Polish journal of veterinary sciences最新文献

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Antibody level comparison after porcine epidemic diarrhea vaccination via different immunization routes. 通过不同免疫途径接种猪流行性腹泻疫苗后的抗体水平比较。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149342
C Hu, X Xie, D Zhao, H Liu, X Liu, T Yang, W Sun
{"title":"Antibody level comparison after porcine epidemic diarrhea vaccination via different immunization routes.","authors":"C Hu, X Xie, D Zhao, H Liu, X Liu, T Yang, W Sun","doi":"10.24425/pjvs.2024.149342","DOIUrl":"10.24425/pjvs.2024.149342","url":null,"abstract":"<p><p>Porcine epidemic diarrhea (PED) is a disease extremely harmful to pig health. Intramuscular and Houhai acupoint injections are the main immunization routes to prevent and control PED. This study aimed to evaluate the efficacy of these two routes in pregnant sows based on serum IgG, IgA, and neutralizing antibody levels. PED virus (PEDV) immunoprophylaxis with live-attenuated and inactivated vaccines was administered. The vaccinations for the intramuscular injections elevated IgG and neutralizing antibody levels more than Houhai acupoint injections at most timepoints after immunization. However, the anti-PEDV IgA antibodies induced by vaccination with the two immunization routes did not differ significantly. In conclusion, intramuscular injections are better than Houhai acupoint injections for PEDV vaccination of pregnant sows.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"143-146"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prepartum behaviors as early indicators for postpartum energy associated biomarkers status in Holstein dairy cows. 产前行为是荷斯坦奶牛产后能量相关生物标志物状况的早期指标。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149340
M H Emam, E Shepley, M M Mahmoud, M Ruch, S Elmaghawry, W Abdelrazik, A M Abdelaal, B A Crooker, L S Caixeta
{"title":"Prepartum behaviors as early indicators for postpartum energy associated biomarkers status in Holstein dairy cows.","authors":"M H Emam, E Shepley, M M Mahmoud, M Ruch, S Elmaghawry, W Abdelrazik, A M Abdelaal, B A Crooker, L S Caixeta","doi":"10.24425/pjvs.2024.149340","DOIUrl":"10.24425/pjvs.2024.149340","url":null,"abstract":"<p><p>Our main aim was to investigate the predictive value of prepartum behaviors such as total daily rumination (TDR), total daily activity (TDA) and dry matter intake (DMI) as early indicators to detect cows at risk for hyperketonemia (HYK), hypoglycemia (HYG) or high non-esterified fatty acid (NEFA) status in the first (wk1) and second week (wk2) postpartum. In a case control study, 64 Holstein cows were enrolled 3 weeks before the expected time of calving and monitored until 15 days in milk (DIM). Postpartum blood samples were taken at D3 and D6 for wk1 and at D12 and D15 for wk2 to measure beta-hydroxybutyrate, NEFA and glucose concentration. Ear-mounted accelerometers were used to measure TDR and TDA. DMI and milk yield were obtained from farm records. Relationships between the average daily rate of change in prepartum TDR (ΔTDR), TDA (ΔTDA), and DMI (ΔDMI) with postpartum HYK, HYG and NEFA status in wk1 and wk2 post-partum were evaluated using linear regression models. Models were adjusted for potential confounding variables, and covariates retained in the final models were determined by backward selection. No evidence was found to support the premise that prepartum ΔTDR, ΔTDA or ΔDMI predicted postpartum HYK, HYG or NEFA status in wk1 or in wk2. Overall, prepartum ΔTDR, ΔTDA and ΔDMI were not effective predictors of HYK, HYG or NEFA status in the first 2 weeks postpartum.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"107-116"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined antimicrobial action of streptomycin and terpenes against atypical mycobacteria isolated from fish. 链霉素和萜类化合物对从鱼类中分离出来的非典型分枝杆菌的联合抗菌作用。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149334
L Guz, K Puk, D Szwajgier, A Pastuszka
{"title":"Combined antimicrobial action of streptomycin and terpenes against atypical mycobacteria isolated from fish.","authors":"L Guz, K Puk, D Szwajgier, A Pastuszka","doi":"10.24425/pjvs.2024.149334","DOIUrl":"10.24425/pjvs.2024.149334","url":null,"abstract":"<p><p>The aim of this study was to investigate the antimycobacterial activity of 39 free terpenes and their activity in combination with streptomycin. Antimicrobial activity was first evaluated by screening 39 free terpenes at concentrations from 1.56 to 400 μg/mL. None of these exhibited positive effects against any of the nontuberculous mycobacteria (NTM) strains tested. However, six of the 39 terpenes (isoeugenol, nerol, (+)-α-terpineol, (1R)-(-)-myrtenol, (+)-terpinen-4-ol, and eugenol) were shown to enhance the activity of streptomycin against the NTM strains isolated from diseased ornamental fish.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"135-138"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-thaw quality of boar spermatozoa is affected by ejaculate fractions and extenders. 公猪精子的解冻后质量受射精成分和扩展剂的影响。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149345
Ł Zasiadczyk, K Kurpanik, L Fraser, W Kordan
{"title":"Post-thaw quality of boar spermatozoa is affected by ejaculate fractions and extenders.","authors":"Ł Zasiadczyk, K Kurpanik, L Fraser, W Kordan","doi":"10.24425/pjvs.2024.149345","DOIUrl":"10.24425/pjvs.2024.149345","url":null,"abstract":"<p><p>The aim of this study was to investigate the effect of different extenders on the post-thaw (PT) quality of sperm originating from the sperm-rich fraction (SRF) and post-sperm-rich fraction (PSRF) of boar ejaculate. Motility and velocity parameters, analyzed using a computer-assisted semen analysis (CASA) system, and membrane integrity parameters were markedly higher in frozen-thawed (FT) spermatozoa of the SRF in both the Belstville Thawing Solution (BTS) and Androhep Plus (AHP) extenders, irrespective of the post-thaw (PT) storage time. Furthermore, reduced cryo-survival was more marked in FT spermatozoa of the PSRF in both extenders following storage for 60 min. It was found that the SRF-stored samples in the AHP extender for 60 min exhibited significantly higher percentages of spermatozoa with total motility, mitochondrial function and acrosome integrity than those stored in the BTS extender. The findings of this study confirm that components of the ejaculate fractions and extender have varying effects on the cryo-survival of boar spermatozoa.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"147-150"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential oil and plant extract of oregano as agents influencing the virulence factors of Candida albicans. 牛至精油和植物提取物是影响白色念珠菌毒力因子的物质。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149330
P Váczi, M Proškovcová, E Čonková, D Marcinčáková, M Bačkorová, M Harčárová
{"title":"Essential oil and plant extract of oregano as agents influencing the virulence factors of Candida albicans.","authors":"P Váczi, M Proškovcová, E Čonková, D Marcinčáková, M Bačkorová, M Harčárová","doi":"10.24425/pjvs.2024.149330","DOIUrl":"10.24425/pjvs.2024.149330","url":null,"abstract":"<p><p>Candida albicans, a polymorphic yeast, is a physiological component of the human and animal commensal microbiome. It is an etiological factor of candidiasis, which is treated by azole antifungals. Growing resistance to azoles is a reason to look for other alternative treatment options. The pharmacotherapeutic use of plant extracts and essential oils has become increasingly important. In our experiment, C. albicans showed susceptibility to four observed plant extracts and essential oils from peppermint ( Mentha piperita), thyme ( Thymus vulgaris), sage ( Salvia officinalis), and oregano ( Origanum vulgare). Oregano plant extract and essential oil showed the highest antifungal activity, at MIC values of 4.9 mg/mL and 0.4 mg/mL respectively. Therefore, it was subjected to further research on the influence of virulence factors - biofilm formation, extracellular phospholipase production and germ tube formation. Oregano plant extract and essential oil showed an inhibitory effect on the observed C. albicans virulence factors at relatively low concentrations. The extract inhibited the adherence of cells at MIC 12.5 mg/mL and essential oil at MIC 0.25 mg/mL. Degradation of the formed biofilm was detected at MIC 14.1 mg/mL for plant extract and at MIC 0.4 mg/mL for essential oil. Extracellular phospholipase production was most effectively inhibited by the essential oil. In particular, the number of isolates with intensive extracellular phospholipase production decreased significantly. Of the 12 isolates intensively producing extracellular phospholipase, only 1 isolate (4.5%) retained intense production. Essential oil caused up to a 100 % reduction in germ tubes formation and plant extract reduced their formation depending on the concentration as follows: 2.6% (0.8 mg/mL), 21.2 % (6.25 mg/mL), and 64.5 % (12.5 mg/mL) compared to the control.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occurrence of Macrorhabdus ornithogaster in exotic birds. 外来鸟类中出现 Macrorhabdus ornithogaster。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149335
B Blagojević, I Davidov, A Galfi Vukomanović, D Tekić, M Došenović Marinković, V Vidović
{"title":"Occurrence of Macrorhabdus ornithogaster in exotic birds.","authors":"B Blagojević, I Davidov, A Galfi Vukomanović, D Tekić, M Došenović Marinković, V Vidović","doi":"10.24425/pjvs.2024.149335","DOIUrl":"10.24425/pjvs.2024.149335","url":null,"abstract":"<p><p>Avian gastric yeast (Macrorhabdus ornithogaster) is a microorganism that infects aviary birds worldwide, both captive and wild. A total number of 352 birds, belonging to 18 avian species, were examined from 2019 to 2022 for M. ornithogaster, using fecal smears of live birds or cytological samples of the proventriculus taken at necropsy. These cytological samples were taken from birds that died from different causes. Some of the birds exhibited symptoms such as lethargy, regurgitation, weight loss and anorexia. Faecal samples were collected from all the birds and analysed for gastric yeast using a direct smear and Gram-staining method. The microorganism was diagnosed most frequently in budgerigars (55.5%), the African gray parrot (33.3%), and nymphs (34.3%). The prevalence of M. ornithogaster in canaries was 10%. The infection was detected in 31% of the examined birds, which shows that the occurrence of M. ornithogaster in exotic birds is common. No clinical signs were observed in the vast majority of birds that tested positive for gastric yeast.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"139-142"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raw diets for dogs and cats: Potential health benefits and threats. 猫狗的生食:潜在的健康益处和威胁。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149344
D Główny, N Sowińska, A Cieślak, M Gogulski, K Konieczny, M Szumacher-Strabel
{"title":"Raw diets for dogs and cats: Potential health benefits and threats.","authors":"D Główny, N Sowińska, A Cieślak, M Gogulski, K Konieczny, M Szumacher-Strabel","doi":"10.24425/pjvs.2024.149344","DOIUrl":"10.24425/pjvs.2024.149344","url":null,"abstract":"<p><p>Raw meat-based diets for pet nutrition are becoming increasingly popular. The percentage of meat content, composition of nutrients, and amount of additives started to play an important role in the recipe of a given food. However, the use of healthier and unprocessed food must also be balanced with the animal's specific needs based on its anatomy, physiology, and behavior. There are many potential advantages and disadvantages of a biologically appropriate raw food (BARF) diet, and all of them should be considered before switching to this approach. Raw meat is considered a diet closest to nature and least processed. However, raw diets threaten pet health because of the potential for nutrient imbalances. The choice of raw meat in pets' everyday diet should be supported by the veterinarian's medical decision and preferably also with nutritionist help. Growing animals require a specific Ca:P ratio in their diet, which may be improper in raw meat. For cats, taurine levels must be carefully checked. In addition, an imbalanced raw-meat diet can be the cause of poor semen quality in males. Females are prone to inhibition of the estrus cycle, especially due to hyperthyroidism. Exogenous thyroid hormone intake is a real concern when feeding a neck/head meat with thyroid glands. There is also a possibility of bacterial or parasitic presence in raw meat. The present paper aims to summarize the current state of knowledge about the benefits and threats of eating a raw meat diet for the health concerns of companion animals.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"151-159"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virulence properties of Listeria monocytogenes isolated from meat and meat contact surfaces in a slaughterhouse. 从屠宰场的肉类和肉类接触表面分离出的单核细胞增生李斯特菌的毒力特性。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149329
F Tasci, M Sudagidan, O Yavuz, A Soyucok, A Aydin
{"title":"Virulence properties of Listeria monocytogenes isolated from meat and meat contact surfaces in a slaughterhouse.","authors":"F Tasci, M Sudagidan, O Yavuz, A Soyucok, A Aydin","doi":"10.24425/pjvs.2024.149329","DOIUrl":"10.24425/pjvs.2024.149329","url":null,"abstract":"<p><p>Listeria monocytogenes is a ubiquitous microorganism that is isolated from a variety of sources such as soil, water, decaying vegetation, sewage, animal feeds, silage, farm environments and food-processing environments. This study aimed to determine the prevalence, serogroups, biofilm formation, virulence factor genes, and genetic relationships of L. monocytogenes strains isolated from beef meat and meat contact surfaces obtained from a slaughterhouse in Burdur, Turkey. In this study, a total of 179 beef meat and meat contact surface samples were analyzed for the presence of L. monocytogenes by polymerase chain reaction (PCR). Out of a total of 179 beef meat and meat contact surface samples, 83 (46.37%) were found to be contaminated with L. monocytogenes, with the highest incidence (53.01%) occurring in beef meat. In the present study, most of the isolated strains belonged to serogroups IIB and IVB (lineage I). The L. monocytogenes strain also contained monoA-B, prfA, plcA, plcB, mpl, hlyA, actA, gtcA, dltA, Fri, flaA, InlA, InlC, InlJ, and iap genes. Biofilm formation was not determined in the tested samples at pH 5.5 and different temperatures (4°C, 10°C, 25°C, and 37°C). However, strong biofilm formation was observed in 6.45% (2/31) of the strains at pH 7.0 after 48 h incubation at 37°C, and in 3.22% (1/31) of the strains at pH 7.0 after 48 h incubation at 4°C and 10°C. Pulsed-field gel electrophoresis (PFGE) results showed that L. monocytogenes isolates were clonally related, and cross-contamination was present. In addition, PFGE results also revealed that AscI had more distinguishing power than the ApaI restriction enzyme. These results indicate that L. monocytogenes detected from meat and meat contact surfaces in the slaughterhouse pose a potential risk to public health.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"13-23"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of adaptive duration to salinity in drinking water on behavior, weight gain and blood biochemical parameters in growing goats. 饮用水盐度适应期对生长山羊行为、增重和血液生化指标的影响
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149343
T Nguyen, N Nguyen Trong, N Chaiyabutr, S Thammacharoen
{"title":"Effects of adaptive duration to salinity in drinking water on behavior, weight gain and blood biochemical parameters in growing goats.","authors":"T Nguyen, N Nguyen Trong, N Chaiyabutr, S Thammacharoen","doi":"10.24425/pjvs.2024.149343","DOIUrl":"10.24425/pjvs.2024.149343","url":null,"abstract":"<p><p>This experiment aimed to determine the effect of adaptive duration to saline water on behaviors, weight gain and blood biochemical parameters in growing goats. The experiment was arranged in a completely randomized design, which included four treatments with five animals per group. The goats were administered either fresh water (control) or seawater with a salinity of 1.5%, with varying durations of adaptation to seawater. The adaptive durations included an abrupt change (A0) from fresh water to seawater with a salinity of 1.5% or stepwise adaptation either 4 (A4) or 7 (A7) days of increasing saline concentrations. The results showed that dry matter intake in the non-adapted goats (A0 group) was lower than that of the control group or the adapted goats throughout the experiment (p<0.05). In contrast, water intake from drinking saline water was greater than that in the control group (p<0.05). Body weigh did not differ among the treatments; however, non-adapted goats exhibited a lower weight gain than the adapted goats (p<0.05). The goats in the A0 and A4 groups exhibited increased plasma levels of urea, AST, and ALT compared with the control and A7 groups. However, blood electrolyte levels remained unchanged and were within the normal range for goats. Therefore, it is concluded that the stepwise adaptation to seawater with a salinity of 1.5% for 21 days has no influence on productivity and health status of goats.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"127-134"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and preclinical evaluation of equine-derived hyperimmune serum against SARS-CoV-2 infection in K-18 hACE2 transgenic (Tg) mice. 在 K-18 hACE2 转基因 (Tg) 小鼠体内开发抗 SARS-CoV-2 感染的马源性超免疫血清并进行临床前评估。
Polish journal of veterinary sciences Pub Date : 2024-03-20 DOI: 10.24425/pjvs.2024.149336
E A Onen, E K Demirci
{"title":"Development and preclinical evaluation of equine-derived hyperimmune serum against SARS-CoV-2 infection in K-18 hACE2 transgenic (Tg) mice.","authors":"E A Onen, E K Demirci","doi":"10.24425/pjvs.2024.149336","DOIUrl":"10.24425/pjvs.2024.149336","url":null,"abstract":"<p><p>This study aimed to develop an equine-derived hyperimmune serum against SARS-CoV-2 and evaluate its efficacy as a potential immunotherapy tool for the treatment of known and potential variants of COVID-19 in preclinical trials. The novelty of this study is the whole virus and ALUM gel adjuvant formula. The horses were immunized using a whole inactivated SARS-CoV-2 antigen, and the final purified hyperimmune serum showed high plaque reduction neutralization (PRNT 50) neutralizing titers. The efficacy of the hyperimmune serum was evaluated histopathologically and biochemically in the lungs, hearts, and serum of K18 hACE2 transgenic mice (n=45), which is an accepted model organism for SARS-CoV-2 studies and was challenged with live SARS-CoV-2. Serum treatment improved the general condition, resulting in lower levels of proinflammatory cytokines in the blood plasma, as well as reduced viral RNA titers in the lungs and hearts. Additionally, it reduced oxidative stress significantly and lessened the severity of interstitial pneumonia in the lungs when compared to infected positive controls. The study concluded that equine-derived anti-SARS-CoV-2 antibodies could be used for COVID-19 prevention and treatment, especially in the early stages of the disease and in combination with antiviral drugs and vaccines. This treatment will benefit special patient populations such as immunocompromised individuals, as specific antibodies against SARS-CoV-2 can neutralize the virus before it enters host cells. The rapid and cost-effective production of the serum allows for its availability during the acute phase of the disease, making it a critical intervention in preventing the spread of the disease and saving lives in new variants where a vaccine is not yet developed.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"27 1","pages":"61-74"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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