The Journal of dermatological treatment最新文献_第5页

Rapid improvement of kimura disease with dupilumab in a patient with suboptimal response to mepolizumab: a case report. dupilumab对mepolizumab反应不佳的患者木村病的快速改善：一个病例报告。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-04-02 DOI: 10.1080/09546634.2025.2486668

Meiying Tao, Tingting Gao, Lili Zhi, Naiqing Cao, Haotian Liu

引用次数: 0

The evolving landscape for vitiligo management. 白癜风管理的发展前景。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-05-02 DOI: 10.1080/09546634.2025.2498581

Alishba Zainab

引用次数: 0

Tofacitinib as a promising treatment for refractory erythroderma-like Hailey-Hailey disease. 托法替尼作为一种治疗难治性红皮病样海莉病的有希望的方法。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-04-29 DOI: 10.1080/09546634.2025.2493936

Huaye Bao, Keyi Yu, Feilong An, Xin-Gang Wu

引用次数: 0

The effects of topical antimicrobial-corticosteroid combination therapy in comparison to topical steroids alone on the skin microbiome of patients with atopic dermatitis. 局部抗菌剂-皮质类固醇联合治疗与单独局部类固醇治疗对特应性皮炎患者皮肤微生物组的影响。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-02-24 DOI: 10.1080/09546634.2025.2470379

Li Tingting, Peixin Zhang, Li Yang, Ruoyu Li, Ruojun Wang

{"title":"The effects of topical antimicrobial-corticosteroid combination therapy in comparison to topical steroids alone on the skin microbiome of patients with atopic dermatitis.","authors":"Li Tingting, Peixin Zhang, Li Yang, Ruoyu Li, Ruojun Wang","doi":"10.1080/09546634.2025.2470379","DOIUrl":"10.1080/09546634.2025.2470379","url":null,"abstract":"Objective: This study aims to analyze the different therapeutic responses between topical antimicrobial-corticosteroid combination and topical corticosteroids alone on improving the skin microbiome and skin barrier of patients with atopic dermatitis (AD).Methods: Forty patients with mild-to-moderate AD were randomly assigned to receive two kinds of treatment. Skin swabs were collected from the lesional sites and nearby nonlesional sites at baseline, after topical medication treatment and 2 weeks post-treatment, and were analyzed by DNA sequencing of the fungal internal transcribed spacer (ITS)1-5 rDNA gene and the V3V4 region of the bacterial 16S rRNA gene.Results: According to our research analysis, both topical steroids alone and combination treatment of steroids and antimicrobials effectively improved the severity of AD and repaired skin barrier. AD lesions were characterized by a decreased sebum level, lower abundance of Cutibacterium and a higher abundance of Staphylococcus. A combined topical treatment with an antimicrobial and steroid showed better responses in increasing skin sebum level and restoring the skin bacterial microbiome, whereas topical steroid alone did not improve skin dysbiosis.Conclusion: A combined therapy with antimicrobial and steroid helps to recover the skin microbiome. Further studies are necessary to explore the therapeutic effects of treatments aiming at balancing the microbiome.","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2470379"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers. 儿童特应性皮炎患者、年轻人和护理人员的治疗目标和偏好。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-05-27 DOI: 10.1080/09546634.2025.2503273

Lisa P van der Rijst, Marjolein S de Bruin-Weller, Nicolaas P A Zuithoff, Saskia Spillekom-van Koulil, Marieke M B Seyger, Marlies de Graaf

{"title":"Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers.","authors":"Lisa P van der Rijst, Marjolein S de Bruin-Weller, Nicolaas P A Zuithoff, Saskia Spillekom-van Koulil, Marieke M B Seyger, Marlies de Graaf","doi":"10.1080/09546634.2025.2503273","DOIUrl":"https://doi.org/10.1080/09546634.2025.2503273","url":null,"abstract":"Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups.Materials and methods: A web-based survey was conducted among children (6-11 years), adolescents (12-17 years), and young adults (18-30 years) with AD and caregivers of AD patients. Survey questions included multiple-choice, four-point Likert scale, and open-ended questions. Goals and preferences were stratified by age, gender, disease severity, current treatment, visible lesions, and atopic comorbidity.Results: A total of 286 respondents were included. Prioritized treatment goals were 'no itch', 'preventing new lesions', and 'no lesions'. Prioritized treatment characteristics were 'high effectiveness' and 'long-term safety'. Young patients (6-30 years) considered convenience of treatment more important than caregivers, while caregivers considered short- and long-term safety more important than young patients. Pediatric patients (6-17 years) considered psychosocial goals more important than young adults. Goals and preferences also differed by disease severity, gender, current treatment, and atopic comorbidity.Conclusions: Young AD patients and caregivers strive to reduce itch and lesions with effective and safe treatment. Goals and preferences differ within individuals at different stages of life, highlighting the importance of addressing individual needs to improve patient-centered care.","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2503273"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and therapeutic strategies for refractory vulvar lichen sclerosus: an 8-year single-center retrospective study and current evidence synthesis. 难治性外阴硬化地衣的特征和治疗策略：一项为期8年的单中心回顾性研究和目前的证据综合。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-07-15 DOI: 10.1080/09546634.2025.2531140

Lin Liu, Jun Cui, Kailv Sun, Min Yang, Qiuli Zhang, Kun Yang, Chang Jianmin

{"title":"Characterization and therapeutic strategies for refractory vulvar lichen sclerosus: an 8-year single-center retrospective study and current evidence synthesis.","authors":"Lin Liu, Jun Cui, Kailv Sun, Min Yang, Qiuli Zhang, Kun Yang, Chang Jianmin","doi":"10.1080/09546634.2025.2531140","DOIUrl":"https://doi.org/10.1080/09546634.2025.2531140","url":null,"abstract":"Objective: Untreated vulvar lichen sclerosus (VLS) can lead to irreversible anatomical changes and increase malignancy risk. Some patients show poor response to standard treatments, resulting in refractory cases (RVLS).Methods: To explore risk factors associated with RVLS and integrate treatment strategies for improved clinical management, we conducted a retrospective analysis, which included patients with VLS who visited our outpatient clinic between March 2017 and March 2025. Additionally, an evidence synthesis of the currently reported treatment regimens for RVLS was conducted.Results: A total of 457 patients were included, of whom 36 were diagnosed with RVLS (7.9%). A multivariable logistic regression model identified comorbid autoimmune thyroid diseases (OR 2.45; 95%CI 1.09-5.34), perianal region involvement (OR 3.20; 95%CI 1.19-8.09), and presence of erosion/fissures (OR 3.13; 95%CI 1.44-7.29) as independent predictors for RVLS. Furthermore, the treatment approaches for 281 patients with RVLS across 20 studies included Janus kinase inhibitors (JAK), adalimumab, methotrexate, cyclosporine, photodynamic therapy (PDT), and laser therapy, with assessments of efficacy, side effects, and recurrence.Conclusions: Our study identified three predictive factors for RVLS, which may help in treatment decisions and reduce ineffective therapy. And therapies such as JAK and PDT show promise as optimized options, although larger studies are needed.","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2531140"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring atopic dermatitis using mobile-app based photography and surveys. 使用基于移动应用程序的摄影和调查来监测特应性皮炎。

IF 3.9

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-09-29 DOI: 10.1080/09546634.2025.2555983

Georgia Marquez-Grap, Andrea Leung, Faye Orcales, Allison Kranyak, Chandler Johnson, Payton Smith, Kathryn Haran, Hunter Mills, Gundolf Schenk, Abhilash Kahlon, Jaskiran Kaur, Navdeep Dhaliwal, Molly Lucas, Vivek Rudrapatna, Gabriela O Cula, Wilson Liao

{"title":"Monitoring atopic dermatitis using mobile-app based photography and surveys.","authors":"Georgia Marquez-Grap, Andrea Leung, Faye Orcales, Allison Kranyak, Chandler Johnson, Payton Smith, Kathryn Haran, Hunter Mills, Gundolf Schenk, Abhilash Kahlon, Jaskiran Kaur, Navdeep Dhaliwal, Molly Lucas, Vivek Rudrapatna, Gabriela O Cula, Wilson Liao","doi":"10.1080/09546634.2025.2555983","DOIUrl":"10.1080/09546634.2025.2555983","url":null,"abstract":"Purpose/aim: Remote clinical research has potential to increase study diversity, reduce costs for researchers and participants, and increase efficiency of studies. This study evaluates the reliability and feasibility of using SkinTracker, a mobile application, for remote AD severity assessment through mobile-app based photography and surveys.Methods: This single-center observational study enrolled 28 participants (18 with AD and 10 healthy controls) in an eight-week hybrid clinical study. Participants completed bi-weekly tasks and submitted standardized skin photographs via the SkinTracker app, and clinic-based skin exams and digital single-lens reflex (SLR) photos were obtained at baseline and week 8. Eczema Area Severity Index and Investigator Global Assessment scores were assigned to the photographs by a grader. Intraclass correlation coefficients were used to evaluate agreement between app-based, in-person, and SLR assessments for the 18 participants with AD.Results: App-based AD assessment scores had excellent agreement with in-person scores, indicating the reliability of SkinTracker to assess disease activity remotely. Furthermore, all participants had high compliance and satisfaction with app-based activities, indicating that using SkinTracker for remote clinical research is achievable and even preferred by participants.Conclusion: Overall, these findings show that SkinTracker is both reliable and feasible for monitoring atopic dermatitis disease activity remotely.","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2555983"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmet needs and treatment patterns in Italian patients with chronic spontaneous urticaria: results from the Urticaria Voices study. 意大利慢性自发性荨麻疹患者未满足的需求和治疗模式：来自荨麻疹声音研究的结果。

IF 3.9

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI: 10.1080/09546634.2025.2566786

Luca Stingeni, Teresa Grieco, Ornella Bonavita, Nadine Chapman-Rothe, Silvia Ferrucci

{"title":"Unmet needs and treatment patterns in Italian patients with chronic spontaneous urticaria: results from the Urticaria Voices study.","authors":"Luca Stingeni, Teresa Grieco, Ornella Bonavita, Nadine Chapman-Rothe, Silvia Ferrucci","doi":"10.1080/09546634.2025.2566786","DOIUrl":"https://doi.org/10.1080/09546634.2025.2566786","url":null,"abstract":"Objectives: Chronic spontaneous urticaria (CSU) is a debilitating disease that impacts patients' wellbeing. Herein, we report the burden of CSU on the health-related quality of life (HRQoL), unmet needs, treatment patterns, and expectations of Italian patients with CSU from the Urticaria Voices study.Methods: Urticaria Voices, a multi-national, cross-sectional, survey study, was conducted in adult patients with CSU. Patients completed an online survey on the impact of CSU on patients' HRQoL, unmet needs, and treatments. Data were analyzed descriptively.Results: Overall, 64 Italian patients with CSU participated in the Urticaria Voices study (mean age: 42.4 years; 70% women). The average time since diagnosis was 7.8 years. Patients rated CSU's negative impact as 6.3/10, with the top impact being reduced confidence (28.1%). The main unmet need was treatments with fewer side effects (39.1%). Most patients (82.8%) used antihistamine, with 77.4% of them being switched to another antihistamine and 43.4% being updosed. Patients reported freedom from itch and hives as the top treatment expectation (7.69/10).Conclusion: CSU imparts a substantial disease burden that negatively impacts the HRQoL of Italian patients. More effective treatments for CSU emerged as an important unmet need. Raising disease awareness and improving access to new treatments can facilitate enhanced CSU care.","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2566786"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion characteristics and efficacy of letibotulinum toxin a in forehead wrinkle treatment. 左肉毒毒素a在额头皱纹治疗中的扩散特性及疗效。

IF 3.9

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-10-05 DOI: 10.1080/09546634.2025.2563656

Young In Lee, Nam Hao Chau, Jemin Kim, Yujin Baek, Ngoc Ha Nguyen, Jihee Kim, Ju Hee Lee

{"title":"Diffusion characteristics and efficacy of letibotulinum toxin a in forehead wrinkle treatment.","authors":"Young In Lee, Nam Hao Chau, Jemin Kim, Yujin Baek, Ngoc Ha Nguyen, Jihee Kim, Ju Hee Lee","doi":"10.1080/09546634.2025.2563656","DOIUrl":"https://doi.org/10.1080/09546634.2025.2563656","url":null,"abstract":"Background: Facial wrinkles, caused by aging and repetitive muscle contractions, are commonly treated with botulinum neurotoxin type A (BoNT-A). However, excessive toxin diffusion can cause side-effects like muscle weakness.Objectives: This study aimed to compare the diffusion, efficacy, and safety of letibotulinum toxin A with two other BoNT-A products for treating forehead wrinkles.Methods: In a double-blind, randomized, split-face controlled trial, 20 participants with moderate-to-severe horizontal forehead wrinkles received letibotulinum toxin A on one side and prabotulinum or onabotulinum toxin A on the other. The primary outcome was diffusion profile assessed via anhidrosis area (iodine-starch test at 2 weeks); secondary outcomes included wrinkle reduction, assessed by photographic analysis, and safety.Results: Results show that letibotulinum toxin A exhibited diffusion patterns and wrinkle-reduction efficacy comparable to the control products. No statistically significant differences were observed be-tween the groups for the primary or secondary outcomes.Conclusion: Letibotulinum toxin A is a safe, effective alternative for wrinkle treatment, potentially minimizing excessive diffusion risks and related side effects, making it a valuable addition to available treatment options.","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2563656"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor submitted in response to "Minoxidil: a comprehensive review". 致编辑的回复“米诺地尔：综合评论”的信。

The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI: 10.1080/09546634.2025.2454936

Michail Penteris, Anastasia Kalogirou, Theodoros K Constantinides, Christos Kontogiorgis

引用次数: 0