Neurologia最新文献

{"title":"Gamification and neurological motor rehabilitation in children and adolescents: a systematic review","authors":"M. Pimentel-Ponce ,&nbsp;R.P. Romero-Galisteo ,&nbsp;R. Palomo-Carrión ,&nbsp;E. Pinero-Pinto ,&nbsp;J. Antonio Merchán-Baeza ,&nbsp;M. Ruiz-Muñoz ,&nbsp;J. Oliver-Pece ,&nbsp;M. González-Sánchez","doi":"10.1016/j.nrleng.2023.12.006","DOIUrl":"10.1016/j.nrleng.2023.12.006","url":null,"abstract":"<div><h3>Introduction</h3><p>Gamification consists of the use of games in non-playful contexts. It is widely employed in the motor rehabilitation of neurological diseases, but mainly in adult patients. The objective of this review was to describe the use of gamification in the rehabilitation of children and adolescents with neuromotor impairment.</p></div><div><h3>Methods</h3><p>We performed a systematic review of clinical trials published to date on the MEDLINE (PubMed), Scielo, SCOPUS, Dialnet, CINAHL, and PEDro databases, following the PRISMA protocol. The methodological quality of the studies identified was assessed using the PEDro scale.</p></div><div><h3>Results</h3><p>From a total of 469 studies, 11 clinical trials met the inclusion criteria. We analysed the gamification systems used as part of the rehabilitation treatment of different neuromotor conditions in children and adolescents. Cerebral palsy was the most frequently studied condition (6 studies), followed by developmental coordination disorder (3), neurological gait disorders (1), and neurological impairment of balance and coordination (1).</p></div><div><h3>Conclusion</h3><p>The use of gamification in rehabilitation is helpful in the conventional treatment of neuromotor disorders in children and adolescents, with increased motivation and therapeutic adherence being the benefits with the greatest consensus among authors. While strength, balance, functional status, and coordination also appear to improve, future research should aim to determine an optimal dosage.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 63-83"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000718/pdfft?md5=9903a16b87f609e73f3473c953ca5490&pid=1-s2.0-S2173580823000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138622264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epileptic and neurodevelopmental encephalopathy associated to SYNGAP1 mutation: Description of a case and treatment response to cannabidiol","authors":"Y. López-Moreno ,&nbsp;P. Cabezudo-García ,&nbsp;N.L. Ciano-Petersen ,&nbsp;G. García-Martín ,&nbsp;P.J. Serrano-Castro","doi":"10.1016/j.nrleng.2023.12.002","DOIUrl":"10.1016/j.nrleng.2023.12.002","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 101-103"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000640/pdfft?md5=ebd82fe25969a11d92da6622ca0ce975&pid=1-s2.0-S2173580823000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronorma Colombia: contributions and methodological characteristics","authors":"A. Espitia ,&nbsp;L. Duarte","doi":"10.1016/j.nrleng.2023.12.001","DOIUrl":"10.1016/j.nrleng.2023.12.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Availability of adequate normative data is essential when performing neuropsychological evaluation; good methodological quality of the studies that propose these data ensures that their conclusions are reliable and valid. We present the methodological characteristics of the Neuronorma Colombia Project in order to analyse its contributions and limitations.</p></div><div><h3>Method</h3><p>We present the characteristics of the normative sample, inclusion and exclusion criteria, statistical analysis, the procedure for obtaining normative data, and the instruments used.</p></div><div><h3>Results</h3><p>We present graphical profiles of patient performance, based on the Neuronorma Work Unit, to illustrate the interpretation of the results obtained when evaluating patients with the Neuronorma Colombia Battery.</p></div><div><h3>Discussion and conclusions</h3><p>Our study presents several methodological advantages, such as its multicentre, co-normalised design and the availability of the Neuronorma Work Unit, which allows the creation of graphical profiles of patient performance, a fundamental tool for diagnosis and research. We present the findings of subsequent research based on the proposed normative data, which demonstrate the value of the battery. The contribution of this study is discussed in the context of its immediate background.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 10-19"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000627/pdfft?md5=8dbff44f37e4cfe478433dbfe8548b8f&pid=1-s2.0-S2173580823000627-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High frequency of endoluminal thrombus in patients with ischaemic stroke following AARS-CoV-2 infection","authors":"P. Gómez-Porro ,&nbsp;B. Cabal-Paz ,&nbsp;S. Valenzuela-Chamorro ,&nbsp;Z. Desanvicente-Celis ,&nbsp;J. Sabin-Muñoz ,&nbsp;C. Ochoa-López ,&nbsp;C. Flórez ,&nbsp;S. Enríquez-Calzada ,&nbsp;R. Martín-García ,&nbsp;Í. Esain-González ,&nbsp;B. García-Fleitas ,&nbsp;L. Silva-Hernández ,&nbsp;Á. Ruiz-Molina ,&nbsp;E. Gamo-González ,&nbsp;A. Durán-Lozano ,&nbsp;R. Velasco-Calvo ,&nbsp;L. Alba-Alcántara ,&nbsp;R. González-Santiago ,&nbsp;A. Callejas-Díaz ,&nbsp;B. Brea-Álvarez ,&nbsp;J. Carneado-Ruiz","doi":"10.1016/j.nrleng.2023.12.008","DOIUrl":"10.1016/j.nrleng.2023.12.008","url":null,"abstract":"<div><h3>Background</h3><p>Ischaemic stroke may be a major complication of SARS-CoV-2 infection. Studying and characterising the different aetiological subtypes, clinical characteristics, and functional outcomes may be valuable in guiding patient selection for optimal management and treatment.</p></div><div><h3>Methods</h3><p>Data were collected retrospectively on consecutive patients with COVID-19 who developed acute focal brain ischaemia (between 1 March and 19 April 2020) at a tertiary university hospital in Madrid (Spain).</p></div><div><h3>Results</h3><p>During the study period, 1594 patients were diagnosed with COVID-19. We found 22 patients with ischaemic stroke (1.38%), 6 of whom did not meet the inclusion criteria. The remaining 16 patients were included in the study (15 cases of ischaemic stroke and one case of transient ischaemic attack).</p><p>Median baseline National Institutes of Health Stroke Scale score was 9 (interquartile range: 16), and mean (standard deviation) age was 73 years (12.8). Twelve patients (75%) were men. Mean time from COVID-19 symptom onset to stroke onset was 13 days. Large vessel occlusion was identified in 12 patients (75%).</p><p>We detected elevated levels of D-dimer in 87.5% of patients and C-reactive protein in 81.2%. The main aetiology was atherothrombotic stroke (9 patients, 56.3%), with the predominant subtype being endoluminal thrombus (5 patients, 31.2%), involving the internal carotid artery in 4 cases and the aortic arch in one. The mortality rate in our series was 44% (7 of 16 patients).</p></div><div><h3>Conclusions</h3><p>In patients with COVID-19, the most frequent stroke aetiology was atherothrombosis, with a high proportion of endoluminal thrombus (31.2% of patients). Our clinical and laboratory data support COVID-19–associated coagulopathy as a relevant pathophysiological mechanism for ischaemic stroke in these patients.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 43-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000755/pdfft?md5=5d5e9b1e66f671a37364d11ebfdd573a&pid=1-s2.0-S2173580823000755-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Flail arm syndrome” with anti-Hu antibodies","authors":"Maria Magdalena Rosselló Vadell,&nbsp;Francesc Miralles","doi":"10.1016/j.nrleng.2023.12.010","DOIUrl":"10.1016/j.nrleng.2023.12.010","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 97-99"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000780/pdfft?md5=21d37408f7544b893f66556f4adb006e&pid=1-s2.0-S2173580823000780-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset sporadic nemaline myopathy presenting as hypercapnic respiratory failure","authors":"D.A. García Estévez ,&nbsp;A. Juanatey-García ,&nbsp;B. San Millán Tejado ,&nbsp;F. Barros Angueira","doi":"10.1016/j.nrleng.2023.01.001","DOIUrl":"10.1016/j.nrleng.2023.01.001","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 99-101"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000639/pdfft?md5=6524e086868b7f4cf2dff5befad4ba67&pid=1-s2.0-S2173580823000639-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk model of seizure cluster or status epilepticus and intervention in the emergency department","authors":"C. Fernández Alonso ,&nbsp;F. González Martínez ,&nbsp;R. Alonso Avilés ,&nbsp;M. Liñán López ,&nbsp;M.E. Fuentes Ferrer ,&nbsp;B. Gros Bañeres ,&nbsp;on behalf of the ACESUR registry","doi":"10.1016/j.nrleng.2021.02.011","DOIUrl":"10.1016/j.nrleng.2021.02.011","url":null,"abstract":"<div><h3>Objectives</h3><p>To identify possible predictors of seizure cluster or status epilepticus (SE) and to evaluate whether these patients receive greater interventions in emergency departments.</p></div><div><h3>Methodology</h3><p>We conducted a secondary analysis of the ACESUR Registry, a multipurpose, observational, prospective, multicentre registry of adult patients with seizures from 18 emergency departments. Clinical and care-related variables were collected. We identified risk factors and risk models for seizure cluster or SE and assessed the effect of interventions by prehospital emergency services and the hospital emergency department.</p></div><div><h3>Results</h3><p>We identified a total of 186 (28%) patients from the ACESUR registry with seizure cluster (126 [19%]) or SE (60 [9%]); the remaining 478 patients (72%) had isolated seizures. The risk model for seizure cluster or SE in the emergency department included Charlson Comorbidity Index scores ≥ 3 (OR: 1.60; 95% CI, 1.05–2.46; <em>P</em> <!-->=<!--> <!-->.030), ≥ 2 habitual antiepileptic drugs (OR: 2.29; 95% CI, 1.49–3.51; <em>P</em> <!-->&lt;<!--> <!-->.001), and focal seizures (OR: 1.56; 95% CI, 1.05–2.32; <em>P</em> <!-->=<!--> <!-->.027). The area under the curve of the model was 0.735 (95% CI, 0.693–0.777; <em>P</em> <!-->=<!--> <!-->.021). Patients with seizure cluster and SE received more aggressive interventions both by prehospital emergency services (OR: 2.89; 95% CI, 1.91–4.36; <em>P</em> <em>&lt;</em> <!-->.001) and at the emergency department (OR: 4.41; 95% CI, 2.69–7.22; <em>P</em> <!-->&lt;<!--> <!-->.001).</p></div><div><h3>Conclusions</h3><p>This risk model may be of prognostic value in identifying adult patients at risk of presenting seizure cluster or SE in the emergency department. In our sample, these patients received more aggressive treatment than adult patients with isolated seizures before arriving at hospital, and even more so in the emergency department.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 20-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000743/pdfft?md5=3c9e19ec1e82c1b225d6a21ba15a41a0&pid=1-s2.0-S2173580823000743-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilingualism and language in children with autistic spectrum disorder: a systematic review","authors":"D. Garrido ,&nbsp;B. López ,&nbsp;G. Carballo","doi":"10.1016/j.nrleng.2023.12.007","DOIUrl":"10.1016/j.nrleng.2023.12.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Communication and language skills are among the most severely affected domains in individuals with autistic spectrum disorder (ASD). When a child diagnosed with ASD lives in a bilingual environment, the parents often express concerns about whether their child should learn both languages simultaneously, turning to specialists for advice. Despite the lack of evidence of any negative effect, some professionals disagree on this subject. In this systematic review we study whether bilingualism affects language development in children with ASD.</p></div><div><h3>Methods</h3><p>We reviewed the literature published in 4 different databases. After applying a series of selection criteria, we selected 12 scientific articles, including a total of 328 children diagnosed with ASD (169 bilingual and 159 monolingual), with ages ranging from 3 to 12 years. These patients were evaluated with different receptive and expressive language assessment instruments covering several areas. The assessments were performed directly on the children, although indirect assessment of parents was also performed in some studies.</p></div><div><h3>Conclusions</h3><p>There seems to be consensus regarding the assertion that bilingualism does not entail any additional difficulty for language development in children with ASD from the age of 3.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 84-96"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217358082300072X/pdfft?md5=23d5b2f81fb006e1657d8fb4004a0391&pid=1-s2.0-S217358082300072X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between psoriasis and dementia: A systematic review","authors":"J. Zhao ,&nbsp;T. Li ,&nbsp;J. Wang","doi":"10.1016/j.nrleng.2023.12.005","DOIUrl":"10.1016/j.nrleng.2023.12.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Risk factors for dementia include genetic factors, aging, environmental factors, certain diseases, and unhealthy lifestyle; most types of dementia share a common chronic systemic inflammatory phenotype. Psoriasis is also considered to be a chronic systemic inflammatory disease. It has been suggested that psoriasis may also contribute to the risk of dementia. The aim of this study was to systematically review the literature on the association between psoriasis and dementia.</p></div><div><h3>Development</h3><p>Articles were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the PubMed and Web of Science databases to identify articles published in peer-reviewed journals and studying the association between psoriasis and dementia. Studies meeting the inclusion criteria were reviewed. We used the Newcastle–Ottawa Scale to assess the quality of each study. After applying the inclusion and exclusion criteria, we included 8 studies for review, 3 of which were found to present a higher risk of bias. Six of the 8 studies supported the hypothesis that prior diagnosis of psoriasis increases the risk of dementia; one study including only a few cases reported that psoriasis decreased the risk of dementia, and one study including relatively young patients found no significant association between psoriasis and the risk of dementia.</p></div><div><h3>Conclusion</h3><p>Most studies included in this review supported the hypothesis that psoriasis constitutes a risk factor for dementia. However, well-designed stratified cohort studies assessing both psoriasis severity and treatment status are still required to determine the real effect of psoriasis on the risk of dementia and its subtypes.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 55-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000706/pdfft?md5=f9cd9a6680407874100e9591cc7ef4fd&pid=1-s2.0-S2173580823000706-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139072463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for respiratory failure among hospitalized patients with Guillain–Barré syndrome","authors":"L.P. Maskin ,&nbsp;M. Wilken ,&nbsp;F. Rodriguez Lucci ,&nbsp;J.P. Wisnivesky ,&nbsp;F. Barroso ,&nbsp;N. Wainsztein","doi":"10.1016/j.nrleng.2023.12.004","DOIUrl":"10.1016/j.nrleng.2023.12.004","url":null,"abstract":"<div><h3>Background</h3><p>Guillain–Barré syndrome (GBS) is an acute inflammatory polyneuropathy that can lead to respiratory failure. In this study, we evaluate early clinical risk factors for respiratory failure at the time of hospital admission.</p></div><div><h3>Methods</h3><p>We studied a retrospective cohort of patients with GBS admitted to a tertiary care center. The potential risk factors studied were sociodemographic characteristics, GBS symptoms, overall and cervical muscle weakness (Medical Research Council [MRC] scores), electromyography findings, and cerebrospinal fluid analysis findings. Unadjusted odds ratios (OR) were calculated and exact logistic regression analysis (adjusted OR) performed to assess the association between baseline risk factors and respiratory failure.</p></div><div><h3>Results</h3><p>Overall, 13 of 113 (12%) patients included in the study developed respiratory failure. Unadjusted analyses showed that involvement of any cranial nerve (OR: 14.7; 95% CI, 1.8–117.1), facial palsy (OR: 17.3; 95% CI, 2.2–138.0), and bulbar weakness (OR: 10.7; 95% CI, 2.3–50.0) were associated with increased risk of respiratory failure. Lower MRC sum scores (for scores &lt;30, OR: 14.0; 95% CI, 1.54–127.2) and neck MRC scores (for scores ≤3, OR: 21.0; 95% CI, 3.5–125.2) were associated with higher likelihood of respiratory failure. Adjusted analyses showed that presence of bulbar weakness (OR: 7.6; 95% CI, 1.3–43.0) and low neck MRC scores (scores ≤3, OR: 9.2; 95% CI, 3.5–125.2, vs scores &gt;3) were independently associated with respiratory failure.</p></div><div><h3>Conclusions</h3><p>Bulbar and neck muscle weakness at admission are clinical predictors of increased risk of respiratory failure in patients with GBS. These findings could guide the adequate management of high-risk patients.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 36-42"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000688/pdfft?md5=b00af410131eb60384263e57049ee15e&pid=1-s2.0-S2173580823000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139072467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}