Puerto Rico health sciences journal最新文献_第3页

Oral Health Knowledge and Oral Hygiene Habits in a Sample of 12-Year-Old Hispanics: A Cross-sectional Study. 12 岁西班牙裔青少年的口腔健康知识和口腔卫生习惯：横断面研究。

Puerto Rico health sciences journal Pub Date : 2024-06-01

Milagros J Toro, Sona Rivas-Tumanyan, Margarita Murillo, Luis Orraca, Bayardo Garcia-Godoy, Ana K Bencosme, Augusto R Elias-Boneta

{"title":"Oral Health Knowledge and Oral Hygiene Habits in a Sample of 12-Year-Old Hispanics: A Cross-sectional Study.","authors":"Milagros J Toro, Sona Rivas-Tumanyan, Margarita Murillo, Luis Orraca, Bayardo Garcia-Godoy, Ana K Bencosme, Augusto R Elias-Boneta","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To explore the association between hygiene knowledge and habits and gingivitis in Puerto Rican school children.Methods: Questionnaires on oral health knowledge and hygiene habits were provided to almost half of the 12-year-olds who participated in an island-wide cross-sectional oral health study. The evaluations included gingival examinations in 2 quadrants. Odds ratios (ORs) (with 95% CIs) were computed using logistic regression models and oral health-related knowledge and hygiene habits to gingivitis.Results: Of the 823 participants who completed the questionnaire 53.43% were female, and 81% had gingivitis. Most reported having received instructions on brushing (98%), flossing (89.5%), and using mouthwash (90%). The majority (75%) rated their gums as healthy, and 44.68% agreed that oral health affects general health. Nearly half (44%) reported brushing their teeth at least 2 times a day, and 80.25%, flossing daily. In multivariate analysis, not having been instructed on how to brush was related to greater odds of having gingivitis (OR: 7.32; 95% CI: 1.5-35.67). Flossing more than once a day was associated with half the odds of gingivitis (OR: 0.50; 95% CI: 0.29-0.88).Conclusion: The children had knowledge of oral hygiene methods but were mostly unaware that gingival health could affect systemic health. Fewer than half reported brushing 2 or more times a day. Not having been instructed on how to brush was associated with higher odds of gingivitis.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 2","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Susceptibility and Characteristics of Neisseria gonorrhoeae Isolates from Puerto Rico, 2012-2017. 2012-2017 年波多黎各淋病奈瑟菌分离物的抗菌药敏感性和特征。

Puerto Rico health sciences journal Pub Date : 2024-06-01

Ramón Scharbaai, Lilliana Serrano, Juliara E Ortiz

{"title":"Antimicrobial Susceptibility and Characteristics of Neisseria gonorrhoeae Isolates from Puerto Rico, 2012-2017.","authors":"Ramón Scharbaai, Lilliana Serrano, Juliara E Ortiz","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Monitoring the susceptibility patterns of Neisseria gonorrhoeae is essential for the continuing compliance with current treatment recommendations. Puerto Rico conducts susceptibility tests on N. gonorrhoeae; however, trends on antimicrobial resistance in the island have not been reported since the mid 80's.Methods: We performed a secondary analysis of a national data repository on the antimicrobial susceptibility of N. gonorrhoeae isolates between 2012 and 2017; a period of time when the CDC recommended a single dose of ceftriaxone and azithromycin for the treatment of uncomplicated gonorrhea. Data on susceptibility to eight antibiotics using the standard disk diffusion method was obtained for 30.0% (84/276) of the samples collected from the Sexually Transmitted Disease clinics in Puerto Rico. We also performed patient demographic analyses linked to resistance.Results: Rates of resistance to ceftriaxone and azithromycin were 0% and 4.0% (2/50), respectively. The percentage of isolates resistant to antimicrobials no longer recommended in Puerto Rico, such as tetracycline, ciprofloxacin, and penicillin, was 86.0% (43/50), 76.0% (38/50), and 38.0% (19/50), respectively. Prevalence of resistant N. gonorrhoeae was higher among men who have sex with men, MSM (79%, 37/47).Discussion: Lack of resistance to ceftriaxone and slow emergence of azithromycin resistance was identified from 2012-2017. It is imperative to continue the surveillance for emerging patterns of resistance, especially for ceftriaxone, as it is part of the current treatment guidelines. Therefore, protocols for culture based surveillance, including sample transport and processing, should be strengthened to ensure quality assured epidemiology of gonococcal resistance in Puerto Rico.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 2","pages":"68-72"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features and Therapeutic Outcomes Comparing Primary Mediastinal Large B-cell Lymphoma to Mediastinal Hodgkin Disease. 比较原发性纵隔大 B 细胞淋巴瘤和纵隔霍奇金病的临床特征和治疗效果。

Puerto Rico health sciences journal Pub Date : 2024-06-01

Rubén J Cruz-Chamorro, Joshua L Rodríguez-López, Michael J González-Soto, Raúl Arroyo-Suárez, Carmen Ortiz-Sánchez, Jarline Encarnación-Medina, Fernando Cabanillas

引用次数: 0

New Synergistic Combination Therapy of Mupirocin and α-Pinene Against Multidrug-Resistant Clinical Strains of Methicillin-Resistant Staphylococcus aureus. 莫匹罗星和α-蒎烯对耐甲氧西林金黄色葡萄球菌耐多药临床菌株的新型协同疗法

Puerto Rico health sciences journal Pub Date : 2024-06-01

Paulo Cáceres-Guido, Nicolás Martín-Vázquez, Adriana Ojeda-Sana, Catalina Van Baren, Ziomara Balbarrey, Silvia Moreno

{"title":"New Synergistic Combination Therapy of Mupirocin and α-Pinene Against Multidrug-Resistant Clinical Strains of Methicillin-Resistant Staphylococcus aureus.","authors":"Paulo Cáceres-Guido, Nicolás Martín-Vázquez, Adriana Ojeda-Sana, Catalina Van Baren, Ziomara Balbarrey, Silvia Moreno","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Increased mupirocin use leads to mupirocin resistance and is associated with persistence of methicillin-resistant Staphylococcus aureus (MRSA) carriers, prolonged hospitalization, and significant economic burdens for health systems. The study aimed to investigate the antimicrobial activity of compounds of Salvia rosmarinus L. (\"rosemary\", formerly Rosmarinus officinalis), alone or in combination with mupirocin, against multidrug resistant MRSA using isolates obtained from pediatric patients.Methods: The in vitro antibacterial activity of the monoterpene α-pinene (α-Pi), a rosemary essential oil constituent, alone and in combination with mupirocin, was evaluated by determining the minimum inhibitory concentrations and minimum bactericidal concentrations (MBCs) and the fractional inhibitory concentration indices (FICIs) and fractional bactericidal concentration indices against multidrug-resistant clinical MRSA strains. The in vivo efficacy of α-Pi, alone and in combination with mupirocin, to eradicate MRSA infection was determined using an optimized mouse model of MRSA-infected wounds. Mouse skin samples (obtained via biopsy) were assessed for toxicity, and rabbit skin samples for irritation.Results: Both in vitro and in vivo, α-Pi was active against MRSA strains and acted synergistically with mupirocin against MRSA strains. Mupirocin-monoterpene combinations exhibited FICI values of 0.2 to 0.4, reducing the MBC of topical mupirocin 33-fold. A topical formulation containing α-Pi and mupirocin enhanced the efficacy of mupirocin in an in vivo MRSA-infected mouse skin model without significantly harming the skin of mice and rabbits.Conclusions: A topical formulation combining mupirocin and α-Pi may aid in the development of innovative agents for treating MRSA infections.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 2","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric Properties of the Family Adaptability and Cohesion Evaluation Scale III in Latin American University Dental Students. 拉丁美洲牙科大学生家庭适应性和凝聚力评估量表 III 的心理测量学特性》（Psychometric Properties of the Family Adaptability and Cohesion Evaluation Scale III in Latin American University Dental Students）。

Puerto Rico health sciences journal Pub Date : 2024-06-01

Víctor Díaz-Narváez, Alejandro Reyes-Reyes, Ana María Erazo-Coronado, Natalia Fortich-Mesa, Nuvia Estrada-Méndez, Farith González-Martínez, María Silva-Vetri, Eugenia González-Díaz, María J Ulloque, Silvina Villalba, Lindsey W Vilca, Aracelis Calzadilla-Núñez, Jorge L Bilbao-Ramírez, Luz Marina Alonso-Palacio, Marcos Cervantes-Mendoza

{"title":"Psychometric Properties of the Family Adaptability and Cohesion Evaluation Scale III in Latin American University Dental Students.","authors":"Víctor Díaz-Narváez, Alejandro Reyes-Reyes, Ana María Erazo-Coronado, Natalia Fortich-Mesa, Nuvia Estrada-Méndez, Farith González-Martínez, María Silva-Vetri, Eugenia González-Díaz, María J Ulloque, Silvina Villalba, Lindsey W Vilca, Aracelis Calzadilla-Núñez, Jorge L Bilbao-Ramírez, Luz Marina Alonso-Palacio, Marcos Cervantes-Mendoza","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The Family Adaptability and Cohesion Evaluation Scale III (FACES III) is a self-report instrument that enables the assessment of the dimensions of adaptability and cohesion within a family, establishing whether or not that family is functional and classifying it according to categories within those dimensions. The objective of this research was to determine the psychometric properties of this instrument using a sample of dental students from 5 Latin American countries.Materials and methods: The FACES III was administered to a sample of 2888 university dental students from Colombia (35.3%), Chile (34.6%), the Dominican Republic (19%), Argentina (6%), and El Salvador (5.1%). Confirmatory factor analysis was used to examine the factorial structure of the scale, comparing 3 models proposed in the Latin American literature, establishing a multigroup analysis to examine invariance among countries.Results: The results revealed a structure composed of 2 dimensions: cohesion and adaptability. These dimensions showed adequate structure and internal consistency. The invariance of the measurement model in the participating countries was confirmed.Conclusion: In general, this study offers evidence of the adequacy of the psychometric properties of FACES III in Colombian, Chilean, Dominican, Argentine, and Salvadoran dental students.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 2","pages":"84-92"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Therapy Dogs in the Pediatric COVID-19 Vaccination at the University of Puerto Rico Medical Sciences Campus. 波多黎各大学医学科学校区在小儿 COVID-19 疫苗接种中使用治疗犬。

Puerto Rico health sciences journal Pub Date : 2024-03-01

Carmen D Zorrilla, Humberto M Guiot, Wanda T Maldonado-Dávila, Francico J Jiménez-Ramírez, Luz V Camacho, Suane Sánchez, Barbara Segarra, Leyra Figueroa

{"title":"The Use of Therapy Dogs in the Pediatric COVID-19 Vaccination at the University of Puerto Rico Medical Sciences Campus.","authors":"Carmen D Zorrilla, Humberto M Guiot, Wanda T Maldonado-Dávila, Francico J Jiménez-Ramírez, Luz V Camacho, Suane Sánchez, Barbara Segarra, Leyra Figueroa","doi":"","DOIUrl":"","url":null,"abstract":"Pet ownership and therapy dogs as companion animals and emotional support have potential health benefits. We report the experiences at a COVID-19 vaccination center after authorizing children's vaccines. When the Pfizer-BioNTech vaccine for children aged 5 to 11 years was authorized for emergency use, we adapted the center's space to receive children, adding cartoon posters and balloons and using children's adhesive bandages, among others. Located at a Campus with six health professional schools, medical students dressed as storybook or movie characters. Children were asked to make drawings during the post vaccination observation period. We incorporated therapy dogs as part of our strategy for a child-friendly center during vaccination activities. Parents expressed that the COVID-19 immunization seemed to be better accepted by children as the dogs in the center entertained them. Many children were in close contact with the dogs while receiving the shots, caressing them, or having the small dogs on their laps. Children's drawings reflected colors, flowers, families, images of happiness, dogs with their names, their own pets, and superhero characters. There were no negative images of syringes, injections, or germs. To our knowledge, this was the only vaccine center in Puerto Rico that implemented therapy dogs as a strategy to create a friendly environment for COVID 19 immunization efforts targeted for children. Based on this experience, we encourage the use of therapy dogs in other immunization activities and will further gather prospective data in the future.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter Pylori and Gastric Cancer: An Update in the Literature. 幽门螺杆菌与胃癌：文献更新

Puerto Rico health sciences journal Pub Date : 2024-03-01

Doris H Toro, Aliana Bofill-Garcia, Miguel Anzalota-Del Toro

{"title":"Helicobacter Pylori and Gastric Cancer: An Update in the Literature.","authors":"Doris H Toro, Aliana Bofill-Garcia, Miguel Anzalota-Del Toro","doi":"","DOIUrl":"","url":null,"abstract":"Of the chronic bacterial infections that affect humans, Helicobacter pylori (H. pylori) infection is one of the most common. It inhabits the stomachs of half of the adult human population. In Puerto Rico, a US territory, it has an overall prevalence of 33%, similar to the prevalence reported in the population of the US as a whole. Helicobacter pylori infection is responsible for mucosal inflammation that may lead to chronic gastritis, most peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The International Agency for Research on Cancer identified H. pylori as a definite carcinogen in 1994, the only bacterium to be given such a classification. Its oncogenic effect has been postulated to be caused by different mechanisms, including bacterial characteristics and host factors. Epidemiologic studies have shown that gastric cancer risk differs among regions. One of the top 10 causes of cancer death in Puerto Rico is gastric cancer. Although the eradication of H. pylori has well-known benefits, there are some concerns when considering mass screening and treatment of infected patients. These include the fact that such eradication could provoke an increase in antibiotic resistance rates, the disturbance of the gut microbiota, an increase in body weight, and the aggravation of existing gastroesophageal reflux symptoms. Gastric cancer is a major health concern, and we should understand the role of H. pylori eradication in its prevention. This article is geared to summarize current knowledge and controversies.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalences of Hypertension, Type 2 Diabetes Mellitus, and Cardiovascular Disease in a Cohort of Puerto Ricans with Non-alcoholic Fatty Liver Disease. 波多黎各非酒精性脂肪肝患者队列中高血压、2 型糖尿病和心血管疾病的患病率。

Puerto Rico health sciences journal Pub Date : 2024-03-01

Adriel González-Rivera, Valerie M Vargas-Figueroa, Emmanuel Candal-Rivera, Esther A Torres

{"title":"Prevalences of Hypertension, Type 2 Diabetes Mellitus, and Cardiovascular Disease in a Cohort of Puerto Ricans with Non-alcoholic Fatty Liver Disease.","authors":"Adriel González-Rivera, Valerie M Vargas-Figueroa, Emmanuel Candal-Rivera, Esther A Torres","doi":"","DOIUrl":"","url":null,"abstract":"Background & objectives: Patients with non-alcoholic fatty liver disease (NAFLD) have high prevalences of hypertension (HTN), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD), and vice versa. The mechanism of this development is unknown but appears to be related to an underlying metabolic derangement that affects multiple organs. This study aimed to determine the prevalences of these conditions in patients with diagnosed NAFLD.Methods: Our cohort study aimed to determine the prevalences of HTN, T2DM, and CVD in NAFLD patients registered in the liver database of the University of Puerto Rico School of Medicine; this information is recorded in their medical records. Patients whose liver disease had a different etiology were excluded. The study was approved by the UPR Medical Sciences Campus Institutional Review Board.Results: Our final sample consisted of 141 NAFLD patients; 64.5% (n = 91) of them were females. The average age was 69 (±10.2 years). The prevalences of HTN, T2DM, and CVD were 53.9%, 57.5%, and 7.8%, respectively. In patients with NAFLD, there was a significant association between T2DM and being 65 years old or older (P < 0.001).Conclusion: Our data indicate that HTN and T2DM are highly prevalent in NAFLD patients in PR; however, CVD prevalence was lower than expected. Additional, studies are required to further define the associations. We recommend metabolic condition screening for all NAFLD patients.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceptions of the Zika Virus, Contraceptive Access, and Motivation to Participate in the Zika Contraception Access Network Program: Qualitative Analysis of Focusgroup Discussions with Puerto Rican Women. 对寨卡病毒的看法、避孕药具的获取以及参与寨卡避孕药具获取网络计划的动机：对波多黎各妇女焦点小组讨论的定性分析》。

Puerto Rico health sciences journal Pub Date : 2024-03-01

Lisa Romero, Edna Acosta-Pérez, Hailey Bednar, Stacey Hurst, Lauren B Zapata, Samaris Vega-Torres, Rachel Powell, Eva Lathrop

{"title":"Perceptions of the Zika Virus, Contraceptive Access, and Motivation to Participate in the Zika Contraception Access Network Program: Qualitative Analysis of Focusgroup Discussions with Puerto Rican Women.","authors":"Lisa Romero, Edna Acosta-Pérez, Hailey Bednar, Stacey Hurst, Lauren B Zapata, Samaris Vega-Torres, Rachel Powell, Eva Lathrop","doi":"","DOIUrl":"","url":null,"abstract":"Objective: During the 2016-2017 Zika virus outbreak in Puerto Rico, the Zika Contraception Access Network (Z-CAN) provided client-centered contraceptive counseling and access to the full range of reversible contraceptive methods at no cost to prevent unintended pregnancies and thereby to reduce Zika-related birth outcomes.Methods: To understand how Puerto Rican women's perceptions of the Zika virus affected contraceptive decisions and assess how they heard about the Z-CAN program and what influenced their participation, or lack thereof, 24 focus-group discussions were conducted among women of reproductive age who did and did not participate in Z-CAN.Results: Women who participated in the discussions often had heard about Z-CAN from their physician or friends; non-participants had heard about Z-CAN from Facebook or friends. Women expressed satisfaction on finding a Z-CAN clinic and valued the same-day provision of contraceptives. When a preferred contraceptive method or a first appointment was not readily available, women reconsidered accessing the program. Women's perceptions and trust of reproductive healthcare providers, their engagement in social networks, and their ability to choose a contraceptive method that best meets their needs can influence participation in contraception-access programs.Conclusion: Focus groups can be used to understand women's knowledge of the Zika virus, barriers and facilitators to contraception access, and motivations for participation in the Z-CAN program.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 1","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Abstinence Syndrome and Corresponding Pharmacotherapy Approaches from 2 University-affiliated Neonatal Intensive Care Units in Puerto Rico (2018-2020). 波多黎各两所大学附属新生儿重症监护室的新生儿戒断综合征及相应药物治疗方法（2018-2020 年）。

Puerto Rico health sciences journal Pub Date : 2024-03-01

Pamela Morales, Laura Santiago, Jessica Rosario, Lourdes Garcia-Fragoso, Jorge Duconge, Naidy Perez, Darlene Santiago

{"title":"Neonatal Abstinence Syndrome and Corresponding Pharmacotherapy Approaches from 2 University-affiliated Neonatal Intensive Care Units in Puerto Rico (2018-2020).","authors":"Pamela Morales, Laura Santiago, Jessica Rosario, Lourdes Garcia-Fragoso, Jorge Duconge, Naidy Perez, Darlene Santiago","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Neonatal abstinence syndrome (NAS) is a set of drug withdrawal symptoms suffered by neonates exposed to drugs in utero. Several studies have widely described NAS incidence and treatment approach; however, little is known regarding the incidence and manifestations of this disease in Puerto Rico (PR). The principal aim of this study was to describe NAS incidence in the neonatal units of hospitals affiliated with the University of PR in terms of occurrence, clinical manifestations, and treatment approaches.Methods: Our study evaluated the medical records of NAS babies diagnosed from 2018 through 2020 at 2 hospitals affiliated with the University of PR Medical Sciences Campus. Descriptive and inferential statistics were employed to analyze trends.Results: We identified 12 neonates diagnosed with NAS, 5 with low birthweights (<2500 g); for a NAS incidence of 2 cases per 1000 admitted for the 3 years of recollected data. The urine toxicology results revealed that 9 had experienced intrauterine polydrug exposure. Phenobarbital loading dose were determined on the day of diagnosis (indicated by Finnegan score). The first manifestation of NAS symptoms varied: 8 neonates showed symptoms within 48 hours after birth, whereas 4 had withdrawal symptoms within 72-120 hours of their births. Differences between dosing practices and guidelines were observed, ranging from a 0.69% to a 25% difference during treatment initiation.Conclusion: Further research on the incidence of NAS in PR (national level) is needed for a deeper understanding that we hope will lead to the development of enhanced treatment protocols in PR.","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"43 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11061712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0