PET clinicsPub Date : 2024-07-01Epub Date: 2025-04-07DOI: 10.1016/j.cpet.2024.06.003
Lisa Bodei, Vetri Sudar Jayaprakasam, Bernadette Zhi Ying Wong, Carina Mari Aparici
{"title":"Neuroendocrine Tumors: Beta Labeled Radiopeptides.","authors":"Lisa Bodei, Vetri Sudar Jayaprakasam, Bernadette Zhi Ying Wong, Carina Mari Aparici","doi":"10.1016/j.cpet.2024.06.003","DOIUrl":"10.1016/j.cpet.2024.06.003","url":null,"abstract":"<p><p>Peptide receptor radionuclide therapy (PRRT) consists of administrating a radiolabeled octreotide derivative that targets somatostatin receptors present on the cell membrane of neuroendocrine tumor cells. Although PRRT was initially performed with 90Y-peptides, currently 177Lu-peptides represent the predominant form of treatment. PRRT results in significant tumor and symptomatic control in patients. Like with other available systemic therapies, responses are relatively short-lived. Several new peptides and strategies to improve the efficacy and tolerability of PRRT have been proposed. A critical step is individualizing treatments based on specific dosimetric estimates for the tumor and normal organs, and determining tissue radiosensitivity.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":"e1-e11"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PET clinicsPub Date : 2010-01-01DOI: 10.1016/j.cpet.2009.12.007
William J Powers, Allyson R Zazulia
{"title":"PET in Cerebrovascular Disease.","authors":"William J Powers, Allyson R Zazulia","doi":"10.1016/j.cpet.2009.12.007","DOIUrl":"https://doi.org/10.1016/j.cpet.2009.12.007","url":null,"abstract":"<p><p>Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. Currently, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects. We review normal human cerebral blood flow and metabolism and human PET studies of ischemic stroke, carotid artery disease, vascular dementia, intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage and discuss how these studies have added to our understanding of the pathophysiology of human cerebrovascular disease.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":"5 1","pages":"83106"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}