI: 1.25-2.98), and 2.20 (95% CI: 1.42-3.41), respectively. After dose escalation, the HRs for treatment discontinuation with adalimumab and etanercept compared with ustekinumab were 3.10 (95% CI: 1.56-6.18) and 7.15 (95% CI: 3.96-12.94), respectively. PASI was higher after compared to before dose escalation for etanercept (<i>p</i> = 0.036), but not for adalimumab (<i>p</i> = 0.832) or ustekinumab (<i>p</i> = 0.300).</p><p><strong>Conclusions: </strong>Dose escalation was comparatively more frequent with ustekinumab than with adalimumab or etanercept; however, treatment discontinuation after dose escalation was more common with adalimumab and etanercept than ustekinumab.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"35 1","pages":"2398170"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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