The international journal of lower extremity wounds最新文献

{"title":"Diabetic foot ulcers and erectile dysfunction.","authors":"Nikolaos D Karakousis, Dimitrios S Karagiannakis, Nikolaos Papanas","doi":"10.1177/15347346261470115","DOIUrl":"https://doi.org/10.1177/15347346261470115","url":null,"abstract":"","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261470115"},"PeriodicalIF":1.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Topical Rifamycin and a Chlorhexidine-Containing Wound Dressing in Infected and Non-Infected Experimental Wound Models.","authors":"Kadir Yağız Türker, Irem Saadet Odabaş, Oya Evirgen, Ebru Evren Yurtçu, Serdal Kenan Köse, Hakan Uncu","doi":"10.1177/15347346261469985","DOIUrl":"https://doi.org/10.1177/15347346261469985","url":null,"abstract":"<p><p>AimTo compare topical rifamycin versus a chlorhexidine-containing wound dressing for wound healing and microbial load in infected and non-infected wound models.MethodsThirty rats were studied in two stages across five groups (n = 6). Full-thickness 1 × 2 cm interscapular wounds were created. Group 1 received saline irrigation (control), Group 2 topical rifamycin, Group 3 chlorhexidine-containing dressing (CHD), Group 4 infection with <i>Staphylococcus aureus</i> ATCC 25923 followed by rifamycin, and Group 5 the same infection followed by CHD. Animals were housed individually. On day 7, rats were sacrificed and wounds excised; specimens were divided equally for microbiology and histology.ResultsOn day-7 histology, the control group had the lowest wound healing score (7.66 ± 0.82). The highest score occurred in the CHD group (11.33 ± 1.75), followed by the rifamycin group (10.5 ± 0.55). No significant differences were found between non-infected groups (p = 0.292) or infected groups (p = 0.360). In infected groups, the CHD group showed lower total bacterial colony counts and fewer colonies per milligram of tissue, but differences were not significant (p = 0.091, p = 0.200).ConclusionCHD tended to outperform rifamycin in wound healing and limiting bacterial growth, but no significant difference was detected. This study informs clinical use of both products.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261469985"},"PeriodicalIF":1.5,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Tibial Transverse Transport Angiogenesis Versus Vascular Surgery in Patients with Chronic Limb Threatening Ischemia: A Systematic Review and Meta-Analysis.","authors":"Lawrence A Lavery, Arthur Tarricone, Chengyu Xie, Lee C Rogers, Michael C Siah, Allen Gee, Prakash Krishnan, Dane Wukich, David C Lavery, Joseph Alderete","doi":"10.1177/15347346261464691","DOIUrl":"https://doi.org/10.1177/15347346261464691","url":null,"abstract":"<p><p>Peripheral arterial disease (PAD) is one of the most common underlying causes of major lower extremity amputations (LEAs). Often revascularization is not adequate to save the leg. Tibial Transverse Transport (TTT) represents a revolutionary approach to increase angiogenesis in people with critical limb threatening ischemia (CLTI). A systematic review and meta-analysis was conducted across six databases. Inclusion criteria required studies to evaluate TTT combined with revascularization versus revascularization or TTT alone as a monotherapy. Outcomes analyzed included tarsal-metatarsal amputation (TMA), wound healing, and change in visual analogue scale (VAS) for pain. A total of five studies were identified across four databases that met inclusion criteria. TTT + Revascularization was shown to have a protective effect in reducing follow up TMA, O.R = 0.44 [0.23, 0.81], p = 0.009. TTT + Revascularization was also found to have an association with wound healing, OR = 3.25 [1.84,5.73], p = 0.0001. Four studies observed the change in Visual Analogue Scale (VAS), and the cumulative effect showed no association between either TTT + Revascularization or monotherapy with change in VAS pain pre and post procedure, standard mean difference = -0.05 [-0.16, 0.05], p = 0.33. TTT in combination with peripheral endovascular revascularization offers a promising addition for patients with CLTI with lower incidence of TMA increase rates of wound healing. However, considering the limited studies available and overall small sample size, further trials are necessary to understand the relationship between this novel therapy and CLTI management.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261464691"},"PeriodicalIF":1.5,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Microcurrent Electrical Stimulation in Tissue Healing and Scar Modulation: A Systematic Review.","authors":"Kanika Wadhwa, Anand Kumar Singh, Ruchir Bhasin Bhatnagar, Karina Kapoor","doi":"10.1177/15347346261469606","DOIUrl":"https://doi.org/10.1177/15347346261469606","url":null,"abstract":"<p><p>ImportanceTissue healing is a complex physiological process that includes the phases of inflammation, proliferation, and remodeling. Interruption in these processes may cause delays in the healing process and lead to abnormal scar formation, which may affect the functional and aesthetic outcomes. Microcurrent electrical stimulation, which uses electrical currents in the range of microamperes, similar to the endogenous bioelectric currents, has been developed as a therapeutic technique to modulate tissue healing and abnormal scar formation.ObjectiveTo assess the clinical effectiveness of microcurrent electrical stimulation in the promotion of tissue healing and the modification of scar formation.Evidence ReviewA systematic review of clinical studies was performed using the PRISMA 2020 approach and registered in PROSPERO (CRD420261285174). An electronic search of PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library was performed, covering all available literature up to 2024. Clinical studies involving human subjects with wounds, tissue injuries, or scar formations treated with microcurrent electrical stimulation (MES) were included. The study types included randomized controlled trials, controlled clinical trials, and prospective or retrospective clinical studies. The main parameters evaluated were the wound healing rate, time for wound healing, and scar thickness, pliability, and appearance. The risk of bias in the included studies was evaluated using the Cochrane Risk of Bias 2 tool.ResultsEleven studies (2012-2024) suggest MES may enhance wound healing and improve scar outcomes; however, results are inconsistent due to variability in protocols, populations, and assessment methods.Conclusionsand Relevance: Microcurrent electrical stimulation (MES) may improve wound healing and scar outcomes, but current evidence is limited by study variability and small sample sizes. It should be considered a complementary therapy, with further robust trials needed to confirm efficacy and optimize treatment protocols.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261469606"},"PeriodicalIF":1.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous CO₂ Therapy Improves Tissue Oxygenation, Ulcer Healing and Pain in Recurrent Hard-to-Heal Diabetic Foot Ulcers: A Randomized Controlled Trial.","authors":"Miloš Potkonjak, Bernardka Ančimer, José Luis Lázaro-Martínez, Marianne Brodmann, Nikolaos Papanas, Igor Frangež","doi":"10.1177/15347346261468402","DOIUrl":"10.1177/15347346261468402","url":null,"abstract":"<p><p>This trial evaluates whether transcutaneous gaseous carbon dioxide therapy (CO₂ therapy) combined with standard of care (SOC) improves healing of hard-to-heal recurrent diabetic foot ulcers (DFUs) compared with SOC alone. A total of 30 participants with recurrent hard-to-heal DFUs were included and randomized 1:1 to an intervention (CO₂ therapy plus SOC) or a control group (SOC only). The intervention consisted of 20 daily 50-minute CO₂ therapy sessions over 4 weeks. After 4 weeks, 46.7% of ulcers in the intervention group were completely healed, versus 0% in the control group (p = 0.005). The intervention group showed a median area reduction of 85.7% (IQR 54.9-100) compared to 17.2% (IQR 0.88-33.5) in controls (p < 0.001), with significantly better Falanga wound-bed scores (p < 0.001). The intervention group demonstrated a significant relative increase in StO₂ (29.6 ± 19.6%), whereas the control group exhibited a decrease (-2.2 ± 6.9%), resulting in a between-group difference of 31.8% (95% CI 20.5%-43.0%; p < 0.001). Pain intensity significantly decreased in the intervention group only (p = 0.002). This trial suggests that CO₂ therapy in combination with SOC is superior to SOC alone in healing recurrent, hard-to-heal DFUs.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261468402"},"PeriodicalIF":1.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pacinian Corpuscle Distribution, Density, and Morphology of the Adult Human Foot in Health and Diabetes: A Scoping Review.","authors":"Sarah Albanozzo, Justin Lee Mifsud, Francis Zarb, Sandro Galea-Soler, Charlie Abela, Robert M Bowker, James Azzopardi, Nikolaos Papanas, Cynthia Formosa","doi":"10.1177/15347346261467522","DOIUrl":"https://doi.org/10.1177/15347346261467522","url":null,"abstract":"<p><p>Pacinian corpuscles (PCs) remain insufficiently investigated in diabetes mellitus, diabetic neuropathy and associated alterations in plantar soft-tissue integrity, despite their role as fast-adapting mechanoreceptors essential for proprioception and locomotor stability. The extent to which PCs contribute to sensory impairment and foot dysfunction in these conditions remains unclear. This scoping review aimed to evaluate research on the distribution, density, and morphology of plantar PCs in the adult human foot among healthy populations and individuals with diabetes. Studies published from 1 January 2015 to 28 February 2026 were identified from 6 electronic sources. Reporting followed PRISMA guidelines, and methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. Four studies met the inclusion criteria. These included a case report, an experimental study, a morphometric analysis, and a combined retrospective-prospective study, each involving relatively small sample sizes. Both histological quantification and magnetic resonance imaging (MRI) can detect PCs and may support early identification of peripheral neuropathy-related sensory changes, but the evidence remains sparse. Accordingly, further research in larger, well-characterised cohorts is needed to establish reliable reference standards and to clarify changes in PC density associated with diabetic neuropathy.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261467522"},"PeriodicalIF":1.5,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Evidence for Adiposity-Related Susceptibility and Heel BMD-Proxied Skeletal Resilience in Charcot Foot: A Two-Sample Mendelian Randomization Study.","authors":"Shaowen Zhong, Quan Sun","doi":"10.1177/15347346261464688","DOIUrl":"https://doi.org/10.1177/15347346261464688","url":null,"abstract":"<p><p>BackgroundCharcot neuro-osteoarthropathy (CNO) is a limb-threatening diabetic foot complication involving neuropathy, repetitive trauma, inflammation, and bone remodeling. Obesity is common in CNO, but observational interpretation is limited by confounding and reverse causation.MethodsWe performed two-sample MR using GWAS summary statistics. The primary outcome was FinnGen R12 Charcot foot. BMI was prespecified as primary; glycemic traits, lipids, metabolic traits, and heel bone mineral density (BMD), a systemic proxy for skeletal strength, were secondary or comparator exposures. Instruments were genome-wide significant and European LD-clumped.ResultsPer standardized BMI increment, higher BMI was strongly associated with Charcot foot (odds ratio [OR], 3.36; 95% CI, 2.30-4.92; P = 4.01 × 10^-10); 1 standardized BMI unit is approximately 4.7 to 4.8 kg/m² in large European cohorts. BMI was nominally associated with diabetic neuropathy (OR, 1.21; 95% CI, 1.04-1.42; P = 0.016). Fasting glucose was suggestive (OR, 2.35; 95% CI, 1.14-4.81; P = 0.020). Higher heel BMD was associated with lower Charcot foot risk (OR, 0.75; 95% CI, 0.59-0.96; P = 0.021).ConclusionsGenetically proxied higher BMI was strongly associated with Charcot foot risk; fasting glucose and heel BMD-proxied skeletal findings were suggestive. These findings support considering adiposity in long-term risk recognition alongside neuropathy surveillance, foot protection, and offloading.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261464688"},"PeriodicalIF":1.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Intensification in Limb Salvage: A Doubly Robust Dual-Center Study Establishing 37.9 g/L as the Physiological Requirement for Diabetic Foot Ulcer Regeneration.","authors":"Terry Hao-Yu Qin, Atiqah Aziz, Xiu-Wen Ling, Amber Haseeb, Eva Mahirah Zulkifli, Tunku Kamarul, Han-Ling Tan, Aiden Yi-Fei Wang","doi":"10.1177/15347346261465333","DOIUrl":"10.1177/15347346261465333","url":null,"abstract":"<p><p>BackgroundClinical guidelines conventionally define nutritional adequacy using a 35 g/L serum albumin threshold. However, its biological sufficiency for driving diabetic foot ulcer (DFU) regeneration remains unvalidated. This investigation utilized a structural modeling framework to interrogate the non-linear relationship between albumin and DFU repair and to identify the precise physiological threshold required for active healing.MethodsThis prospective, dual-center cohort study of 733 DFU patients utilized a 20-week observation window anchored to baseline enrollment (Time Zero, T0). To isolate the independent metabolic effect of albumin from systemic inflammatory confounding, we implemented a doubly robust framework integrating generalized propensity score (GPS) weighting with restricted cubic spline (RCS) modeling. The primary endpoint was Percentage Area Reduction (PAR) at 20 weeks.ResultsBaseline albumin was identified as a significant independent driver of wound reduction (β = 3.25; 95% CI: 0.76-5.73; P = 0.01) and a protective factor against major amputation (OR = 0.89; 95% CI: 0.79-0.99; P = 0.037). RCS analysis revealed a highly significant non-linear trajectory (P for non-linearity < 0.001) with a biological inflection point at 37.9 g/L. No significant regenerative progress occurred within the 31.4-37.9 g/L stagnation plateau. Sensitivity analysis confirmed the conventional 35 g/L cutoff failed to differentiate healing outcomes (P = 0.869), resulting in 45.8% of normoalbuminemic patients being misclassified within a state of regenerative arrest. The calculated E-value of 3.40 confirms profound robustness against unmeasured confounding.ConclusionsThe conventional 35 g/L albumin threshold is clinically inadequate to sustain the metabolic demands of DFU repair. To breach the identified stagnation plateau and transition the wound bed toward active regeneration, clinicians should prioritize a new physiological target of 37.9 g/L (clinically operationalized as ≥ 38 g/L). This necessitates a strategic shift toward metabolic intensification in limb salvage protocols.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261465333"},"PeriodicalIF":1.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Kangfuxin Liquid Adjuvant Therapy Versus Standard Dressing in Treating Stage II-III Pressure Ulcers: A Meta-Analysis of Randomized Controlled Trials.","authors":"Yu Cheng, Jinhua Liao, Feiyun Wu, Xingxing Lu","doi":"10.1177/15347346261462602","DOIUrl":"https://doi.org/10.1177/15347346261462602","url":null,"abstract":"<p><p>BackgroundKangfuxin Liquid, with properties of promoting tissue repair, anti-inflammation, and bacteriostasis, requires systematic evaluation regarding its efficacy and safety in adjuvant treatment of pressure ulcers.MethodsDatabases including PubMed, Embase, Cochrane Library, CNKI, and Wanfang were searched for randomized controlled trials (RCTs) published from January 2015 to June 2025, comparing Kangfuxin Liquid adjuvant therapy with standard dressing in treating stage II-III pressure ulcers. Two researchers independently screened literature, extracted data, and evaluated quality. Meta-analysis was performed using RevMan 5.4 software. Outcome indicators included wound healing rate, healing time, wound area reduction rate after 2 weeks of treatment, and adverse reaction rate.ResultsA total of 12 RCTs involving 886 patients were included, with 450 patients in the experimental group (Kangfuxin Liquid + standard dressing) and 436 in the control group (standard dressing alone). Meta-analysis showed that the experimental group had significantly higher wound healing rate [RR = 1.44, 95% CI (1.32, 1.56), P < 0.0001, I² = 79.4%], significantly shorter healing time [MD = -6.77 days, 95% CI (-7.22, -6.32), P < 0.0001, I² = 82.8%], significantly increased wound area reduction rate after 2 weeks of treatment [MD = 19.02%, 95% CI (17.94, 20.09), P < 0.0001, I² = 81.7%], and a lower adverse reaction rate with no statistically significant difference [RR = 0.73, 95% CI (0.47, 1.12), P = 0.15, I² = 83.2%]. Kangfuxin Liquid adjuvant therapy is well-tolerated with a favorable safety profile, as adverse events in the control group were mostly infection-related, while those in the KFX group were mild local irritation.ConclusionKangfuxin Liquid adjuvant therapy can significantly improve wound healing rate, shorten healing time, promote wound reduction, and ensure high safety in treating stage II-III pressure ulcers, which is worthy of clinical promotion.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261462602"},"PeriodicalIF":1.5,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Association Between Dietary Quality index and Diabetic Foot Ulcer: A Case-Control Study.","authors":"Lijun Song, Jingkun Dao, Nan Chen, Rui Lin, Ningling Dong","doi":"10.1177/15347346261451573","DOIUrl":"https://doi.org/10.1177/15347346261451573","url":null,"abstract":"<p><p>ObjectiveDiabetic foot ulcers (DFUs) are a serious complication of type 2 diabetes mellitus (T2DM). Diet quality may influence DFU risk; however, evidence remains limited. This study investigated the association between overall diet quality and DFU prevalence.MethodsIn this case-control study, 390 adults with T2DM were enrolled, including 130 patients with clinically confirmed DFUs and 260 controls without DFU. Habitual dietary intake was evaluated using a validated 147-item Food Frequency Questionnaire supplemented with a recall interview. Multivariable logistic regression model was applied to examine the association between overall diet quality and DFU.ResultsMean total overall diet quality scores were significantly lower in participants with DFUs than in controls (56.3 ± 8.2 vs 61.2 ± 8.5; P < 0.001). All diet quality components, variety, adequacy, moderation, and overall balance, were also lower among DFU cases (P < .01). In fully adjusted model, the association between diet quality score and DFU was no statistically significant when analyzed as a continuous variable (OR = 0.90; 95% CI: 0.78-1.03). However, participants in the highest diet quality tertile had significantly lower odds of DFU compared with those in the lowest tertile (OR = 0.71; 95% CI: 0.49-0.99), with a significant dose-response trend observed across tertiles (P for trend = 0.031).ConclusionsDiet quality score was not significantly associated with DFU when modeled as a continuous variable; however, higher diet quality tertiles were associated with lower odds of diabetic foot ulcer, suggesting a potential protective relationship of overall dietary patterns after accounting for major sociodemographic and clinical risk factors.</p>","PeriodicalId":94229,"journal":{"name":"The international journal of lower extremity wounds","volume":" ","pages":"15347346261451573"},"PeriodicalIF":1.5,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}