{"title":"Non-operating room anaesthesia: An unresolved issue in our hospitals.","authors":"P A Vullo, J J Ariño Irujo","doi":"10.1016/j.redare.2026.502105","DOIUrl":"10.1016/j.redare.2026.502105","url":null,"abstract":"","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502105"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Méndez Martínez, C García Cebrián, A M González González, P Sanabria Carretero, F Munar Bauzá, G Alcaraz García-Tejedor, P González Pizarro, D Méndez Marín, F Cassinello, J Encarnación Martínez, K Sifontes Romero, M Almena Marjalizo, C L Errando Oyonarte, F J Escribà Alepuz, J García Fernández
{"title":"Severe adverse events associated with general anesthesia with halogenated agents in patients of Venezuelan ancestry. Recommendations for clinical practice.","authors":"E Méndez Martínez, C García Cebrián, A M González González, P Sanabria Carretero, F Munar Bauzá, G Alcaraz García-Tejedor, P González Pizarro, D Méndez Marín, F Cassinello, J Encarnación Martínez, K Sifontes Romero, M Almena Marjalizo, C L Errando Oyonarte, F J Escribà Alepuz, J García Fernández","doi":"10.1016/j.redare.2026.502167","DOIUrl":"10.1016/j.redare.2026.502167","url":null,"abstract":"<p><p>The mtND4 Working Group of the Spanish Society of Anesthesiology and Resuscitation (SEDAR) has issued clinical practice recommendations. This article stems from reports of neurological injury and death following general in adult and patients of maternal Venezuelan ancestry, in whom a possible mitochondrial susceptibility associated with the mtND4 m.11232T>C variant of respiratory chain complex I has been identified. This document is for informational and guidance purposes only. The final clinical decision should be individualized for each patient, taking into account the urgency of the procedure, therapeutic alternatives, and the resources available at each center.</p>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502167"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Arranz Chamorro, P Blanco-Schweizer, E Ruiz Pesini, M Busto Busto, T Ticona Espinoza, J Rodríguez Jiménez
{"title":"An adult case of acute encephalopathy associated with general anaesthesia and the m.11232T > C MT-ND4 variant.","authors":"I Arranz Chamorro, P Blanco-Schweizer, E Ruiz Pesini, M Busto Busto, T Ticona Espinoza, J Rodríguez Jiménez","doi":"10.1016/j.redare.2026.502103","DOIUrl":"10.1016/j.redare.2026.502103","url":null,"abstract":"<p><p>We report the case of a 20-year-old woman who developed acute encephalopathy after uneventful general anaesthesia with sevoflurane, propofol, and opioids. The patient presented neurological impairment followed by metabolic acidosis and hyperlactatemia and neuroimaging findings involving the basal ganglia, brainstem, and cerebellum. Genetic testing confirmed the mitochondrial variant m.11232T > C in the MT-ND4 gene, previously described only in paediatric patients. This case could be one of the first cases described in the literature of acute encephalopathy associated with this mutation in an adult patient, possibly precipitated by exposure to volatile anesthetics. The patient's favorable clinical and radiological evolution after intensive neuroprotective management and suboccipital decompressive craniectomy highlights the importance of early diagnosis and individualized treatment. Mitochondrial dysfunction should be considered in atypical neurological presentations following general anesthesia, especially when accompanied by lactic acidosis and unusual neuroimaging findings.</p>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502103"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"General anaesthesia or local anaesthesia with or without sedation for mechanical thrombectomy: from clinical evidence to organizational challenges.","authors":"M Taboada, J Fernández","doi":"10.1016/j.redare.2026.502070","DOIUrl":"10.1016/j.redare.2026.502070","url":null,"abstract":"","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502070"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Á Gómez-Ríos, A Abad-Gurumeta, A A J Van Zundert
{"title":"Spain's historical, innovative contribution to airway management.","authors":"M Á Gómez-Ríos, A Abad-Gurumeta, A A J Van Zundert","doi":"10.1016/j.redare.2026.502049","DOIUrl":"10.1016/j.redare.2026.502049","url":null,"abstract":"","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502049"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic value of RDW and lactate for short- and long-term mortality in critically ill patients with acute kidney injury.","authors":"A Guevara-Tirado","doi":"10.1016/j.redare.2026.502175","DOIUrl":"10.1016/j.redare.2026.502175","url":null,"abstract":"<p><strong>Introduction: </strong>In intensive care units, the strong association between acute kidney injury and mortality has led to a pressing need for simple biomarkers to improve prognostic stratification.</p><p><strong>Objective: </strong>To evaluate the prognostic value of RDW and lactate for short- and long-term mortality in critically ill patients with acute kidney injury.</p><p><strong>Materials and methods: </strong>An analytical study of an open dataset of 2,139 patients with acute kidney injury during their first ICU admission. The main biomarkers were RDW and lactate measured within the first 24 h, classified into 4 combined categories. Outcomes were 28-day, 90-day, and 1-year mortality. Multivariable logistic regression, Kaplan-Meier survival curves, and Cox adjusted proportional hazards models were used. Results were reported as odds ratios (OR) and hazard ratios (HR) with 95% confidence intervals.</p><p><strong>Results: </strong>Mortality increased across the combined RDW-lactate categories, with the highest rates observed in patients with both biomarkers elevated: 32.1% at 28 days, 43.6% at 90 days, and 53.0% at 1 year. In adjusted models, both RDW and lactate were independently associated with higher mortality. The RDW × lactate interaction was significant for 90-day mortality (OR 1.13). Cox analysis confirmed a higher risk of 90-day mortality in patients with both biomarkers elevated (HR 1.57). Kaplan-Meier curves showed significant differences in survival (log-rank p < 0.001).</p><p><strong>Conclusions: </strong>The combined evaluation of RDW and lactate may improve short- and long-term mortality risk stratification in critically ill patients with acute kidney injury.</p>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502175"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R P Sá, M B Antunes, R Torres, A T Cruz, A Marinho, T Meira, I Cerqueira
{"title":"General anesthesia versus non-GA for endovascular thrombectomy of posterior circulation stroke: A five-year retrospective analysis of the impact on patient outcomes.","authors":"R P Sá, M B Antunes, R Torres, A T Cruz, A Marinho, T Meira, I Cerqueira","doi":"10.1016/j.redare.2026.502171","DOIUrl":"10.1016/j.redare.2026.502171","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal anesthesia strategy during endovascular thrombectomy (EVT) for posterior circulation acute ischemic stroke (PC-AIS) remains unclear.</p><p><strong>Methods: </strong>We conducted a 5-year retrospective cohort study of consecutive PC-AIS patients treated with EVT and categorized by anesthetic modality: general anesthesia (GA) or non-GA. The primary outcome was functional independence at 90 days, defined as a modified Rankin Scale (mRS) score of 0-2. Secondary outcomes included successful reperfusion (mTICI 2b-3) and 3-month mortality. Multivariable logistic regression was used to adjust for confounding factors.</p><p><strong>Results: </strong>Of 132 patients, 55 (41.7%) underwent EVT under GA. Good functional outcome was achieved in 61.5% of GA patients versus 47.9% of non-GA patients. However, after adjustment, GA was not independently associated with functional independence (adjusted OR 0.72, 95% CI 0.22-2.31; p = 0.571). Reperfusion rates were similar for both groups (successful reperfusion: GA 84.1% vs. non-GA 81.7%, p = 0.458) and mortality at 3 months did not differ significantly (GA: 18.2% vs. non-GA: 20.8%; adjusted OR 2.41, 95% CI 0.78-7.47; p = 0.127).</p><p><strong>Discussion: </strong>There is no significant difference in outcomes between patients with PC-AIS undergoing EVT with GA versus non-GA. These findings align with recent evidence, suggesting comparable functional, angiographic, and survival outcomes across anesthetic strategies, though limitations related to retrospective design and practice variability remain.</p><p><strong>Conclusion: </strong>Anesthetic modality (GA vs. non-GA) does not significantly affect 3-month functional outcomes, successful reperfusion, or mortality during EVT for PC-AIS, supporting an individualized, patient- and procedure-based approach.</p>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502171"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitochondrial hypersensitivity to sevoflurane: Pharmacogenetics and the role of scientific societies.","authors":"Y Hernández-Castillo, E Ruiz-Pesini","doi":"10.1016/j.redare.2026.502197","DOIUrl":"10.1016/j.redare.2026.502197","url":null,"abstract":"","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502197"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M G Saad, N K Gaballa, H R Alkashgari, A Abodonya, A G Salah Elsawy, A M Abouelnasr Khalifa, S Abdalla Moursi, M Mostafa Elshamy, M Hegab, E F Ismail, A Deyab, R Elsafty, I Eltanani
{"title":"Baskar® Mask versus ProSeal™ laryngeal mask airway for airway sealing and clinical performance in gynecologic laparoscopic surgery: A randomized trial.","authors":"M G Saad, N K Gaballa, H R Alkashgari, A Abodonya, A G Salah Elsawy, A M Abouelnasr Khalifa, S Abdalla Moursi, M Mostafa Elshamy, M Hegab, E F Ismail, A Deyab, R Elsafty, I Eltanani","doi":"10.1016/j.redare.2026.502196","DOIUrl":"10.1016/j.redare.2026.502196","url":null,"abstract":"<p><strong>Objective: </strong>To compare the oropharyngeal leak pressure and clinical performance of the Baska® mask and the ProSeal™ laryngeal mask airway (LMA) during controlled ventilation in gynecologic laparoscopic surgery.</p><p><strong>Methods: </strong>This prospective randomized controlled trial included 100 adult women with American Society of Anesthesiologists (ASA) physical status I-II undergoing elective gynecologic laparoscopic surgery. After induction of general anesthesia, patients were randomized to insertion of either the Baska mask (BM group, n = 50) or the ProSeal laryngeal mask airway (PL group, n = 50). The primary outcome was oropharyngeal leak pressure measured 10 min after establishment of pneumoperitoneum. Secondary outcomes included insertion time, ease of insertion, number of insertion attempts, intraoperative device displacement, and perioperative airway-related complications.</p><p><strong>Results: </strong>Oropharyngeal leak pressure was significantly higher in the BM group than in the PL group (median [IQR], 31 [28-33] vs 26 [25-28] cmH<sub>2</sub>O; p < 0.001). Insertion time was significantly shorter with the Baska mask (9 [7-10] s vs 15 [13-16.8] s; p < 0.001). First-attempt success rates were comparable (96% vs 90%). Device displacement, blood-tinged sputum, and postoperative pharyngolaryngeal discomfort were not significantly different between groups. No patient required endotracheal intubation, and no episodes of vomiting occurred.</p><p><strong>Conclusion: </strong>In gynecologic laparoscopic surgery, the Baska mask provided higher oropharyngeal leak pressure and faster insertion than the ProSeal LMA, with a comparable perioperative safety profile.</p>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502196"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Ripollés-Melchor, P Galán-Menéndez, Á V Espinosa, D Fernández-García, A Abad-Motos, R Navarro-Pérez, R Budithi, P Fernández-Valdes-Bango, A Abad-Gurumeta, C Aldecoa
{"title":"Association of preoperative lactate concentration with in-hospital mortality after emergency surgery.","authors":"J Ripollés-Melchor, P Galán-Menéndez, Á V Espinosa, D Fernández-García, A Abad-Motos, R Navarro-Pérez, R Budithi, P Fernández-Valdes-Bango, A Abad-Gurumeta, C Aldecoa","doi":"10.1016/j.redare.2026.502208","DOIUrl":"10.1016/j.redare.2026.502208","url":null,"abstract":"<p><strong>Introduction: </strong>Lactate is widely used as a marker of metabolic and circulatory stress, but its prognostic value in emergency surgical populations remains incompletely defined.</p><p><strong>Methods: </strong>We performed a retrospective cohort study using the INSPIRE dataset, including emergency surgical procedures with a preoperative lactate measurement obtained within 6 h of incision. The primary outcome was in-hospital mortality. Multivariable logistic regression adjusted for age, sex, ASA physical status, surgical department, anaesthesia type, preoperative haemoglobin and creatinine. Lactate was analysed using restricted cubic splines and in prespecified categories (<2, 2-<4 and ≥4 mmol l<sup>-</sup>¹). Incremental prognostic value was assessed by comparing a baseline clinical model with and without lactate.</p><p><strong>Results: </strong>The analytic cohort included 3729 emergency surgical procedures, of which 360 resulted in in-hospital death (9.7%). Mortality increased across lactate categories: 6.9% for lactate <2 mmol l<sup>-</sup>¹, 13.9% for lactate 2-<4 mmol l<sup>-</sup>¹ and 42.2% for lactate ≥4 mmol l<sup>-</sup>¹. After adjustment, lactate was still associated with mortality (odds ratio 1.79 [95% CI 1.23-2.59] for 2-<4 mmol l<sup>-</sup>¹ and 7.34 [4.65-11.57] for ≥4 mmol l<sup>-</sup>¹ vs <2 mmol l<sup>-</sup>¹). Adding lactate to the standard clinical model improved discrimination (AUC 0.755 vs 0.801) and reduced the Brier score (0.094 vs 0.088). Results were consistent across alternative measurement windows and after multiple imputation.</p><p><strong>Conclusion: </strong>Preoperative lactate concentration was strongly associated with in-hospital mortality and provided incremental prognostic information beyond routinely available variables. In emergency surgical pathways, lactate may support early risk stratification.</p>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":" ","pages":"502208"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}