二极管激光疗法与姜黄提取物外用软膏在促进小鼠模型伤口愈合方面的效果比较。

Zahra Al-Timimi
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摘要

伤口愈合这一复杂的生物过程受到多种治疗技术的影响。本研究调查了姜黄提取物外用软膏和二极管激光疗法对小鼠模型伤口愈合的影响。在 60 只小鼠中,我们创建了三组,每组 20 只雄性小鼠。三组分别接受治疗:第一组为对照组,不接受任何治疗;第二组接受 5%姜黄素的局部涂抹,每天两次;第三组接受二极管激光治疗,每天五分钟,输出功率为 100 毫瓦,波长为 810 纳米。在两周的时间里,研究人员检查了组织学变化和伤口闭合率。在第 0 天到第 14 天,用数字卡尺测量伤口面积,以提供有关愈合过程的量化统计数据。在组织学分析中,除了炎症细胞外,还使用苏木精和伊红染色法对上皮化和胶原沉积进行了调查。通过与对照组的结果比较,证明二极管激光疗法和姜黄提取物软膏都是成功的治疗方案。结果表明,不同的疗法虽然效果不同,但都能大大加快伤口的愈合过程。根据这些结果,外用姜黄提取物软膏可作为一种附加或辅助疗法,在医疗过程中帮助伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Effectiveness of Diode Laser Therapy and Topical Turmeric Extract Ointment in Promoting Healing of Wounds in a Murine Model.

The intricate biological process of wound healing is influenced by a wide range of therapeutic techniques. In this work, the effects of topical turmeric extract ointment and diode laser therapy on wound healing in a mouse model were investigated. Out of the sixty mice, three groups of twenty male mice each were created. Three groups received treatment: the first was a control group that got no treatment; the second group received topical application of 5% curcumin twice a day; and the third group received diode laser therapy, which involved direct laser beam therapy for five minutes a day at an output power of 100 mW at an 810 nm wavelength. Over the course of two weeks, the study examined histological changes and wound closure rates. On days 0 through 14, the wound area was measured with digital calipers to provide quantifiable statistics about the process of healing. In histological analyses, epithelializations, and collagen deposition, in addition to inflammatory cells, were investigated using hematoxylin and eosin staining. It was demonstrated by comparing the outcomes to those of a control group that diode laser therapy and turmeric extract ointment are both successful therapeutic options. The results demonstrate that different therapies, while with differing degrees of effectiveness, greatly quicken the healing process of wounds. According to these results, topical turmeric extract ointment could be used as an additional or supporting therapy to aid in the healing of wounds during medical treatments.

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