Neurologia最新文献

{"title":"Memory changes in patients with hippocampal sclerosis submitted to surgery to treat mesial temporal lobe epilepsy","authors":"E. Leal-Conceição ,&nbsp;M. Muxfeldt Bianchin ,&nbsp;W. Vendramini Borelli ,&nbsp;V. Spencer Escobar ,&nbsp;L. Januário de Oliveira ,&nbsp;M. Bernardes Wagner ,&nbsp;A. Palmini ,&nbsp;E. Paglioli ,&nbsp;G. Radaelli ,&nbsp;J. Costa da Costa ,&nbsp;M. Wetters Portuguez","doi":"10.1016/j.nrleng.2021.07.007","DOIUrl":"10.1016/j.nrleng.2021.07.007","url":null,"abstract":"<div><h3>Purpose</h3><p>This study was performed with the purpose of analysing the relationship between epileptological and surgical variables and post-operative memory performance, following surgery for refractory mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS).</p></div><div><h3>Methods</h3><p>Logical memory (LM) and visual memory (VM) scores for immediate and late follow-up of 201 patients operated for MTLE/HS were reviewed. Scores were standardized with a control group of 54 healthy individuals matched for age and education. The Reliable Change Index (RCI) was calculated to verify individual memory changes for late LM and VM scores. A multiple linear regression analysis was carried out with the RCI, using LM and VM scores as well as the clinical variables.</p></div><div><h3>Results</h3><p>A total of 112 (56%) patients had right HS. The RCI of the right HS group demonstrated that 6 (7%) patients showed improvement while 5 (6%) patients showed decreased scores in late LM; for late VM, 7 (8%) patients presented improvement, and 2 (3%) patients showed poorer scores. RCI of the left HS group showed that 3 (3%) individuals showed improved scores, while scores of 5 (4%) patients worsened for late LM; for late VM, 3 (3%) patients presented higher scores and 6 (5%) showed lower scores. Left HS and advanced age at onset of the first epileptic seizure were predictors of late LM loss (<em>p</em> <!-->&lt;<!--> <!-->.05).</p></div><div><h3>Conclusion</h3><p>Left MTLE/HS and seizure onset at advanced ages were predictive factors for the worsening of late LM. We observed poorer baseline LM function in the left HS group and improvement of LM in some patients who had resection of the right MTL. Patients in the right HS group showed a higher percentage of reliable post-operative improvement for both VM and LM scores.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 5","pages":"Pages 399-407"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217358082400052X/pdfft?md5=09b95be9cc7d76ae573018f32d68e285&pid=1-s2.0-S217358082400052X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of destination at discharge after spinal cord injury","authors":"E. Bárbara-Bataller ,&nbsp;J.L. Méndez-Suárez ,&nbsp;C. Alemán-Sánchez ,&nbsp;P. Peñaloza-Polo ,&nbsp;J. Sánchez-Enríquez ,&nbsp;P. Saavedra-Santana","doi":"10.1016/j.nrleng.2021.09.011","DOIUrl":"10.1016/j.nrleng.2021.09.011","url":null,"abstract":"<div><h3>Introduction</h3><p>One of the main goals of the rehabilitation of patients with spinal cord injury (SCI) is the reintegration of the individual to their family, social, and work setting. The objective of this study was to identify the factors that determine the discharge destination after a traumatic spinal cord injury.</p></div><div><h3>Material and methods</h3><p>We conducted a retrospective descriptive study of 305 patients with SCI who completed the rehabilitation treatment at the spinal injury unit of Hospital Insular de Gran Canaria between 2001 and 2018.</p></div><div><h3>Results</h3><p>During the study period, we observed an increase in the number of patients referred to long-term care centres, from 9.14% between 2001 and 2010 to 18.4% between 2011 and 2018 (<em>P</em> &lt; .01). Of 20 variables that presented a significant association with destination at discharge in the univariate study, 7 presented a significant association in the multivariate study: age (OR: 1.05; 95% CI, 1.02–1.08), living with a partner (OR: 0.26; 95% CI, 0.09−0.76), residing on another island (OR: 3.57; 95% CI, 1.32–9.63), smoking (OR: 3.44; 95% CI, 1.26–9.44), diabetes (OR: 6.51; 95% CI, 1.46–29.02), history of psychiatric disorders (OR: 3.79; 95% CI, 1.31–10.93), and scores on the Spinal Cord Independence Measure-III (SCIM-III) (OR: 0.48; 95% CI, 0.33−0.69).</p></div><div><h3>Conclusions</h3><p>Our findings identified advanced age, living on the island of Tenerife, not being married, smoking, type 2 diabetes mellitus, history of psychiatric disorders, and low SCIM-III scores as predictive factors of referral to a long-term care centre in patients with traumatic SCI in the Canary Islands.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 5","pages":"Pages 432-441"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000251/pdfft?md5=fc87f36773a03982b26d2a65f05c85d4&pid=1-s2.0-S2173580823000251-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel multifunctional nanoliposomes inhibit α-synuclein fibrillization, attenuate microglial activation, and silence the expression of SNCA gene","authors":"A. Jebali ,&nbsp;M. Rashidi ,&nbsp;R. Keikha ,&nbsp;K. Daliri ,&nbsp;T.F. Outeiro","doi":"10.1016/j.nrleng.2021.08.003","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.08.003","url":null,"abstract":"<div><h3>Introduction</h3><p>The aim of this study was to compare the effect of five types of PEGlated nanoliposomes (PNLs) on α-synuclein (α-syn) fibrillization, attenuation of microglial activation, and silence of the <em>SNCA</em> gene, which encodes α-syn.</p></div><div><h3>Methods</h3><p>To evaluate the inhibition of α-syn fibrillization, we used standard in vitro assay based on Thioflavin T (ThT) fluorescence. Next, to evaluate the attenuation of microglial activation, the concentration of TNF-a and IL-6 was quantified by ELISA assay in BV2 microglia cells treated with 100<!--> <!-->nM A53T α-syn and PNLs. In order to determine the silencing of the <em>SNCA</em>, real-time PCR and Western blot analysis was used. Finally, the efficacy of PNLs was confirmed in a transgenic mouse model expressing human α-syn.</p></div><div><h3>Results</h3><p>ThT assay showed both PNL1 and PNL2 significantly inhibited a-syn fibrillization. ELISA test also showed the production of TNF-a and IL-6 was significantly attenuated when microglial cells treated with PNL1 or PNL2. We also found that <em>SNCA</em> gene, at both mRNA and protein levels, was significantly silenced when BV2 microglia cells were treated with PNL1 or PNL2. Importantly, the efficacy of PNL1 and PNL2 was finally confirmed in vivo in a transgenic mouse model.</p></div><div><h3>Conclusions</h3><p>In conclusion, the novel multifunctional nanoliposomes tested in our study inhibit α-syn fibrillization, attenuate microglial activation, and silence <em>SNCA</em> gene<em>.</em> Our findings suggest the therapeutic potential of PNL1 and PNL2 for treating synucleinopathies.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 321-328"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580824000348/pdfft?md5=a2231bf81278cf87a92e3b9bf7281d15&pid=1-s2.0-S2173580824000348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra and inter-rater remote assessment of bradykinesia in Parkinson's disease","authors":"L.M.D. Luiz,&nbsp;I.A. Marques,&nbsp;J.P. Folador,&nbsp;A.O. Andrade","doi":"10.1016/j.nrleng.2021.08.006","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.08.006","url":null,"abstract":"<div><h3>Introduction</h3><p>Reliable assessment of individuals with Parkinson's disease (PD) is essential for providing adequate treatment. Clinical assessment is a complex and time-consuming task, especially for bradykinesia, since its evaluation can be influenced by the degree of experience of the examiner, patient collaboration and individual bias. Improvement of the clinical evaluation can be obtained by considering assessments from several professionals. However, this is only true when inter and intra-rater agreement are high. Recently, the Movement Disorder Society highlighted, during the COVID-19 pandemic, the need to develop and validate technologies for remote assessment of the motor status of people with PD. Thus, this study introduces an objective strategy for the remote evaluation of bradykinesia using multi-specialist analysis.</p></div><div><h3>Methods</h3><p>Twelve volunteers with PD participated and these were asked to execute finger tapping, hand opening/closing and pronation/supination movements. Each task was recorded and rated by fourteen PD health experts for each patient. The scores were assessed on an individual basis. Intra and inter-rater agreement and correlation were estimated.</p></div><div><h3>Results</h3><p>The results showed that agreements and correlations between experienced examiners were high with low variability. In addition, group analysis was noted as possessing the potential to solve individual inconsistency bias.</p></div><div><h3>Conclusion</h3><p>Furthermore, this study demonstrated the need for a group with prior training and experience, along with indicating the importance for the development of a clinical protocol that can use telemedicine for the evaluation of individuals with PD, as well as the inclusion of a specialized mediating group. In Addition, this research helps to the development of a valid remote assessment of bradykinesia.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 345-352"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580824000567/pdfft?md5=803ffd7791944c3107ed558ce5ffb08a&pid=1-s2.0-S2173580824000567-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticonvulsant effects of Paeonia daurica subsp. macrophylla root extracts in pentylenetetrazol-induced seizure models in mice","authors":"E. Tahmasebi ,&nbsp;H. Monsef-Esfahani ,&nbsp;M. Vazirian ,&nbsp;P. Sharafi-Badr ,&nbsp;M. Sharifzadeh ,&nbsp;S.N. Sadati Lamardi","doi":"10.1016/j.nrleng.2021.08.004","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.08.004","url":null,"abstract":"<div><h3>Introduction</h3><p>In the present study, anticonvulsant effects of aqueous extract (AE), hydro-alcoholic crude extract (HE), and its fractions (F-CHCl₃, F-EtOAc, F-MeOH) of <em>Paeonia daurica</em> subsp. <em>macrophylla</em> (<em>P. daurica</em> ssp. <em>macrophylla</em>) root examined by using a pentylenetetrazol-induced model (PTZ) on mice.</p></div><div><h3>Methods</h3><p>HE and its fractions as well as AE, in concentrations of (100, 200 and 400<!--> <!-->mg/kg), valproate (Val) (100 and 200<!--> <!-->mg/kg), and saline (negative control) (10<!--> <!-->mg/kg) were injected intraperitoneally (i.p.) 30<!--> <!-->min before PTZ (80<!--> <!-->mg/kg, i.p.). The time taken before the onset of myoclonic convulsions (MC), MC duration, time taken before the onset of generalized tonic-clonic seizures (GTCS), the duration of GTCS, and the percentage of GTCS and mortality protection recorded. The plant's anticonvulsant mechanisms were assessed using flumazenil (5<!--> <!-->mg/kg, i.p.) before AE (100, 200, and 400<!--> <!-->mg/kg, i.p.) injection. GraphPad Prism software was used to compare the differences between various treatment groups with one-way analysis of variance (ANOVA) followed by Tukey–Krammer multiple comparison tests.</p></div><div><h3>Results</h3><p>All the plant samples except F-EtOAc significantly delayed the onset and decreased the duration of PTZ-induced MCS and GTCS, and significantly reduced the GTCS and mortality rate. Pretreatment with flumazenil diminished the significant anticonvulsant effects of AE against PTZ-induced seizures.</p></div><div><h3>Conclusions</h3><p>It can report that extract of <em>P</em>. <em>daurica</em> ssp. <em>macrophylla</em> might be a helpful guide for future studies in the treatment of epilepsy.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 329-339"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217358082400035X/pdfft?md5=3ba45cb7f228c23924ab5ab3a9963386&pid=1-s2.0-S217358082400035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice","authors":"P. Pérez-Torre ,&nbsp;J.L. López-Sendón ,&nbsp;V. Mañanes Barral ,&nbsp;I. Parees ,&nbsp;S. Fanjul-Arbós ,&nbsp;E. Monreal ,&nbsp;A. Alonso-Canovas ,&nbsp;J.C. Martínez Castrillo","doi":"10.1016/j.nrleng.2021.08.005","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.08.005","url":null,"abstract":"<div><h3>Background and purpose</h3><p>The aim of this study was to assess the possible pharmacological interactions between safinamide and antidepressants, and in particular the appearance of serotonin syndrome with data from real life.</p></div><div><h3>Methods</h3><p>We conducted a retrospective observational study of patients with Parkinson's disease from our Movement Disorders Unit, who were under treatment with any antidepressant drug and safinamide. Specifically, symptoms suggestive of serotonin syndrome were screened for. Also, we collected time of simultaneous use, doses of levodopa and other antiparkinsonian drugs.</p></div><div><h3>Results</h3><p>Clinical records were reviewed for the study period of September 2018 to September 2019. Seventy-eight PD patients who were treated with safinamide of which 25 (32.05%) had a concomitant treatment with an antidepressant drug, being sertraline and escitalopram the most frequent. Mean age was 80 years<!--> <!-->±<!--> <!-->8.43 and H&amp;Y stage was 3 [2–4]. Mean dose of levodopa used was 703.75<!--> <!-->mg<!--> <!-->±<!--> <!-->233.15. Median duration of concomitant treatment with safinamide and antidepressant drug was 6 months (IQR 20.5), and over eighteen months in 5 cases. No case of serotonin syndrome was recorded, neither was any of its typical manifestations combined or in isolation.</p></div><div><h3>Conclusions</h3><p>Our real clinical practice study suggests that concomitant use of safinamide with antidepressant drugs in PD patients seemed to be safe and well tolerated, even in the long term. However, caution is warranted, individualizing treatment regimens and monitoring the potential appearance of adverse effects.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 340-344"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580824000361/pdfft?md5=2257d8b81f4fd87afd9a8edc2202ed0c&pid=1-s2.0-S2173580824000361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting resolution of oculomotor nerve palsy following endovascular embolization of posterior communicating artery aneurysms","authors":"C.G. Chen ,&nbsp;J.W. Wang ,&nbsp;J.F. Li ,&nbsp;C.H. Li ,&nbsp;B.L. Gao","doi":"10.1016/j.nrleng.2021.07.006","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.07.006","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the effect of endovascular embolization of posterior communicating artery (Pcom) aneurysms on concomitant oculomotor nerve palsy (OMNP) and factors affecting the effect of treatment.</p></div><div><h3>Materials and methods</h3><p>Patients with the Pcom aneurysms concomitant with OMNP were retrospectively enrolled for endovascular treatment of the aneurysms. All patients had the endovascular management. The clinical effect, degree of OMNP, size of the aneurysm, type of treatment, subarachnoid hemorrhage (SAH), and time from onset to treatment were analyzed on the resolution of OMNP.</p></div><div><h3>Results</h3><p>Ninety-six patients with 99 Pcom aneurysms were enrolled and treated endovascularly, with the success rate of 100%. Immediately after endovascular treatment, 75 aneurysms (75.75%) got complete occlusion, and 24 (24.24%) nearly complete occlusion. Followed up for 3–18 (mean 8.52<!--> <!-->±<!--> <!-->0.56) months, complete resolution of the OMNP was achieved in 63 patients (65.63%), partial resolution in 21 (21.88%), and non-recovery in the other 12 (12.50%). The degree of OMNP at onset, SAH, and time from onset to treatment were significantly (<em>P</em> <!-->&lt;<!--> <!-->0.05) correlated with the resolution of OMNP. Univariate analysis revealed that younger age of the patient, degree of OMNP at onset, presence of subarachnoid hemorrhage, and time from disease onset to treatment were significantly (<em>P</em> <!-->&lt;<!--> <!-->0.05) associated with the recovery of OMNP. Multivariate analysis revealed that the younger age, degree of OMNP at onset, and time from disease onset to treatment were significantly (<em>P</em> <!-->&lt;<!--> <!-->0.05) associated with the recovery of OMNP.</p></div><div><h3>Conclusion</h3><p>Endovascular embolization of Pcom aneurysms concomitant with OMNP can effectively improve the OMNP symptoms, especially for patients with moderate and a shorter history of OMNP. Younger age, degree of oculomotor nerve palsy at onset, and time from onset to treatment may significantly affect recovery of oculomotor nerve palsy.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 315-320"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580824000336/pdfft?md5=95f4e949df4fe0ec9dc625df047b1dd5&pid=1-s2.0-S2173580824000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of long non-coding RNA HAS2-AS1 as a diagnostic and prognostic marker of glioma","authors":"A. You ,&nbsp;J. Gu ,&nbsp;J. Wang ,&nbsp;J. Li ,&nbsp;Y. Zhang ,&nbsp;G. Rao ,&nbsp;X. Ge ,&nbsp;K. Zhang ,&nbsp;X. Gao ,&nbsp;D. Wang","doi":"10.1016/j.nrleng.2021.06.008","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.06.008","url":null,"abstract":"<div><h3>Background</h3><p>Glioma presents high incidence and poor prognosis, and therefore more effective treatments are needed. Studies have confirmed that long non-coding RNAs (lncRNAs) basically regulate various human diseases including glioma. It has been theorized that HAS2-AS1 serves as an lncRNA to exert an oncogenic role in varying cancers. This study aimed to assess the value of lncRNA HAS2-AS1 as a diagnostic and prognostic marker for glioma.</p></div><div><h3>Methods</h3><p>The miRNA expression data and clinical data of glioma were downloaded from the TCGA database for differential analysis and survival analysis. In addition, pathological specimens and specimens of adjacent normal tissue from 80 patients with glioma were used to observe the expression of HAS2-AS1. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic ability and prognostic value of HAS2-AS1 in glioma. Meanwhile, a Kaplan–Meier survival curve was plotted to evaluate the survival of glioma patients with different HAS2-AS1 expression levels.</p></div><div><h3>Results</h3><p>HAS2-AS1 was significantly upregulated in glioma tissues compared with normal tissue. The survival curves showed that overexpression of HAS2-AS1 was associated with poor overall survival (OS) and progression-free survival (PFS). Several clinicopathological factors of glioma patients, including tumor size and WHO grade, were significantly correlated with HAS2-AS1 expression in tissues. The ROC curve showed an area under the curve (AUC) value of 0.863, indicating that HAS2-AS1 had good diagnostic value. The ROC curve for the predicted OS showed an AUC of 0.906, while the ROC curve for predicted PFS showed an AUC of 0.88. Both suggested that overexpression of HAS2-AS1 was associated with poor prognosis.</p></div><div><h3>Conclusions</h3><p>Normal tissues could be clearly distinguished from glioma tissues based on HAS2-AS1 expression. Moreover, overexpression of HAS2-AS1 indicated poor prognosis in glioma patients. Therefore, HAS2-AS1 could be used as a diagnostic and prognostic marker for glioma.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 353-360"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580824000580/pdfft?md5=ea765987229063810b4a91cda81888ae&pid=1-s2.0-S2173580824000580-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic predisposition of BDNF (rs6265) gene is susceptible to Schizophrenia: A prospective study and updated meta-analysis","authors":"M. Vajagathali,&nbsp;V. Ramakrishnan","doi":"10.1016/j.nrleng.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.nrleng.2024.03.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Genetic polymorphism in the <em>BDNF</em> gene has been found to cause neuronal alterations and has been identified as a causal factor for many neuropsychiatric disorders. Therefore, various neurological case–control studies and meta-analyses have been conducted to find the possible link between <em>BDNF</em> and susceptibility to schizophrenia.</p></div><div><h3>Method</h3><p>This meta-analysis gathered data from 25 case–control studies including a total of 8384 patients with schizophrenia and 8821 controls in order to identify the relationship between the rs6265 single nucleotide polymorphism and the disease, evaluating the combined odds ratio and 95% confidence intervals under 5 different genetic models. Validation followed the “Leave one out” method, and we used the Egger test and Begg's funnel plot to identify publication bias.</p></div><div><h3>Results</h3><p>Research into the rs6265 (G/A) polymorphism revealed a non-significant association with schizophrenia in all 5 genetic models; in the subgroup analysis, no association was found between white and Asian populations, with a <em>p</em> value<!--> <!-->&gt;<!--> <!-->.05.</p></div><div><h3>Conclusions</h3><p>Overall, the updated meta-analysis revealed that rs6265 exonic polymorphisms do not increase susceptibility to this disease. However, to better understand the pathogenesis of the disease, there is a need for further case–control studies into the <em>BDNF</em> polymorphism including larger sample sizes and different ethnic groups.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 4","pages":"Pages 361-371"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217358082400049X/pdfft?md5=2cf6c1ac13b0b0707d2c11dee02f25ea&pid=1-s2.0-S217358082400049X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between inflammation and oxidative stress and its effect on multiple sclerosis","authors":"E.J. Ramos-González ,&nbsp;O.K. Bitzer-Quintero ,&nbsp;G. Ortiz ,&nbsp;J.J. Hernández-Cruz ,&nbsp;L.J. Ramírez-Jirano","doi":"10.1016/j.nrleng.2021.10.010","DOIUrl":"https://doi.org/10.1016/j.nrleng.2021.10.010","url":null,"abstract":"<div><h3>Introduction</h3><p>This paper highlights the relationship of inflammation and oxidative stress as damage mechanisms of Multiple Sclerosis (MS), considered an inflammatory and autoimmune disease.</p></div><div><h3>Development</h3><p>The oxidative stress concept has been defined by an imbalance between oxidants and antioxidants in favor of the oxidants. There is necessary to do physiological functions, like the respiration chain, but in certain conditions, the production of reactive species overpassed the antioxidant systems, which could cause tissue damage. On the other hand, it is well established that inflammation is a complex reaction in the vascularized connective tissue in response to diverse stimuli. However, an unregulated prolonged inflammatory process also can induce tissue damage.</p></div><div><h3>Conclusion</h3><p>Both inflammation and oxidative stress are interrelated since one could promote the other, leading to a toxic feedback system, which contributes to the inflammatory and demyelination process in MS.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"39 3","pages":"Pages 292-301"},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580824000324/pdfft?md5=81676caa9915196572f9fb21c478d335&pid=1-s2.0-S2173580824000324-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}