Yuxia Wu, Yiyuan Chen, Hui Wang, Suyun Dong, Hai-Ou Yan, Juan Xie
{"title":"Comparison of the Effectiveness and Safety of Different Non-surgical Offloading Interventions for Diabetic Foot Ulcers: A Network Meta-analysis of Randomized Controlled Trials.","authors":"Yuxia Wu, Yiyuan Chen, Hui Wang, Suyun Dong, Hai-Ou Yan, Juan Xie","doi":"10.1177/15347346251329609","DOIUrl":"https://doi.org/10.1177/15347346251329609","url":null,"abstract":"<p><p>ObjectiveThe aim of this study is to conduct a network meta-analysis of the effectiveness and safety of different non-surgical offloading interventions for patients with diabetic foot ulcers.MethodsWe searched PubMed, EMBASE, OVID, Web of Science, and Cochrane Library for randomized controlled trials (RCTS) on the efficacy of non-surgical interventions for DFU offloading. Outcome measures included the rate of ulcer healing, reduction in ulcer area, and incidence of adverse events. The Cochrane Risk of Bias Tool version was used to assess the risk of bias of the included trials.ResultsA total of 22 RCTs involving 1226 patients were included. Network meta-analysis showed that compared to removable knee high offloading device (OR = 3.66, 95% CI (1.78, 8.46)], removable ankle high offloading device (OR = 3.17, 95% CI (1.32, 7.85)], therapeutic shoe (OR = 3.72, 95% CI (1.53, 9.78)], standard treatment (OR = 4.15, 95% CI (1.05, 13.89)], TCC significantly increased the ulcer healing rate (<i>P</i> < .05). The analyses did not reveal any statistically significant differences between the results of the various types of non-surgical offloading measures in terms of ulcer reduction area and incidence of adverse events. The ranking probability graph showed that TCC (SUCRA = 0.59) was most likely to improve ulcer healing rates, therapeutic shoes (SUCRA = 0.25) performed best in terms of ulcer reduction area, and non-removable walkers (SUCRA = 0.63) were most likely to reduce the incidence of adverse events.ConclusionsNon-removable offloading devices (TCC and non-removable walkers) have the best effectiveness and safety in the non-surgical offloading interventions of patients with diabetic foot ulcers, which is of great significance in promoting ulcer healing and improving prognosis.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251329609"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federico Rolando Bonanni, Marco Meloni, Martina Salvi, Ermanno Bellizzi, Valeria Ruotolo, Aikaterini Andreadi, Alfonso Bellia, Davide Lauro
{"title":"Characteristics and Outcomes of Patients Admitted for Diabetic Foot Attack.","authors":"Federico Rolando Bonanni, Marco Meloni, Martina Salvi, Ermanno Bellizzi, Valeria Ruotolo, Aikaterini Andreadi, Alfonso Bellia, Davide Lauro","doi":"10.1177/15347346251328724","DOIUrl":"https://doi.org/10.1177/15347346251328724","url":null,"abstract":"<p><p>The current study aimed to evaluate characteristics and outcomes of patients admitted for a diabetic foot attack (DFA). It is a retrospective observational study including a population of patients admitted for diabetic foot ulcers (DFU) in a specialized diabetic foot service. Based on the type of hospital admission (emergency or elective), patients were divided into two groups: those with DFA and those without DFA (chronic diabetic foot, CDF). The DFA was considered in case of ischemia, infection and Charcot foot requiring urgent hospitalization. The following in-hospital outcomes were evaluated: minor and major amputation, number of surgical procedures, length of stay (LOS), mortality. Overall, 150 patients were included. The mean age was 70.3 ± 12.2 years, most patients were male (76.0%) and had type 2 diabetes (92.7%) with a mean duration of 22.1 ± 13.2 years; 88 (58.7%) patients presented DFA while 62 (41.3%) presented CDF. The DFA group reported a greater rate of foot infection (81.8 vs 50.0%, p = 0.002), higher HbA1c values (67.9 ± 22 vs 56.6 ± 14.3 mmol/mol, p = 0.0005) and more cases of first assessment for DFUs (43.2 vs 12.9%, p = 0.005) compared with the CDF group. Outcomes for DFA and CDF were minor amputation (36.4 vs 21%, p = 0.04), major amputation (2.3 vs 1.6%, p = 0.7), need for surgical procedures (>1) (27.3 vs 11.3%, p = 0.0001), LOS (17 ± 9.6 vs 12 ± 6.3 days, p = 0.0004), mortality (1.1 vs 0%, p = 0.6). In addition, foot infection and poor glycometabolic control were independently related to the DFA presentation. The DFA increases the risk of minor amputations, more surgical procedures and longer hospitalization. Foot infection and poor metabolic control resulted closely related to the DFA.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251328724"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Effrosyni Blathra, Ioanna A Anastasiou, Ioanna Eleftheriadou, Nikolaos Papanas, Nicholas Tentolouris
{"title":"Charcot Osteoarthropathy: A Comprehensive Analysis of Recent Research on Novel Biomarkers for Early Detection.","authors":"Effrosyni Blathra, Ioanna A Anastasiou, Ioanna Eleftheriadou, Nikolaos Papanas, Nicholas Tentolouris","doi":"10.1177/15347346251328436","DOIUrl":"https://doi.org/10.1177/15347346251328436","url":null,"abstract":"<p><p>Charcot osteoarthropathy (CO) is an unusual and frequently misdiagnosed complication of diabetes mellitus. The delayed diagnosis can have severe consequences for patients' limb and life. Its diagnosis is based firstly in its clinical suspicion, is mainly clinical and is confirmed by imaging tests, like magnetic resorance imaging. Specific biomarkers for its early detection and therapy have not been found yet. The understanding of CO pathogenesis and measurement of molecules involved in this can head to this direction. The purpose of this review is to summarize/describe the most current studies measuring biomarkers in people with CO. Confocal corneal microscopy (CCM), inflammatory markers including IL-1, IL-6 and TNF-a, bone metabolism markers like RANK, RANKL, OPG, advanced glycation end products (AGEs) and bone mineral density (BMD) were among the most popular ones included in a large number of studies of the last 20 years and people with CO have significant different levels of the above comparing to non-Charcot groups. Future and larger studies can lead to the discovery of novel biomarkers of the prompt detection of this special entity at an early stage.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251328436"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Procalcitonin Levels in Diabetic Foot Ulcer Infection and Osteomyelitis: A Systematic Review and Meta-Analysis.","authors":"Farahnaz Karbasiun, Samaneh Shahrokh, Maryam Yazdi, Mansour Siavash, Aliye Tabatabaee","doi":"10.1177/15347346251325898","DOIUrl":"https://doi.org/10.1177/15347346251325898","url":null,"abstract":"<p><p>BackgroundFoot ulcers represent a major complication in patients with diabetes and are often challenging for clinicians. Distinguishing between infected and non-infected diabetes foot ulcers (DFUs) can prevent many irreversible injuries such as inappropriate antibiotic therapy, amputation, and even death. Procalcitonin (PCT) has been proposed in the diagnosis of infection and osteomyelitis in diabetes foot ulcers. The present study aimed to compare PCT levels between patients with and without infected diabetes foot ulcer (IDFU).MethodThis review searched three databases including PubMed, Web of Science, and Scopus to identify all articles reporting PCT levels in two groups of infected diabetes foot ulcer (IDFU) and non-infected diabetes foot ulcer (NIDFU). Quality has been assessed using the NIH tool. The pooled mean difference (MD) of PCT level between groups was estimated by random effect meta-analysis. In addition, The PRISMA 2020 statement has been used to update guidelines for reporting present systematic reviews.ResultTwenty-three studies were eligible for meta-analysis, of which data from 2412 people was extracted. Pooled estimation of PCT level was significantly higher in IDFU patients compared with NIDFU patients (MD = 0.25 ng/l, 95% CI: 0.14-0.37). According to the meta-analysis results, PCT level was not significantly higher in patients with Osteomyelitis compared with those without Osteomyelitis (MD = 0.59 ng/l, 95% CI: -0.19, 1.38, I<sup>2 </sup>= 98.5%).ConclusionSince the results of the present study showed higher PCT levels in patients with IDFU compared to those without, it can be suggested that procalcitonin might be applied as an additional biomarker for the differentiation of NIDFU from IDFU. It needs more evidence to conclude about the role of PCT in terms of osteomyelitis and amputation.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251325898"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoumeh Askari, Amirhesam Keshavarz Zarjani, Ali Sayyahi, Raziye Badpa, Ali Naghizadeh
{"title":"Chitosan Nanoparticles: A Promising Candidate in Wound Healing.","authors":"Masoumeh Askari, Amirhesam Keshavarz Zarjani, Ali Sayyahi, Raziye Badpa, Ali Naghizadeh","doi":"10.1177/15347346251325057","DOIUrl":"https://doi.org/10.1177/15347346251325057","url":null,"abstract":"<p><p>The wound healing process is really interesting, dynamic, and complex, captivating researchers for a long time. With the growing worldwide concern regarding the prevalence of wounds and the associated healthcare challenges, efforts to expedite this natural process have intensified. Fortunately, with a particular focus on improving wound dressings, significant advancements have been made in wound care management including using of nanoparticle-based delivery systems. These nanoparticles, similar to molecular messengers, purchase vast promise for revolutionizing wound treatment. Among them, chitosan nanoparticles stand out as remarkable candidates. Their safety profile, biocompatibility, and bioactivity make them particularly appealing for wound care. In this article, we will delve into the intricacies of wound healing and then discuss the wound-healing properties of chitosan nanoparticles, supported by comprehensive study results. Current evidence highlights the wound-healing effects of chitosan nanoparticles, which can be considered independent agents for wound management. In conclusion, the utilization of chitosan nanoparticles for wound healing presents significant opportunities and potential.Graphical abstract [Formula: see text].</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251325057"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Efficacy of Low-Temperature Atmospheric-Pressure Plasma (LTAPP) in the Multicenter Treatment of Pressure Ulcers: A Randomized Controlled Trial.","authors":"Warangkana Tonaree, Sitthichoke Taweepraditpol, Natthapong Kongkunnavat, Nattanit Poungjantaradej, Boonyaporn Kotistienkul, Min Yongsuvimol, Kusuma Chinaroonchai, Pitawan Rachata, Pattana Ongkasuwan, Orawan Chansanti, Atthawit Mongkornwong, Chonlathorn Chaichote, Apirag Chuangsuwanich","doi":"10.1177/15347346251323940","DOIUrl":"https://doi.org/10.1177/15347346251323940","url":null,"abstract":"<p><p>IntroductionThis study is to examine the reduction in wound size between the LTAPP and the control group and also investigate the wound healing effect factor.MethodsA randomized controlled trial was conducted at five study centers. Participated patients were between 18-80 years old who had pressure ulcer wound(s) and excluded patients with high risk or receiving other treatment such as previous radiation therapy in the affected area, pregnancy, sepsis, and immunocompromised host. The study divided participant into LTAPP group and standard of care (SOC) group, the LTAPP group would received a dressing of non-Ag materials and administer LTAPP for 1 min per 1 cm<sup>2</sup> (maximum of 20 min). The SOC group would received standard dressing wound protocol. Both groups would be followed until the end of study (ninth visit) or until the wound healed.ResultsWhen considering patients who attended follow-up ≥4 visits, only 45 ulcers were eligible, of which consisted of 21 ulcers in the LTAPP group and 24 ulcers in the SOC group. The results showed significant healing rate of the LTAPP group, whether to be the wound size: wound area and wound volume, wound healing: exudate reduction, granulation and lesser necrotic tissue or Pressure Ulcer Scale for Healing (PUSH) score. The LTAPP group had better bacterial load reduction without the use of tropical antibiotic, this also signified the quality in bacterial eradication of LTAPP.ConclusionLTAPP showed outstanding performance in treating pressure ulcer wounds. The LTAPP gave greater outcome in wound size, wound healing indicators, microbiological analyses and cost-effective comparison. Although, the absence of statistical significance, it did not affect the outcome trends. This study suggested further investigation of the potential role of LTAPP therapy in different wound types in near future.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251323940"},"PeriodicalIF":0.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of CONUT Score and Serum Zinc Levels in Patients with Diabetic Foot Ulcers.","authors":"Hideharu Nakamura, Takaya Makiguchi, Yumi Yamada, Aya Tsunoda, Nana Tomaru, Satoshi Yokoo","doi":"10.1177/15347346251326247","DOIUrl":"https://doi.org/10.1177/15347346251326247","url":null,"abstract":"<p><p>BackgroundDiabetic foot ulcer (DFU) is a severe complication of diabetes. Nutritional deficiencies, including poor nutritional status reflected by a high CONUT score and low serum zinc have been implicated in the severity and wound healing failure of DFU. However, the association between these factors and DFU remains unclear.MethodsA retrospective cohort study was performed in 319 patients categorized into three groups: healthy controls (HC, n = 213), patients with diabetes without foot ulcer (DM, n = 67), and patients with diabetes with foot ulcer (DFU, n = 39). Demographic, clinical, nutritional, and biochemical data were collected, including age, sex, body mass index, the presence of chronic limb-threatening ischemia (CLTI), the presence of maintenance dialysis, CONUT score, hemoglobin A1c, hemoglobin (Hb), total protein (TP), and zinc levels. The severity of DFU was assessed using the PEDIS score, while wound healing failure was defined based on specific clinical criteria. Statistical analyses were conducted to identify factors associated with DFU severity and wound healing failure.ResultsDFU cases had significantly lower Hb, TP, and zinc levels and higher CONUT score compared to the HC and DM cases. Within the DFU group, high PEDIS score (>8) was associated with significantly higher CONUT score, lower TP levels, and the presence of CLTI. Patients with wound healing failure had significantly lower zinc and Hb levels and a higher prevalence of CLTI. Multivariable logistic regression identified CONUT score and the prevalence of CLTI as independent factors associated with DFU severity, while serum zinc levels and the prevalence of CLTI were independently associated with wound healing failure.ConclusionsThis study highlighted the critical role of poor nutritional status, as indicated by high CONUT score, and zinc deficiency in the severity and poor healing outcomes of DFU. These findings underscore the critical role of nutritional management in comprehensive treatment of DFU.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251326247"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giammarco Granieri, Alessandra Michelucci, Bianca Cei, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini
{"title":"Ultra-High Frequency Ultrasound (UHFUS) Features of Pyoderma Gangrenosum, Venous Leg Ulcers, and Acute Ulcerative Lesions.","authors":"Giammarco Granieri, Alessandra Michelucci, Bianca Cei, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini","doi":"10.1177/15347346251324503","DOIUrl":"https://doi.org/10.1177/15347346251324503","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) is a neutrophilic dermatological disorder, marked by the dysregulation of both innate and adaptive immunity. Recently, non-invasive imaging techniques, including the use of Ultra-High Frequency Ultrasound (UHFUS), have been used to assess patients with PG. The primary objective of this study is to characterize the UHFUS differences among various cutaneous ulcerative diseases. We enrolled 45 patients: 15 patients suffered from PG (Group 1), distinguished in inflammatory phase (PG-i) and non-inflammatory phase (PG-ni); 15 patients had Venous Leg Ulcers (VLU) (Group 2); and 15 patients had Acute Injury (AI) (Group 3). For each lesion, UHFUS examination was performed with a 70 MHz linear probe to examine the angle of ulceration, epidermal and dermal morphological characteristics vascular morphology and the \"scattering\" signal. The study identified significant differences in the ulceration angle among various ulcerative pathologies: obtuse in Group 2, flat or straight in Group 3, predominantly acute or straight in Group 1. Moreover, PG-i phase exhibited significant fragmentation of the dermoepidermal junction (DEJ). The presence of a Subepidermal Low Echogenic Band (SLEB), hypoechogenicity of the dermis, and fluid collections were predominantly observed in the PG-i. The predominant vascular morphology in Groups 2 and 3 was regular, while in Groups 1 was irregular, presenting a high degree of \"scattering\" signals. The study highlights the usefulness of UHFUS as an imaging tool for assessing skin ulcers, especially those related to PG. This approach could be promising for improving diagnosis and treatment. However, further research is needed for standardization and clinical implementation.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346251324503"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tracking a Fatal Disease: Lower Limb Gas Gangrene's Mortality-Related Factors.","authors":"Mohamed Farès Mahjoubi, Bochra Rezgui, Mohamed Maatouk, Nada Essid, Yasser Karoui, Hajer Kandara, Mounir Ben Moussa","doi":"10.1177/15347346231158858","DOIUrl":"10.1177/15347346231158858","url":null,"abstract":"<p><strong>Introduction: </strong>Because of its rarity compared to dry and wet gangrene of the lower limb, the gaseous form has often been considered as the most severe form of gangrenous disease. We aimed to report clinical, paraclinical, and therapeutic features, and to identify mortality risk factors of gas gangrene of the lower limb.</p><p><strong>Patients and methods: </strong>We conducted a one-center case series retrospective study over a period of 13 years from January 2006 to December 2018.</p><p><strong>Results: </strong>A total of 19 patients were included: 12 men, 7 women. Mean age was 59.3 ± 11.3 years. There were 17 diabetic patients and one patient was on radio-chemotherapy for lower rectal cancer. Septic shock was initially present in 4 cases. Hyperleukocytosis was noted in 17 patients. C-reactive protein was elevated in 11 patients. All patients were put on antibiotics then operated on. A total of 8 patients died postoperatively (42%) in an average time of 9.6 days after surgery. On univariate analysis, factors associated with mortality were: Septic shock on admission (<b>p = 0.02</b>); local signs limited to foot (<b>p = 0.05</b>) or extended above the knee (<b>p = 0.02</b>); leukocytosis (<b>p = 0.005</b>); glycemia level (<b>p = 0.02</b>); antibiotic therapy duration (<b>p = 0.04</b>); antibiotic association of Penicillin G, metronidazole, and gentamicin (<b>p = 0.02</b>); amputation procedure solely (<b>p = 0.04</b>) or debridement procedure without amputation (<b>p = 0.05</b>); intraoperative transfusion (<b>p = 0.006</b>); and hospital stay (<b>p = 0.01</b>).</p><p><strong>Conclusion: </strong>Identifying gas gangrene mortality factors is fundamental to standardize management. Our study was able to build on the small size of our series, but further prospective and large-scale studies are required.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":"18 8 1","pages":"192-197"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83201539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of Specific Single-Use Incisional Negative Pressure Wound Therapy (PICO System) After Major Lower Extremity Amputation.","authors":"Hiroshi Takahashi, Shinsuke Takeda, Yoshihiro Tanaka, Ryutaro Shibata, Hiroki Ito, Shingo Kurahashi, So Mitsuya, Hideki Murakami","doi":"10.1177/15347346231221116","DOIUrl":"10.1177/15347346231221116","url":null,"abstract":"<p><p>Lower extremity amputation (LEA), particularly in patients with diabetes or peripheral vascular disease, often results in complications such as surgical site infections (SSIs) and wound dehiscence. This study examined whether utilizing the portable and user-friendly PICO system (Smith and Nephew Medical Ltd, Hull, UK) as incisional negative-pressure wound therapy can reduce post-LEA complications. This study was conducted at a Japanese tertiary medical center and involved a retrospective analysis of LEA cases (n = 32) between January 2021 and December 2022. The PICO dressing group (n = 16) was compared to the conventional dressing group (n = 16) for post-LEA wound management. The primary outcome was the incidence of postoperative wound complications, including SSI and wound dehiscence, within 15 days of LEA. Superficial/deep SSI and wound dehiscence occurred less frequently in the PICO dressing group than in the conventional dressing group (12.5% vs 43.8%; p = .054). There were no cases of deep SSIs in the PICO dressing group. Although this study has limitations owing to its retrospective design and small sample size, the results suggest the potential of the PICO system for improving outcomes in post-LEA wound management.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"130-134"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}