Neurorehabilitation and neural repair最新文献

筛选
英文 中文
A Blinded, Controlled Randomized Clinical Trial on the Efficacy of Neck Muscle Vibration in Patients with Post-Stroke Spatial Neglect. 颈部肌肉振动治疗脑卒中后空间忽视疗效的盲法、对照、随机临床试验。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-01-26 DOI: 10.1177/15459683251412287
Britta Stammler, Carina Thiel, Anne Lieb, Heike Meißner, Hans-Otto Karnath
{"title":"A Blinded, Controlled Randomized Clinical Trial on the Efficacy of Neck Muscle Vibration in Patients with Post-Stroke Spatial Neglect.","authors":"Britta Stammler, Carina Thiel, Anne Lieb, Heike Meißner, Hans-Otto Karnath","doi":"10.1177/15459683251412287","DOIUrl":"10.1177/15459683251412287","url":null,"abstract":"<p><strong>Background and aim: </strong>Unilateral spatial neglect (UN) impairs patients' ability to detect and respond to stimuli on the contralesional side, severely limiting functional recovery after right-hemispheric stroke. Neck muscle vibration (NMV) has been shown to be a bottom-up, proprioceptive intervention to modulate spatial neglect. Although preliminary studies found promising effects, the isolated efficacy of NMV for neglect rehabilitation has not yet been tested in a randomized, blinded controlled trial. This study aimed to evaluate whether NMV alone improves neglect symptoms and activities of daily living (ADL).</p><p><strong>Methods: </strong>Twenty patients with right-hemispheric stroke and UN were randomly assigned to receive either active or placebo NMV (combined, but not simultaneously with computer-based training) over 2 weeks (5 sessions/week, 20 minutes/day). In the computer training, the placebo NMV group completed neglect-specific modules (standard neglect therapy [SNT], e.g., visual exploration training), while the active NMV group performed only general cognitive tasks unrelated to neglect. This allowed the isolated effect of NMV to be examined. Assessments included standard neglect diagnostics (e.g., Letter Cancellation), the Free Exploration Test (FET), and 2 ADL-based measures (NET, CBS), conducted before, immediately after, and (NMV group only) 1 month post-treatment.</p><p><strong>Results: </strong>The active NMV group showed significant improvements in 3 of 4 standard neglect tests, exploration behavior (FET), and ADL performance, with effects remaining stable at 1-month follow-up. The SNT group with placebo NMV showed comparable gains in ADL outcomes but improved in 1 standard neglect test only. Between-group analyses revealed no statistically significant differences, suggesting similar efficacy of both interventions.</p><p><strong>Conclusion: </strong>NMV alone yields clinically meaningful and lasting improvements in neglect symptoms and ADL, comparable to SNT. Its passive nature makes it a promising tool, particularly for early rehabilitation.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"347-356"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trajectories of Objective Sleep Quality and Their Association With Neurological Functional Recovery After Stroke: A Prospective Longitudinal Study. 客观睡眠质量轨迹及其与脑卒中后神经功能恢复的关系:一项前瞻性纵向研究。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.1177/15459683261416417
Fan-Jiayi Yang, Jia-Ning Wei, Chen-Shuang Li, Chang-Qing Sun, Yan-Jin Liu, Xiao-Fang Dong
{"title":"Trajectories of Objective Sleep Quality and Their Association With Neurological Functional Recovery After Stroke: A Prospective Longitudinal Study.","authors":"Fan-Jiayi Yang, Jia-Ning Wei, Chen-Shuang Li, Chang-Qing Sun, Yan-Jin Liu, Xiao-Fang Dong","doi":"10.1177/15459683261416417","DOIUrl":"10.1177/15459683261416417","url":null,"abstract":"<p><p>ObjectiveTo explore the latent trajectory classes of objective sleep quality in stroke patients and their impact on neurological functional recovery.MethodsA multicenter cluster sampling method was used to recruit 362 stroke patients from the neurology departments of 5 tertiary hospitals in China between November 2023 and July 2024. Baseline data were collected using a general information questionnaire and related scales. Objective sleep data were obtained using ActiGraph GT3X triaxial accelerometers during the acute (T0), recovery (T1), and chronic (T2) phases of stroke. Neurological recovery was assessed at 12 months post-onset (T3) using the modified Rankin Scale. Parallel-process latent class growth modeling was used to identify trajectory classes. Binary logistic regression examined the association between sleep trajectories and neurological recovery.ResultsA total of 306 patients were followed up. Four distinct trajectory classes were identified: Consistently good sleep quality group (34.31%), Short sleep-increased efficiency-improved fragmentation group (49.02%), Long sleep-reduced efficiency-deteriorated fragmentation group (7.84%), and Consistently poor sleep quality group (8.82%). Compared to the consistently good sleep quality group, patients in the Long sleep-reduced efficiency-deteriorated fragmentation group and Consistently poor sleep quality group had 5.728 (95% confidence interval [CI]: 2.124-15.444) and 6.769 (95% CI: 2.580-17.758) times higher risks of poor neurological recovery, respectively.ConclusionStroke patients exhibit heterogeneous sleep quality trajectories, with differential impacts on neurological recovery. Healthcare providers should implement personalized sleep management strategies to optimize both sleep quality and functional outcomes.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"368-378"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Pressure Increases in Spinal Stimulation: Reviewing Autonomic Dysreflexia and the Necessity for its Redefinition. 脊柱刺激血压升高:回顾自主神经反射障碍及其重新定义的必要性。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-02-26 DOI: 10.1177/15459683261417269
Einat Engel-Haber, Ryan Solinsky, Steven Kirshblum, Gail F Forrest
{"title":"Blood Pressure Increases in Spinal Stimulation: Reviewing Autonomic Dysreflexia and the Necessity for its Redefinition.","authors":"Einat Engel-Haber, Ryan Solinsky, Steven Kirshblum, Gail F Forrest","doi":"10.1177/15459683261417269","DOIUrl":"10.1177/15459683261417269","url":null,"abstract":"<p><p>The expanding application of spinal stimulation therapies in spinal cord injury (SCI) rehabilitation necessitates a critical reexamination of cardiovascular (CV) responses to these interventions. A key question arises: How should blood pressure (BP) responses to stimulation be interpreted, and does the conventional definition of autonomic dysreflexia (AD) adequately capture these phenomena? Researchers remain divided-some classify BP elevations during stimulation as AD, while others attribute them to intentional neuromodulation targeting sympathetic preganglionic neurons. This review scrutinizes the various AD definitions in the literature, including the conventional threshold (systolic BP increase >20 mmHg), revealing substantial limitations in research contexts. While symptomatic AD occurs in only 4-7% of stimulation study participants, asymptomatic BP increases are considerably more frequent. This established threshold lacks robust physiological rationale and creates significant interpretive challenges, particularly when evaluating interventions designed to modulate BP responses. The current limitations of guideline-based definitions of AD challenge research interpretation and clinical translation. Although several publications describe AD as \"unregulated\" or \"uncontrolled,\" it has not yet been incorporated into formal guideline definitions. This review underscores the need for a collaborative effort to refine AD definitions in research, particularly in the context of spinal stimulation. Future consensus development should address whether uniform thresholds should apply across different contexts, how to integrate heart rate dynamics and absolute BP values alongside symptomatic status, and how to meaningfully distinguish therapeutic BP modulation from adverse autonomic responses. This is essential for standardizing research approaches, optimizing stimulation parameters, and ensuring efficacy and safety as spinal stimulation technologies advance clinically.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"414-427"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive Balance Deficits Differ in People After Mild Traumatic Brain Injury Based on Chronicity of Self-Reported Symptoms. 基于自述症状的慢性性,轻度创伤性脑损伤后反应性平衡缺陷的差异
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-01-26 DOI: 10.1177/15459683251412303
Cecilia Monoli, Paula K Johnson, Amanda J Morris, Ryan M Pelo, Leland E Dibble, Peter C Fino
{"title":"Reactive Balance Deficits Differ in People After Mild Traumatic Brain Injury Based on Chronicity of Self-Reported Symptoms.","authors":"Cecilia Monoli, Paula K Johnson, Amanda J Morris, Ryan M Pelo, Leland E Dibble, Peter C Fino","doi":"10.1177/15459683251412303","DOIUrl":"10.1177/15459683251412303","url":null,"abstract":"<p><strong>Background: </strong>Mild traumatic brain injury (mTBI) can lead to persistent balance impairments, affecting daily functioning. While mTBI deficits in static and dynamic balance are well-documented, reactive balance-essential for recovering from perturbations-remains understudied, and the relationship with symptom severity and quality of life remains unclear.</p><p><strong>Objective: </strong>Examine reactive balance across different stages of mTBI recovery and its association with self-reported symptoms and quality of life.</p><p><strong>Methods: </strong>This cross-sectional study included 82 participants: 19 with acute (4-14 days post-injury), 11 with sub-acute (3-12 weeks post-injury), 11 with chronic (>12 weeks post-injury) mTBI, and 41 healthy controls. Reactive balance was assessed using the Instrumented-modified Push and Release under both single and cognitive dual-task conditions, measuring time to stability and step latency.</p><p><strong>Results: </strong>Participants with acute mTBI had longer step latencies (<i>P</i> = .004 single-task; <i>P</i> = .016 dual-task) but no differences in time to stability compared to controls, while people with chronic mTBI exhibited longer time to stability (<i>P</i> = .004 single-task; <i>P</i> = .017 dual-task) but no difference in step latencies compared to controls. Dizziness and total symptom severity were moderately associated with single- and dual-task time to stability and dual-task step latency acutely, and with single-task time to stability and dual-task step latency in the sub-acute phase.</p><p><strong>Conclusions: </strong>Reactive balance deficits persist chronically after mTBI and differ between people with acute, sub-acute, and chronic symptoms. These differences suggest people with chronic symptoms may prioritize different aspects of balance control compared to the people in the acute stage of recovery related to functional adaptations to self-reported symptoms.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"357-367"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrality of Pain in Post-Stroke Shoulder Pain: A Case-Control Study. 卒中后肩部疼痛的中心性:一项病例对照研究。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.1177/15459683261416418
Hasan Hüseyin Gökpınar, Büşra Arı, Dilan Bulut Özkaya, İsmail Saraçoğlu
{"title":"Centrality of Pain in Post-Stroke Shoulder Pain: A Case-Control Study.","authors":"Hasan Hüseyin Gökpınar, Büşra Arı, Dilan Bulut Özkaya, İsmail Saraçoğlu","doi":"10.1177/15459683261416418","DOIUrl":"10.1177/15459683261416418","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to examine whether centrality of pain behavior differs between individuals with post-stroke shoulder pain (PSSP) and those with non-hemiplegic chronic shoulder pain.</p><p><strong>Methods: </strong>Participants with a history of cerebrovascular accident (CVA) were assigned to the PSSP group, whereas those without a history of CVA were classified as the non-hemiplegic shoulder pain group. Pain intensity was measured with the numeric pain scale. The Centrality of Pain Scale (COPS) assessed pain centralizing behavior. Shoulder pain and functional status were evaluated using the Shoulder Pain and Disability Index (SPADI).</p><p><strong>Results: </strong>A total of 130 participants were included: 65 individuals with PSSP (mean age = 61.84 ± 11.47) and 65 with non-hemiplegic shoulder pain (mean age = 57.09 ± 11.80). The PSSP group demonstrated significantly higher COPS scores (MD = -3.21; 95% confidence interval [CI] = -5.78 to -0.65; <i>P</i> = .014) and higher SPADI disability (MD = -28.01; 95% CI = -54.77 to -1.24; <i>P</i> = .040) and total scores (MD = -10.09; 95% CI = -16.85 to -3.33; <i>P</i> = .004) compared with the non-hemiplegic shoulder pain group. Pain intensity and duration showed no clinically meaningful differences. COPS further explained 54% of the variance in SPADI pain scores and 51.1% of the variance in SPADI total scores.</p><p><strong>Conclusion: </strong>Individuals with PSSP demonstrated significantly higher pain centralizing behavior despite similar pain intensity and shorter pain duration compared with non-hemiplegic shoulder pain. Moreover, COPS scores explained a meaningful portion of pain and disability, highlighting the role of central mechanisms in PSSP.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"379-386"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment and Rehabilitation of Post-Stroke Visual Field Impairments: Current Approaches and Emerging Technologies. 脑卒中后视野损害的评估和康复:目前的方法和新兴技术。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-04-03 DOI: 10.1177/15459683261416400
Mahmoud Fayed, Benjamin Rheault, Eric D Ragan, Alvaro J Mejia-Vergara, Daniel P Ferris, Teng J Peng
{"title":"Assessment and Rehabilitation of Post-Stroke Visual Field Impairments: Current Approaches and Emerging Technologies.","authors":"Mahmoud Fayed, Benjamin Rheault, Eric D Ragan, Alvaro J Mejia-Vergara, Daniel P Ferris, Teng J Peng","doi":"10.1177/15459683261416400","DOIUrl":"10.1177/15459683261416400","url":null,"abstract":"<p><p>BackgroundVisual field defect following stroke can severely impair activities of daily living, such as visual exploration, reading, and mobility - significantly reducing quality of life. While neuroplasticity enables partial visual recovery in the first few months after stroke, the potential for recovery diminishes over time. Therefore, timely identification and treatment of visual field defects is critical.ObjectiveThis narrative review explores traditional methods and emerging technologies in visual assessment and rehabilitation. We examine traditional visual field screening methods, including static and kinetic perimetry. We also review current approaches to visual field rehabilitation, which include (1) visual substitution therapy, (2) eye movement-based therapy, and (3) visual restitution therapies such as border-field training, blindsight training, and brain stimulation. To address the limitations of current modalities, we explored technologies like wearable virtual reality headsets.ResultsVisual substitution therapies such as prisms expand the perceived visual field but are limited by adherence and side effects. Eye movement-based training improves scanning efficiency and functional performance. Visual restitution approaches, such as border-field and blindsight training, show inconsistent evidence for visual field restoration. Technologies such as virtual reality may offer more accessible and precise approaches to visual field screening and rehabilitation.ConclusionCurrent rehabilitation strategies show variable effectiveness in restoring visual fields. Further studies are needed to evaluate the effectiveness of virtual reality technologies.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"387-403"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pelvic Floor Dysfunction and Rehabilitation in Neurological Disorders: Bridging Pathophysiology With Multidisciplinary Approaches-A Focused Mini-Review. 神经系统疾病的盆底功能障碍和康复:用多学科方法桥接病理生理学-一个集中的小型综述。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-05-01 Epub Date: 2026-02-12 DOI: 10.1177/15459683261416432
Tugba Birben Kurt, Derya Caglar
{"title":"Pelvic Floor Dysfunction and Rehabilitation in Neurological Disorders: Bridging Pathophysiology With Multidisciplinary Approaches-A Focused Mini-Review.","authors":"Tugba Birben Kurt, Derya Caglar","doi":"10.1177/15459683261416432","DOIUrl":"10.1177/15459683261416432","url":null,"abstract":"<p><strong>Background: </strong>Pelvic floor dysfunction (PFD) is a frequent yet underrecognized complication of neurological disorders such as multiple sclerosis (MS), Parkinson's disease (PD), and stroke. Its multifactorial pathophysiology involves complex neural mechanisms affecting bladder, bowel, and sexual function, often resulting in decreased quality of life and psychosocial distress.</p><p><strong>Objective: </strong>This focused mini-review aims to synthesize current evidence on the pathophysiology, clinical features, and rehabilitation approaches for neurogenic PFD in major neurological conditions.</p><p><strong>Methods: </strong>A targeted literature search was performed in PubMed, Scopus, and Web of Science databases to identify clinical and experimental studies published between 1990 and 2025 addressing urinary and PFD in neurological populations. Special attention was given to rehabilitation-based interventions such as pelvic floor muscle training (PFMT), biofeedback, neuromuscular electrical stimulation (NMES), and percutaneous tibial nerve stimulation.</p><p><strong>Findings: </strong>Neurogenic PFD is highly prevalent, with up to 90% of MS patients, 60% of PD patients, and nearly half of stroke survivors experiencing urinary symptoms. Conservative rehabilitation, particularly PFMT combined with biofeedback and NMES, improves muscle function, reduces incontinence frequency, and enhances quality of life. However, standardized rehabilitation protocols are lacking, and adherence remains a major barrier.</p><p><strong>Conclusion: </strong>Evidence supports a multidisciplinary rehabilitation approach integrating PFMT and adjunct modalities for neurogenic PFD. Further large-scale randomized studies are required to establish standardized, evidence-based clinical guidelines.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"404-413"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motor, Cognitive, Psychological, and Neural Predictors of Concern About Falling in Persons With Multiple Sclerosis. 多发性硬化症患者跌倒的运动、认知、心理和神经预测因素。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-04-01 Epub Date: 2026-02-15 DOI: 10.1177/15459683251412284
Taylor N Takla, Patrick G Monaghan, Maryam M Abbawi, Merrill R Landers, Hilary A Marusak, Ana M Daugherty, Nora E Fritz
{"title":"Motor, Cognitive, Psychological, and Neural Predictors of Concern About Falling in Persons With Multiple Sclerosis.","authors":"Taylor N Takla, Patrick G Monaghan, Maryam M Abbawi, Merrill R Landers, Hilary A Marusak, Ana M Daugherty, Nora E Fritz","doi":"10.1177/15459683251412284","DOIUrl":"10.1177/15459683251412284","url":null,"abstract":"<p><p>BackgroundConcern about falling (CAF) is highly prevalent in multiple sclerosis (MS) and is linked to poor motor, cognitive, and psychological functioning. Although CAF has been associated with impairments in these domains, the unique and combined contributions of motor, cognitive, psychological, and neural factors remain unclear. This study used a comprehensive approach to identify behavioral and neural predictors of CAF.MethodsForty-three individuals with MS completed motor, cognitive, and psychological assessments, and underwent a structural magnetic resonance imaging scan. Linear regression models examined domain-specific predictors of CAF, controlling for disease severity. A discriminant function analysis (DFA) evaluated the combined predictive value of all variables in classifying individuals into high versus low CAF groups based on a median split.ResultsCAF was significantly associated with impairments across all behavioral domains (|<i>r</i>| = .32-.78). Regression models explained 57% to 74% of variance in CAF. Greater physical fatigue (β = .46), slower backward walking speed (β = -.41), slower processing speed (β = -.44), impaired task-switching (β = .32), higher anxiety (β = .38), and avoidance behavior (β = .58) predicted greater CAF. Hippocampal and cerebellar volumes were not significant predictors after accounting for disease severity. DFA classified participants with high accuracy (73.9% low CAF; 65.0% high CAF).ConclusionCAF in MS reflects a complex interplay of physical, cognitive, and emotional factors. While structural brain measures were not independently predictive, the combined influence of motor, cognitive, and psychological factors highlight the need for multidomain assessments and treatments to reduce CAF and its negative consequences in MS.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"265-277"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Advancing Rigor and Relevance in Neurorehabilitation: New Article Types at Neurorehabilitation and Neural Repair. 社论:推进神经康复的严谨性和相关性:神经康复和神经修复的新文章类型。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-04-01 Epub Date: 2026-03-13 DOI: 10.1177/15459683261432095
Randolph J Nudo
{"title":"Editorial: Advancing Rigor and Relevance in Neurorehabilitation: New Article Types at <i>Neurorehabilitation and Neural Repair</i>.","authors":"Randolph J Nudo","doi":"10.1177/15459683261432095","DOIUrl":"10.1177/15459683261432095","url":null,"abstract":"","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"263-264"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technology-Assisted Solutions to Enhance Auditory-Motor Synchronization During Walking in Progressive Multiple Sclerosis. 技术辅助解决方案:增强进行性多发性硬化症患者行走时的听觉-运动同步。
IF 3.7
Neurorehabilitation and neural repair Pub Date : 2026-04-01 Epub Date: 2026-02-06 DOI: 10.1177/15459683251412280
Nele Vanbilsen, Peter Feys, Gianluca Florio, Bart Moens, Bart Van Wijmeersch, Daphne Kos, Marc Leman, Lousin Moumdjian
{"title":"Technology-Assisted Solutions to Enhance Auditory-Motor Synchronization During Walking in Progressive Multiple Sclerosis.","authors":"Nele Vanbilsen, Peter Feys, Gianluca Florio, Bart Moens, Bart Van Wijmeersch, Daphne Kos, Marc Leman, Lousin Moumdjian","doi":"10.1177/15459683251412280","DOIUrl":"10.1177/15459683251412280","url":null,"abstract":"<p><p>BackgroundStudies show that beat-based cues from music and metronomes benefit gait in persons with progressive multiple sclerosis (PwPMS) during short walking. While useful for controlled assessment, prolonged walking better reflects real-world function. Adaptive beat-alignment algorithms using biofeedback may enhance synchronization and benefit gait dynamics but their effects in PwPMS remain unknown.AimsTo investigate the effect of walking with and without an adaptive beat-alignment algorithm on synchronization consistency during 8 minutes of walking compared to walking in silence, and its effects on gait. We also examined how clinical factors like dynamic balance and cognition affect synchronization consistency during walking with music and metronomes, with and without adaptive beat alignment.MethodsHealthy controls (HCs) and PwPMS walked for 8 minutes under 5 conditions: silence, music, and metronomes, with or without adaptive beat alignment, at their preferred pace. The algorithm adjusted phase and tempo in real time to restore baseline cadence. We measured synchronization, gait parameters, dynamics, and clinical outcomes.ResultsTwenty-one PwPMS and 18 HCs participated. Adaptive beat-alignment improved synchronization consistency and gait dynamics compared to fixed-tempo walking. Cognitive flexibility and working memory explained 10% of variance in the non-adaptive and 6% in the adaptive conditions, while dynamic balance (40%) impaired synchronization across both algorithms. Auditory cues resulted in slower walking and shorter strides compared to silence.ConclusionThis study demonstrates the feasibility of adaptive beat-alignment strategies enhancing synchronization consistency and gait dynamics in PwPMS; however, cognitive flexibility, working memory, and dynamic balance influenced synchronization performance.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"291-305"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书