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Post-Y90 PET Dosimetry. 90后PET剂量测定。
PET clinics Pub Date : 2025-05-08 DOI: 10.1016/j.cpet.2025.03.002
Ali Afrasiabi, Johannes L du Pisanie, Bahareh Gholami, Hui Wang, Sandra Gad, Nima Kokabi
{"title":"Post-Y90 PET Dosimetry.","authors":"Ali Afrasiabi, Johannes L du Pisanie, Bahareh Gholami, Hui Wang, Sandra Gad, Nima Kokabi","doi":"10.1016/j.cpet.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.cpet.2025.03.002","url":null,"abstract":"<p><p>Transarterial radioembolization with yttrium-90 is widely used to treat unresectable liver cancer by delivering radiation directly to tumors. While post-treatment imaging generally relies on single-photon emission computed tomography (SPECT) and SPECT/computed tomography (CT), lower signal-to-noise ratio and spatial resolution limit its application. PET/CT and PET/MR imaging have proven to provide more effective image quality, yielding clearer images for accurate dose quantification and correlation with treatment response. PET-based imaging is crucial for refining dose-response and dose-toxicity relationships in personalized dosimetry, although its limited availability challenges its widespread use.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET-based Quantitative Techniques in Assessing Efficacy of Interventional Radiology Procedures in Oncology. 基于pet的定量技术评估肿瘤介入放射治疗的疗效。
PET clinics Pub Date : 2025-05-07 DOI: 10.1016/j.cpet.2025.03.005
Aadil Adnan, Sandip Basu
{"title":"PET-based Quantitative Techniques in Assessing Efficacy of Interventional Radiology Procedures in Oncology.","authors":"Aadil Adnan, Sandip Basu","doi":"10.1016/j.cpet.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.cpet.2025.03.005","url":null,"abstract":"<p><p>Interventional radiology (IR) is a super specialised branch where imaging modalities are employed to guide disease specific diagnostic and therapeutic interventions. IR interventions have gained popularity in various oncological and non-oncological indications due to it's ability to effectively diagnose the disease and direct specific targeted treatment. Hybrid imaging using PET CT and PET MRI combines the best of morphological and functional informations and offers improved sensitivity and specificity for detection of lesion; helps in accurate mapping of tumour burden, thereby aiding in planning curative vs palliative intent intervention; more accurate response evaluation to plan redo session in cases of residual / recurrent disease or for follow up evaluation and for prognostication and predicting response. Albeit visual analysis of PET images by specialist is most commonly performed for reading PET scans, PET has a remarkable capability to provide quantitative information. The present review provides a comprehensive assessment of the role of various aspects of quantitative PET parameters in assessing the efficacy of IR interventions. The insights provided will help clinicians, researchers, and medical professionals understand the role of PET imaging in advancing patient care and enhancing the therapeutic outcomes of IR procedures.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET/CT-guided Tumor Ablation: Technical Insights and Clinical Applications. PET/ ct引导下的肿瘤消融：技术见解和临床应用。
PET clinics Pub Date : 2025-04-28 DOI: 10.1016/j.cpet.2025.03.003
David-Dimitris Chlorogiannis, Constantinos T Sofocleous, Liwei Jiang, Vlasios S Sotirchos
{"title":"PET/CT-guided Tumor Ablation: Technical Insights and Clinical Applications.","authors":"David-Dimitris Chlorogiannis, Constantinos T Sofocleous, Liwei Jiang, Vlasios S Sotirchos","doi":"10.1016/j.cpet.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.cpet.2025.03.003","url":null,"abstract":"<p><p>PET/CT-guided ablation is increasingly being used in interventional oncology, due to its unique ability for precise tumor targeting and real-time intraprocedural evaluation of treatment completeness. This modality is extremely useful for targeting hypermetabolic tumors that may not be conspicuous on anatomic imaging. Intraprocedural postablation PET/CT can detect residual unablated tumor and depict ablation margins, permitting repeat ablation within the same treatment session. Moreover, intraprocedural PET metrics are a predictive biomarker of local tumor progression. This review summarizes the indications, workflow, and outcomes of PET/CT-guided tumor ablations.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of Fibroblast Activation Protein Inhibitor-PET in Interventional Oncology. 成纤维细胞活化蛋白抑制剂pet在介入肿瘤学中的应用。
PET clinics Pub Date : 2025-04-28 DOI: 10.1016/j.cpet.2025.03.004
Yuriko Mori, Emil Novruzov, Frederik L Giesel, Abass Alavi
{"title":"Applications of Fibroblast Activation Protein Inhibitor-PET in Interventional Oncology.","authors":"Yuriko Mori, Emil Novruzov, Frederik L Giesel, Abass Alavi","doi":"10.1016/j.cpet.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.cpet.2025.03.004","url":null,"abstract":"<p><p>Molecular imaging-guided techniques increase precision in surgical procedure and reduce postinterventional morbidity. Fibroblast activation protein (FAP) ligands may contribute to the superior preoperative assessment compared with conventional radionuclides due to its higher sensitivity and tumor delineation in epithelial malignancies. Wide spectrum of currently available FAP ligands including diagnostic and therapeutic emitters allows a flexibility regarding the optimal choice for individual need. Moreover, newly introduced hybrid tracers with fluorescence-based FAP probes enrich this spectrum by providing intraoperative FAP-targeting without radiation exposure. Thus, the use of FAP ligands in interventional oncology has great promise in improving the efficiency of local-interventional surgery.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and Developing Applications of PET in Interventional Radiology. PET在介入放射学中的应用现状及发展趋势。
PET clinics Pub Date : 2025-04-25 DOI: 10.1016/j.cpet.2025.04.005
Charles B Simone, Stephen J Hunt, Abass Alavi, Steven J Feigenberg
{"title":"Current and Developing Applications of PET in Interventional Radiology.","authors":"Charles B Simone, Stephen J Hunt, Abass Alavi, Steven J Feigenberg","doi":"10.1016/j.cpet.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.cpet.2025.04.005","url":null,"abstract":"","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET Imaging and Key Radiotracers for Evaluating Response to Locoregional Therapy in Hepatocellular Carcinoma. PET显像和关键放射示踪剂评价肝癌局部治疗的疗效。
PET clinics Pub Date : 2025-04-25 DOI: 10.1016/j.cpet.2025.03.001
Yubei He, Julian M M Rogasch, Lynn Jeanette Savic
{"title":"PET Imaging and Key Radiotracers for Evaluating Response to Locoregional Therapy in Hepatocellular Carcinoma.","authors":"Yubei He, Julian M M Rogasch, Lynn Jeanette Savic","doi":"10.1016/j.cpet.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.cpet.2025.03.001","url":null,"abstract":"<p><p>Locoregional therapies (LRTs) play a considerable role in the management of hepatocellular carcinoma (HCC), especially for patients who are not suitable for radical resection or transplantation. In clinical practice, assessment of LRTs is mainly based on computed tomography and MR imaging, but functional and metabolic information is less accessible. This article reviews the use of various the standardized uptake value parameters based on PET and multiple radiotracers for managing HCC after treatment with different LRTs, as well as parts of preclinical research. It discusses the current use of PET in more detail, as well as its advantages, disadvantages, and prospects.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine Tumors: Beta Labeled Radiopeptides. 神经内分泌肿瘤：β标记的放射性多肽。
PET clinics Pub Date : 2024-07-01 Epub Date: 2025-04-07 DOI: 10.1016/j.cpet.2024.06.003
Lisa Bodei, Vetri Sudar Jayaprakasam, Bernadette Zhi Ying Wong, Carina Mari Aparici
{"title":"Neuroendocrine Tumors: Beta Labeled Radiopeptides.","authors":"Lisa Bodei, Vetri Sudar Jayaprakasam, Bernadette Zhi Ying Wong, Carina Mari Aparici","doi":"10.1016/j.cpet.2024.06.003","DOIUrl":"10.1016/j.cpet.2024.06.003","url":null,"abstract":"<p><p>Peptide receptor radionuclide therapy (PRRT) consists of administrating a radiolabeled octreotide derivative that targets somatostatin receptors present on the cell membrane of neuroendocrine tumor cells. Although PRRT was initially performed with 90Y-peptides, currently 177Lu-peptides represent the predominant form of treatment. PRRT results in significant tumor and symptomatic control in patients. Like with other available systemic therapies, responses are relatively short-lived. Several new peptides and strategies to improve the efficacy and tolerability of PRRT have been proposed. A critical step is individualizing treatments based on specific dosimetric estimates for the tumor and normal organs, and determining tissue radiosensitivity.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":"e1-e11"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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