Neurologia最新文献

{"title":"Aseptic lymphocytic meningitis and intracranial hypertension in a probable context of consumption of “tusi” or “pink cocaine”","authors":"A. Cartanyà-Gutiérrez, Á. Domenech-Cubí, A. Conde-Martín, M. Vicente-Pascual","doi":"10.1016/j.nrleng.2026.501946","DOIUrl":"10.1016/j.nrleng.2026.501946","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 501946"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two consecutive double-blind phases for two-period disease-modifying therapy trials: A personal viewpoint methodological proposal","authors":"D. Santos-García, Á. Solleiro, T.M. Figueiras Vázquez","doi":"10.1016/j.nrleng.2026.502010","DOIUrl":"10.1016/j.nrleng.2026.502010","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502010"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic and cultural adaptation of the Barcelona-2 Test in 6 Latin American dialect variants","authors":"J. Peña-Casanova,&nbsp;F. Diéguez-Vide,&nbsp;M. Jaén,&nbsp;L. Vinaixa,&nbsp;J. Cortaberría,&nbsp;T. Villaseñor,&nbsp;Y. Castro,&nbsp;L. García,&nbsp;C. Castillo,&nbsp;C. Dechent,&nbsp;A.V. Ferreira,&nbsp;E. Torrealba,&nbsp;N. Ocampo,&nbsp;A. Rocchini,&nbsp;L. Arévalo,&nbsp;Y. Godoy,&nbsp;A. Silva,&nbsp;the Latin American Barcelona Test Group","doi":"10.1016/j.nrleng.2026.502037","DOIUrl":"10.1016/j.nrleng.2026.502037","url":null,"abstract":"<div><h3>Introduction</h3><div>Neuropsychological tests must be adapted to local sociocultural realities. The Barcelona-2 test (TB-2) is a tool used in Spain and Hispanic America to perform a general neuropsychological assessment. The objective of this study was to develop versions of the TB-2 for 6 major dialects of Spanish-speaking Latin American countries, taking into account cross-cultural and cross-linguistic factors.</div></div><div><h3>Method</h3><div>Working documents consisting of sheets with 3 columns were established: original version, proposals for changes and justification of the proposals. The phonetic-prosodic aspect of the evaluation, which was controlled by local evaluators, was excluded. The documents were completed by at least two researchers for each dialect and subsequently agreed upon. The proposals were compared with the meanings of the Royal Spanish Academy and the Dictionary of Americanisms of the Association of Academies of the Spanish Language. The final versions were the subject of 6 acceptability studies.</div></div><div><h3>Results</h3><div>Versions have been established for 19 countries with 47 working documents for the Mexican, Caribbean, Central American, Andean, Austral, and Chilean TB-2 dialect varieties.</div></div><div><h3>Conclusions</h3><div>For the first time a neuropsychological test, initially developed in Catalan and Spanish, is simultaneously adapted to the 6 major Hispanic American dialects. These versions will avoid local interpretations and improvisations when administering the test in any Spanish-speaking territory. Administration to broad populations without and with cognitive impairment should allow for completing or modifying some of the changes and, perhaps, adjusting the score ranges.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502037"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative care in stroke: Guidelines of the Spanish Society of Neurology’s Stroke Study Group","authors":"Á. Ximénez-Carrillo,&nbsp;J.C. López Fernández,&nbsp;M. Alonso de Leciñana,&nbsp;E. López-Cancio Martinez,&nbsp;F. Moniche,&nbsp;M. Rubiera,&nbsp;O. Ayo,&nbsp;M. Castellanos,&nbsp;J. Marta-Moreno,&nbsp;A.M. Morales,&nbsp;A. Ponz,&nbsp;J.M. Ramírez-Moreno,&nbsp;S. Tur,&nbsp;M. Freijo Guerrero","doi":"10.1016/j.nrleng.2026.502035","DOIUrl":"10.1016/j.nrleng.2026.502035","url":null,"abstract":"<div><div>These guidelines address the relief of suffering and the optimal management of patients with stroke at the end of life. Their main purpose is to contribute to the development of skills in communication, setting goals of care, and decision-making. Furthermore, they focus on symptom management and specific care in patients with severe stroke.</div><div>The recommendations are based on a systematic review of the literature and international guidelines on the subject. The levels of evidence and grade of recommendation are based on those established in the 2016 classification of the American College of Cardiology and the American Heart Association Task Force.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502035"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid regression of myeloradicular compression following anti-BCMA CAR-T therapy in refractory multiple myeloma","authors":"C. Pérez-Prol,&nbsp;D. Aquerreta,&nbsp;P. Rodríguez-Otero,&nbsp;J.Gállego Pérez-Larraya","doi":"10.1016/j.nrleng.2026.502012","DOIUrl":"10.1016/j.nrleng.2026.502012","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502012"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semiological value of rhythmic ictal non-clonic hand (RINCH) motions in epileptic seizures","authors":"M. Garcés-Pellejero,&nbsp;S. López-Maza,&nbsp;I. Pérez Vizuete,&nbsp;M. Quintana,&nbsp;D. Campos-Fernández,&nbsp;L. Abraira,&nbsp;E. Santamarina Pérez,&nbsp;I. Casado-Naranjo,&nbsp;M. Toledo,&nbsp;E. Fonseca","doi":"10.1016/j.nrleng.2026.502031","DOIUrl":"10.1016/j.nrleng.2026.502031","url":null,"abstract":"<div><h3>Objective</h3><div>To study the semiological significance of rhythmic ictal non-clonic hand (RINCH) motions in epileptic seizures, as observed in prolonged video-EEG monitoring (VEM).</div></div><div><h3>Material and methods</h3><div>Retrospective observational study of patients with epilepsy admitted for prolonged VEM between 2020 and 2024, who exhibited RINCH motions during recorded seizures. Electroclinical data were collected and analysed, focusing on the duration and associated semiology of RINCH motions.</div></div><div><h3>Results</h3><div>Among 379 patients admitted for VEM, RINCH motions were observed in 12 (66.6% male, mean age [standard deviation], 44.7 [11.3] years). All patients were right-handed. Seizure onset occurred in the temporal lobe in 10 cases (83.3%) and left hemisphere in 11 (91.6%). Aetiology was structural in 9 patients (75%), unknown in 2 (6,7%), and autoimmune in 1 (8.3%).</div><div>All seizures were associated with impaired awareness and automatisms. Ictal or postictal language impairment were observed in 9 patients (75%). Only one case progressed to bilateral tonic-clonic seizure. RINCH motions involved the right hand in all seizures, and in one case spread to the contralateral hand. These movements appeared within a median of 25 seconds (Q₁–Q₃, 12–90) after clinical onset, with a median duration of 19 seconds (Q₁–Q₃, 11−48). EEG onset occurred after clinical onset in 7 cases (58.3%), and was consistently observed over the left anterior temporal region, except for one case with a parietal origin.</div></div><div><h3>Conclusion</h3><div>RINCH motions represent an uncommon but distinctive manifestation of epileptic seizures, often accompanied by impaired awareness, automatisms and aphasia. These movements typically occur in the hand contralateral to the seizure onset zone. The most frequent seizure onset localisation is the left temporal lobe (dominant) in right-handed patients.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502031"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating an opportunity in status epilepticus management through EEG monitoring and the use of ketamine. A case report","authors":"Á. Juiz Fernández,&nbsp;X. Rodríguez Osorio,&nbsp;F.J. López González,&nbsp;P. Cacabelos Pérez","doi":"10.1016/j.nrleng.2026.501951","DOIUrl":"10.1016/j.nrleng.2026.501951","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 501951"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cenobamate: a new drug that may change the concept of drug-resistant focal epilepsy","authors":"J.J. Poza","doi":"10.1016/j.nrleng.2026.502033","DOIUrl":"10.1016/j.nrleng.2026.502033","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the constant approval of new antiseizure medications in recent years, the percentage of patients whose epilepsy is not fully controlled remains stable, at approximately 30%-40% of cases. This is because the newly approved drugs, despite providing benefits in terms of tolerability, ease of use, and reduction of pharmacokinetic interactions, have not achieved greater efficacy against seizures than previous drugs.</div></div><div><h3>Development</h3><div>Cenobamate has changed this scenario. Both in clinical trials and clinical practice series, it has achieved hitherto unseen seizure freedom rates in patients showing no response to 2 or more drugs. Its tolerability is similar to that of its predecessors. The most frequently reported adverse reactions include somnolence, dizziness, headache, fatigue, and diplopia. In general, they were mild or moderate in intensity, with a tendency to decrease with time. To avoid these as far as is possible, proper management of polymedication is important, especially in patients with a high pharmacological burden when cenobamate is introduced. Given its action mechanism, the most relevant pharmacodynamic interactions will involve other voltage-dependent sodium channels and benzodiazepines, especially clobazam.</div></div><div><h3>Conclusion</h3><div>Considering the response rates obtained, cenobamate may change the concept of drug-resistant epilepsy. Failure of any 2 drugs will no longer be sufficient to define this condition; rather, it will require failure of the most efficacious drug.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502033"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese identical twins with cerebrotendinous xanthomatosis: A family report and literature review","authors":"Y. Niu,&nbsp;S. Zhao,&nbsp;Y. Wang,&nbsp;Y. Zhang,&nbsp;Q. Weng","doi":"10.1016/j.nrleng.2026.501941","DOIUrl":"10.1016/j.nrleng.2026.501941","url":null,"abstract":"<div><div>Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of cholesterol metabolism, characterised by childhood-onset diarrhoea, juvenile cataracts, tendon xanthomas, and progressive neuropsychiatric symptoms. CTX is caused by mutations in the sterol 27-hydroxylase gene (<em>CYP27A1</em>) and sterol 27-hydroxylase deficiency. CTX is particularly rare in the Chinese population; to the best of our knowledge, this is the first report of identical twins with CTX in China. The present study also includes a review of the literature on the clinical presentation, imaging findings, and genetic results in identical twins and triplets with CTX. Our twin patients carried a homozygous transition mutation in intron 7 and displayed clinical manifestations of atypical parkinsonism and cognitive impairment; furthermore, they exhibited different phenotypes, which may be attributed to lifestyle differences. Early diagnosis and treatment are crucial to the prognosis of CTX, and genetic testing should be conducted to confirm the diagnosis.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 501941"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic opsoclonus–myoclonus ataxia syndrome associated with breast carcinoma: Report of two cases with distinct clinical and immunological profiles","authors":"Ş. Benli,&nbsp;F. Dal,&nbsp;E.M. Sözüer,&nbsp;F.F. Erdoğan","doi":"10.1016/j.nrleng.2026.502011","DOIUrl":"10.1016/j.nrleng.2026.502011","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"41 7","pages":"Article 502011"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}